{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T06:15:49Z","timestamp":1788156949669,"version":"build-2803163510"},"reference-count":53,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T00:00:00Z","timestamp":1788134400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Public Health"],"abstract":"<jats:p>\n                    Glaucoma remains one of the leading causes of acquired irreversible blindness worldwide, with normal-tension glaucoma representing the dominant subtype in Japan and several East Asian populations. The insidious, asymptomatic progression of this condition, combined with the demonstrated inadequacy of intraocular pressure alone as a screening criterion, creates a critical gap between disease burden and case detection. Population-based epidemiological studies consistently reveal that the majority of individuals with glaucoma are undiagnosed. Two responses have been suggested: incorporation of retinal imaging into annual health checkups, which warrants formal prospective evaluation, and characterization of individuals at higher risk \u2014 integrating genomic risk, oxidative stress biomarkers, systemic lifestyle factors, and ocular blood flow dynamics \u2014 which may help identify those in whom damage is most likely to occur. The principal contribution of this Perspective is therefore the implementation model rather than the individual screening components. We introduce the\n                    <jats:italic>Living Lab<\/jats:italic>\n                    (\u2018neighborhood health lab\u2019), a community co-creation platform established under the Japan Science and Technology Agency COI-NEXT \u2018Vision to Connect\u2019 hub at Tohoku University, as a scalable model for operationalizing this framework. Embedded within commercial retail environments, the\n                    <jats:italic>Living Lab<\/jats:italic>\n                    integrates non-invasive screening, longitudinal health data collection, and evidence-based health product development\u2014exemplified by the\n                    <jats:italic>Ronbun Recipe<\/jats:italic>\n                    \u00ae concept\u2014within a stakeholder-aligned ecosystem encompassing citizens, researchers, industry, and municipal authorities. Conceived as a platform for well-being rather than as a disease-specific screening service, it engages individuals who are asymptomatic, undiagnosed, and outside existing screening pathways, and who would not otherwise be assessed at all.\n                  <\/jats:p>","DOI":"10.3389\/fpubh.2026.1915134","type":"journal-article","created":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T05:40:51Z","timestamp":1788154851000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Beyond the clinic: a community-embedded, multidomain framework for early detection of glaucoma"],"prefix":"10.3389","volume":"14","author":[{"given":"Akiko","family":"Hanyuda","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Keio University School of Medicine","place":["Tokyo, Japan"]},{"name":"Department of Ophthalmology, Tohoku University Graduate School of Medicine","place":["Sendai, Miyagi, Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tetsuya","family":"Yamada","sequence":"additional","affiliation":[{"name":"Head Office of Enterprise Partnerships, Tohoku University","place":["Sendai, Miyagi, Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoru","family":"Tsuda","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Tohoku University Graduate School of Medicine","place":["Sendai, Miyagi, Japan"]},{"name":"Division of Ophthalmic Precision Medicine Development, United Centers for Advanced Research and Translational Medicine (ART), Tohoku University Graduate School of Medicine","place":["Sendai, Miyagi, Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noriko","family":"Himori","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Tohoku University Graduate School of Medicine","place":["Sendai, Miyagi, Japan"]},{"name":"Department of Aging Vision Healthcare, Tohoku University Graduate School of Biomedical Engineering","place":["Sendai, Miyagi, Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toru","family":"Nakazawa","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Tohoku University Graduate School of Medicine","place":["Sendai, Miyagi, Japan"]},{"name":"Division of Ophthalmic Precision Medicine Development, United Centers for Advanced Research and Translational Medicine (ART), Tohoku University Graduate School of Medicine","place":["Sendai, Miyagi, Japan"]},{"name":"Department of Retinal Disease Control, Tohoku University Graduate School of Medicine","place":["Sendai, Miyagi, Japan"]},{"name":"Department of Advanced Ophthalmic Medicine, Tohoku University Graduate School of Medicine","place":["Sendai, Miyagi, Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,8,31]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"2081","DOI":"10.1016\/j.ophtha.2014.05.013","article-title":"Global prevalence of glaucoma and projections of glaucoma burden through 2040: a systematic review and meta-analysis","volume":"121","author":"Tham","year":"2014","journal-title":"Ophthalmology"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"1711","DOI":"10.1016\/s0140-6736(04)16257-0","article-title":"Primary open-angle glaucoma","volume":"363","author":"Weinreb","year":"2004","journal-title":"Lancet"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"1641","DOI":"10.1016\/S0161-6420(04)00665-7","article-title":"The prevalence of primary open-angle glaucoma in Japanese: the Tajimi 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