{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T16:51:36Z","timestamp":1791305496699,"version":"4.3.1"},"reference-count":27,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T00:00:00Z","timestamp":1791244800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Public Health"],"abstract":"\n Background<\/jats:title>\n Newborn screening (NBS) can reduce morbidity from some inherited metabolic diseases (IMDs) through early detection and timely treatment. Clear antenatal communication can support informed participation and timely follow-up by helping parents understand the purpose and pathway of screening. Evidence on pregnant women\u2019s perceived understanding, attitudes, antenatal information engagement, and screening- and follow-up-related intentions regarding newborn IMD screening in China remains limited. This study described these four domains and examined their associations with sociodemographic and reproductive-history characteristics in southwestern China.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n This hospital-based cross-sectional survey used a purposive sample recruited at a tertiary women\u2019s and children\u2019s hospital (National Regional Medical Center in China) from January 2024 to December 2024. After data-quality review, 1,320 eligible records were analyzed. All 21 questionnaire items were retained and analyzed as four domains: perceived understanding, attitudes, antenatal information engagement, and screening\/follow-up intentions. Internal consistency,\n post hoc<\/jats:italic>\n exploratory factor analysis, Pearson correlations, and four fully adjusted linear models with HC3 robust standard errors were evaluated. Benjamini-Hochberg false-discovery-rate (FDR) correction was applied across 92 non-intercept coefficients.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Parallel analysis supported four factors (Kaiser-Meyer-Olkin\u202f=\u202f0.912; Bartlett \u03c7\n 2<\/jats:sup>\n = 21,719.21,\n p<\/jats:italic>\n &lt;\u202f0.001), explaining 67.5% of variance. Mean (SD) scores were 15.15 (4.54)\/35 for perceived understanding, 25.43 (3.77)\/30 for attitudes, 9.34 (2.31)\/15 for antenatal information engagement, and 20.09 (3.16)\/25 for intentions; Cronbach\u2019s \u03b1 values were 0.918, 0.950, 0.745, and 0.914. Fifteen coefficients had nominal\n p<\/jats:italic>\n &lt;\u202f0.05, but none remained significant after FDR correction (all q\u202f\u2265\u202f0.051); adjusted R\n 2<\/jats:sup>\n values were 0.010\u20130.039.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n Participants reported limited self-perceived understanding alongside favorable attitudes, moderate antenatal information engagement, and strong stated intentions. Adjusted R\n 2<\/jats:sup>\n values of 0.010\u20130.039 and the absence of FDR-significant predictors indicate that the measured sociodemographic and reproductive-history variables had negligible explanatory value and should not be used for subgroup prediction or targeting. The domain pattern supports universal, nursing-led antenatal communication focused on screening procedures, abnormal-result interpretation, recall, confirmation, and follow-up, while future work should refine the questionnaire and test whether education improves observed participation and follow-up.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.3389\/fpubh.2026.1865107","type":"journal-article","created":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T15:59:32Z","timestamp":1791302372000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Pregnant women\u2019s perceived understanding and antenatal information needs regarding newborn screening for inherited metabolic diseases in southwestern China: a cross-sectional study"],"prefix":"10.3389","volume":"14","author":[{"given":"Hao","family":"Yang","sequence":"first","affiliation":[{"name":"Center for Medical Genetics, West China Second University Hospital, Sichuan University","place":["Chengdu, China"]},{"name":"Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education","place":["Chengdu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fenghua","family":"He","sequence":"additional","affiliation":[{"name":"Center for Medical Genetics, West China Second University Hospital, Sichuan University","place":["Chengdu, China"]},{"name":"Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education","place":["Chengdu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Xia","sequence":"additional","affiliation":[{"name":"Center for Medical Genetics, West China Second University Hospital, Sichuan University","place":["Chengdu, China"]},{"name":"Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education","place":["Chengdu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xihong","family":"Wang","sequence":"additional","affiliation":[{"name":"West China School of Public Health and West China Fourth Hospital, Sichuan University","place":["Chengdu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongqian","family":"Liu","sequence":"additional","affiliation":[{"name":"Center for Medical Genetics, West China Second University Hospital, Sichuan University","place":["Chengdu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,10,6]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"164","DOI":"10.1002\/jimd.12348","article-title":"An international classification of inherited metabolic disorders (ICIMD)","volume":"44","author":"Ferreira","year":"2021","journal-title":"J Inherit Metab 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