{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T13:47:55Z","timestamp":1782481675865,"version":"3.54.5"},"reference-count":52,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T00:00:00Z","timestamp":1782432000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Public Health"],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Anxiety and depression commonly coexist in later life, yet little is known about the heterogeneous manifestations of anxious\u2013depression symptoms and their cognitive correlates among community-dwelling older adults in China. The purpose of this study is to identify heterogeneous anxious-depression symptom profiles and examine their associations with cognitive function among community-dwelling older adults in China.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A total of 5,116 community-dwelling older adults aged \u226560\u202fyears were surveyed. Anxiety and depressive symptoms were assessed using the 7-item Generalized Anxiety Disorder Scale and the 15-item Geriatric Depression Scale, with latent class analysis (LCA) used to identify anxious\u2013depression symptom patterns. Cognitive function was assessed using the brief Community Screening Inventory for Dementia. Multivariable linear regression analyses were performed to examine the associations between anxious\u2013depression phenotypes and cognitive function.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      LCA identified four anxious-depression symptom profiles: high anxious-depression (7.41%), moderate anxious-depression (8.64%), high depression (13.94%), and low anxious-depression (70.01%). After adjusting for covariates, both anxious-depression and depression-dominant phenotypes were significantly linked to lower cognitive function scores (all\n                      <jats:italic>p<\/jats:italic>\n                      \u202f&amp;lt;\u202f0.001). Individuals with comorbid anxiety and depression showed greater cognitive decline compared to those with predominantly depressive symptoms, with the high anxious-depression group exhibiting the most pronounced reduction in cognitive scores (\n                      <jats:italic>p<\/jats:italic>\n                      \u202f&amp;lt;\u202f0.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Distinct anxious-depression symptom subtypes were identified among community-dwelling older adults. The more pronounced the anxiety and depression symptoms, the poorer the cognitive function. These findings underscore the importance of addressing anxiety and depression in community-based cognitive screening and prevention programs.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fpubh.2026.1851644","type":"journal-article","created":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T12:58:51Z","timestamp":1782478731000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Association between anxious-depression and cognitive function in community-dwelling older adults: a latent class analysis"],"prefix":"10.3389","volume":"14","author":[{"given":"Yiran","family":"Deng","sequence":"first","affiliation":[{"name":"School of Mental Health and Psychological Sciences, Anhui Medical University","place":["Hefei, China"]},{"name":"Hefei Fourth People\u2019s Hospital, Affiliated Psychological Hospital of Anhui Medical University, Anhui Medical University","place":["Hefei, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siwen","family":"Lv","sequence":"additional","affiliation":[{"name":"Hefei Fourth People\u2019s Hospital, Affiliated Psychological Hospital of Anhui Medical University, Anhui Medical University","place":["Hefei, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Letian","family":"Yang","sequence":"additional","affiliation":[{"name":"School of Mental Health and Psychological Sciences, Anhui Medical University","place":["Hefei, China"]},{"name":"Hefei Fourth People\u2019s Hospital, Affiliated Psychological Hospital of Anhui Medical University, Anhui Medical University","place":["Hefei, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyu","family":"Gao","sequence":"additional","affiliation":[{"name":"School of Mental Health and Psychological Sciences, Anhui Medical University","place":["Hefei, China"]},{"name":"Hefei Fourth People\u2019s Hospital, Affiliated Psychological Hospital of Anhui Medical University, Anhui Medical University","place":["Hefei, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Geng","sequence":"additional","affiliation":[{"name":"Hefei Fourth People\u2019s Hospital, Affiliated Psychological Hospital of Anhui Medical University, Anhui Medical University","place":["Hefei, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siwen","family":"Liu","sequence":"additional","affiliation":[{"name":"School of Mental Health and Psychological Sciences, Anhui Medical University","place":["Hefei, China"]},{"name":"Hefei Fourth People\u2019s Hospital, Affiliated Psychological Hospital of Anhui Medical University, Anhui Medical University","place":["Hefei, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoming","family":"Kong","sequence":"additional","affiliation":[{"name":"Hefei Fourth People\u2019s Hospital, Affiliated Psychological Hospital of Anhui Medical 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