{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T05:39:16Z","timestamp":1777354756285,"version":"3.51.4"},"reference-count":53,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T00:00:00Z","timestamp":1777334400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Public Health"],"abstract":"<jats:p>\n                    To examine whether psychological symptoms influence relapse propensity among individuals with drug dependence through the dopamine (DA) system, after controlling for confounders such as age. Ninety Women Individuals in Compulsory Drug Rehabilitation, aged 18\u201360\u202fyears, were enrolled. Key measures included psychological status [assessed via the Montreal Cognitive Assessment (MoCA), Self-rating Depression Scale (SDS), Symptom Checklist-90 (SCL-90), and Pittsburgh Sleep Quality Index (PSQI)]; physiological indicators [blood concentrations of serotonin (5-HT), interleukin-6 (IL-6), gamma-aminobutyric acid (GABA), and dopamine (DA)]; and socio-demographic and drug-use characteristics (age, education, marital status, years of drug use, etc.). Relapse propensity was quantified using a Relapse Propensity Scale score. Data analysis included Pearson correlation, stepwise multiple linear regression, and mediation analysis using the bootstrap method (PROCESS Model 4). Bivariate analysis revealed that relapse propensity was significantly correlated with age (\n                    <jats:italic>r<\/jats:italic>\n                    \u202f=\u202f0.322,\n                    <jats:italic>p<\/jats:italic>\n                    \u202f&amp;lt;\u202f0.01), SCL-90 GSI (\n                    <jats:italic>r<\/jats:italic>\n                    \u202f=\u202f0.261,\n                    <jats:italic>p<\/jats:italic>\n                    \u202f&amp;lt;\u202f0.05), and DA concentration (\n                    <jats:italic>r<\/jats:italic>\n                    \u202f=\u202f0.341,\n                    <jats:italic>p<\/jats:italic>\n                    \u202f&amp;lt;\u202f0.01). Stepwise regression identified DA concentration (\n                    <jats:italic>\u03b2<\/jats:italic>\n                    \u202f=\u202f0.321,\n                    <jats:italic>p<\/jats:italic>\n                    \u202f=\u202f0.001) and age (\n                    <jats:italic>\u03b2<\/jats:italic>\n                    \u202f=\u202f0.301,\n                    <jats:italic>p<\/jats:italic>\n                    \u202f=\u202f0.002) as the only significant independent predictors, jointly accounting for 18.8% of the variance in relapse propensity (adjusted R\n                    <jats:sup>2<\/jats:sup>\n                    \u202f=\u202f0.188). Crucially, mediation analysis confirmed a significant indirect effect of SCL-90 on relapse propensity through DA (indirect effect\u202f=\u202f0.018, 95% CI [0.005, 0.035]). The direct effect was non-significant (\n                    <jats:italic>p<\/jats:italic>\n                    \u202f=\u202f0.170), indicating full mediation. The mediated effect accounted for 35.6% of the total effect. This study indicates that psychological symptoms indirectly increase relapse propensity in Compulsory Drug Rehabilitation by elevating DA concentration. DA fully mediates the relationship between psychological symptoms and relapse propensity. Age independently predicts relapse propensity but does not act through the DA system. These findings support an integrated \u201cpsychological\u2013neurobiological\u201d intervention approach. In clinical practice, relapse prevention strategies should combine psychological symptom management with DA system modulation, alongside age-tailored interventions.\n                  <\/jats:p>","DOI":"10.3389\/fpubh.2026.1816411","type":"journal-article","created":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T04:45:59Z","timestamp":1777351559000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Dopamine system as a mediator between psychological symptoms and relapse tendency: a cross-sectional study in women undergoing compulsory rehabilitation in Zhengzhou, China"],"prefix":"10.3389","volume":"14","author":[{"given":"Chunxia","family":"Jin","sequence":"first","affiliation":[{"name":"College of Health Promotion, Gdansk University of Physical Education and Sport","place":["Gdansk, Poland"]},{"name":"Huanghe Science and Technology University","place":["Zhengzhou, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuxia","family":"Chen","sequence":"additional","affiliation":[{"name":"Henan Sports Science and Technology Center (Henan Anti-Doping Center)","place":["Zhengzhou, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kai","family":"Xu","sequence":"additional","affiliation":[{"name":"College of Health Promotion, Gdansk University of Physical Education and Sport","place":["Gdansk, Poland"]},{"name":"Huanghe Science and Technology University","place":["Zhengzhou, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bensheng","family":"Guo","sequence":"additional","affiliation":[{"name":"Faculty of Health Sciences and Sports, Macao Polytechnic University","place":["Macau, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hai","family":"Li","sequence":"additional","affiliation":[{"name":"College of Sport, Neijiang Normal University","place":["Neijiang, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zijian","family":"Zhao","sequence":"additional","affiliation":[{"name":"College of Health Promotion, Gdansk University of Physical Education and Sport","place":["Gdansk, Poland"]},{"name":"School of Kinesiology and Physical Education, Zhengzhou University","place":["Zhengzhou, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2026,4,28]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"1689","DOI":"10.1001\/jama.284.13.1689","article-title":"Drug dependence, a chronic medical illness: implications for treatment, insurance, and outcomes evaluation","volume":"284","author":"McLellan","year":"2000","journal-title":"JAMA"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1016\/s0140-6736(11)61138-0","article-title":"Extent of illicit drug use and dependence, and their contribution to the global burden of disease","volume":"379","author":"Degenhardt","year":"2012","journal-title":"Lancet"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"760","DOI":"10.1016\/S2215-0366(16)00104-8","article-title":"Neurobiology of addiction: a neurocircuitry analysis","volume":"3","author":"Koob","year":"2016","journal-title":"Lancet Psychiatry"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"218","DOI":"10.1038\/s41380-020-0661-4","article-title":"The changing opioid crisis: development, challenges and opportunities","volume":"26","author":"Volkow","year":"2021","journal-title":"Mol Psychiatry"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"1575","DOI":"10.1016\/S0140-6736(13)61611-6","article-title":"Global burden of disease attributable to mental and substance use disorders: findings from the global burden of disease study 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Sci"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1038\/35053570","article-title":"Molecular basis of long-term plasticity underlying addiction","volume":"2","author":"Nestler","year":"2001","journal-title":"Nat Rev Neurosci"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"557","DOI":"10.1038\/sj.mp.4001507","article-title":"Dopamine in drug abuse and addiction: results from imaging studies and treatment implications","volume":"9","author":"Volkow","year":"2004","journal-title":"Mol Psychiatry"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1016\/j.tics.2010.11.001","article-title":"Reward, dopamine and the control of food intake: implications for obesity","volume":"15","author":"Volkow","year":"2011","journal-title":"Trends Cogn Sci"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1146\/annurev-psych-010418-103337","article-title":"Dopamine and 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Psychiatry"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1034\/j.1600-0447.106.s412.26.x","article-title":"The effects of drug abuse on the stress responsive hypothalamic\u2013pituitary\u2013adrenal axis and the dopaminergic and endogenous opioid systems","volume":"106","author":"Schlussman","year":"2002","journal-title":"Acta Psychiatr Scand"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1016\/j.dcn.2016.10.004","article-title":"Sensitive periods of substance abuse: early risk for the transition to dependence","volume":"25","author":"Jordan","year":"2017","journal-title":"Dev Cogn Neurosci"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"S16","DOI":"10.1002\/mpr.254","article-title":"What are the high risk periods for incident substance use and transitions to abuse and dependence? Implications for early intervention and prevention","volume":"17","author":"Wittchen","year":"2008","journal-title":"Int J Methods Psychiatr Res"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.drugalcdep.2006.05.012","article-title":"Substance abuse treatment entry, retention, and outcome in women: a review of the literature","volume":"86","author":"Greenfield","year":"2007","journal-title":"Drug Alcohol Depend"},{"key":"ref24","volume-title":"Diagnostic and Statistical Manual of Mental Disorders: Dsm-5","author":"Guha","year":"2014"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"e59645","DOI":"10.1371\/journal.pone.0059645","article-title":"Dissociated grey matter changes with prolonged addiction and extended abstinence in cocaine users","volume":"8","author":"Connolly","year":"2013","journal-title":"PLoS One"},{"key":"ref26","first-page":"31","volume-title":"Mental Health Assessment Scale Manual","author":"Wang","year":"1999"},{"key":"ref27","first-page":"375","volume-title":"Mental Health Assessment Scale Manual","author":"Wang","year":"1999"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"993","DOI":"10.1037\/0022-006x.68.6.993","article-title":"A cross-cultural comparison of depressive symptom manifestation: China and the United States","volume":"68","author":"Yen","year":"2000","journal-title":"J Consult Clin Psychol"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1016\/j.paid.2016.06.069","article-title":"Effect size guidelines for individual differences researchers","volume":"102","author":"Gignac","year":"2016","journal-title":"Pers Individ Differ"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"398","DOI":"10.1007\/s11920-011-0224-0","article-title":"New findings on biological factors predicting addiction relapse vulnerability","volume":"13","author":"Sinha","year":"2011","journal-title":"Curr Psychiatry 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addiction","volume":"99","author":"Volkow","year":"2019","journal-title":"Physiol Rev"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1523\/JNEUROSCI.12-02-00483.1992","article-title":"Opioids excite dopamine neurons by hyperpolarization of local interneurons","volume":"12","author":"Johnson","year":"1992","journal-title":"J Neurosci"},{"key":"ref36","volume-title":"Introduction to Mediation, Moderation, and Conditional process Analysis: A Regression-based Approach","author":"Hayes","year":"2017"},{"key":"ref37","doi-asserted-by":"publisher","first-page":"388","DOI":"10.1080\/19371918.2013.774673","article-title":"Integrated treatment of substance use and psychiatric disorders","volume":"28","author":"Kelly","year":"2013","journal-title":"Soc Work Public Health"},{"key":"ref38","doi-asserted-by":"publisher","first-page":"851","DOI":"10.1002\/da.22771","article-title":"Self-medication with alcohol or drugs for mood and anxiety disorders: a narrative review of the epidemiological literature","volume":"35","author":"Turner","year":"2018","journal-title":"Depress Anxiety"},{"key":"ref39","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1146\/annurev-pharmtox-010611-134625","article-title":"Addiction circuitry in the human brain","volume":"52","author":"Volkow","year":"2012","journal-title":"Annu Rev Pharmacol Toxicol"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"1440","DOI":"10.1176\/ajp.156.9.1440","article-title":"Prediction of reinforcing responses to psychostimulants in humans by brain dopamine D2 receptor levels","volume":"156","author":"Volkow","year":"1999","journal-title":"Am J Psychiatry"},{"key":"ref41","doi-asserted-by":"publisher","first-page":"688","DOI":"10.1038\/npp.2013.252","article-title":"Neural correlates of alcohol-approach bias in alcohol addiction: the spirit is willing but the flesh is weak for spirits","volume":"39","author":"Wiers","year":"2014","journal-title":"Neuropsychopharmacology"},{"key":"ref42","doi-asserted-by":"publisher","first-page":"891","DOI":"10.1001\/jamadermatol.2020.1587","article-title":"Association between medication use and bullous pemphigoid: a systematic review and meta-analysis","volume":"156","author":"Liu","year":"2020","journal-title":"JAMA Dermatol"},{"key":"ref43","doi-asserted-by":"publisher","first-page":"106034","DOI":"10.1016\/j.ypmed.2020.106034","article-title":"Adverse childhood experiences, internalizing\/externalizing symptoms, and associated prescription opioid misuse: a mediation analysis","volume":"134","author":"Tang","year":"2020","journal-title":"Prev Med"},{"key":"ref44","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41380-025-03419-w","article-title":"Burden of mental and substance use disorders in China and its provinces, 1990-2021: a systematic analysis for the global burden of disease study 2021","author":"Sun","year":"2025","journal-title":"Mol Psychiatry"},{"key":"ref45","doi-asserted-by":"publisher","first-page":"879","DOI":"10.3758\/BRM.40.3.879","article-title":"Asymptotic and resampling strategies for assessing and comparing indirect effects in multiple mediator models","volume":"40","author":"Preacher","year":"2008","journal-title":"Behav Res Methods"},{"key":"ref46","doi-asserted-by":"publisher","first-page":"511","DOI":"10.1016\/j.psc.2010.04.012","article-title":"Cognitive-behavioral therapy for substance use disorders","volume":"33","author":"McHugh","year":"2010","journal-title":"Psychiatr Clin North Am"},{"key":"ref47","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1016\/S0376-8716(02)00011-X","article-title":"Dialectical behavior therapy versus comprehensive validation therapy plus 12-step for the treatment of opioid dependent women meeting criteria for borderline personality disorder","volume":"67","author":"Linehan","year":"2002","journal-title":"Drug Alcohol Depend"},{"key":"ref48","doi-asserted-by":"publisher","first-page":"1563","DOI":"10.1016\/j.addbeh.2012.04.001","article-title":"Mindfulness-based relapse prevention for substance craving","volume":"38","author":"Witkiewitz","year":"2013","journal-title":"Addict Behav"},{"key":"ref49","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1111\/nyas.12479","article-title":"Transcranial magnetic stimulation in the treatment of substance addiction","volume":"1327","author":"Gorelick","year":"2014","journal-title":"Ann N Y Acad Sci"},{"key":"ref50","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1016\/j.euroneuro.2015.11.011","article-title":"Transcranial magnetic stimulation of dorsolateral prefrontal cortex reduces cocaine use: a pilot study","volume":"26","author":"Terraneo","year":"2016","journal-title":"Eur Neuropsychopharmacol"},{"key":"ref51","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1037\/a0022658","article-title":"Effect size measures for mediation models: Quantitative strategies for communicating indirect effects","volume":"16","author":"Preacher","year":"2011","journal-title":"Psychological Methods,"},{"key":"ref52","doi-asserted-by":"publisher","first-page":"1149","DOI":"10.3758\/BRM.41.4.1149","article-title":"Statistical power analyses using G* Power 3.1: Tests for correlation and regression analyses","volume":"41","author":"Faul","year":"2019","journal-title":"Behavior research methods,"},{"key":"ref53","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1177\/014662168801200410","article-title":"Set correlation and contingency tables","volume":"12","author":"Cohen","year":"1988","journal-title":"Applied psychological measurement,"}],"container-title":["Frontiers in Public 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