{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T08:01:51Z","timestamp":1773820911022,"version":"3.50.1"},"reference-count":20,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T00:00:00Z","timestamp":1773792000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Radiol."],"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Endovascular partial splenic embolization (PSE) represents a therapeutic alternative for managing portal hypertension and hypersplenism that preserves splenic parenchyma and maintains immune function. This study aimed to describe the therapeutic response and safety profile of PSE in pediatric patients treated over an eleven-year period at a tertiary care center in Colombia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This was a descriptive, retrospective case series. We included 12 pediatric patients aged 8\u201315 years with hypersplenism secondary to portal hypertension who underwent PSE between 2012 and 2023 at our institution. Hematological parameters, endoscopic findings, and post-procedural complications were analyzed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The median age was 13 years; nine patients (75%) had portal hypertension and hypersplenism due to portal vein thrombosis, and three (25%) due to hepatic fibrosis. The median percentage of embolized splenic parenchyma was 40% [IQR (25\u201360)]. Baseline platelet counts were 58,000\u2009\u00d7\u200910\u2079\/L (50,250\u201367,000), and baseline leukocyte counts were 3,485\u2009\u00d7\u200910\u2079\/L (2,728\u20134,090). Following PSE, statistically significant increases (delta) were observed in platelet count (median 235,000\u2009\u00d7\u200910\u2079\/L, 95% CI 119,500\u2013450,500;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.0004) and white blood cell count (median 5,600\u2009\u00d7\u200910\u2079\/L, 95% CI 2,883\u20138,925;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.002). Eight patients underwent endoscopic follow-up; six demonstrated improvement in esophageal varices grade. Complications included transient abdominal pain and fever. No major adverse events, such as splenic abscess, infarction, rupture or hematoma, were recorded.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In our series, PSE demonstrated safety and efficacy in managing portal hypertension-related hypersplenism in pediatric patients, with significant improvements in hematological parameters and esophageal varices grade in most cases. PSE represents a valuable minimally invasive alternative to splenectomy, preserving splenic function while achieving therapeutic goals, even in patients requiring repeat interventions.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fradi.2026.1731300","type":"journal-article","created":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T07:00:51Z","timestamp":1773817251000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Partial splenic embolization as management of portal hypertension-related hypersplenism in pediatric patients"],"prefix":"10.3389","volume":"6","author":[{"given":"Karen Juliana","family":"Salinas-Castro","sequence":"first","affiliation":[{"name":"Facultad de Ciencias de la Salud, Universidad Icesi","place":["Cali, Colombia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valentina","family":"Mejia-Qui\u00f1ones","sequence":"additional","affiliation":[{"name":"Facultad de Ciencias de la Salud, Universidad Icesi","place":["Cali, Colombia"]},{"name":"Centro de Investigaciones Cl\u00ednicas, Fundacion Valle del Lili","place":["Cali, Colombia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Santiago","family":"Quiceno-Ramirez","sequence":"additional","affiliation":[{"name":"Centro de Investigaciones Cl\u00ednicas, Fundacion Valle del Lili","place":["Cali, Colombia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan Sebastian","family":"Toro-Gutierrez","sequence":"additional","affiliation":[{"name":"Departamento de Radiolog\u00eda e Im\u00e1genes Diagn\u00f3sticas, Fundacion Valle del Lili","place":["Cali, Colombia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ver\u00f3nica","family":"Botero","sequence":"additional","affiliation":[{"name":"Departamento de Gastroenterolog\u00eda Pedi\u00e1trica, Fundacion Valle del Lili","place":["Cali, Colombia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luis Alfonso","family":"Bustamante-Cristancho","sequence":"additional","affiliation":[{"name":"Departamento de Ciencias Cl\u00ednico-Quir\u00fargicas, Pontificia Universidad Javeriana","place":["Cali, Colombia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alfonso Jos\u00e9","family":"Holgu\u00edn-Holgu\u00edn","sequence":"additional","affiliation":[{"name":"Departamento de Radiolog\u00eda e Im\u00e1genes Diagn\u00f3sticas, Fundacion Valle del Lili","place":["Cali, Colombia"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2026,3,18]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"793","DOI":"10.1097\/MPG.0000000000002332","article-title":"Partial splenic embolization is a safe and effective alternative in the management of portal hypertension in 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