{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T14:54:30Z","timestamp":1790780070288,"version":"4.1.0"},"reference-count":47,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T00:00:00Z","timestamp":1788912000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Public Health"],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>This study assessed the disease burden and health-related quality of life (HRQoL) among adults aged 50\u202fyears and older with herpes zoster (HZ) in Huzhou, China, and identified factors associated with increased disease burden.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A cross-sectional study was conducted among adults aged 50\u202fyears or older who developed HZ between 1 June 2024 and 1 June 2025 in Huzhou, China. Participants completed a structured questionnaire in September 2025 after the acute phase and retrospectively reported HRQoL during the acute HZ phase; participants with PHN also reported HRQoL during the PHN phase. Disease-burden and HRQoL distributions were compared using the Mann\u2013Whitney U test or Kruskal\u2013Wallis test, as appropriate. Gamma generalized linear models (GLMs) with a log link were used to identify factors associated with total, direct, and indirect burden.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 222 participants were included, of whom 62 (27.9%) developed PHN. Costs were recorded in RMB as gross disease-related expenditures before reimbursement and converted using USD\u202f=\u202fRMB\/7.1. The median direct burden was RMB 39,998.58 (P25, P75: RMB 11,792.27, 277,962.43), equivalent to USD 5,633.62 (P25, P75: USD 1,660.88, 39,149.64), and the median indirect burden was RMB 1,843.59 (USD 259.66; P25, P75: USD 155.79, 519.31). Participants with PHN had a higher median total burden than those without PHN (USD 10,958.43 vs. USD 4,740.60;\n                      <jats:italic>p<\/jats:italic>\n                      \u202f&amp;lt;\u202f0.001). During the acute HZ phase, the median EQ-5D-5L utility and EQ-VAS scores were 0.40 (P25, P75: \u22120.03, 0.53) and 10.00 (P25, P75: 10.00, 10.00), respectively. Treatment setting, PHN status, and age were associated with disease burden.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Herpes zoster was associated with substantial disease burden and markedly impaired HRQoL among adults aged 50\u202fyears or older in Huzhou. PHN and inpatient treatment identified subgroups with particularly high burden. These regional estimates may inform prevention policy and future evaluations of HZ vaccination.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fpubh.2026.1929296","type":"journal-article","created":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T05:49:43Z","timestamp":1788932983000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Disease burden and health-related quality of life among adults aged 50\u202fyears or older with herpes zoster in Huzhou, China"],"prefix":"10.3389","volume":"14","author":[{"given":"Shangyan","family":"Han","sequence":"first","affiliation":[{"name":"School of Public Health, Hangzhou Medical College","place":["Hangzhou, Zhejiang, China"]},{"name":"Institute of Immunization, Zhejiang Provincial Center for Disease Control and Prevention","place":["Hangzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Gong","sequence":"additional","affiliation":[{"name":"Institute for Health Policy, Hangzhou Medical College","place":["Hangzhou, Zhejiang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianyong","family":"Shen","sequence":"additional","affiliation":[{"name":"Institute of Immunization, Huzhou Center for Disease Control and Prevention","place":["Huzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaofu","family":"Luo","sequence":"additional","affiliation":[{"name":"Institute of Immunization, Huzhou Center for Disease Control and Prevention","place":["Huzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zizhe","family":"Zhang","sequence":"additional","affiliation":[{"name":"Institute of Immunization, Huzhou Center for Disease Control and Prevention","place":["Huzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoqi","family":"Liu","sequence":"additional","affiliation":[{"name":"Institute of Immunization, Huzhou Center for Disease Control and Prevention","place":["Huzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Hu","sequence":"additional","affiliation":[{"name":"Institute of Immunization, Zhejiang Provincial Center for Disease Control and Prevention","place":["Hangzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,9,9]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"1356","DOI":"10.12688\/f1000research.7153.1","article-title":"Varicella zoster virus in the nervous system","volume":"4","author":"Gilden","year":"2015","journal-title":"F1000Res"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"e004833","DOI":"10.1136\/bmjopen-2014-004833","article-title":"Systematic 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