{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T07:01:40Z","timestamp":1780038100828,"version":"3.53.1"},"reference-count":47,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T00:00:00Z","timestamp":1780012800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82470500"],"award-info":[{"award-number":["82470500"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Public Health"],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Acute aortic dissection (AAD) is a cardiovascular catastrophe with substantial early mortality. Although ambient cold has been implicated as a trigger, existing evidence derives predominantly from temperate and subtropical settings. Populations enduring protracted severe winters\u2013a hallmark of cold temperate zones\u2013remain underrepresented, leaving the cardiovascular hazard of sustained extreme cold poorly defined.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this retrospective time-stratified case-crossover study, we analyzed 1 384 patients with AAD admitted to a tertiary cardiovascular center in Harbin, China\u2013a city in the cold temperate zone of Northeast Asia with a harsh continental monsoon climate. Meteorological data (2014\u20132023) were interrogated using distributed lag non-linear models combined with conditional logistic regression to quantify exposure lag-response relationships between daily mean temperature and temperature change between neighboring days (TCN) with the AAD onset.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A near-linear increase in AAD risk was observed with decreasing daily mean temperature, with minimum morbidity at 25.9 \u00b0C. Extreme cold (\u221223.4 \u00b0C, 1st percentile) raised the risk significantly within 3 days. A pronounced risk elevation followed temperature drops between consecutive days\u2013a decline of 9.2 \u00b0C was associated with a RR of 9.57 (95% CI 1.21\u201375.76). In contrast, temperature rises conferred protection. These effects were accentuated in winter and during the period of centralized indoor heating.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In a cold temperate region marked by severe winters, both low ambient temperature and abrupt cooling act as potent environmental triggers for AAD. These findings call for enhanced clinical awareness and tailored preventive measures during cold exposure in such climates.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fpubh.2026.1848286","type":"journal-article","created":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T06:02:56Z","timestamp":1780034576000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Low ambient temperature and sudden temperature drop increases the incidence of acute aortic dissection: a retrospective analysis from the northeast region of China"],"prefix":"10.3389","volume":"14","author":[{"given":"Zhenyu","family":"Liao","sequence":"first","affiliation":[{"name":"Department of Cardiology, The First Affiliated Hospital, Harbin Medical University","place":["Harbin, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaorui","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Cardiology, The First Affiliated Hospital, Harbin Medical University","place":["Harbin, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Ding","sequence":"additional","affiliation":[{"name":"Department of Cardiology, The First Affiliated Hospital, Harbin Medical University","place":["Harbin, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Heilongjiang Provincial Hospital","place":["Harbin, Heilongjiang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Cardiology, The First Affiliated Hospital, Harbin Medical University","place":["Harbin, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yike","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Cardiology, The First Affiliated 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Prevention","place":["Harbin, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiyu","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Cardiology, The First Affiliated Hospital, Harbin Medical University","place":["Harbin, China"]},{"name":"Key Laboratory of Cardiovascular Disease Acousto-Optic Electromagnetic Diagnosis and Treatment in Heilongjiang Province, The First Affiliated Hospital of Harbin Medical University","place":["Harbin, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Song","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Cardiology, The First Affiliated Hospital, Harbin Medical University","place":["Harbin, China"]},{"name":"NHC Key Laboratory of Cell Transplantation, The First Affiliated hospital of Harbin Medical University","place":["Harbin, Heilongjiang, China"]},{"name":"Key Laboratory of Cardiac Diseases and Heart Failure, Harbin Medical 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