{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T07:02:14Z","timestamp":1782975734221,"version":"3.54.5"},"reference-count":46,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T00:00:00Z","timestamp":1782950400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Public Health"],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Associations between long-term adult weight change and cardiovascular disease (CVD) risk remain incompletely understood, especially regarding life-stage-specific patterns. We examined how weight-change trajectories across adulthood relate to CVD prevalence and mortality in a representative population.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We analyzed 35,998 adults aged \u2265 40\u202fyears in multiple townships or sub-districts, Xinyang City, Henan Province, China from 2010 to 2024. BMI at age 25, 10\u202fyears before baseline, and baseline was used to classify patterns: stable normal weight, maximum overweight, obese-to-non-obese, non-obese-to-obese, and stable obesity. Multivariable logistic regression estimated odds ratios (ORs) for CVD prevalence and subtypes; Cox models estimated hazard ratios (HRs) for CVD mortality, accounting for survey design.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>At baseline, 6,112 participants had prevalent CVD. Over a median follow-up of 9.2\u202fyears (310,647 person-years), 2,314 participants died from CVD-related causes. From young to mid-adulthood, stable obesity was associated with higher odds of overall CVD (OR 1.92; 95% CI 1.38\u20132.65) and heart failure (OR 3.49; 95% CI 2.41\u20135.06). Transitioning from non-obesity to obesity also increased CVD risk. From mid to late adulthood, transitioning from obesity to non-obesity was associated with higher CVD prevalence (OR 2.00; 95% CI 1.61\u20132.48) and CVD mortality (HR 1.58; 95% CI 1.22\u20132.05). Large weight gain (\u2265 20\u202fkg) increased CVD risk, whereas later-life weight loss was associated with elevated CVD mortality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Adult weight change relates to CVD risk in life-stage-specific and heterogeneous ways. Maintaining normal weight from early adulthood and preventing excessive long-term weight gain may reduce CVD risk. Considering the timing of body weight changes across the adult lifespan is of great public health significance for cardiovascular risk assessment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fpubh.2026.1879396","type":"journal-article","created":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T05:34:08Z","timestamp":1782970448000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Adult weight change across the life course and cardiovascular disease prevalence and mortality: a population-based study"],"prefix":"10.3389","volume":"14","author":[{"given":"Ju","family":"Li","sequence":"first","affiliation":[{"name":"Xinyang Vocational and Technical College","place":["Xinyang, Henan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yajie","family":"Zhao","sequence":"additional","affiliation":[{"name":"Xinyang Vocational and Technical College","place":["Xinyang, Henan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xueqiang","family":"Wu","sequence":"additional","affiliation":[{"name":"Henan Engineering Research Center for Digital & Intelligent Diagnosis and Treatment of Hematology & Oncology","place":["Xinyang, Henan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Tao","sequence":"additional","affiliation":[{"name":"Xinyang Vocational and Technical College","place":["Xinyang, Henan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,7,2]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"2982","DOI":"10.1016\/j.jacc.2020.11.010","article-title":"Global burden of cardiovascular diseases and risk factors, 1990-2019: update from the GBD 2019 study","volume":"76","author":"Roth","year":"2020","journal-title":"J Am Coll 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