{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T05:08:08Z","timestamp":1784092088557,"version":"3.55.0"},"reference-count":46,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T00:00:00Z","timestamp":1784073600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Public Health"],"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Hyperuricemia, a precursor to gout and a risk factor for various cardiometabolic and renal disorders, is influenced by a complex interplay of lifestyle, physiological, and environmental factors. This study aimed to investigate the independent and combined effects of a sedentary lifestyle and obstructive sleep apnea (OSA) on hyperuricemia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We analyzed data from 14,808 participants aged 40\u201380\u202fyears in the Korea National Health and Nutrition Examination Survey (2019\u20132022). Sedentary lifestyle was defined based on daily sedentary time, categorized as \u22646 or &amp;gt;6\u202fh\/day. OSA risk was assessed using the STOP-Bang questionnaire (Snoring, Tiredness, Observed apnea, blood Pressure, Body mass index, Age, Neck circumference, Gender), classifying participants into high- and low-risk groups. Hyperuricemia was defined as serum uric acid levels \u22657.0\u202fmg\/dL in males and \u22656.0\u202fmg\/dL in females. Adjusted odds ratios (AORs) and 95% confidence intervals (CIs) were calculated using multiple logistic regression, and interaction effects were evaluated through relative excess risk due to interaction (RERI), attributable proportion (AP), and synergy index (SI).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Sedentary time [AOR\u202f=\u202f1.16 (95% CI: 1.04\u20131.29)] was independently associated with increased hyperuricemia risk. High OSA risk was associated with hyperuricemia in the partially adjusted model [AOR\u202f=\u202f1.94 (95% CI: 1.71\u20132.19)], although this association was attenuated and no longer statistically significant after further adjustment for variables incorporated into the STOP-Bang questionnaire [AOR\u202f=\u202f1.12 (95% CI: 0.98\u20131.28)]. A significant synergistic interaction was evident when both coexisted [RERI\u202f=\u202f0.14 (95% CI: 0.08\u20130.19), AP\u202f=\u202f0.17 (95% CI: 0.09\u20130.25), SI\u202f=\u202f1.17 (95% CI: 1.01\u20131.37)].<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>These findings highlight the need for integrated screening and management strategies targeting sedentary lifestyles and OSA to mitigate hyperuricemia and its associated health burdens in at-risk populations.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fpubh.2026.1854396","type":"journal-article","created":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T04:46:52Z","timestamp":1784090812000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Independent and synergistic effects of sedentary lifestyle and obstructive sleep apnea on hyperuricemia: a nationwide cross-sectional study in Korea"],"prefix":"10.3389","volume":"14","author":[{"given":"Hyewon","family":"Lee","sequence":"first","affiliation":[{"name":"College of Medicine, Chung-Ang University","place":["Seoul, Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wanhyung","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine, College of Medicine, Chung-Ang University","place":["Seoul, Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seung-Yeon","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Family Medicine, International Healthcare Center, Seoul National University Bundang Hospital","place":["Seongnam-si, Gyeonggi-do, Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,7,15]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"4314","DOI":"10.1038\/s41598-018-22570-9","article-title":"Prevalence and correlates of hyperuricemia in the middle-aged and older adults in China","volume":"8","author":"Song","year":"2018","journal-title":"Sci Rep"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"186","DOI":"10.1097\/BOR.0000000000000028","article-title":"Definition of hyperuricemia and gouty conditions","volume":"26","author":"Bardin","year":"2014","journal-title":"Curr Opin Rheumatol"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"4632","DOI":"10.3390\/ijerph16234632","article-title":"Association of serum uric acid with cardiovascular disease risk scores in Koreans","volume":"16","author":"Lee","year":"2019","journal-title":"Int J Environ Res Public 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