{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T06:15:28Z","timestamp":1783577728887,"version":"3.55.0"},"reference-count":47,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T00:00:00Z","timestamp":1783555200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100004319","name":"Pfizer","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004319","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Public Health"],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Community-acquired pneumonia (CAP) in adults represents a significant burden on the healthcare system in M\u00e9xico, particularly among high-risk groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and methods<\/jats:title>\n                    <jats:p>\n                      Adults hospitalized with chest X-ray-confirmed CAP (2018\u20132021) were prospectively enrolled across four cities in M\u00e9xico (Mexico City, Durango, M\u00e9rida, and Tijuana). Urine samples were screened for\n                      <jats:italic>Streptococcus pneumoniae<\/jats:italic>\n                      (\n                      <jats:italic>S. pneumoniae<\/jats:italic>\n                      ) using the BinaxNOW\n                      <jats:sup>\u00ae<\/jats:sup>\n                      test and serotype-specific urine antigen detection (ssUAD) assays targeting 24 serotypes, and blood was obtained for pneumococcal culture.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Of the 1,275 patients screened for CAP, 389 had clinically or radiologically confirmed CAP (65.3% male; median age, 60\u202fyears; 39.3% aged \u226565\u202fyears). Pneumococcal CAP (pCAP) was identified in 12.1% of patients (47\/389; 95% CI: 9.01\u201315.74). Based on CRB-65 scores, pCAP was more frequent among high-risk CAP patients (25.5%, 12\/47) than among low- or moderate-risk CAP patients (10.2%, 35\/342). Nevertheless, the 30-day mortality rate was 34.0% among pCAP patients versus 29.5% among\n                      <jats:italic>S. pneumoniae<\/jats:italic>\n                      -negative CAP patients. The most prevalent serotypes were 3 (13.0%), 6A (8.7%), and 19A (8.7%), and PCV20 would have covered 54.3% (25\/46) of pCAP serotypes identified in this study.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>During the study period, CAP was associated with a substantial mortality burden among hospitalized adult patients in M\u00e9xico, with pCAP more frequent among high-risk patients. These findings underscore the needs for enhanced diagnostic approaches and risk group-targeted adult pneumococcal vaccination programs.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fpubh.2026.1803418","type":"journal-article","created":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T05:34:24Z","timestamp":1783575264000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Pneumococcal community-acquired pneumonia in hospitalized adults in M\u00e9xico 2018\u20132021: serotype distribution and clinical characteristics"],"prefix":"10.3389","volume":"14","author":[{"given":"Juan Carlos","family":"Tinoco","sequence":"first","affiliation":[{"name":"Hospital General, Servicios de Salud del Estado de Durango","place":["Durango, Mexico"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marivel","family":"Guereca","sequence":"additional","affiliation":[{"name":"Hospital General, Servicios de Salud del Estado de Durango","place":["Durango, Mexico"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Onwumeh-Okwundu","sequence":"additional","affiliation":[{"name":"RWE Epidemiology & Operations, Chief Medical Office, Pfizer","place":["Collegeville, PA, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yolanda","family":"Martinez-Lopez","sequence":"additional","affiliation":[{"name":"Instituto de Investigaci\u00f3n Cientifica, Universidad Juarez del Estado de Durango","place":["Durango, Mexico"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia","family":"Rodr\u00edguez-Zulueta","sequence":"additional","affiliation":[{"name":"Hospital General Dr. Manuel Gea Gonzalez","place":["Mexico City, Mexico"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ver\u00f3nica","family":"Aquino-Cruz","sequence":"additional","affiliation":[{"name":"Hospital General Dr. Manuel Gea Gonzalez","place":["Mexico City, Mexico"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mussaret B","family":"Zaidi","sequence":"additional","affiliation":[{"name":"Hospital General O'Horan","place":["Merida, Yucatan, Mexico"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel","family":"Navarro-Alvarez","sequence":"additional","affiliation":[{"name":"Hospital General de Tijuana","place":["Tijuana, Mexico"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Derek","family":"Daigle","sequence":"additional","affiliation":[{"name":"US Medical Affairs, Vaccines and Antivirals, Pfizer","place":["New York City, NY, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad","family":"Ali","sequence":"additional","affiliation":[{"name":"Pfizer","place":["Collegeville, New York City, New 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