{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T06:30:21Z","timestamp":1786516221646,"version":"build-2736575974"},"reference-count":55,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T00:00:00Z","timestamp":1786492800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Public Health"],"abstract":"\n Background<\/jats:title>\n Global developmental delay (GDD) is a common neurodevelopmental disorder in preschool children. Early screening and integrated intervention are critical for optimal neurodevelopment, yet robust evidence remains limited.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n A non-randomized controlled trial was conducted included 3,216 children aged 3\u20136\u202fyears for three-level GDD screening. Thirty children with confirmed GDD [defined as total General Quotient &lt;70 on the Chinese version of the Griffiths Mental Development Scales (GDS-C)] were allocated to receive 6-month medical-educational integrated intervention or conventional training (exploratory pilot trial); both the overall General Quotient and domain-specific subscale developmental quotients (DQ) were evaluated via GDS-C.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n The prevalence of GDD was 1.3%, with higher rates in boys and suburban areas. The integrated intervention group showed significantly greater DQ improvements in social, language, eye-hand coordination, visual performance, and practical reasoning domains (all\n p<\/jats:italic>\n \u202f&lt;\u202f0.05), while no significant difference was observed in gross motor domain.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n A comprehensive multi-component intervention program, encompassing integrated medical-educational components, structured parent training, and home-based intervention measures, yielded preliminary short-term developmental benefits compared with single institutional rehabilitation.<\/jats:p>\n <\/jats:sec>","DOI":"10.3389\/fpubh.2026.1860897","type":"journal-article","created":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T05:54:33Z","timestamp":1786514073000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Bridging medicine and education for global developmental delay: a cluster sampling study on screening, diagnosis, and intervention in preschool children"],"prefix":"10.3389","volume":"14","author":[{"given":"Yiyi","family":"Zhang","sequence":"first","affiliation":[{"name":"Chengdu Women's and Children's Central Hospital, School of Medicine, University of Electronic Science and Technology of China","place":["Chengdu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Chengdu Women's and Children's Central Hospital, School of Medicine, University of Electronic Science and Technology of China","place":["Chengdu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,8,12]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"17254","DOI":"10.1038\/s41598-023-44472-1","article-title":"Prevalence and trends of developmental disabilities among US children and adolescents aged 3 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