{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T06:10:02Z","timestamp":1784182202636,"version":"3.55.0"},"reference-count":50,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T00:00:00Z","timestamp":1784160000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Public Health"],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Diminished ovarian reserve (DOR) is a condition that severely impacts female fertility, and there are currently no effective treatment strategies for DOR. Moxibustion may offer a non-invasive, low-risk intervention. This study aims to assess the clinical efficacy of moxibustion in improving ovarian reserve in women with DOR and to explore its underlying central neural mechanisms using resting-state functional magnetic resonance imaging.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This prospective, single-center, parallel-group randomized controlled trial will be conducted at the Hubei Provincial Hospital of Traditional Chinese Medicine. Participants diagnosed with DOR will be randomly assigned in a 1:1 ratio to either an intervention group or a control group. They will both receive a lifestyle intervention. In addition, the intervention group will receive 16-week Yin-Yang Regulating Moxibustion. The primary outcome include changes in antral follicle count. Secondary outcomes include serum levels of anti-M\u00fcllerian hormone, follicle-stimulating hormone, and luteinizing hormonechanges in menopausal symptoms, anxiety, depression, and quality of life. Rs-fMRI will be used to investigate the brain\u2019s central neural mechanisms.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>The results of this study will provide new insights into the adjunctive treatment of DOR and elucidate its potential mechanisms through neuroimaging.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Clinical trial registration<\/jats:title>\n                    <jats:p>\n                      <jats:ext-link>https:\/\/itmctr.ccebtcm.org.cn\/<\/jats:ext-link>\n                      , identifier ITMCTR2025001808\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fpubh.2026.1805995","type":"journal-article","created":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T05:39:38Z","timestamp":1784180378000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Clinical efficacy and mechanism exploration of Moxibustion for diminished ovarian reserve: a randomized controlled trial protocol"],"prefix":"10.3389","volume":"14","author":[{"given":"Yumeng","family":"He","sequence":"first","affiliation":[{"name":"College of Acupuncture and Orthopedics, Hubei University of Chinese Medicine","place":["Wuhan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun","family":"Duan","sequence":"additional","affiliation":[{"name":"Department of Ultrasound, Hubei Provincial Hospital of Traditional Chinese Medicine","place":["Wuhan, China"]},{"name":"Department of Ultrasound, Affiliated Hospital of Hubei University of Chinese 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Moxibustion Center, Affiliated Hospital of Hubei University of Chinese Medicine","place":["Wuhan, China"]},{"name":"Hubei Shizhen Laboratory","place":["Wuhan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiqing","family":"Kong","sequence":"additional","affiliation":[{"name":"College of Acupuncture and Orthopedics, Hubei University of Chinese Medicine","place":["Wuhan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kun","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Rehabilitation, Taihe Hospital","place":["Shiyan, China"]},{"name":"Department of Orthopedic Rehabilitation, Affiliated Hospital of Hubei University of Medicine","place":["Shiyan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Wuhan Hospital of Traditional Chinese and Western Medicine","place":["Wuhan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Hu","sequence":"additional","affiliation":[{"name":"Acupuncture and Moxibustion Center, Hubei Provincial Hospital of Traditional Chinese Medicine","place":["Wuhan, China"]},{"name":"Hubei Provincial Clinical Research Center for Acupuncture and Moxibustion in Obesity Treatment","place":["Wuhan, China"]},{"name":"Acupuncture and Moxibustion Center, Affiliated Hospital of Hubei University of Chinese Medicine","place":["Wuhan, China"]},{"name":"Hubei Shizhen Laboratory","place":["Wuhan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengwei","family":"Fu","sequence":"additional","affiliation":[{"name":"Acupuncture and Moxibustion Center, Hubei Provincial Hospital of Traditional Chinese Medicine","place":["Wuhan, China"]},{"name":"Hubei Provincial Clinical Research Center for Acupuncture and Moxibustion in Obesity Treatment","place":["Wuhan, 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