{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T06:49:57Z","timestamp":1791355797891,"version":"4.3.1"},"reference-count":42,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T00:00:00Z","timestamp":1791331200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Public Health"],"abstract":"\n Background<\/jats:title>\n \n Helicobacter pylori<\/jats:italic>\n (\n H. pylori<\/jats:italic>\n ) infection may be related to metabolic disorders, with inflammation activation considered as a potential link. The study investigated the association between\n H. pylori<\/jats:italic>\n infection and metabolic syndrome (MetS), and explored the potential role of inflammatory cells in this association.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n This study was conducted in a health check-up group from a tertiary hospital in northwest China. Logistic regression models were used to examine the association between\n H. pylori<\/jats:italic>\n and MetS. Restricted cubic splines (RCS) were employed to examine both linear and nonlinear relationships between inflammatory markers and MetS. Additionally, the mediating role of inflammatory cells was examined.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n The study comprised 20,491 participants (9,586 women, 10,905 men). 32.5% was the infection rate for\n H. pylori<\/jats:italic>\n . Univariate analysis showed that MetS and its five components were significantly associated to\n H. pylori<\/jats:italic>\n infection. After controlling for covariates,\n H. pylori<\/jats:italic>\n infection was positively associated with MetS (OR: 1.27, 95% CI: 1.17\u20131.38). Furthermore,\n H. pylori<\/jats:italic>\n infection was significantly associated with central obesity, hypertriglyceridemia, reduced high-density lipoprotein cholesterol, and elevated blood pressure (OR ranging from 1.11 to 1.17, all\n p<\/jats:italic>\n &lt; 0.05). However, no significant correlation was found between\n H. pylori<\/jats:italic>\n infection and hyperglycemia. The RCS analysis showed that, with the exception of Monocyte-to-Lymphocyte Ratio (MLR), all other inflammatory markers show a nonlinear association with MetS. Exploratory mediation analysis suggested that leukocytes, lymphocytes, neutrophils, and monocytes accounted for 27.7%, 19.0%, 18.3%, and 6.9% of the statistical association between\n H. pylori<\/jats:italic>\n infection and MetS, respectively.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n This study indicates that\n H. pylori<\/jats:italic>\n infection was positively associated with MetS and its components (dyslipidemia, abdominal obesity, and elevated blood pressure). Inflammatory indices may be involved in this association.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.3389\/fpubh.2026.1913635","type":"journal-article","created":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T05:53:35Z","timestamp":1791352415000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["The role of inflammatory cells in the association between helicobacter pylori and metabolic syndrome: a cross-sectional study"],"prefix":"10.3389","volume":"14","author":[{"given":"Haiyan","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, The Second Affiliated Hospital of Xi'an Jiaotong University","place":["Xi'an, Shaanxi, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liuying","family":"He","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, The Second Affiliated Hospital of Xi'an Jiaotong University","place":["Xi'an, Shaanxi, 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Jiaotong University","place":["Xi'an, Shaanxi, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, The Second Affiliated Hospital of Xi'an Jiaotong University","place":["Xi'an, Shaanxi, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,10,7]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"868","DOI":"10.1111\/apt.14561","article-title":"Systematic review with meta-analysis: the worldwide prevalence of Helicobacter pylori infection","volume":"47","author":"Zamani","year":"2018","journal-title":"Aliment Pharmacol Ther."},{"key":"B2","doi-asserted-by":"publisher","first-page":"553","DOI":"10.1016\/S2468-1253(23)00070-5","article-title":"Global prevalence of Helicobacter pylori infection between 1980 and 2022: a systematic review and 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