{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T06:18:15Z","timestamp":1787811495610,"version":"build-2784847793"},"reference-count":38,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T00:00:00Z","timestamp":1787788800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100020208","name":"Shanghai Minhang District Health Commission","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100020208","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Public Health"],"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study examined the associations between meteorological exposures and major cancer mortality, with a focus on exposure-lag relationships.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We collected daily cancer death records and weather data from Minhang District, Shanghai, 2014 to 2023. Joinpoint regression estimated annual percent changes in age-standardized cancer mortality rates. Spearman's rank correlation was employed to explore how meteorological factors related to cancer death. Finally, a distributed lag non-linear model (DLNM) evaluated exposure-lag effects of meteorological factors on daily cancer death risk.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>This study included 26,684 cancer deaths. Spearman correlation analysis showed no significant linear associations between meteorological factors and daily mortality. However, the DLNM revealed significant non-linear and delayed effects, with low temperature and low humidity showing increased risks at specific lag days. Over a 0\u201321-day lag period, extreme weather affected lung cancer death risk more strongly than colorectal or gastric cancer risk. When daily mean temperature dropped to its 2.5th percentile, the estimated relative risk (RR) was 2.807, with a 95% confidence interval (95% CI) of 1.412\u20135.579. At the same percentile of daily minimum temperature, the cumulative RR for lung cancer death was 3.386 (95% CI: 1.697\u20136.755). When relative humidity was at its 2.5th percentile, the RR was 1.690 (95% CI: 1.269\u20132.250). Low temperature and low humidity showed increasing cumulative death risk with longer lag times.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Lower temperatures and humidity may raise major cancer mortality, especially for lung cancer. Focusing on extreme weather and early warnings could thus improve health management for high-risk groups.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fpubh.2026.1923874","type":"journal-article","created":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T05:34:18Z","timestamp":1787808858000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Association of meteorological exposures with major cancer mortality in Minhang District, Shanghai: a time series study based on distributed lag non-linear models"],"prefix":"10.3389","volume":"14","author":[{"given":"Jiaqi","family":"Guo","sequence":"first","affiliation":[{"name":"Information Management Section, Shanghai Minhang District Center for Disease Control and Prevention (Shanghai Minhang District Health Supervision Institute)","place":["Shanghai, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junhui","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Tuberculosis Prevention and Control, Shanghai Minhang District Center for Disease Control and Prevention (Shanghai Minhang District Health Supervision Institute)","place":["Shanghai, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Zhongshan Hospital, Fudan University","place":["Shanghai, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuili","family":"Xuan","sequence":"additional","affiliation":[{"name":"Information Management Section, Shanghai Minhang District Center for Disease Control and Prevention (Shanghai Minhang District Health Supervision Institute)","place":["Shanghai, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingyi","family":"Ni","sequence":"additional","affiliation":[{"name":"Information Management Section, Shanghai Minhang District Center for Disease Control and Prevention (Shanghai Minhang District Health Supervision Institute)","place":["Shanghai, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Liu","sequence":"additional","affiliation":[{"name":"Information Management Section, Shanghai Minhang District Center for Disease Control and Prevention (Shanghai Minhang District Health Supervision Institute)","place":["Shanghai, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linli","family":"Chen","sequence":"additional","affiliation":[{"name":"Director's Office, Shanghai Minhang District Center for Disease Control and Prevention (Shanghai Minhang District Health Supervision Institute)","place":["Shanghai, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yibin","family":"Zhou","sequence":"additional","affiliation":[{"name":"Director's Office, Shanghai Minhang District Center for Disease Control and Prevention (Shanghai Minhang District Health Supervision Institute)","place":["Shanghai, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,8,27]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"e1700","DOI":"10.1016\/S2214-109X(23)00406-0","article-title":"Quantitative estimates of preventable and treatable deaths from 36 cancers worldwide: a population-based study","volume":"11","author":"Frick","year":"2023","journal-title":"Lancet Glob Health."},{"key":"B2","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1016\/S1470-2045(23)00619-8","article-title":"Current and projected gaps in the availability of radiotherapy in the Asia-Pacific region: a country income-group analysis","volume":"25","author":"Abu Awwad","year":"2024","journal-title":"Lancet Oncol."},{"key":"B3","unstructured":"Ferlay\n              J\n            \n            \n              Ervik\n              M\n            \n            \n              Lam\n              F\n            \n            \n              Laversanne\n              M\n            \n            \n              Colombet\n              M\n            \n            \n              Mery\n              L\n            \n          \n          Global Cancer Observatory: cancer Today\n          \n          2024"},{"key":"B4","unstructured":"\u201cThe lancet countdown collaborators,\u201d in The 2025 Report of the Lancet Countdown on Health and Climate Change [Internet]\n          \n          \n            \n              Romanello\n              M\n            \n          \n          \n          2025"},{"key":"B5","doi-asserted-by":"publisher","first-page":"k4306","DOI":"10.1136\/bmj.k4306","article-title":"Association between ambient temperature and mortality risk and burden: time series study in 272 main Chinese cities","volume":"363","author":"Chen","year":"2018","journal-title":"BMJ."},{"key":"B6","doi-asserted-by":"publisher","first-page":"346","DOI":"10.1186\/s12889-023-15200-1","article-title":"The influence of meteorological factors and total malignant tumor health risk in Wuhu city in the context of climate change","volume":"23","author":"Pan","year":"2023","journal-title":"BMC Public Health."},{"key":"B7","doi-asserted-by":"publisher","first-page":"110985","DOI":"10.1016\/j.envres.2021.110985","article-title":"Disparities of weather type and geographical location in the impacts of temperature variability on cancer mortality: a multicity case-crossover study in Jiangsu Province, China","volume":"197","author":"Yi","year":"2021","journal-title":"Environ Res."},{"key":"B8","doi-asserted-by":"publisher","first-page":"2224","DOI":"10.1002\/sim.3940","article-title":"Distributed lag non-linear models","volume":"29","author":"Gasparrini","year":"2010","journal-title":"Stat Med."},{"key":"B9","doi-asserted-by":"publisher","first-page":"2630","DOI":"10.3390\/ijerph19052630","article-title":"Using distributed lag non-linear models to estimate exposure lag-response associations between long-term air pollution exposure and incidence of cardiovascular disease","volume":"19","author":"Kriit","year":"2022","journal-title":"Int J Environ Res Public Health."},{"key":"B10","volume-title":"A Study on the Impact of Climate Change on Tourism Behavior","author":"Zhang","year":"2024"},{"key":"B11","doi-asserted-by":"publisher","first-page":"1","DOI":"10.18637\/jss.v043.i08","article-title":"Distributed lag linear and non-linear models in R: the package dlnm","volume":"43","author":"Gasparrini","year":"2011","journal-title":"J Stat Softw."},{"key":"B12","doi-asserted-by":"publisher","first-page":"1187","DOI":"10.1093\/ije\/dyt092","article-title":"Time series regression studies in environmental epidemiology","volume":"42","author":"Bhaskaran","year":"2013","journal-title":"Int J Epidemiol."},{"key":"B13","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1111\/j.1467-985X.2006.00410.x","article-title":"Model choice in time series studies of air pollution and mortality","volume":"169","author":"Peng","year":"2006","journal-title":"J R Stat Soc Ser A Stat Soc."},{"key":"B14","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1016\/S0140-6736(14)62114-0","article-title":"Mortality risk attributable to high and low ambient temperature: a multicountry observational study","volume":"386","author":"Gasparrini","year":"2015","journal-title":"Lancet."},{"key":"B15","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1016\/j.scitotenv.2017.01.218","article-title":"Nonlinear relationship between extreme temperature and mortality in different temperature zones: a systematic study of 122 communities across the mainland of China","volume":"586","author":"Wang","year":"2017","journal-title":"Sci Total Environ"},{"key":"B16","doi-asserted-by":"publisher","first-page":"3106","DOI":"10.20043\/j.cnki.MPM.202110530","article-title":"Case-crossover study on the impact of short-term effects of air pollutants on lung cancer mortality among residents in Pudong New Area, Shanghai","volume":"49","author":"Chen","year":"2022","journal-title":"Modern Prev Med."},{"key":"B17","doi-asserted-by":"publisher","first-page":"753","DOI":"10.19428\/j.cnki.sjpm.2024.24013","article-title":"Correlation between varicella incidence and temperature in Minhang District, Shanghai","volume":"36","author":"Zhao","year":"2024","journal-title":"Shanghai J Prev Med."},{"key":"B18","doi-asserted-by":"publisher","first-page":"436","DOI":"10.16117\/j.cnki.31-1974\/r.201805019","article-title":"Trends and analysis of cancer mortality over 30 years among residents in Minhang District, Shanghai","volume":"13","author":"Tian","year":"2018","journal-title":"Health Educ Health Prom."},{"key":"B19","doi-asserted-by":"publisher","first-page":"549","DOI":"10.13421\/j.cnki.hjwsxzz.2023.07.012","article-title":"Research progress on environmental influencing factors of common global cancers in the context of climate change","volume":"13","author":"Zhang","year":"2023","journal-title":"J Environ Hyg."},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.13421\/j.cnki.hjwsxzz.2023.06.005","article-title":"Assessment of the impact of daily mean temperature on mortality risk among residents in Zhenjiang City using a distributed lag non-linear model","author":"Chen","year":"2023","journal-title":"J Environ Hyg"},{"key":"B21","unstructured":"Time series study on the correlation between non-accidental mortality and daily mean temperature among residents in Pudong New Area, Shanghai\n          \n          \n            \n              Chen\n              YC\n            \n            \n              Chen\n              H\n            \n            \n              Qu\n              XB\n            \n            \n              Gu\n              JY\n            \n            \n              Zhao\n              YJ\n            \n            \n              Yang\n              C\n            \n          \n          Modern Prev Med\n          \n          2022"},{"key":"B22","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1016\/j.envres.2014.11.016","article-title":"The temperature\u2013mortality relationship in China: an analysis from 66 Chinese communities","volume":"137","author":"Ma","year":"2015","journal-title":"Environ Res."},{"key":"B23","doi-asserted-by":"publisher","first-page":"268","DOI":"10.11847\/zgggws1116894","article-title":"Effect of PM10 on cumulative lag mortality among the elderly across different temperature ranges in Chengdu","volume":"34","author":"Zhang","year":"2018","journal-title":"Chin J Public Health."},{"key":"B24","doi-asserted-by":"publisher","first-page":"406","DOI":"10.13421\/j.cnki.hjwsxzz.2024.05.006","article-title":"Time series analysis of extreme temperatures and circulatory system disease mortality in Hefei, 2016\u20132021","volume":"14","author":"Xiao","year":"2024","journal-title":"J Environ Hyg."},{"key":"B25","doi-asserted-by":"publisher","first-page":"1739","DOI":"10.1152\/jappl.1996.81.4.1739","article-title":"Changes in airway resistance induced by nasal inhalation of cold dry, dry, or moist air in normal individuals","volume":"81","author":"Fontanari","year":"1985","journal-title":"J Appl Physiol"},{"key":"B26","doi-asserted-by":"publisher","first-page":"1243","DOI":"10.1152\/jappl.1992.72.4.1243","article-title":"Nasal flow-resistive responses to challenge with cold dry air","volume":"72","author":"Strohl","year":"1992","journal-title":"J Appl Physiol"},{"key":"B27","doi-asserted-by":"publisher","first-page":"1475075","DOI":"10.3389\/fclim.2024.1475075","article-title":"Impact of comorbidities and personal characteristics on weather-related risk for community-acquired pneumonia","volume":"6","author":"Brenner","year":"2024","journal-title":"Front Clim."},{"key":"B28","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1038\/s41467-019-13855-2","article-title":"Immune-mediated genetic pathways resulting in pulmonary function impairment increase lung cancer susceptibility","volume":"11","author":"Kachuri","year":"2020","journal-title":"Nat Commun."},{"key":"B29","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1146\/annurev-virology-012420-022445","article-title":"Seasonality of respiratory viral infections","volume":"7","author":"Moriyama","year":"2020","journal-title":"Annu Rev Virol."},{"key":"B30","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1016\/j.lungcan.2008.05.019","article-title":"Death certificates provide an adequate source of cause of death information when evaluating lung cancer mortality: an example from the Mayo Lung Project","volume":"63","author":"Doria-Rose","year":"2009","journal-title":"Lung Cancer."},{"key":"B31","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1177\/18333583221144665","article-title":"Evaluation of medical certification of cause of death in tertiary cancer hospitals in Northern India","volume":"53","author":"Anand","year":"2024","journal-title":"Health Inf Manag J."},{"key":"B32","doi-asserted-by":"publisher","first-page":"102680","DOI":"10.1016\/j.eclinm.2024.102680","article-title":"Lung cancer in Asia: the impact of climate change","volume":"74","author":"De Guzman","year":"2024","journal-title":"EClinMed."},{"key":"B33","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1080\/09603123.2024.2361453","article-title":"The association between ambient air pollution and colorectal cancer: a Mendelian randomization study","volume":"35","author":"Xu","year":"2025","journal-title":"Int J Environ Health Res."},{"key":"B34","doi-asserted-by":"publisher","first-page":"817","DOI":"10.1164\/rccm.202011-4063OC","article-title":"Air pollution, genetic factors, and the risk of lung cancer: a prospective study in the UK Biobank","volume":"204","author":"Huang","year":"2021","journal-title":"Am J Respir Crit Care Med."},{"key":"B35","doi-asserted-by":"publisher","first-page":"986","DOI":"10.1038\/s41416-025-02999-2","article-title":"Particulate matter air pollution as a cause of lung cancer: epidemiological and experimental evidence","volume":"132","author":"Wang","year":"2025","journal-title":"Br J Cancer."},{"key":"B36","doi-asserted-by":"publisher","first-page":"105126","DOI":"10.1016\/j.ebiom.2024.105126","article-title":"Impact of ambient air pollution on colorectal cancer risk and survival: insights from a prospective cohort and epigenetic Mendelian randomization study","volume":"103","author":"Jiang","year":"2024","journal-title":"EBioMed."},{"key":"B37","doi-asserted-by":"publisher","first-page":"1652216","DOI":"10.3389\/fpubh.2025.1652216","article-title":"Global, regional, and national disease burden of pneumoconiosis, chronic obstructive pulmonary disease, tracheal-bronchus-and-lung cancer, and asthma attributable to occupational risks, 1990\u20132021: a systematic analysis for the global burden of disease study 2021","volume":"13","author":"Lin","year":"2025","journal-title":"Front Public Health."},{"key":"B38","doi-asserted-by":"publisher","first-page":"6927","DOI":"10.21037\/jtd-2025-1003","article-title":"Global trends and projections of tracheal, bronchial, and lung (TBL) cancers associated with occupational exposure to diesel engine exhaust (DEE): insights from the Global Burden of Disease (GBD) 2021 Study for 1990 to 2021 and projections to 2035","volume":"17","author":"Guo","year":"2025","journal-title":"J Thorac Dis."}],"container-title":["Frontiers in Public Health"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fpubh.2026.1923874\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T05:34:27Z","timestamp":1787808867000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fpubh.2026.1923874\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,27]]},"references-count":38,"alternative-id":["10.3389\/fpubh.2026.1923874"],"URL":"https:\/\/doi.org\/10.3389\/fpubh.2026.1923874","relation":{},"ISSN":["2296-2565"],"issn-type":[{"value":"2296-2565","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,27]]},"article-number":"1923874"}}