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The free radical theory of ageing has been proposed long before ageing has been considered a \u201cscientific discipline\u201d and, since then, has been discussed and upgraded as a major contributor to aberrant ageing. Assuming that ageing results merely from the accumulation of oxidative modifications of biomolecules is not only a simplistic and reductive view of such a complex and dynamic process, but also free radicals and related oxidants are now considered pivotal signalling molecules. The fine modulation of critical signalling pathways by redox compounds demands a novel approach to tackle the role of free radicals in ageing. Nitric oxide (<jats:sup>\u22c5<\/jats:sup>NO) is a paradigmatic example given its biological functions in cardiovascular, neurologic and immune systems. In addition to the canonical <jats:sup>\u22c5<\/jats:sup>NO synthesis by a family of enzymes, nitrate from green leafy vegetables, is reduced to nitrite in the oral cavity which is further reduced to <jats:sup>\u22c5<\/jats:sup>NO in the stomach. Boosting this nitrate-nitrite-NO pathway has been shown to improve gastrointestinal, cardiovascular, metabolic and cognitive performance both in humans and in animal models of disease. In the elderly, nitrate-derived <jats:sup>\u22c5<\/jats:sup>NO has been shown improve several physiological functions that typically decline during ageing. In this paper, the role of nitrate and derived nitrogen oxides will be discussed while reviewing pre-clinical and clinical data on the cardiovascular, neuronal, musculoskeletal and metabolic effects of nitrate during healthy ageing.<\/jats:p>","DOI":"10.3389\/fragi.2021.778467","type":"journal-article","created":{"date-parts":[[2021,11,17]],"date-time":"2021-11-17T10:45:57Z","timestamp":1637145957000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":30,"title":["The Nitrate-Nitrite-Nitric Oxide Pathway on Healthy Ageing: A Review of Pre-clinical and Clinical Data on the Impact of Dietary Nitrate in the Elderly"],"prefix":"10.3389","volume":"2","author":[{"given":"B\u00e1rbara S.","family":"Rocha","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2021,11,17]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"211","DOI":"10.3389\/fphys.2015.00211","article-title":"On the Mechanism by Which Dietary Nitrate Improves Human Skeletal Muscle Function","volume":"6","author":"Affourtit","year":"2015","journal-title":"Front. 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