{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T17:36:58Z","timestamp":1789148218995,"version":"build-2803163510"},"reference-count":49,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T00:00:00Z","timestamp":1780444800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Public Health"],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Chronic kidney disease (CKD) and depression frequently co-occur, yet population-level mortality trends for their joint occurrence are poorly characterized.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Using the CDC WONDER multiple-cause-of-death database, we examined annual age-adjusted mortality rates (AAMR) per 100,000 population among U.S. adults aged \u2265 25\u202fyears with CKD and co-occurring depression from 1999 to 2023. Joinpoint regression was employed to estimate annual percent change (APC) and average annual percent change (AAPC). Trends were stratified by sex, age, race, census region, and urban\u2013rural residence. A Poisson log-linear model tested trend heterogeneity between CKD overall and CKD with depression during 2016\u20132021.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      11,076 deaths were attributed to CKD with co-occurring depression. Overall AAMR increased from 0.12 to 0.22 per 100,000 (AAPC, 2.32%; 95% CI, \u22123.48 to 8.47%). Joinpoint analysis identified a critical inflection point in 2015, after which mortality surged at an APC of 9.89% (95% CI, 6.39 to 13.50%;\n                      <jats:italic>p<\/jats:italic>\n                      \u202f&amp;lt;\u202f0.001). In contrast, CKD overall mortality decelerated after 2016 and plateaued recently. The post-2015 slope for CKD with depression significantly exceeded that of CKD overall (\n                      <jats:italic>p<\/jats:italic>\n                      for interaction &amp;lt; 0.0001). Acceleration was most pronounced among men, adults aged \u226585\u202fyears, residents of the South, and nonmetropolitan populations. Sensitivity analysis restricted to 2013\u20132023 yielded a sustained upward APC of 7.38% (95% CI, 5.00\u201310.41%;\n                      <jats:italic>p<\/jats:italic>\n                      \u202f&amp;lt;\u202f0.0001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Mortality among CKD with co-occurring depression has accelerated sharply since 2015, diverging markedly from the plateauing trend of CKD overall. Routine depression screening integration into nephrology care is urgently warranted, especially for high-risk populations.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fpubh.2026.1860838","type":"journal-article","created":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T04:55:26Z","timestamp":1780462526000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Temporal trends and disparities in mortality among US adults with chronic kidney disease and comorbid depression: a population-based analysis, 1999\u20132023"],"prefix":"10.3389","volume":"14","author":[{"given":"Pengcheng","family":"Zhao","sequence":"first","affiliation":[{"name":"Key Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education, West China Second Hospital, Sichuan University","place":["Chengdu, Sichuan, China"]},{"name":"Department of Pediatric General Surgery, West China Second Hospital, Sichuan University","place":["Chengdu, Sichuan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Libo","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Pediatric General Surgery, West China Second Hospital, Sichuan University","place":["Chengdu, Sichuan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Pediatric General Surgery, West China Second Hospital, Sichuan University","place":["Chengdu, Sichuan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingan","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Pediatric General Surgery, West China Second Hospital, Sichuan University","place":["Chengdu, Sichuan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun","family":"He","sequence":"additional","affiliation":[{"name":"Department of Pediatric General Surgery, West China Second Hospital, Sichuan University","place":["Chengdu, Sichuan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,6,3]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"2133","DOI":"10.1016\/s0140-6736(24)00757-8","article-title":"Global incidence, prevalence, years lived with disability (YLDs), disability-adjusted life-years (DALYs), and healthy life expectancy (HALE) for 371 diseases and injuries in 204 countries and territories and 811 subnational locations, 1990-2021: a systematic analysis for the global burden of disease study 2021","volume":"403","year":"2024","journal-title":"Lancet"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1186\/s12882-023-03173-7","article-title":"The effect of a novel, digital physical activity and emotional well-being intervention on health-related quality of life in people with chronic kidney disease: trial design and baseline 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