{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T12:47:20Z","timestamp":1788266840101,"version":"build-2803163510"},"reference-count":64,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T00:00:00Z","timestamp":1784851200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000026","name":"National Institute on Drug Abuse","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000026","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Public Health"],"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study aims to build a rural Appalachian cohort to examine how US Food and Drug Administration (FDA) Center for Tobacco Products (CTP) regulatory policies influence tobacco and nicotine product use across levels of rurality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The AppalTRUST (Appalachian Tobacco Regulatory Science Team) Cohort integrates four inter-connected Community-engaged Research + Technology (CEnRT) elements to support recruitment and retention: (1) building trust and cultural relevance; (2) addressing barriers to participation in research; (3) focusing on ethics and confidentiality; and (4) fostering ongoing and consistent collaboration between the scientific and field teams. The study uses a dual sampling design to recruit 1,000 quota-based non-probability sample participants and 1,000 address-based probability sample participants. Eligible adults (ages 18+) are recruited from two Appalachian Kentucky catchments spanning rural and peri-urban counties. A local field team combines culturally relevant engagement strategies with technology-enabled procedures, including virtual consent and participant tracking, to foster trust and relevance with an underserved population.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Anticipated results<\/jats:title>\n                    <jats:p>Recruitment is ongoing. Feasibility indicators include enrollment of 985 non-probability sample participants and 209 probability sample participants, a 16% direct-mail response rate, and a 62% participant preference for text-based consent and survey reminders. Expected outcomes include guidance for applying CEnRT approaches in underserved populations, characterization of tobacco and nicotine use trends across the rural\u2013peri-urban continuum, and description of marketing exposure and consumer choice among subgroups of young adults and daily users in Appalachia. Findings will inform FDA CTP regulatory decision-making in rural Appalachian communities.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>This integrated CEnRT approach shows promise for recruiting and retaining rural Appalachian adults by centering community voice, trust, confidentiality, and practical engagement strategies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fpubh.2026.1867960","type":"journal-article","created":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T05:36:16Z","timestamp":1784871376000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Integration of community-engaged research technology and methods to guide tobacco regulatory science in rural communities"],"prefix":"10.3389","volume":"14","author":[{"given":"Melissa 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