{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T15:18:28Z","timestamp":1793114308437,"version":"4.5.0"},"reference-count":129,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,1,26]],"date-time":"2024-01-26T00:00:00Z","timestamp":1706227200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Antibiot."],"abstract":"<jats:p>Multidrug-resistant organisms are bacteria that are no longer controlled or killed by specific drugs. One of two methods causes bacteria multidrug resistance (MDR); first, these bacteria may disguise multiple cell genes coding for drug resistance to a single treatment on resistance (R) plasmids. Second, increased expression of genes coding for multidrug efflux pumps, which extrude many drugs, can cause MDR. Antibiotic resistance is a big issue since some bacteria may withstand almost all antibiotics. These bacteria can cause serious sickness, making them a public health threat. Methicillin-resistant <jats:italic>Staphylococcus aureus<\/jats:italic> (MRSA), vancomycin-resistant <jats:italic>Enterococcus<\/jats:italic> (VRE), Multidrug resistant <jats:italic>Mycobacterium tuberculosis<\/jats:italic> (TB), and CRE are gut bacteria that resist antibiotics. Antimicrobial resistance is rising worldwide, increasing clinical and community morbidity and mortality. Superbugs have made antibiotic resistance in some environmental niches even harder to control. This study introduces new medicinal plants, gene-editing methods, nanomaterials, and bacterial vaccines that will fight MDR bacteria in the future.<\/jats:p>","DOI":"10.3389\/frabi.2023.1309107","type":"journal-article","created":{"date-parts":[[2024,1,26]],"date-time":"2024-01-26T04:34:22Z","timestamp":1706243662000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":12,"title":["Transient comparison of techniques to counter multi-drug resistant bacteria: prime modules in curation of bacterial infections"],"prefix":"10.3389","volume":"2","author":[{"given":"Muhammad","family":"Naveed","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad","family":"Waseem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Izma","family":"Mahkdoom","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nouman","family":"Ali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farrukh","family":"Asif","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jawad ul","family":"Hassan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hamza","family":"Jamil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2024,1,26]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1064","DOI":"10.5851\/kosfa.2018.e40","article-title":"Antimicrobial activity of a bacteriocin produced by Enterococcus faecalis KT11 against some pathogens and antibiotic-resistant bacteria","volume":"38","author":"Abanoz","year":"2018","journal-title":"Korean J. Food Sci. Anim. Resour."},{"key":"B2","doi-asserted-by":"publisher","first-page":"2910","DOI":"10.1128\/AEM.04265-14","article-title":"Solution structure of acidocin B, a circular bacteriocin produced by Lactobacillus acidophilus M46","volume":"81","author":"Acedo","year":"2015","journal-title":"Appl. Environ. Microbiol."},{"key":"B3","doi-asserted-by":"publisher","first-page":"3222","DOI":"10.3748\/wjg.v24.i29.3222","article-title":"ATP-binding cassette transporters in progression and clinical outcome of pancreatic cancer: What is the way forward","volume":"24","author":"Adamska","year":"2018","journal-title":"World J. Gastroenterol."},{"key":"B4","doi-asserted-by":"publisher","first-page":"881","DOI":"10.3390\/antibiotics10070881","article-title":"High prevalence of ESBL and plasmid-mediated quinolone resistance genes in Salmonella enterica isolated from retail meats and slaughterhouses in Egypt","volume":"10","author":"Adel","year":"2021","journal-title":"Antibiotics"},{"key":"B5","volume-title":"Molecular profile of gram-negative ESKAPE pathogens from Komfo Anokye Teaching Hospital in Ghana","author":"Agyepong","year":"2017"},{"key":"B6","doi-asserted-by":"crossref","DOI":"10.1002\/9783527609987","volume-title":"Modern phytomedicine: Turning medicinal plants into drugs","author":"Ahmad","year":"2006"},{"key":"B7","doi-asserted-by":"publisher","first-page":"756","DOI":"10.1016\/j.mset.2020.09.002","article-title":"Bactericidal activity of silver nanoparticles: A mechanistic review","volume":"3","author":"Ahmad","year":"2020","journal-title":"Mater. Sci. Energy Technol."},{"key":"B8","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1080\/14787210.2022.1990040","article-title":"Virulence factors, antibiotic resistance patterns, and molecular types of clinical isolates of Klebsiella Pneumoniae","volume":"20","author":"Ahmadi","year":"2022","journal-title":"Expert Rev. Anti-Infective Ther."},{"key":"B9","doi-asserted-by":"publisher","first-page":"590","DOI":"10.1089\/mdr.2017.0147","article-title":"Vancomycin-resistant enterococci: a review of antimicrobial resistance mechanisms and perspectives of human and animal health","volume":"24","author":"Ahmed","year":"2018","journal-title":"Microb. Drug Resist."},{"key":"B10","article-title":"The growing genetic and functional diversity of extended spectrum beta-lactamases","volume":"2018","author":"Ali","year":"2018","journal-title":"BioMed. Res. Int."},{"key":"B11","doi-asserted-by":"publisher","first-page":"212","DOI":"10.1016\/j.ijbiomac.2020.05.172","article-title":"Interaction of LysM BON family protein domain with carbapenems: A putative mechanism of carbapenem resistance","volume":"160","author":"Ali","year":"2020","journal-title":"Int. J. Biol. Macromol."},{"key":"B12","doi-asserted-by":"publisher","first-page":"AB29","DOI":"10.1016\/j.jaci.2018.12.091","article-title":"Perioperative use and safety of cephalosporin antibiotics in patients with documented penicillin allergy","volume":"143","author":"Anstey","year":"2019","journal-title":"J. Allergy Clin. Immunol."},{"key":"B13","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1556\/1886.2017.00001","article-title":"Finding novel antibiotic substances from medicinal plants\u2014antimicrobial properties of Nigella sativa directed against multidrug resistant bacteria","volume":"7","author":"Bakal","year":"2017","journal-title":"Eur. J. Microbiol. Immunol."},{"key":"B14","doi-asserted-by":"publisher","first-page":"889","DOI":"10.1042\/BST20150047","article-title":"Structural basis for the mechanism of ABC transporters","volume":"43","author":"Beis","year":"2015","journal-title":"Biochem. Soc. Trans."},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.01755","article-title":"Challenges for clinical development of vaccines for prevention of hospital-acquired bacterial infections","volume":"11","author":"Bekeredjian-Ding","year":"2020","journal-title":"Front. Immunol."},{"key":"B16","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s40168-017-0353-8","article-title":"Identification of 76 novel B1 metallo-\u03b2-lactamases through large-scale screening of genomic and metagenomic data","volume":"5","author":"Berglund","year":"2017","journal-title":"Microbiome"},{"key":"B17","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1016\/j.jgar.2021.02.008","article-title":"Carbapenemase detection testing in the era of ceftazidime\/avibactam-resistant KPC-producing Enterobacterales: A 2-year experience","volume":"24","author":"Bianco","year":"2021","journal-title":"J. Global Antimicrob. Resist."},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.02315","article-title":"Bacterial vaccine antigen discovery in the reverse vaccinology 2.0 Era: Progress and challenges","volume":"9","author":"Bidmos","year":"2018","journal-title":"Front. Immunol."},{"key":"B19","doi-asserted-by":"publisher","first-page":"2013695","DOI":"10.1080\/21688370.2021.2013695","article-title":"Bacterial effluxome as a barrier against antimicrobial agents: structural biology aspects and drug targeting","volume":"10","author":"Brindangnanam","year":"2022","journal-title":"Tissue Barriers"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1128\/aac.01076-18","article-title":"Past and present perspectives on \u03b2-lactamases","volume":"62","author":"Bush","year":"2018","journal-title":"Antimicrob. Agents Chemother."},{"key":"B21","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1038\/s41579-019-0159-8","article-title":"Interplay between \u03b2-lactamases and new \u03b2-lactamase inhibitors","volume":"17","author":"Bush","year":"2019","journal-title":"Nat. Rev. Microbiol."},{"key":"B22","volume-title":"Investigation of the sheltering effect of \u03b2-lactam-resistant K. pneumoniae species on twosusceptible E. coli and S. aureus strains","author":"Caprari","year":"2021"},{"key":"B23","doi-asserted-by":"publisher","first-page":"995","DOI":"10.3390\/antibiotics10080995","article-title":"Old and new beta-lactamase inhibitors: Molecular structure, mechanism of action, and clinical Use","volume":"10","author":"Carcione","year":"2021","journal-title":"Antibiotics"},{"key":"B24","doi-asserted-by":"publisher","first-page":"dlab092","DOI":"10.1093\/jacamr\/dlab092","article-title":"Extended-spectrum \u03b2-lactamases: an update on their characteristics, epidemiology and detection","volume":"3","author":"Castanheira","year":"2021","journal-title":"JAC Antimicrob. Resist."},{"key":"B25","doi-asserted-by":"publisher","first-page":"815","DOI":"10.1002\/psp4.12452","article-title":"Semimechanistic pharmacodynamic modeling of aztreonam-avibactam combination to understand its antimicrobial activity against multidrug-resistant gram-negative bacteria","volume":"8","author":"Chauzy","year":"2019","journal-title":"CPT: Pharmacometrics Syst. Pharmacol."},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1128\/aac.01929-18","article-title":"Development of a broad-spectrum antimicrobial combination for the treatment of Staphylococcus aureus and Pseudomonas aeruginosa corneal infections","volume":"63","author":"Chojnacki","year":"2019","journal-title":"Antimicrob. Agents Chemother."},{"key":"B27","doi-asserted-by":"publisher","first-page":"24656","DOI":"10.3390\/ijms161024656","article-title":"Staphylococcus aureus and MRSA growth and biofilm formation after treatment with antibiotics and SeNPs","volume":"16","author":"Cihalova","year":"2015","journal-title":"Int. J. Mol. Sci."},{"key":"B28","doi-asserted-by":"publisher","first-page":"114852","DOI":"10.1016\/j.diagmicrobio.2019.06.004","article-title":"Genotypic analysis of Italian MRSA strains exhibiting low-level ceftaroline and ceftobiprole resistance","volume":"95","author":"Dafne","year":"2019","journal-title":"Diagn. Microbiol. Infect. Dis."},{"key":"B29","doi-asserted-by":"publisher","first-page":"2055","DOI":"10.1021\/acs.accounts.0c00863","article-title":"Designing inhibitors of \u03b2-lactamase enzymes to overcome carbapenem resistance in Gram-negative bacteria","volume":"54","author":"Davies","year":"2021","journal-title":"Accounts Chem. Res."},{"key":"B30","doi-asserted-by":"publisher","first-page":"578","DOI":"10.7732\/kjpr.2020.33.6.578","article-title":"Assessment of \u03b2-Lactamase Inhibitor Potential of Medicinal Plant Extracts against Antibiotic-resistant Staphylococcus aureus","volume":"33","author":"Dawan","year":"2020","journal-title":"Korean J. Plant Resour."},{"key":"B31","doi-asserted-by":"publisher","first-page":"808","DOI":"10.1016\/j.bbapap.2008.11.005","article-title":"Outer membrane permeability and antibiotic resistance","volume":"1794","author":"Delcour","year":"2009","journal-title":"Biochim. Biophys. Acta (BBA) Proteins Proteom."},{"key":"B32","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12906-016-1105-1","article-title":"Antibacterial and antibiotic-modulation activity of six Cameroonian medicinal plants against Gram-negative multi-drug resistant phenotypes","volume":"16","author":"Djeussi","year":"2016","journal-title":"BMC Complement. Altern. Med."},{"key":"B33","first-page":"536","article-title":"Antibiotics: mode of action and mechanisms of resistance","volume":"1","author":"Dowling","year":"2017","journal-title":"Antimicrob. Res.: Novel Bioknowledge Educ. Programs"},{"key":"B34","doi-asserted-by":"publisher","first-page":"37","DOI":"10.3390\/antibiotics8020037","article-title":"Epidemiology and mechanisms of resistance of extensively drug resistant Gram-negative bacteria","volume":"8","author":"Eichenberger","year":"2019","journal-title":"Antibiotics"},{"key":"B35","doi-asserted-by":"publisher","first-page":"e0245126","DOI":"10.1371\/journal.pone.0245126","article-title":"Molecular analysis of bla SHV, bla TEM, and bla CTX-M in extended-spectrum \u03b2-lactamase producing Enterobacteriaceae recovered from fecal specimens of animals","volume":"16","author":"Ejaz","year":"2021","journal-title":"PloS One"},{"key":"B36","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1038\/s41589-019-0401-8","article-title":"Discovery of an antivirulence compound that reverses \u03b2-lactam resistance in MRSA","volume":"16","author":"El-Halfawy","year":"2020","journal-title":"Nat. Chem. Biol."},{"key":"B37","first-page":"PMC. S14459","volume-title":"Antibiotics and bacterial resistance in the 21st century. Perspectives in medicinal chemistry","author":"Fair","year":"2014"},{"key":"B38","doi-asserted-by":"publisher","first-page":"2307","DOI":"10.1016\/j.drudis.2020.09.028","article-title":"Efflux pumps as interventions to control infection caused by drug-resistance bacteria","volume":"25","author":"Farhat","year":"2020","journal-title":"Drug Discovery Today"},{"key":"B39","doi-asserted-by":"publisher","first-page":"e00450","DOI":"10.1128\/spectrum.00450-22","article-title":"Broad-Spectrum Inhibitors against Class A, B, and C Type \u03b2-Lactamases to Block the Hydrolysis against Antibiotics: Kinetics and Structural Characterization","volume":"10","author":"Farhat","year":"2022","journal-title":"Microbiol. Spectrum"},{"key":"B40","doi-asserted-by":"publisher","first-page":"2436","DOI":"10.1128\/JCM.00211-16","article-title":"Resistance mechanisms, epidemiology, and approaches to screening for vancomycin-resistant Enterococcus in the health care setting","volume":"54","author":"Faron","year":"2016","journal-title":"J. Clin. Microbiol."},{"key":"B41","doi-asserted-by":"crossref","DOI":"10.1088\/1755-1315\/116\/1\/012034","article-title":"The effectiveness of heterotrophic bacteria isolated from Dumai marine waters of Riau, used as antibacterial against pathogens in fish culture","author":"Feliatra","year":"2018"},{"key":"B42","doi-asserted-by":"publisher","first-page":"7.4. 9","DOI":"10.1128\/9781683670131.ch24","article-title":"Pathogenicity of enterococci","volume":"7","author":"Fiore","year":"2019","journal-title":"Microbiol. Spectrum"},{"key":"B43","doi-asserted-by":"publisher","first-page":"3412","DOI":"10.1021\/acs.chemrev.0c01010","article-title":"\u03b2-Lactams against the Fortress of the Gram-Positive Staphylococcus aureus Bacterium","volume":"121","author":"Fisher","year":"2020","journal-title":"Chem. Rev."},{"key":"B44","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1007\/978-3-031-26078-0_2","volume-title":"New Cephalosporins: Fifth and Sixth Generations. New Antimicrobials: For the Present and the Future","author":"Fong","year":"2023"},{"key":"B45","doi-asserted-by":"publisher","first-page":"52","DOI":"10.3390\/antibiotics8020052","article-title":"The continuing threat of methicillin-resistant Staphylococcus aureus","volume":"8","author":"Gajd\u00e1cs","year":"2019","journal-title":"Antibiotics"},{"key":"B46","doi-asserted-by":"publisher","first-page":"1457","DOI":"10.1080\/14787210.2021.1924674","article-title":"Multidrug-resistant Klebsiella pneumoniae: mechanisms of resistance including updated data for novel \u03b2-lactam-\u03b2-lactamase inhibitor combinations","volume":"19","author":"Galani","year":"2021","journal-title":"Expert Rev. Anti-Infective Ther."},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/9981915","article-title":"Antibacterial potency of medicinal plants including Artemisia annua and Oxalis corniculata against multi-drug resistance E. coil","volume":"2021","author":"Golbarg","year":"2021","journal-title":"BioMed. Res. Int."},{"key":"B48","doi-asserted-by":"publisher","first-page":"123","DOI":"10.4103\/JLP.JLP_122_18","article-title":"Prevalence and characterization of beta-lactamase-producing Escherichia coli isolates from a tertiary care hospital in India","volume":"11","author":"Govindaswamy","year":"2019","journal-title":"J. Lab. Physicians"},{"key":"B49","doi-asserted-by":"publisher","first-page":"186","DOI":"10.3390\/antibiotics9040186","article-title":"The current burden of carbapenemases: Review of significant properties and dissemination among gram-negative bacteria","volume":"9","author":"Hammoudi Halat","year":"2020","journal-title":"Antibiotics"},{"key":"B50","doi-asserted-by":"publisher","first-page":"615","DOI":"10.1007\/s00109-020-01893-z","article-title":"Mitigating off-target effects in CRISPR\/Cas9-mediated in vivo gene editing","volume":"98","author":"Han","year":"2020","journal-title":"J. Mol. Med."},{"key":"B51","doi-asserted-by":"publisher","first-page":"1383","DOI":"10.1111\/febs.13248","article-title":"Genetic screens and functional genomics using CRISPR\/Cas9 technology","volume":"282","author":"Hartenian","year":"2015","journal-title":"FEBS J."},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/8281623","article-title":"Characterisation of bacteriocins produced by Lactobacillus spp. isolated from the traditional Pakistani yoghurt and their antimicrobial activity against common foodborne pathogens","volume":"2020","author":"Hassan","year":"2020","journal-title":"BioMed. Res. Int."},{"key":"B53","doi-asserted-by":"publisher","first-page":"1432","DOI":"10.1038\/s41564-019-0503-9","article-title":"Defining and combating antibiotic resistance from One Health and Global Health perspectives","volume":"4","author":"Hernando-Amado","year":"2019","journal-title":"Nat. Microbiol."},{"key":"B54","doi-asserted-by":"publisher","first-page":"105040","DOI":"10.1016\/j.micpath.2021.105040","article-title":"Genetic basis of molecular mechanisms in \u03b2-lactam resistant gram-negative bacteria","volume":"158","author":"Hussain","year":"2021","journal-title":"Microb. Pathogen."},{"key":"B55","doi-asserted-by":"publisher","first-page":"12341","DOI":"10.1021\/acsnano.0c05937","article-title":"Antimicrobial nanomaterials and coatings: Current mechanisms and future perspectives to control the spread of viruses including SARS-CoV-2","volume":"14","author":"Imani","year":"2020","journal-title":"ACS Nano"},{"key":"B56","doi-asserted-by":"publisher","first-page":"2111","DOI":"10.1007\/s10143-020-01376-2","article-title":"De novo methicillin-resistant Staphylococcus aureus vs. methicillin-sensitive Staphylococcus aureus infections of the spine, similar clinical outcome, despite more severe presentation in surgical patients","volume":"44","author":"Ishak","year":"2021","journal-title":"Neurosurg. Rev"},{"key":"B57","doi-asserted-by":"publisher","first-page":"87","DOI":"10.3390\/pathogens9020087","article-title":"Novel cytoplasmic bacteriocin compounds derived from Staphylococcus epidermidis selectively kill Staphylococcus aureus, including methicillin-resistant Staphylococcus aureus (MRSA)","volume":"9","author":"Jang","year":"2020","journal-title":"Pathogens"},{"key":"B58","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1038\/nm.4465","article-title":"The role of vaccines in preventing bacterial antimicrobial resistance","volume":"24","author":"Jansen","year":"2018","journal-title":"Nat. Med."},{"key":"B59","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1016\/j.jmii.2021.07.015","article-title":"Multicenter surveillance of antimicrobial susceptibilities and resistance mechanisms among Enterobacterales species and non-fermenting Gram-negative bacteria from different infection sources in Taiwan from 2016 to 2018","volume":"55","author":"Jean","year":"2022","journal-title":"J. Microbiol. Immunol. Infect."},{"key":"B60","doi-asserted-by":"publisher","first-page":"1050","DOI":"10.3762\/bjnano.9.98","article-title":"Review on nanoparticles and nanostructured materials: history, sources, toxicity and regulations","volume":"9","author":"Jeevanandam","year":"2018","journal-title":"Beilstein J. Nanotechnol."},{"key":"B61","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1038\/s41467-021-27193-9","article-title":"Hydrophilic nanoparticles that kill bacteria while sparing mammalian cells reveal the antibiotic role of nanostructures","volume":"13","author":"Jiang","year":"2022","journal-title":"Nat. Commun."},{"key":"B62","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1038\/nri.2016.147","article-title":"Programmed cell death as a defence against infection","volume":"17","author":"Jorgensen","year":"2017","journal-title":"Nat. Rev. Immunol."},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/6644185","article-title":"High level of multidrug-resistant gram-negative pathogens causing burn wound infections in hospitalized children in dar es salaam, Tanzania","volume":"2021","author":"Kabanangi","year":"2021","journal-title":"Int. J. Microbiol."},{"key":"B64","doi-asserted-by":"publisher","first-page":"1044","DOI":"10.3390\/antibiotics10091044","article-title":"Phytochemicals: a promising weapon in the arsenal against antibiotic-resistant bacteria","volume":"10","author":"Khameneh","year":"2021","journal-title":"Antibiotics"},{"key":"B65","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12917-020-02519-9","article-title":"Antimicrobial resistance pattern in domestic animal-wildlife-environmental niche via the food chain to humans with a Bangladesh perspective; a systematic review","volume":"16","author":"Khan","year":"2020","journal-title":"BMC Vet. Res."},{"key":"B66","first-page":"333","article-title":"Characterization of extended-spectrum \u00ee\u2019-lactamase-producing Escherichia coli strains isolated from dairy products","volume":"3","author":"Khoshbakht","year":"2014","journal-title":"J. Microbiol. Biotechnol. Food Sci."},{"key":"B67","doi-asserted-by":"publisher","first-page":"196","DOI":"10.1016\/j.jep.2016.04.001","article-title":"Cytotoxicity of 15 Cameroonian medicinal plants against drug sensitive and multi-drug resistant cancer cells","volume":"186","author":"Kuete","year":"2016","journal-title":"J. Ethnopharmacol."},{"key":"B68","doi-asserted-by":"publisher","first-page":"4932","DOI":"10.1039\/D0CS01026J","article-title":"Chemically modified and conjugated antimicrobial peptides against superbugs","volume":"50","author":"Li","year":"2021","journal-title":"Chem. Soc. Rev."},{"key":"B69","doi-asserted-by":"publisher","first-page":"8007","DOI":"10.1007\/s00253-022-12272-8","article-title":"Cephalosporins as key lead generation beta-lactam antibiotics","volume":"106","author":"Lin","year":"2022","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"B70","doi-asserted-by":"publisher","first-page":"104915","DOI":"10.1016\/j.micpath.2021.104915","article-title":"Emerging resistance mechanisms for 4 types of common anti-MRSA antibiotics in Staphylococcus aureus: A comprehensive review","volume":"156","author":"Liu","year":"2021","journal-title":"Microb. Pathogen."},{"key":"B71","volume-title":"Discovery of taniborbactam (VNRX-5133): a broad-spectrum serine-and metallo-\u03b2-lactamase inhibitor for carbapenem-resistant bacterial infections","author":"Liu","year":"2019"},{"key":"B72","doi-asserted-by":"publisher","first-page":"487","DOI":"10.1038\/nsmb.3216","article-title":"Mechanistic diversity in ATP-binding cassette (ABC) transporters","volume":"23","author":"Locher","year":"2016","journal-title":"Nat. Struct. Mol. Biol."},{"key":"B73","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2018.02179","article-title":"The role of antibiotic-target-modifying and antibiotic-modifying enzymes in Mycobacterium abscessus drug resistance","volume":"9","author":"Luthra","year":"2018","journal-title":"Front. Microbiol."},{"key":"B74","doi-asserted-by":"publisher","first-page":"462","DOI":"10.3390\/plants10030462","article-title":"Antibacterial and COX-2 inhibitory tetrahydrobisbenzylisoquinoline alkaloids from the Philippine medicinal plant Phaeanthus ophthalmicus","volume":"10","author":"Magpantay","year":"2021","journal-title":"Plants"},{"key":"B75","doi-asserted-by":"publisher","first-page":"4713","DOI":"10.2147\/IDR.S290835","article-title":"Antimicrobial stewardship: Fighting antimicrobial resistance and protecting global public health","author":"Majumder","year":"2020","journal-title":"Infect. Drug Resist."},{"key":"B76","doi-asserted-by":"publisher","first-page":"1245","DOI":"10.1080\/14787210.2020.1796638","article-title":"Tackling antimicrobial resistance by promoting antimicrobial stewardship in medical and allied health professional curricula","volume":"18","author":"Majumder","year":"2020","journal-title":"Expert Rev. Anti-Infective Ther."},{"key":"B77","doi-asserted-by":"publisher","first-page":"467","DOI":"10.1038\/nrmicro2577","article-title":"Evolution and classification of the CRISPR\u2013Cas systems","volume":"9","author":"Makarova","year":"2011","journal-title":"Nat. Rev. Microbiol."},{"key":"B78","doi-asserted-by":"publisher","first-page":"1034","DOI":"10.1016\/j.tim.2021.04.010","article-title":"Immunopeptidomics for next-generation bacterial vaccine development","volume":"29","author":"Mayer","year":"2021","journal-title":"Trends Microbiol."},{"key":"B79","doi-asserted-by":"publisher","first-page":"1","DOI":"10.31083\/j.jmcm.2021.01.208","article-title":"Antimicrobial peptides-An alternative candidates to antibiotics against Staphylococcus aureus and its antibiotic-resistant strains","volume":"4","author":"Mazumdar","year":"2021","journal-title":"J. Mol. Clin. Med."},{"key":"B80","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1007\/s15010-019-01291-9","article-title":"AmpC \u03b2-lactamase-producing Enterobacterales: what a clinician should know","volume":"47","author":"Meini","year":"2019","journal-title":"Infection"},{"key":"B81","doi-asserted-by":"publisher","first-page":"257","DOI":"10.3390\/antibiotics8040257","article-title":"Efficacy and mechanism of traditional medicinal plants and bioactive compounds against clinically important pathogens","volume":"8","author":"Mickymaray","year":"2019","journal-title":"Antibiotics"},{"key":"B82","first-page":"75","article-title":"Anti-bacterial efficacy of bacteriocin produced by marine Bacillus subtilis against clinically important extended spectrum beta-lactamase strains and methicillin-resistant Staphylococcus aureus","volume":"7","author":"Mickymaray","year":"2018","journal-title":"Int. J. Med. Res. Health Sci."},{"key":"B83","doi-asserted-by":"publisher","first-page":"727","DOI":"10.1007\/s12223-021-00910-z","article-title":"Mechanism of drug resistance in bacteria: efflux pump modulation for designing of new antibiotic enhancers","volume":"66","author":"Mohanty","year":"2021","journal-title":"Folia Microbiol."},{"key":"B84","doi-asserted-by":"publisher","first-page":"1255","DOI":"10.3390\/ijms20061255","article-title":"Thinking outside the bug: molecular targets and strategies to overcome antibiotic resistance","volume":"20","author":"Monserrat-Martinez","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"B85","doi-asserted-by":"publisher","first-page":"1623","DOI":"10.1039\/D1MD00200G","article-title":"\u03b2-Lactam antibiotic targets and resistance mechanisms: from covalent inhibitors to substrates","volume":"12","author":"Mora-Ochomogo","year":"2021","journal-title":"RSC Medicinal Chem."},{"key":"B86","first-page":"3","article-title":"Mechanisms of action and antimicrobial activity of ceftobiprole","volume":"32","author":"Morosini","year":"2019","journal-title":"Rev. Espa\u00f1ola Quimioterapia"},{"key":"B87","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1139\/cjm-2019-0309","article-title":"Renaissance of vancomycin: Approaches for breaking antibiotic resistance in multidrug-resistant bacteria","volume":"66","author":"M\u00fchlberg","year":"2020","journal-title":"Can. J. Microbiol."},{"key":"B88","doi-asserted-by":"publisher","first-page":"200","DOI":"10.3390\/antibiotics11020200","article-title":"Progress in alternative strategies to combat antimicrobial resistance: Focus on antibiotics","volume":"11","author":"Murugaiyan","year":"2022","journal-title":"Antibiotics"},{"key":"B89","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/4374891","article-title":"Current applications of bacteriocin","volume":"2020","author":"Negash","year":"2020","journal-title":"Int. J. Microbiol."},{"key":"B90","doi-asserted-by":"publisher","first-page":"1585","DOI":"10.1007\/s00204-016-1727-6","article-title":"Antibiotic resistance mechanisms in M. tuberculosis: an update","volume":"90","author":"Nguyen","year":"2016","journal-title":"Arch. Toxicol."},{"key":"B91","doi-asserted-by":"publisher","first-page":"929","DOI":"10.1007\/s00775-019-01717-7","article-title":"Antimicrobial activities of biologically synthesized metal nanoparticles: an insight into the mechanism of action","volume":"24","author":"Nisar","year":"2019","journal-title":"JBIC J. Biol. Inorganic Chem."},{"key":"B92","doi-asserted-by":"publisher","first-page":"1782","DOI":"10.3390\/ani10101782","article-title":"Antimicrobial activity of some essential oils against methicillin-susceptible and methicillin-resistant Staphylococcus pseudintermedius-associated pyoderma in dogs","volume":"10","author":"Nocera","year":"2020","journal-title":"Animals"},{"key":"B93","doi-asserted-by":"publisher","first-page":"160","DOI":"10.1016\/j.copbio.2019.12.023","article-title":"Antimicrobials for food and feed; a bacteriocin perspective","volume":"61","author":"O\u2019Connor","year":"2020","journal-title":"Curr. Opin. Biotechnol."},{"key":"B94","volume-title":"Global tuberculosis report 2013","year":"2013"},{"key":"B95","doi-asserted-by":"publisher","first-page":"854","DOI":"10.3390\/biom10060854","article-title":"Metallo-\u03b2-lactamase inhibitors inspired on snapshots from the catalytic mechanism","volume":"10","author":"Palacios","year":"2020","journal-title":"Biomolecules"},{"key":"B96","doi-asserted-by":"publisher","first-page":"e0186415","DOI":"10.1371\/journal.pone.0186415","article-title":"A novel bacteriocin from Enterococcus faecalis 478 exhibits a potent activity against vancomycin-resistant enterococci","volume":"12","author":"Phumisantiphong","year":"2017","journal-title":"PloS One"},{"key":"B97","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1038\/s41541-020-00232-0","article-title":"Expanding the role of bacterial vaccines into life-course vaccination strategies and prevention of antimicrobial-resistant infections","volume":"5","author":"Poolman","year":"2020","journal-title":"NPJ Vaccines"},{"key":"B98","doi-asserted-by":"publisher","first-page":"1319","DOI":"10.1016\/S1473-3099(18)30554-1","article-title":"Cefiderocol versus imipenem-cilastatin for the treatment of complicated urinary tract infections caused by Gram-negative uropathogens: a phase 2, randomised, double-blind, non-inferiority trial","volume":"18","author":"Portsmouth","year":"2018","journal-title":"Lancet Infect. Dis."},{"key":"B99","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1089\/mdr.2016.0017","article-title":"Alterations in outer membrane permeability favor drug-resistant phenotype of Klebsiella pneumoniae","volume":"23","author":"Pulzova","year":"2017","journal-title":"Microb. Drug Resist."},{"key":"B100","doi-asserted-by":"publisher","first-page":"2239","DOI":"10.3390\/ani10122239","article-title":"Escherichia coli as commensal and pathogenic bacteria among food-producing animals: Health implications of extended spectrum \u03b2-lactamase (ESBL) production","volume":"10","author":"Ramos","year":"2020","journal-title":"Animals"},{"key":"B101","doi-asserted-by":"publisher","DOI":"10.37897\/RJPhP.2020.3.2","article-title":"The new fifth-generation cephalosporins\u2013a balance between safety and efficacy","volume":"52","author":"Rusu","year":"2020","journal-title":"Romanian J. Pharm. PRACTICE| Vol XIII"},{"key":"B102","doi-asserted-by":"publisher","first-page":"1113","DOI":"10.2147\/IDR.S189341","article-title":"Emergence of multidrug resistance and extensive drug resistance among enterococcal clinical isolates in Egypt","author":"Said","year":"2019","journal-title":"Infect. Drug Resist."},{"key":"B103","doi-asserted-by":"publisher","first-page":"292","DOI":"10.3390\/nano10020292","article-title":"Metal-based nanoparticles as antimicrobial agents: an overview","volume":"10","author":"S\u00e1nchez-L\u00f3pez","year":"2020","journal-title":"Nanomaterials"},{"key":"B104","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s40560-020-0429-6","article-title":"Molecular diversity of extended-spectrum \u03b2-lactamases and carbapenemases, and antimicrobial resistance","volume":"8","author":"Sawa","year":"2020","journal-title":"J. Intensive Care"},{"key":"B105","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1016\/j.ijantimicag.2017.06.022","article-title":"In-vitro activity of the novel fluorocycline eravacycline against carbapenem non-susceptible Acinetobacter baumannii","volume":"51","author":"Seifert","year":"2018","journal-title":"Int. J. Antimicrob. Agents"},{"key":"B106","doi-asserted-by":"publisher","first-page":"1815","DOI":"10.5958\/0974-360X.2016.00369.3","article-title":"Efficacy of fifth generation cephalosporins against methicillin-resistant Staphylococcus aureus-A review","volume":"9","author":"Selvan","year":"2016","journal-title":"Res. J. Pharm. Technol."},{"key":"B107","doi-asserted-by":"publisher","first-page":"2306","DOI":"10.3390\/nano11092306","article-title":"Synthesis of sodium alginate\u2013silver nanocomposites using plasma activated water and cold atmospheric plasma treatment","volume":"11","author":"Sharmin","year":"2021","journal-title":"Nanomaterials"},{"key":"B108","doi-asserted-by":"publisher","first-page":"2848","DOI":"10.1038\/s41467-020-16600-2","article-title":"Mode of action of teixobactins in cellular membranes","volume":"11","author":"Shukla","year":"2020","journal-title":"Nat. Commun."},{"key":"B109","doi-asserted-by":"publisher","first-page":"1391","DOI":"10.1089\/mdr.2018.0391","article-title":"Mechanism of action and biofilm inhibitory activity of lupinifolin against multidrug-resistant enterococcal clinical isolates","volume":"25","author":"Sianglum","year":"2019","journal-title":"Microb. Drug Resist."},{"key":"B110","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1016\/j.meegid.2018.03.029","article-title":"Phenotype and genotype alteration during adaptive evolution of Enterococcus faecalis to antimicrobials","volume":"62","author":"Sun","year":"2018","journal-title":"Infect. Genet. Evol."},{"key":"B111","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1080\/21505594.2016.1207834","article-title":"Role of newer and re-emerging older agents in the treatment of infections caused by carbapenem-resistant Enterobacteriaceae","volume":"8","author":"Thaden","year":"2017","journal-title":"Virulence"},{"key":"B112","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/1472-6882-14-258","article-title":"Antibiotic-potentiation activities of four Cameroonian dietary plants against multidrug-resistant Gram-negative bacteria expressing efflux pumps","volume":"14","author":"Touani","year":"2014","journal-title":"BMC Complement. Altern. Med."},{"key":"B113","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2021.637656","article-title":"Genomic insights into last-line antimicrobial resistance in multidrug-resistant Staphylococcus and vancomycin-resistant Enterococcus","volume":"12","author":"Turner","year":"2021","journal-title":"Front. Microbiol."},{"key":"B114","doi-asserted-by":"crossref","DOI":"10.1099\/mgen.0.000134","article-title":"Genome-guided identification of novel head-to-tail cyclized antimicrobial peptides, exemplified by the discovery of pumilarin","volume":"3","author":"van Heel","year":"2017","journal-title":"Microb. Genomics"},{"key":"B115","doi-asserted-by":"publisher","first-page":"593","DOI":"10.3390\/antibiotics10050593","article-title":"Bacterial resistance to antimicrobial agents","volume":"10","author":"Varela","year":"2021","journal-title":"Antibiotics"},{"key":"B116","doi-asserted-by":"publisher","first-page":"1227","DOI":"10.2147\/IJN.S121956","article-title":"The antimicrobial activity of nanoparticles: present situation and prospects for the future","author":"Wang","year":"2017","journal-title":"Int. J. Nanomed."},{"key":"B117","doi-asserted-by":"publisher","first-page":"20920","DOI":"10.1021\/acsomega.3c01597","article-title":"Molecular Characterization of spa, hld, fmhA, and l ukD Genes and Computational Modeling the Multidrug Resistance of Staphylococcus Species through Callindra harrisii Silver Nanoparticles","volume":"8","author":"Waseem","year":"2023","journal-title":"ACS Omega"},{"key":"B118","doi-asserted-by":"publisher","first-page":"268","DOI":"10.1111\/lam.13596","article-title":"Antibacterial activity and action mechanism of a novel chitosan oligosaccharide derivative against dominant spoilage bacteria isolated from shrimp Penaeus vannamei","volume":"74","author":"Wei","year":"2022","journal-title":"Lett. Appl. Microbiol."},{"key":"B119","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s13756-019-0614-3","article-title":"The effect of varying multidrug-resistence (MDR) definitions on rates of MDR gram-negative rods","volume":"8","author":"Wolfensberger","year":"2019","journal-title":"Antimicrob. Resist. Infect. Control"},{"key":"B120","doi-asserted-by":"publisher","first-page":"801","DOI":"10.1111\/ijfs.13026","article-title":"The prevention of fish spoilage by high antioxidant Australian culinary plants: Shewanella putrefaciens growth inhibition","volume":"51","author":"Wright","year":"2016","journal-title":"Int. J. Food Sci. Technol."},{"key":"B121","doi-asserted-by":"publisher","first-page":"1707","DOI":"10.1016\/j.celrep.2019.10.006","article-title":"Native CRISPR-Cas-mediated genome editing enables dissecting and sensitizing clinical multidrug-resistant P. aeruginosa","volume":"29","author":"Xu","year":"2019","journal-title":"Cell Rep."},{"key":"B122","doi-asserted-by":"crossref","first-page":"100151","DOI":"10.1016\/j.medidd.2023.100151","article-title":"Exploring the potential of phytochemicals and nanomaterial: A boon to antimicrobial treatment","author":"Yadav","year":"2023","journal-title":"Med. Drug Discovery"},{"key":"B123","doi-asserted-by":"crossref","first-page":"3042","DOI":"10.1038\/s41598-020-59456-8","article-title":"Study on antibiotic susceptibility of Salmonella typhimurium L forms to the third and forth generation cephalosporins","volume":"10","author":"Yang","year":"2020","journal-title":"Sci. Rep."},{"key":"B124","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2014.00241","article-title":"Antibacterial activities of bacteriocins: application in foods and pharmaceuticals","volume":"5","author":"Yang","year":"2014","journal-title":"Front. Microbiol."},{"key":"B125","first-page":"3986","article-title":"Targeting ABCB1-mediated tumor multidrug resistance by CRISPR\/Cas9-based genome editing","volume":"8","author":"Yang","year":"2016","journal-title":"Am. J. Trans. Res."},{"key":"B126","doi-asserted-by":"publisher","first-page":"809","DOI":"10.2165\/00003495-200969070-00003","article-title":"Ceftaroline: a novel broad-spectrum cephalosporin with activity against meticillin-resistant Staphylococcus aureus","volume":"69","author":"Zhanel","year":"2009","journal-title":"Drugs"},{"key":"B127","doi-asserted-by":"publisher","first-page":"e02740","DOI":"10.1128\/spectrum.02740-21","article-title":"Synergistic activity of imipenem in combination with ceftazidime\/avibactam or avibactam against non-MBL-producing extensively drug-resistant Pseudomonas aeruginosa","volume":"10","author":"Zhang","year":"2022","journal-title":"Microbiol. Spectrum"},{"key":"B128","doi-asserted-by":"publisher","first-page":"108","DOI":"10.21179\/2308-4057-2017-1-108-117","article-title":"Determination of the intensity of bacteriocin production by strains of lactic acid bacteria and their effectiveness","volume":"5","author":"Zimina","year":"2017","journal-title":"Foods Raw Mater."},{"key":"B129","doi-asserted-by":"publisher","first-page":"164","DOI":"10.3390\/antibiotics10020164","article-title":"Sorting out the superbugs: Potential of sortase A inhibitors among other antimicrobial strategies to tackle the problem of antibiotic resistance","volume":"10","author":"Zrelovs","year":"2021","journal-title":"Antibiotics"}],"container-title":["Frontiers in Antibiotics"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/frabi.2023.1309107\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,26]],"date-time":"2024-01-26T04:34:38Z","timestamp":1706243678000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/frabi.2023.1309107\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1,26]]},"references-count":129,"alternative-id":["10.3389\/frabi.2023.1309107"],"URL":"https:\/\/doi.org\/10.3389\/frabi.2023.1309107","relation":{},"ISSN":["2813-2467"],"issn-type":[{"value":"2813-2467","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,1,26]]},"article-number":"1309107"}}