{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T06:14:57Z","timestamp":1778220897745,"version":"3.51.4"},"reference-count":51,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T00:00:00Z","timestamp":1778198400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Public Health"],"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This pilot feasibility study aimed to evaluate the efficacy of a telephone-delivered motivational interviewing (MI) intervention in alleviating loneliness, depressive symptoms, and anxiety among patients with drug-resistant tuberculosis (DR-TB).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Employing a single-group pre-post design, 74 DR-TB patients were recruited from the tuberculosis wards of Chengdu Public Health Clinical Medical Center between January and December 2021. Participants underwent a 12-week MI-based telephone intervention, with assessments at baseline (Week 0) and post-intervention (Week 16). Primary outcomes included changes in psychological measures using validated instruments: the University of California, Los Angeles Loneliness Scale (UCLA-LS), Self-Rating Depression Scale (SDS), and Hamilton Anxiety Rating Scale (HAMA). Secondary outcomes encompassed sleep quality, assessed by the Pittsburgh Sleep Quality Index (PSQI), and medication adherence, defined as a binary outcome based on pill count.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The intervention significantly reduced loneliness (UCLA-LS: 47.23\u202f\u00b1\u202f10.14\u202f\u2192\u202f40.23\u202f\u00b1\u202f12.76,\n                      <jats:italic>p<\/jats:italic>\n                      \u202f&amp;lt;\u202f0.001; 14.8% decrease), anxiety (HAMA: 14.73\u202f\u00b1\u202f8.85\u202f\u2192\u202f12.06\u202f\u00b1\u202f7.34,\n                      <jats:italic>p<\/jats:italic>\n                      \u202f=\u202f0.017; 18.1% reduction), and depressive symptoms (SDS: 50.47\u202f\u00b1\u202f9.33\u202f\u2192\u202f34.85\u202f\u00b1\u202f9.06,\n                      <jats:italic>p<\/jats:italic>\n                      \u202f&amp;lt;\u202f0.001; 30.9% decline). Sleep quality improved (PSQI: 7.75\u202f\u00b1\u202f0.68\u202f\u2192\u202f4.20\u202f\u00b1\u202f1.44,\n                      <jats:italic>p<\/jats:italic>\n                      \u202f&amp;lt;\u202f0.001; 45.8% decline), while medication adherence increased from 89.2 to 95.4%, this change was not statistically significant (\n                      <jats:italic>p<\/jats:italic>\n                      \u202f&amp;gt;\u202f0.05, McNemar\u2019s test).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This pilot pre-post study provides preliminary evidence that telephone-delivered MI is associated with improved psychological outcomes in DR-TB patients. The findings support its promise as an accessible intervention, but the exploratory design necessitates further investigation through controlled trials to confirm efficacy and establish causal inference.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fpubh.2026.1817457","type":"journal-article","created":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T05:51:12Z","timestamp":1778219472000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Alleviating psychosocial distress in drug-resistant tuberculosis: a pre-post study on telephone-delivered motivational interviewing"],"prefix":"10.3389","volume":"14","author":[{"given":"Fanghui","family":"Xie","sequence":"first","affiliation":[{"name":"Department of Tuberculosis, Public Health Clinical Center of Chengdu","place":["Chengdu, Sichuan, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Enchun","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of Tuberculosis, Public Health Clinical Center of Chengdu","place":["Chengdu, Sichuan, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoyi","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Tuberculosis, Public Health Clinical Center of Chengdu","place":["Chengdu, Sichuan, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bin","family":"Wan","sequence":"additional","affiliation":[{"name":"Department of Nursing, Public Health Clinical Center of Chengdu","place":["Chengdu, Sichuan, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rong","family":"Yao","sequence":"additional","affiliation":[{"name":"Department of Tuberculosis, Public Health Clinical Center of Chengdu","place":["Chengdu, Sichuan, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2026,5,8]]},"reference":[{"key":"ref1","volume-title":"Global Tuberculosis Report 2024","year":"2024"},{"key":"ref2","volume-title":"Study on the Status and Influencing Factors of Medication Adherence in Patients with Multidrug-Resistant Tuberculosis","author":"Gui","year":"2022"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"e0255357","DOI":"10.1371\/journal.pone.0255357","article-title":"Active surveillance for adverse events in patients on longer treatment regimens for multidrug-resistant tuberculosis in Viet Nam","volume":"16","author":"Ngoc","year":"2021","journal-title":"PLoS One"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"1117","DOI":"10.1111\/tmi.13637","article-title":"Depression and its associated factors among people with multidrug-resistant tuberculosis in Myanmar","volume":"26","author":"Theingi","year":"2021","journal-title":"Trop 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