{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T14:33:58Z","timestamp":1789050838744,"version":"build-2803163510"},"reference-count":19,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T00:00:00Z","timestamp":1783468800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100013139","name":"Humanities and Social Science Fund of Ministry of Education of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013139","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Public Health"],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Evidence linking sensory impairment to depression is predominantly Western. We quantified longitudinal associations of single and dual sensory impairment (DSI) with incident depression using harmonized data from six countries.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We analyzed 72,177 older adults (aged \u226550) from HRS (USA), ELSA (UK), SHARE (Europe), CHARLS (China), KLOSA (South Korea), and MHAS (Mexico). Participants free of depression at baseline (2010\u20132015) were followed for 2\u201310 years. Sensory status was categorized as no impairment, vision impairment only (VI), hearing impairment only (HI), and DSI. We used multivariable Cox models and individual participant data (IPD) meta-analysis to estimate pooled hazard ratios (HRs).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Findings<\/jats:title>\n                    <jats:p>Sensory impairment was consistently associated with an increased depression risk. DSI conferred the highest risk (pooled HR 1.39, 95% CI 1.32\u20131.46), followed by HI (HR 1.21, 1.16\u20131.27) and VI (HR 1.15, 1.11\u20131.20). Associations were stronger in Western cohorts (DSI HRs \u22651.84 in UK\/USA) than in Asian and Latin American populations. Subgroup analyses showed higher DSI-associated risk among individuals with college education (HR 1.68) compared to those with lower education (HR 1.35).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Interpretation<\/jats:title>\n                    <jats:p>Sensory impairment, particularly DSI, is robustly associated with incident depression globally, though effects vary by geopolitical and socioeconomic context. Integrated sensory and mental health screening is critical for preventing late-life depression.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fpubh.2026.1834248","type":"journal-article","created":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T06:56:27Z","timestamp":1783493787000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Sensory impairment and risk of incident depression in older adults: a harmonized longitudinal analysis of 72,177 individuals across six international cohorts"],"prefix":"10.3389","volume":"14","author":[{"given":"Lin","family":"Guo","sequence":"first","affiliation":[{"name":"School of Management, Shandong Second Medical University","place":["Weifang, Shandong, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linlin","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Management, Shandong Second Medical University","place":["Weifang, Shandong, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zengying","family":"Zhuang","sequence":"additional","affiliation":[{"name":"School of Management, Shandong Second Medical University","place":["Weifang, Shandong, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanjie","family":"Jiang","sequence":"additional","affiliation":[{"name":"School of Management, Shandong Second Medical University","place":["Weifang, Shandong, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linlin","family":"Yue","sequence":"additional","affiliation":[{"name":"School of Management, Shandong Second Medical University","place":["Weifang, Shandong, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,7,8]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1520552","DOI":"10.3389\/fpubh.2025.1520552","article-title":"Change in depressive symptom scores to assess the risk of new-onset dual sensory impairment in middle-aged and older adults: a nationwide cohort study","volume":"13","author":"Wang","year":"2025","journal-title":"Front. 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