{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T06:49:25Z","timestamp":1791355765994,"version":"4.3.1"},"reference-count":55,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T00:00:00Z","timestamp":1791331200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Public Health"],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Self-management behaviors are central to long-term care for chronic hepatitis B (CHB), but the independent associations of social support and disease-specific quality-of-life domains with self-management remain unclear. This study assessed self-management and its associated factors among patients with CHB.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This multicenter cross-sectional study included 583 patients with CHB recruited by convenience sampling at three tertiary hospitals in Hengyang, China, from March to October 2025. Participants completed the Chronic Hepatitis B Self-Management Scale (CHBSMS), Social Support Rating Scale (SSRS), and Chronic Hepatitis B Quality of Life Instrument (CHBQOL). Hierarchical multiple linear regression, HC3 robust standard errors, and sensitivity analyses were used.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The mean total CHBSMS score was 85.03\u202f\u00b1\u202f19.38. The sociodemographic model yielded an\n                      <jats:italic>R<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      of 0.194. Adding clinical and healthcare utilization factors increased the explained variance (\u0394\n                      <jats:italic>R<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u202f=\u202f0.083), and adding social support and the four CHBQOL domain scores further increased the explained variance (\u0394\n                      <jats:italic>R<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u202f=\u202f0.102), yielding a final\n                      <jats:italic>R<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      of 0.379. In the fully adjusted model, social support (\n                      <jats:italic>B<\/jats:italic>\n                      \u202f=\u202f0.577, 95% CI: 0.416\u20130.739,\n                      <jats:italic>p<\/jats:italic>\n                      \u202f&amp;lt;\u202f0.001), the emotional symptoms domain (\n                      <jats:italic>B<\/jats:italic>\n                      \u202f=\u202f0.170, 95% CI: 0.039\u20130.301,\n                      <jats:italic>p<\/jats:italic>\n                      \u202f=\u202f0.011), and the social stigma domain (\n                      <jats:italic>B<\/jats:italic>\n                      \u202f=\u202f0.235, 95% CI: 0.082\u20130.388,\n                      <jats:italic>p<\/jats:italic>\n                      \u202f=\u202f0.003) were positively associated with self-management scores. Higher scores in the latter two domains indicated fewer emotional symptoms and less social stigma, respectively. For a 1-SD higher value of each predictor, the corresponding CHBSMS differences were 4.79, 1.90, and 2.15 points for social support, emotional symptoms, and social stigma, respectively, equivalent to 4.79, 1.90, and 2.15% of the score range. The somatic symptoms and belief domains were not significantly associated with self-management. Robustness and sensitivity analyses did not materially alter the main findings.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Among patients with CHB recruited from three tertiary hospitals, social support, the emotional symptoms domain, and the social stigma domain were associated with self-management after adjustment for sociodemographic, clinical, and healthcare utilization factors. Further longitudinal research is needed to clarify the temporal direction and clinical relevance of these associations.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fpubh.2026.1962656","type":"journal-article","created":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T05:50:14Z","timestamp":1791352214000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Associations of social support and disease-specific quality of life with self-management among patients with chronic hepatitis B: a multicenter cross-sectional study"],"prefix":"10.3389","volume":"14","author":[{"given":"Wen-Ting","family":"Yi","sequence":"first","affiliation":[{"name":"Department of International and Humanistic Nursing, Hunan Science Popularization Education Base, School of Nursing, Hengyang Medical School, University of South China","place":["Hengyang, 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and Humanistic Nursing, Hunan Science Popularization Education Base, School of Nursing, Hengyang Medical School, University of South China","place":["Hengyang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia-Jun","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of International and Humanistic Nursing, Hunan Science Popularization Education Base, School of Nursing, Hengyang Medical School, University of South China","place":["Hengyang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-Jing","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of International and Humanistic Nursing, Hunan Science Popularization Education Base, School of Nursing, Hengyang Medical School, University of South China","place":["Hengyang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Yan","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of International and Humanistic Nursing, Hunan Science Popularization Education Base, School of Nursing, Hengyang Medical School, University of South China","place":["Hengyang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing-Zhi","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of International and Humanistic Nursing, Hunan Science Popularization Education Base, School of Nursing, Hengyang Medical School, University of South China","place":["Hengyang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ke-Hao","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of International and Humanistic Nursing, Hunan Science Popularization Education Base, School of Nursing, Hengyang Medical School, University of South China","place":["Hengyang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Zeng","sequence":"additional","affiliation":[{"name":"Department of International and Humanistic Nursing, Hunan Science Popularization Education Base, School of Nursing, Hengyang Medical School, University of South China","place":["Hengyang, China"]},{"name":"Hunan Engineering Research Center for Early Diagnosis and Treatment of Liver Cancer, Hunan Province Key Laboratory of Tumor Cellular & Molecular Pathology, Cancer Research Institute, Hengyang Medical School, University of South China","place":["Hengyang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,10,7]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1097\/ID9.0000000000000098","article-title":"Guidelines for the prevention and treatment of chronic hepatitis B (version 2022)","volume":"3","author":"You","year":"2023","journal-title":"Infect Dis Immun"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"879","DOI":"10.1016\/s2468-1253(23)00197-8","article-title":"Global prevalence, cascade of 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