{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T05:55:33Z","timestamp":1791266133906,"version":"4.1.0"},"reference-count":33,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T00:00:00Z","timestamp":1791244800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Public Health"],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Hypertension constitutes a leading global public health challenge, with early detection in young adults critical for primordial and primary prevention. Premarital health examinations represent an underutilized platform for population-based cardiovascular screening. This study aimed to estimate the prevalence of hypertension and identify associated factors among individuals undergoing premarital examination in Guangxi, China.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This large cross-sectional study was conducted at the Maternal and Child Health Hospital of Guangxi Zhuang Autonomous Region from 2022 to 2024, enrolling 11,283 consecutive premarital participants aged 20\u201350\u202fyears (5,641 males, 5,642 females). Sociodemographic, anthropometric, and metabolic indicators were collected using standardized questionnaires, physical measurements, and fasting biochemical tests. According to local premarital health policy, fasting blood glucose was measured only in female participants. Hypertension was defined as SBP\u202f\u2265\u202f140\u202fmmHg and\/or DBP\u202f\u2265\u202f90\u202fmmHg, or self-reported physician-diagnosed hypertension. Univariate tests, multivariate logistic regression and restricted cubic spline (RCS) models were applied to identify correlates and dose\u2013response relationships.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The overall prevalence of hypertension was 7.68%, with a significantly higher rate in men (10.28%) than in women (5.09%). In univariate analysis, age, body mass index (BMI), fasting blood glucose (FBG), alanine aminotransferase (ALT), sex, BMI classification, alcohol drinking, education level, abnormal FBG, and abnormal ALT were significantly associated with hypertension in the total population (all\n                      <jats:italic>p<\/jats:italic>\n                      \u202f&amp;lt;\u202f0.05). Multivariate regression identified overweight (OR\u202f=\u202f1.88, 95%CI: 1.27\u20132.77,\n                      <jats:italic>p<\/jats:italic>\n                      \u202f=\u202f0.002), obesity (OR\u202f=\u202f3.90, 95%CI: 2.29\u20136.64,\n                      <jats:italic>p<\/jats:italic>\n                      \u202f&amp;lt;\u202f0.001), lower education level (OR\u202f=\u202f1.64, 95%CI: 1.13\u20132.38,\n                      <jats:italic>p<\/jats:italic>\n                      \u202f=\u202f0.009), abnormal ALT (OR\u202f=\u202f1.69, 95%CI: 1.12\u20132.56,\n                      <jats:italic>p<\/jats:italic>\n                      \u202f=\u202f0.013) and annual age increment (OR\u202f=\u202f1.04, 95%CI: 1.01\u20131.08,\n                      <jats:italic>p<\/jats:italic>\n                      \u202f=\u202f0.011) as factors associated with higher odds of hypertension, while underweight was associated with lower odds (OR\u202f=\u202f0.42, 95%CI: 0.19\u20130.93,\n                      <jats:italic>p<\/jats:italic>\n                      \u202f=\u202f0.033). In sex-stratified analyses, abnormal fasting blood glucose was independently associated with higher odds of hypertension in women (OR\u202f=\u202f1.96, 95%CI: 1.21\u20133.16,\n                      <jats:italic>p<\/jats:italic>\n                      \u202f=\u202f0.006). RCS analyses confirmed positive dose\u2013response correlations between BMI, ALT, age and the odds of hypertension (all P for overall &amp;lt;0.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Hypertension imposes a non-negligible health burden among premarital adults in Guangxi, with a markedly higher prevalence observed in males. Overweight, obesity, elevated liver enzyme levels, low educational attainment, advancing age, and abnormal fasting glucose (in women) are key correlates of hypertension in this population. Routine premarital health services should integrate comprehensive cardiovascular risk screening covering blood pressure measurement and BMI assessment, with targeted health education, to support long-term cardiovascular health among young reproductive-age populations.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fpubh.2026.1948319","type":"journal-article","created":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T05:21:53Z","timestamp":1791264113000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Prevalence and factors associated with hypertension among individuals undergoing premarital examination in Guangxi, China: a large cross-sectional study, 2022\u20132024"],"prefix":"10.3389","volume":"14","author":[{"given":"BinLin","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Clinical Nutrition, Maternal and Child Health Hospital of Guangxi Zhuang Autonomous Region","place":["Nanning, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"SuHua","family":"Xia","sequence":"additional","affiliation":[{"name":"Department of Women\u2019s Health, Maternal and Child Health Hospital of Guangxi Zhuang Autonomous Region","place":["Nanning, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"YuHua","family":"Deng","sequence":"additional","affiliation":[{"name":"Department of Women\u2019s Health, Maternal and Child Health Hospital of Guangxi Zhuang Autonomous Region","place":["Nanning, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Maternal and Child Health Hospital of Guangxi Zhuang Autonomous Region","place":["Nanning, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MingMing","family":"Zhang","sequence":"additional","affiliation":[{"name":"Medical Examination Center, Maternal and Child Health Hospital of Guangxi Zhuang Autonomous Region","place":["Nanning, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,10,6]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"785","DOI":"10.1038\/s41569-021-00559-8","article-title":"Global epidemiology, health burden and effective interventions for elevated blood pressure and hypertension","volume":"18","author":"Zhou","year":"2021","journal-title":"Nat Rev Cardiol"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"1","DOI":"10.26599\/1671-5411.2025.01.008","article-title":"Chinese guidelines for the prevention and treatment of hypertension (2024 revision)","volume":"22","author":"Wang","year":"2025","journal-title":"J Geriatr Cardiol"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"740","DOI":"10.1097\/HJH.0000000000002698","article-title":"Trends in hypertension prevalence, awareness, treatment and 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