{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T16:43:53Z","timestamp":1786466633319,"version":"build-2736575974"},"reference-count":43,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T00:00:00Z","timestamp":1779926400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Public Health"],"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To investigate the status of Traditional Chinese Medicine (TCM) constitution, sleep quality, and Cancer-Related Fatigue (CRF) in breast cancer (BC) patients and explore the relationships among these three factors, thereby providing a basis for reducing the level of CRF in individuals with BC.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>BC patients were enrolled from two Tertiary Level-A Hospitals in Shandong Province, China, using convenience sampling. Data were collected using the General Information Questionnaire, the Self-Measurement Scale for the Classification and Determination of TCM constitutions, the Pittsburgh Sleep Quality Index (PSQI), and the Piper Fatigue Scale (PFS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 320 breast cancer patients were included, predominantly exhibiting unbalanced constitutions (72.19%). Correlation analysis indicated that a balanced constitution was negatively associated with cancer-related fatigue (CRF) (\n                      <jats:italic>r<\/jats:italic>\n                      = \u22120.461,\n                      <jats:italic>P<\/jats:italic>\n                      &amp;lt; 0.01), In contrast, Qi deficiency, Yang deficiency, phlegm-dampness, dampness-heat, Qi stagnation constitutions, and poorer sleep quality were positively correlated with CRF (all\n                      <jats:italic>P<\/jats:italic>\n                      &amp;lt; 0.01). Multiple linear regression identified Qi deficiency, Yang deficiency, and Qi stagnation as significant independent predictors of CRF (\n                      <jats:italic>P<\/jats:italic>\n                      &amp;lt; 0.05). Furthermore, structural equation modeling revealed that sleep quality partially mediated the relationship between CRF and these three constitutions, with mediation proportions of 22.47%, 22.52%, and 37.5%, respectively.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The level of CRF in patients with BC is moderate and multifactorial. Therefore, medical personnel can alleviate CRF by addressing patients' unbalanced constitutions to improve sleep quality.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fpubh.2026.1823328","type":"journal-article","created":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T04:52:23Z","timestamp":1779943943000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Correlations among traditional Chinese medicine constitutions, sleep quality, and cancer-related fatigue in patients with breast cancer"],"prefix":"10.3389","volume":"14","author":[{"given":"Yi","family":"Lu","sequence":"first","affiliation":[{"name":"Nursing School, Shandong University of Traditional Chinese Medicine, Jinan","place":["Shandong, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanmin","family":"Xue","sequence":"additional","affiliation":[{"name":"Nursing School, Shandong University of Traditional Chinese 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