{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T06:57:15Z","timestamp":1790751435217,"version":"4.1.0"},"reference-count":54,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:00:00Z","timestamp":1790726400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Public Health"],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Perioperative health education is essential for patients undergoing gastrointestinal surgery, but conventional approaches are often limited by time, workload, continuity, and personalization. Artificial intelligence (AI) may offer a more accessible and interactive approach to patient education. This trial aims to evaluate whether a WeChat-based, expert knowledge-constrained AI health education system can improve anxiety and other patient-reported outcomes in patients undergoing gastrointestinal surgery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This is a single-center, open-label, parallel-group randomized controlled trial with a 1:1 allocation ratio. A total of 120 eligible patients will be recruited from the Department of Gastrointestinal Surgery at Chengdu Third People\u2019s Hospital and randomly assigned to either an intervention group or a control group. The control group will receive usual perioperative care and conventional health education, while the intervention group will additionally receive a WeChat-based AI-supported health education intervention for 3\u202fmonths. The primary outcome is anxiety measured by the Hospital Anxiety and Depression Scale-Anxiety subscale. Secondary outcomes include depression, perceived social support, self-efficacy, health-related quality of life, and eHealth literacy. Outcomes will be assessed at baseline, discharge, 3\u202fmonths, and 6\u202fmonths. Analyses will primarily follow the intention-to-treat principle.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Ethics and dissemination<\/jats:title>\n                    <jats:p>This study is a low-risk behavioral intervention trial. Study findings will be disseminated through peer-reviewed publications and other academic channels. Ethical approval for the study was obtained from the Medical Ethics Committee of Chengdu Third People\u2019s Hospital (Ethics No: 2026-S-69). The clinical trial is registered under ChiCTR2600122411, with registration completed on April 2026.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Clinical trial registration<\/jats:title>\n                    <jats:p>\n                      <jats:ext-link>https:\/\/www.chictr.org.cn\/<\/jats:ext-link>\n                      , identifier ChiCTR2600122411.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fpubh.2026.1862627","type":"journal-article","created":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T06:06:29Z","timestamp":1790748389000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["A WeChat-based, expert knowledge-constrained artificial intelligence health education intervention for patients undergoing gastrointestinal surgery: protocol for a randomized controlled trial"],"prefix":"10.3389","volume":"14","author":[{"given":"Li","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Medical Affairs, The Third People's Hospital of Chengdu","place":["Chengdu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xu","family":"Du","sequence":"additional","affiliation":[{"name":"Department of Nursing, The Fourth People's Hospital of Chengdu","place":["Chengdu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangli","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Medical Affairs, Chengdu Women's and Children's Central Hospital","place":["Chengdu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuyao","family":"Xiang","sequence":"additional","affiliation":[{"name":"Department of Quality Evaluation and Medical Record Management, The Third People's Hospital of Chengdu","place":["Chengdu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Medical Affairs, The Third People's Hospital of Chengdu","place":["Chengdu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, The Fourth People's Hospital of Zigong","place":["Zigong, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun-Hua","family":"Li","sequence":"additional","affiliation":[{"name":"School of Education, Chengdu College of Arts and Sciences","place":["Chengdu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongtao","family":"Yu","sequence":"additional","affiliation":[{"name":"Hospital Administration Office, The Third People's Hospital of Chengdu","place":["Chengdu, 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