{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T06:28:16Z","timestamp":1787120896079,"version":"build-2736575974"},"reference-count":30,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T00:00:00Z","timestamp":1787097600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Public Health"],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Combined aerobic and resistance training is recommended for adults with cardiometabolic risk factors, but evidence from hospital-based integrated sports and health service settings remains limited.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This 12-week randomized trial evaluated the effects of supervised combined aerobic and resistance training on body composition and physical function in overweight or obese adults with multiple cardiometabolic risk factors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Adults with overweight or obesity and at least one additional clinically diagnosed cardiometabolic risk factor were randomized in a planned 2:1 ratio to intervention or control using a computer-generated stratified permuted-block sequence with allocation concealment. The intervention group completed supervised exercise three times weekly for 12 weeks. Each 60 min session included warm-up, aerobic exercise, resistance exercise, and flexibility\/cool-down, with intensity monitored using heart rate, heart-rate reserve, perceived exertion, symptoms, and tolerance. Controls maintained usual lifestyle and dietary habits and received weekly telephone follow-up. Co-primary outcomes were whole-body fat mass and handgrip strength. Baseline-adjusted linear mixed-effects models estimated week 12 between-group differences.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Of 60 individuals screened, 52 were randomized, and all completed week 12 assessment. At week 12, the intervention group had greater reductions in whole-body fat mass than controls (adjusted difference, \u22121.48 kg; 95% CI, \u22121.85 to \u22121.11; Holm-adjusted\n                      <jats:italic>P<\/jats:italic>\n                      &amp;lt; 0.001) and greater improvement in handgrip strength (1.16 kg; 95% CI, 0.56 to 1.77; Holm-adjusted\n                      <jats:italic>P<\/jats:italic>\n                      &amp;lt; 0.001). Exploratory secondary analyses with unadjusted\n                      <jats:italic>P<\/jats:italic>\n                      values suggested improvements in body weight, body mass index, body fat percentage, trunk fat mass, lower-limb explosive power, 4-m gait speed, one-leg standing balance, and sit-and-reach flexibility. Trunk muscle mass and whole-body response time were not statistically significant. Mean attendance was 86.7%, with no serious adverse events.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In this single-center randomized trial, 12-week supervised combined aerobic and resistance training was associated with modest improvements in fat-related body composition and selected physical-function outcomes in overweight or obese adults with multiple cardiometabolic risk factors. Cardiometabolic biomarkers were not reassessed at follow-up, and findings should be interpreted as preliminary.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fpubh.2026.1896850","type":"journal-article","created":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T05:48:58Z","timestamp":1787118538000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Effects of 12-week supervised combined aerobic and resistance training on body composition and physical function in overweight or obese adults with multiple cardiometabolic risk factors: a randomized trial"],"prefix":"10.3389","volume":"14","author":[{"given":"Jineng","family":"Chen","sequence":"first","affiliation":[{"name":"School of Physical Education, Sanming University, Sanming","place":["Fujian, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junlin","family":"Chen","sequence":"additional","affiliation":[{"name":"Quanzhou 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