{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T07:46:04Z","timestamp":1782459964984,"version":"3.54.5"},"reference-count":24,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T00:00:00Z","timestamp":1781568000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Public Health"],"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To assess the prevalence of depressive symptoms and examine their associations with tuberculosis-related knowledge, attitudes, and practices (KAP) among patients with multidrug-resistant tuberculosis (MDR-TB).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A cross-sectional study was conducted among 528 MDR-TB patients. Depressive symptoms were measured using the Patient Health Questionnaire-9 (PHQ-9), with a score of \u226510 indicating clinically relevant depression. KAP domains were assessed using a structured scoring system. Associations were analyzed using Spearman correlation and multivariable logistic regression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The mean PHQ-9 score was 5.32\u202f\u00b1\u202f4.35, and 14.96% of participants (\n                      <jats:italic>n<\/jats:italic>\n                      \u202f=\u202f79) had clinically relevant depressive symptoms. Among them, 57 had moderate, 17 had moderately severe, and 5 had severe symptoms. Multivariable analysis showed that higher attitude scores were associated with lower odds of depression (aOR\u202f=\u202f0.936; 95% CI: 0.886\u20130.990;\n                      <jats:italic>p<\/jats:italic>\n                      \u202f=\u202f0.02). Higher practice scores were also strongly associated with reduced depression risk (aOR\u202f=\u202f0.837; 95% CI: 0.778\u20130.901;\n                      <jats:italic>p<\/jats:italic>\n                      \u202f&amp;lt;\u202f0.001). Knowledge score was not independently associated with depression (\n                      <jats:italic>p<\/jats:italic>\n                      \u202f=\u202f0.622).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Depressive symptoms are common among MDR-TB patients and are more strongly linked to attitudes and practices than to knowledge alone. These findings suggest the potential value of integrating mental health screening and behavioral support into MDR-TB management programs to improve comprehensive patient care.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fpubh.2026.1851867","type":"journal-article","created":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T08:09:56Z","timestamp":1781597396000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Depressive symptoms and their associations with tuberculosis-related knowledge, attitudes, and practices among patients with multidrug-resistant tuberculosis"],"prefix":"10.3389","volume":"14","author":[{"given":"Binh Huy","family":"Nguyen","sequence":"first","affiliation":[{"name":"Hanoi Medical University, National Lung Hospital","place":["Hanoi, Vietnam"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huy Le","family":"Ngoc","sequence":"additional","affiliation":[{"name":"Hanoi Medical University, National Lung Hospital","place":["Hanoi, Vietnam"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hoa B.","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Vietnam National Lung Hospital","place":["Hanoi, Vietnam"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giang M.","family":"Le","sequence":"additional","affiliation":[{"name":"Hanoi Medical University, National Lung Hospital","place":["Hanoi, Vietnam"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luong V.","family":"Dinh","sequence":"additional","affiliation":[{"name":"Vietnam National Lung Hospital","place":["Hanoi, Vietnam"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,6,16]]},"reference":[{"key":"ref1","volume-title":"Global Tuberculosis Report 2025","year":"2025"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"e623","DOI":"10.1093\/cid\/ciaf363","article-title":"Long-term outcomes among people with multidrug-resistant tuberculosis in Vietnam","volume":"81","author":"MacLean","year":"2025","journal-title":"Clin Infect Dis"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1186\/s40249-024-01196-2","article-title":"Is convenience really king? 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