{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T05:03:58Z","timestamp":1789707838963,"version":"4.0.1"},"reference-count":43,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T00:00:00Z","timestamp":1789689600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001589","name":"Environmental Protection Agency","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001589","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["RF1NS130672"],"award-info":[{"award-number":["RF1NS130672"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Public Health"],"abstract":"<jats:p>\n                    Reference epigenome projects, such as the NIH roadmap, ENCODE, and the international human epigenome consortium, have started mapping the baseline regulatory states of human cell types with extraordinary detail. However, these projects were not designed to address the urgent questions posed by exposome science and child-health policy: how these states\n                    <jats:italic>change<\/jats:italic>\n                    after environmental exposure, in whom, during which developmental window, and whether they can recover. I argue that the missing object is a human response epigenome: the cell-type-specific change in epigenomic state over time following a defined exposure or mixture, conditioned on internal dose, genotype, developmental stage, sex, ancestry, prior exposure, and time since exposure. Developmental neurotoxicity is the sentinel case for building it: the developing brain is the most vulnerable target organ, neurodevelopmental disorders are rising, several of the highest-confidence genetic risk factors are themselves components of the epigenetic machinery, and the prevention of childhood chronic disease is now an explicit policy priority. I distinguish the response epigenome from the reference and disease epigenomes, define its mapping unit, specify minimum standards and a tiered, sentinel-exposure pilot for its construction, and set the causal and ethical bar it must clear. The claim is deliberately bound: the epigenome is a principal, not the sole, durable interface between genome and environment. Mapping its\n                    <jats:italic>responses<\/jats:italic>\n                    , beginning with the developing brain, is the tractable next step toward prevention.\n                  <\/jats:p>","DOI":"10.3389\/fpubh.2026.1916784","type":"journal-article","created":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T04:36:08Z","timestamp":1789706168000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["From reference epigenomes to response epigenomes: a public-health case built on the developing brain"],"prefix":"10.3389","volume":"14","author":[{"given":"Thomas","family":"Hartung","sequence":"first","affiliation":[{"name":"Center for Alternatives to Animal Testing (CAAT), Department of Environmental Health and Engineering, Johns Hopkins Bloomberg School of Public Health","place":["Baltimore, MD, United States"]},{"name":"CAAT-Europe, University of Konstanz","place":["Konstanz, 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