{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T06:05:18Z","timestamp":1790057118753,"version":"4.0.1"},"reference-count":34,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T00:00:00Z","timestamp":1790035200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Public Health"],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Ulcerative colitis (UC) lacks established primary prevention strategies despite its economic burden. Physical activity (PA) is promising, yet studies using self-reported data show inconsistent results. We examined the association between accelerometer-measured physical activity and UC risk in a large prospective cohort.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This cohort study analyzed data from 95,197 UK Biobank participants without baseline inflammatory bowel disease and with valid accelerometer data, with follow-up from 2013 to 2015 through 2023. Machine learning models estimated time spent in sedentary behavior, light physical activity (LPA), and moderate-to-vigorous physical activity (MVPA). MVPA patterns were categorized as active weekend warriors (\u2265231.5\u202fmin\/week, \u226550% in 1\u20132\u202fdays), active regular (\u2265231.5\u202fmin\/week, not meeting weekend warrior criteria), and inactive (&amp;lt;231.5\u202fmin\/week). Cox proportional hazards regression assessed associations between PA and UC risk.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Over 8.86\u202fyears median follow-up, 247 incident UC cases were recorded. MVPA showed a dose\u2013response relationship with UC risk (trend\n                      <jats:italic>p<\/jats:italic>\n                      =\u202f0.004). Compared to the lowest MVPA quartile, the third (231.5 to &amp;lt;402.3\u202fmin\/week) and highest (&amp;gt;402.3\u202fmin\/week) quartiles showed multivariable adjusted hazard ratios (aHRs) of 0.59 and 0.63 (95% CI: 0.40\u20130.85 and 0.43\u20130.91). Neither LPA nor sedentary time showed significant associations with UC risk. Both weekend warrior (aHR: 0.72, 95% CI: 0.53\u20130.99) and regular MVPA patterns (aHR: 0.57, 95% CI: 0.39\u20130.82) correlated with reduced UC risk. These associations remained robust across various subgroups and sensitivity analyses.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Accelerometer-measured MVPA is associated with reduced UC risk. Both weekend warrior and regular MVPA patterns conferred protection, suggesting that flexibility in exercise scheduling may be feasible.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fpubh.2026.1955306","type":"journal-article","created":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T05:39:25Z","timestamp":1790055565000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Accelerometer-measured physical activity and risk of incident ulcerative colitis: a population-based prospective study"],"prefix":"10.3389","volume":"14","author":[{"given":"Zitong","family":"Li","sequence":"first","affiliation":[{"name":"Integrative Clinical Microecology Center, Shenzhen Key Laboratory of Gastrointestinal Microbiota and Disease, Shenzhen Clinical Research Center for Digestive Disease, Shenzhen Technology Research Center of Gut Microbiota Transplantation, Department of Gastroenterology, Shenzhen Hospital, Southern Medical University","place":["Shenzhen, China"]},{"name":"Department of Gastroenterology, The First Affiliated Hospital of Shantou University Medical College","place":["Shantou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haoran","family":"Ke","sequence":"additional","affiliation":[{"name":"Hepatology Unit, Department of Infectious Diseases, Nanfang Hospital, Southern Medical University","place":["Guangzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanxiao","family":"Feng","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, State Key Laboratory of Organ Failure Research, Guangdong Provincial Key Laboratory of Gastroenterology, Nanfang Hospital, Southern Medical University","place":["Guangzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qianyun","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Beijing Friendship Hospital, Capital Medical University","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ye","family":"Chen","sequence":"additional","affiliation":[{"name":"Integrative Clinical Microecology Center, Shenzhen Key Laboratory of Gastrointestinal Microbiota and Disease, Shenzhen Clinical Research Center for Digestive Disease, Shenzhen Technology Research Center of Gut Microbiota Transplantation, Department of Gastroenterology, Shenzhen Hospital, Southern Medical University","place":["Shenzhen, China"]},{"name":"Department of Gastroenterology, State Key Laboratory of Organ Failure Research, Guangdong Provincial Key Laboratory of Gastroenterology, Nanfang Hospital, Southern Medical University","place":["Guangzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,9,22]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"571","DOI":"10.1016\/S0140-6736(23)00966-2","article-title":"Ulcerative colitis","volume":"402","author":"Le Berre","year":"2023","journal-title":"Lancet"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"2769","DOI":"10.1016\/S0140-6736(17)32448-0","article-title":"Worldwide incidence and prevalence of inflammatory bowel disease in the 21st century: a systematic review of population-based studies","volume":"390","author":"Ng","year":"2017","journal-title":"Lancet"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"2211","DOI":"10.1016\/j.cgh.2022.06.030","article-title":"Global hospitalization trends for Crohn\u2019s disease and ulcerative colitis in the 21st century: a systematic review with temporal 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