{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T05:47:05Z","timestamp":1782798425033,"version":"3.54.5"},"reference-count":69,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T00:00:00Z","timestamp":1782777600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Public Health"],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The WHO recommends \u2265150\u202fmin\/week of moderate-to-vigorous physical activity (MVPA) for optimal health. Whether weekend warrior (WW) or regular physical activity (PA) patterns differently influence risks of irritable bowel syndrome (IBS) and subsequent depression is unclear. This study explored these associations using accelerometer-derived PA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We included 84,799 UK Biobank participants with one-week accelerometer data to assess incident IBS using Cox models. Restricted cubic splines evaluated dose\u2013response relationships and identified optimal and minimal candidate MVPA doses. Participants were classified as inactive, WW, or regularly active using guideline (150\u202fmin\/week) and statistical thresholds. Among 3,976 baseline IBS patients, guideline-based groups were used to examine MVPA and subsequent depression risk with Cox models.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Over a median follow-up of 8.0\u202fyears, 962 participants developed IBS. MVPA showed a nonlinear inverse association, plateauing at 225\u202fmin\/week, with a minimal candidate dose of 80\u202fmin\/week. Both WW and regular activity were linked to lower IBS risk using 150\u202fmin\/week (WW: HR 0.75, 95% CI 0.65\u20130.87; regular: HR 0.73, 95% CI 0.61\u20130.88) and 80\u202fmin\/week thresholds (WW: HR 0.75, 95% CI 0.64\u20130.88; regular: HR 0.68, 95% CI 0.56\u20130.83). Among IBS patients, both WW (HR 0.61, 95% CI 0.42\u20130.89) and regular activity (HR 0.65, 95% CI 0.41\u20131.03) demonstrated comparable inverse associations with subsequent depression, with no significant difference between the two patterns.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Both WW and regular MVPA were similarly associated with a lower IBS risk, with minimal and optimal candidate doses of 80 and 225\u202fmin\/week, respectively. Among IBS patients, both activity patterns demonstrated comparable inverse associations with subsequent depression, although findings were constrained by limited statistical power.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fpubh.2026.1865206","type":"journal-article","created":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T05:40:50Z","timestamp":1782798050000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Accelerometer-derived \u201cweekend warrior\u201d and regular physical activity on long-term risk of irritable bowel syndrome and subsequent depression: a large-scale prospective cohort study"],"prefix":"10.3389","volume":"14","author":[{"given":"Chujie","family":"Tu","sequence":"first","affiliation":[{"name":"Division of Gastroenterology, Tongji Medical College, Union Hospital, Huazhong University of Science and Technology","place":["Wuhan, Hubei, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Endoscopy, Zhejiang Cancer Hospital, Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences","place":["Hangzhou, Zhejiang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Wang","sequence":"additional","affiliation":[{"name":"Ministry of Education Key Lab of Environment and Health, Department of Epidemiology and Biostatistics, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology","place":["Wuhan, Hubei, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaqi","family":"Hu","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Tongji Medical College, Union Hospital, Huazhong University of Science and Technology","place":["Wuhan, Hubei, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohua","family":"Hou","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Tongji Medical College, Union Hospital, Huazhong University of Science and Technology","place":["Wuhan, Hubei, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Bai","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, College of Medicine, Tianyou Hospital, Wuhan University of Science and Technology","place":["Wuhan, China"]},{"name":"Department of Clinical Medicine, College of Medicine, Wuhan University of Science and Technology","place":["Wuhan, China"]},{"name":"Division of Gastroenterology, Tongji Medical College, The Central Hospital of Wuhan, Huazhong University of Science and Technology","place":["Wuhan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Liu","sequence":"additional","affiliation":[{"name":"Ministry of Education Key Lab of Environment and Health, Department of Epidemiology and Biostatistics, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology","place":["Wuhan, Hubei, China"]},{"name":"Hubei Provincial Clinical Research Center for Colorectal Cancer","place":["Wuhan, Hubei, China"]},{"name":"Wuhan Clinical Research Center for Colorectal Cancer","place":["Wuhan, Hubei, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,6,30]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"1675","DOI":"10.1016\/S0140-6736(20)31548-8","article-title":"Irritable bowel syndrome","volume":"396","author":"Ford","year":"2020","journal-title":"Lancet"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1038\/s41575-020-0286-8","article-title":"Global burden of irritable bowel syndrome: trends, predictions and risk factors","volume":"17","author":"Black","year":"2020","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"1257","DOI":"10.1053\/j.gastro.2016.03.035","article-title":"Rome IV\u2014functional GI disorders: disorders of gut-brain interaction","volume":"150","author":"Drossman","year":"2016","journal-title":"Gastroenterology"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"908","DOI":"10.1016\/S2468-1253(20)30217-X","article-title":"Global prevalence of irritable bowel syndrome according to Rome III or IV criteria: a systematic review and meta-analysis","volume":"5","author":"Oka","year":"2020","journal-title":"Lancet Gastroenterol Hepatol"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"582","DOI":"10.1038\/s41575-023-00794-z","article-title":"Irritable bowel syndrome and mental health comorbidity\u2014approach to multidisciplinary management","volume":"20","author":"Staudacher","year":"2023","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1111\/apt.15325","article-title":"Systematic review with meta-analysis: the prevalence of anxiety and depression in patients with irritable bowel syndrome","volume":"50","author":"Zamani","year":"2019","journal-title":"Aliment Pharmacol Ther"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"17","DOI":"10.14309\/ajg.0000000000001036","article-title":"ACG clinical guideline: Management of Irritable Bowel Syndrome","volume":"116","author":"Lacy","year":"2021","journal-title":"Am J Gastroenterol"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"1214","DOI":"10.1136\/gutjnl-2021-324598","article-title":"British Society of Gastroenterology guidelines on the management of irritable bowel syndrome","volume":"70","author":"Vasant","year":"2021","journal-title":"Gut"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"1451","DOI":"10.1136\/bjsports-2020-102955","article-title":"World Health Organization 2020 guidelines on physical activity and sedentary behaviour","volume":"54","author":"Bull","year":"2020","journal-title":"Br J Sports Med"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"1493","DOI":"10.1093\/aje\/kwu087","article-title":"Age- and sex-specific criterion validity of the health survey for England physical activity and sedentary behavior assessment questionnaire as compared with Accelerometry","volume":"179","author":"Scholes","year":"2014","journal-title":"Am J Epidemiol"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"2472","DOI":"10.1093\/eurheartj\/ehab250","article-title":"Accelerometer-derived physical activity and risk of atrial fibrillation","volume":"42","author":"Khurshid","year":"2021","journal-title":"Eur Heart J"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"CD011497","DOI":"10.1002\/14651858.CD011497.pub2","article-title":"Physical activity for treatment of irritable bowel syndrome","volume":"2022","author":"Nunan","year":"2022","journal-title":"Cochrane Database Syst Rev"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1016\/j.jshs.2023.02.002","article-title":"Associations of daily sedentary behavior, physical activity, and sleep with irritable bowel syndrome: a prospective analysis of 362,193 participants","volume":"13","author":"Gao","year":"2024","journal-title":"J Sport Health Sci"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1186\/s12966-020-01042-2","article-title":"Advancing the global physical activity agenda: recommendations for future research by the 2020 WHO physical activity and sedentary behavior guidelines development group","volume":"17","author":"DiPietro","year":"2020","journal-title":"Int J Behav Nutr Phys Act"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1001\/jama.2023.10875","article-title":"Accelerometer-derived \u201cweekend warrior\u201d physical activity and incident cardiovascular disease","volume":"330","author":"Khurshid","year":"2023","journal-title":"JAMA"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1053\/j.gastro.2020.04.014","article-title":"Worldwide prevalence and burden of functional gastrointestinal disorders, results of Rome foundation global study","volume":"160","author":"Sperber","year":"2021","journal-title":"Gastroenterology"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"2660","DOI":"10.1016\/j.cgh.2023.01.017","article-title":"The socioeconomic impact of irritable bowel syndrome: an analysis of direct and indirect health care costs","volume":"21","author":"Bosman","year":"2023","journal-title":"Clin Gastroenterol Hepatol"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"748","DOI":"10.14309\/ajg.0000000000000989","article-title":"Contrasting clinician and insurer perspectives to managing irritable bowel syndrome: multilevel modeling analysis","volume":"116","author":"Shah","year":"2021","journal-title":"Am J Gastroenterol"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"e1001779","DOI":"10.1371\/journal.pmed.1001779","article-title":"UK biobank: an open access resource for identifying the causes of a wide range of complex diseases of middle and old age","volume":"12","author":"Sudlow","year":"2015","journal-title":"PLoS Med"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"e0169649","DOI":"10.1371\/journal.pone.0169649","article-title":"Large scale population assessment of physical activity using wrist worn accelerometers: the UK biobank study","volume":"12","author":"Doherty","year":"2017","journal-title":"PLoS One"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"398","DOI":"10.1186\/s12916-024-03618-2","article-title":"Accelerometer-derived moderate-to-vigorous physical activity and incident nonalcoholic fatty liver disease","volume":"22","author":"Liu","year":"2024","journal-title":"BMC Med"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"1008","DOI":"10.1136\/bjsports-2021-104050","article-title":"Reallocation of time between device-measured movement behaviours and risk of incident cardiovascular disease","volume":"56","author":"Walmsley","year":"2022","journal-title":"Br J Sports Med"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1016\/j.ypmed.2016.06.017","article-title":"Feedback from physical activity monitors is not compatible with current recommendations: a recalibration study","volume":"91","author":"Thompson","year":"2016","journal-title":"Prev Med"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"922","DOI":"10.1136\/gutjnl-2023-331254","article-title":"Association of healthy lifestyle behaviours with incident irritable bowel syndrome: a large population-based prospective cohort study","volume":"73","author":"Ho","year":"2024","journal-title":"Gut"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"1394","DOI":"10.1038\/s43587-024-00688-y","article-title":"Accelerometer-derived \u2018weekend warrior\u2019 physical activity pattern and brain health","volume":"4","author":"Min","year":"2024","journal-title":"Nat Aging"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"3083","DOI":"10.1002\/sim.3697","article-title":"Balance diagnostics for comparing the distribution of baseline covariates between treatment groups in propensity-score matched samples","volume":"28","author":"Austin","year":"2009","journal-title":"Stat Med"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"e0146021","DOI":"10.1371\/journal.pone.0146021","article-title":"Dose-response analysis using R","volume":"10","author":"Ritz","year":"2015","journal-title":"PLoS One"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"4801","DOI":"10.1093\/eurheartj\/ehac572","article-title":"Vigorous physical activity, incident heart disease, and cancer: how little is enough?","volume":"43","author":"Ahmadi","year":"2022","journal-title":"Eur Heart J"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1093\/eurjpc\/zwae248","article-title":"Association of accelerometer-derived physical activity with all-cause and cause-specific mortality among individuals with cardiovascular diseases: a prospective cohort study","volume":"32","author":"Cao","year":"2025","journal-title":"Eur J Prev Cardiol"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"zwaf604","DOI":"10.1093\/eurjpc\/zwaf604","article-title":"Accelerometer-measured physical activity timing and risk of incident atrial fibrillation: a UK biobank cohort study","author":"Zhang","year":"2025","journal-title":"Eur J Prev Cardiol"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"506","DOI":"10.1186\/s12916-025-04344-z","article-title":"Accelerometer-derived \u201cweekend warrior\u201d physical activity pattern and cardiovascular disease in individuals with hypertension: a prospective cohort study","volume":"23","author":"Qiao","year":"2025","journal-title":"BMC Med"},{"key":"ref32","doi-asserted-by":"publisher","first-page":"1154","DOI":"10.1002\/oby.24278","article-title":"Accelerometer-derived \u201cweekend warrior\u201d and regularly active physical activity and incident diabetes","volume":"33","author":"Lei","year":"2025","journal-title":"Obesity"},{"key":"ref33","doi-asserted-by":"publisher","first-page":"5164","DOI":"10.1038\/s41467-024-49542-0","article-title":"Accelerometer-derived physical activity and mortality in individuals with type 2 diabetes","volume":"15","author":"Cao","year":"2024","journal-title":"Nat Commun"},{"key":"ref34","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1186\/s12933-025-02676-x","article-title":"Accelerometer-derived \u201cweekend warrior\u201d physical activity pattern and incident type 2 diabetes","volume":"24","author":"Cao","year":"2025","journal-title":"Cardiovasc Diabetol"},{"key":"ref35","doi-asserted-by":"publisher","first-page":"512","DOI":"10.1016\/j.jagp.2024.10.015","article-title":"Accelerometer-derived physical activity, sedentary behavior, and the risk of depression and anxiety in middle-aged and older adults: a prospective cohort study of 71,556 UK biobank participants","volume":"33","author":"Yu","year":"2025","journal-title":"Am J Geriatr Psychiatry"},{"key":"ref36","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1016\/j.jad.2025.03.110","article-title":"Accelerometer-derived \u201cweekend warrior\u201d physical activity, genetic susceptibility, and risk of depression and anxiety: the UK biobank study","volume":"380","author":"Liu","year":"2025","journal-title":"J Affect Disord"},{"key":"ref37","doi-asserted-by":"publisher","first-page":"224","DOI":"10.1038\/s41746-023-00969-7","article-title":"Association of accelerometer-measured physical activity intensity, sedentary time, and exercise time with incident Parkinson\u2019s disease","volume":"6","author":"Liu","year":"2023","journal-title":"Npj Digit Med"},{"key":"ref38","doi-asserted-by":"publisher","first-page":"2593","DOI":"10.1186\/s12889-025-23820-y","article-title":"Association between physical activity patterns and the risk of stroke phenotypes: an accelerometer-based prospective cohort study from the UK biobank","volume":"25","author":"Shi","year":"2025","journal-title":"BMC Public Health"},{"key":"ref39","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1186\/s13195-024-01657-8","article-title":"Accelerometer-derived \u201cweekend warrior\u201d physical activity, sedentary behavior, and risk of dementia","volume":"17","author":"Ning","year":"2025","journal-title":"Alzheimer's Res Ther"},{"key":"ref40","doi-asserted-by":"publisher","first-page":"3831972","DOI":"10.1155\/2017\/3831972","article-title":"Exercise modifies the gut microbiota with positive health effects","volume":"2017","author":"Monda","year":"2017","journal-title":"Oxidative Med Cell Longev"},{"key":"ref41","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1016\/j.jshs.2022.09.002","article-title":"Unlocking a novel determinant of athletic performance: the role of the gut microbiota, short-chain fatty acids, and \u201cbiotics\u201d in exercise","volume":"12","author":"Sales","year":"2023","journal-title":"J Sport Health Sci"},{"key":"ref42","doi-asserted-by":"publisher","first-page":"2355","DOI":"10.1007\/s40279-022-01696-x","article-title":"The connection between physical exercise and gut microbiota: implications for competitive sports athletes","volume":"52","author":"Wegierska","year":"2022","journal-title":"Sports Med"},{"key":"ref43","doi-asserted-by":"publisher","first-page":"2211","DOI":"10.3390\/nu15092211","article-title":"Short-chain fatty-acid-producing Bacteria: key components of the human gut microbiota","volume":"15","author":"Fusco","year":"2023","journal-title":"Nutrients"},{"key":"ref44","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1016\/j.jshs.2016.05.001","article-title":"Endurance exercise and gut microbiota: a review","volume":"6","author":"Mach","year":"2017","journal-title":"J Sport Health Sci"},{"key":"ref45","doi-asserted-by":"publisher","first-page":"2325","DOI":"10.1194\/jlr.R036012","article-title":"The role of short-chain fatty acids in the interplay between diet, gut microbiota, and host energy metabolism","volume":"54","author":"den Besten","year":"2013","journal-title":"J Lipid Res"},{"key":"ref46","doi-asserted-by":"publisher","first-page":"4466","DOI":"10.3390\/nu15204466","article-title":"Roles of short-chain fatty acids in inflammatory bowel disease","volume":"15","author":"Shin","year":"2023","journal-title":"Nutrients"},{"key":"ref47","doi-asserted-by":"publisher","first-page":"582","DOI":"10.3390\/nu15030582","article-title":"Synergistic effect of rhodiola rosea and caffeine supplementation on the improvement of muscle strength and muscular endurance: a pilot study for rats, resistance exercise-untrained and -trained volunteers","volume":"15","author":"Liu","year":"2023","journal-title":"Nutrients"},{"key":"ref48","doi-asserted-by":"publisher","first-page":"1505","DOI":"10.3390\/life13071505","article-title":"Exercise for mental well-being: exploring neurobiological advances and intervention effects in depression","volume":"13","author":"Ren","year":"2023","journal-title":"Life"},{"key":"ref49","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1080\/19490976.2016.1218585","article-title":"Irritable bowel syndrome, the microbiota and the gut-brain axis","volume":"7","author":"Raskov","year":"2016","journal-title":"Gut Microbes"},{"key":"ref50","doi-asserted-by":"publisher","first-page":"e2300599","DOI":"10.1002\/mnfr.202300599","article-title":"Urolithin a ameliorates athletic ability and intestinal microbiota in sleep deprivation from the perspective of the gut-muscle Axis","volume":"68","author":"Zhu","year":"2024","journal-title":"Mol Nutr Food Res"},{"key":"ref51","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2014\/429031","article-title":"The role of physical exercise in inflammatory bowel disease","volume":"2014","author":"Bilski","year":"2014","journal-title":"Biomed Res Int"},{"key":"ref52","doi-asserted-by":"publisher","first-page":"120","DOI":"10.4314\/ahs.v18i1.16","article-title":"Inflammatory cytokines and immune system modulation by aerobic versus resisted exercise training for elderly","volume":"18","author":"Abd El-Kader","year":"2018","journal-title":"Afr Health Sci"},{"key":"ref53","doi-asserted-by":"publisher","first-page":"345","DOI":"10.2147\/JIR.S174982","article-title":"The role of inflammation in irritable bowel syndrome (IBS)","volume":"11","author":"Ng","year":"2018","journal-title":"J Inflamm Res"},{"key":"ref54","doi-asserted-by":"publisher","first-page":"608","DOI":"10.1177\/15598276211012968","article-title":"Dietary modification for the restoration of gut microbiome and Management of Symptoms in irritable bowel syndrome","volume":"16","author":"Thomas","year":"2022","journal-title":"Am J Lifestyle Med"},{"key":"ref55","doi-asserted-by":"publisher","first-page":"1539","DOI":"10.3390\/nu15061539","article-title":"Physical exercise and diet: regulation of gut microbiota to prevent and treat metabolic disorders to maintain health","volume":"15","author":"Zhang","year":"2023","journal-title":"Nutrients"},{"key":"ref56","doi-asserted-by":"publisher","first-page":"1292673","DOI":"10.3389\/fphys.2023.1292673","article-title":"A systematic review on the effects of exercise on gut microbial diversity, taxonomic composition, and microbial metabolites: identifying research gaps and future directions","volume":"14","author":"Cullen","year":"2023","journal-title":"Front Physiol"},{"key":"ref57","doi-asserted-by":"publisher","first-page":"915","DOI":"10.1038\/ajg.2010.480","article-title":"Physical activity improves symptoms in irritable bowel syndrome: a randomized controlled trial","volume":"106","author":"Johannesson","year":"2011","journal-title":"Am J Gastroenterol"},{"key":"ref58","doi-asserted-by":"publisher","first-page":"778","DOI":"10.1055\/s-2008-1038600","article-title":"The effects of exercise upon symptoms and quality of life in patients diagnosed with irritable bowel syndrome: a randomised controlled trial","volume":"29","author":"Daley","year":"2008","journal-title":"Int J Sports Med"},{"key":"ref59","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1016\/j.jbmt.2018.02.003","article-title":"The effect of aerobic exercises among women with mild and moderate irritable bowel syndrome: a pilot study","volume":"23","author":"Fani","year":"2019","journal-title":"J Bodyw Mov Ther"},{"key":"ref60","doi-asserted-by":"publisher","first-page":"16014","DOI":"10.1038\/nrdp.2016.14","article-title":"Irritable bowel syndrome","volume":"2","author":"Enck","year":"2016","journal-title":"Nat Rev Dis Primers"},{"key":"ref61","doi-asserted-by":"publisher","first-page":"2159","DOI":"10.1007\/s11845-022-03258-6","article-title":"Burden of anxiety and depression among hospitalized patients with irritable bowel syndrome: a nationwide analysis","volume":"192","author":"Tarar","year":"2023","journal-title":"Ir J Med Sci"},{"key":"ref62","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1016\/S2468-1253(20)30363-0","article-title":"Common mental disorders in irritable bowel syndrome: pathophysiology, management, and considerations for future randomised controlled trials","volume":"6","author":"Staudacher","year":"2021","journal-title":"Lancet Gastroenterol Hepatol"},{"key":"ref63","doi-asserted-by":"publisher","first-page":"550","DOI":"10.1001\/jamapsychiatry.2022.0609","article-title":"Association between physical activity and risk of depression: a systematic review and Meta-analysis","volume":"79","author":"Pearce","year":"2022","journal-title":"JAMA Psychiatry"},{"key":"ref64","doi-asserted-by":"publisher","first-page":"2066","DOI":"10.1001\/jama.2022.8997","article-title":"Even low amounts of physical activity reduce depression risk","volume":"327","author":"Slomski","year":"2022","journal-title":"JAMA"},{"key":"ref65","doi-asserted-by":"publisher","first-page":"1203","DOI":"10.1136\/bjsports-2022-106195","article-title":"Effectiveness of physical activity interventions for improving depression, anxiety and distress: an overview of systematic reviews","volume":"57","author":"Singh","year":"2023","journal-title":"Br J Sports Med"},{"key":"ref66","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1001\/jamapsychiatry.2018.4175","article-title":"Assessment of bidirectional relationships between physical activity and depression among adults: a 2-sample Mendelian randomization study","volume":"76","author":"Choi","year":"2019","journal-title":"JAMA Psychiatry"},{"key":"ref67","doi-asserted-by":"publisher","first-page":"103285","DOI":"10.1016\/j.eclinm.2025.103285","article-title":"Association between physical activity and risk of anxiety: a dose-response meta-analysis of 11 international cohorts","volume":"84","author":"Li","year":"2025","journal-title":"EClinicalMedicine"},{"key":"ref68","doi-asserted-by":"publisher","first-page":"1865","DOI":"10.14309\/ajg.0000000000003498","article-title":"Association of leisure-time physical activity patterns with constipation: evidence from the national health and nutrition examination survey","volume":"120","author":"Yang","year":"2025","journal-title":"Am J Gastroenterol"},{"key":"ref69","doi-asserted-by":"publisher","first-page":"dyag014","DOI":"10.1093\/ije\/dyag014","article-title":"Reproducibility and associated regression dilution bias of accelerometer-derived physical activity and sleep in UK biobank","volume":"55","author":"Zisou","year":"2026","journal-title":"Int J Epidemiol"}],"container-title":["Frontiers in Public Health"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fpubh.2026.1865206\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T05:40:51Z","timestamp":1782798051000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fpubh.2026.1865206\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,30]]},"references-count":69,"alternative-id":["10.3389\/fpubh.2026.1865206"],"URL":"https:\/\/doi.org\/10.3389\/fpubh.2026.1865206","relation":{},"ISSN":["2296-2565"],"issn-type":[{"value":"2296-2565","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,30]]},"article-number":"1865206"}}