{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T19:53:16Z","timestamp":1791229996251,"version":"4.1.0"},"reference-count":72,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2021,12,23]],"date-time":"2021-12-23T00:00:00Z","timestamp":1640217600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01AG059586 R01AG059586-03S1"],"award-info":[{"award-number":["R01AG059586 R01AG059586-03S1"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001642","name":"Glenn Foundation for Medical Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001642","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017834","name":"University of Connecticut Health Center","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100017834","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Aging"],"abstract":"<jats:p><jats:italic>I\u2019m Not Dead Yet (Indy)<\/jats:italic> is a fly homologue of the mammalian SLC13A5 (mSLC13A5) plasma membrane citrate transporter, a key metabolic regulator and energy sensor involved in health, longevity, and disease. Reduction of <jats:italic>Indy<\/jats:italic> gene activity in flies, and its homologs in worms, modulates metabolism and extends longevity. The metabolic changes are similar to what is obtained with caloric restriction (dietary restriction). Similar effects on metabolism have been observed in mice and rats. As a citrate transporter, INDY regulates cytoplasmic citrate levels. <jats:italic>Indy<\/jats:italic> flies heterozygous for a P-element insertion have increased spontaneous physical activity, increased fecundity, reduced insulin signaling, increased mitochondrial biogenesis, preserved intestinal stem cell homeostasis, lower lipid levels, and increased stress resistance. Mammalian <jats:italic>Indy<\/jats:italic> knockout (<jats:italic>mIndy<\/jats:italic>-KO) mice have higher sensitivity to insulin signaling, lower blood pressure and heart rate, preserved memory and are protected from the negative effects of a high-fat diet and some of the negative effects of aging. Reducing <jats:italic>mIndy<\/jats:italic> expression in human hepatocarcinoma cells has recently been shown to inhibit cell proliferation. Reduced <jats:italic>Indy<\/jats:italic> expression in the fly intestine affects intestinal stem cell proliferation, and has recently been shown to also inhibit germ cell proliferation in males with delayed sperm maturation and decreased spermatocyte numbers. These results highlight a new connection between energy metabolism and cell proliferation. The overrall picture in a variety of species points to a conserved role of INDY for metabolism and health. This is illustrated by an association of high <jats:italic>mIndy<\/jats:italic> gene expression with non-alcoholic fatty liver disease in obese humans. <jats:italic>mIndy<\/jats:italic> (<jats:italic>mSLC13A5<\/jats:italic>) coding region mutations (e.g., loss-of-function) are also associated with adverse effects in humans, such as autosomal recessive early infantile epileptic encephalopathy and Kohlschu\u0308tter\u2212To\u0308nz syndrome. The recent findings illustrate the importance of <jats:italic>mIndy<\/jats:italic> gene for human health and disease. Furthermore, recent work on small-molecule regulators of INDY highlights the promise of INDY-based treatments for ameliorating disease and promoting healthy aging.<\/jats:p>","DOI":"10.3389\/fragi.2021.782162","type":"journal-article","created":{"date-parts":[[2021,12,23]],"date-time":"2021-12-23T15:11:08Z","timestamp":1640272268000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":9,"title":["INDY\u2014From Flies to Worms, Mice, Rats, Non-Human Primates, and Humans"],"prefix":"10.3389","volume":"2","author":[{"given":"Dushyant","family":"Mishra","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kavitha","family":"Kannan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kali","family":"Meadows","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacob","family":"Macro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stewart","family":"Frankel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Blanka","family":"Rogina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2021,12,23]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"314","DOI":"10.1016\/j.ymgme.2017.06.009","article-title":"Analyses of SLC13A5 -Epilepsy Patients Reveal Perturbations of TCA Cycle","volume":"121","author":"Bainbridge","year":"2017","journal-title":"Mol. Genet. Metab."},{"key":"B2","doi-asserted-by":"publisher","first-page":"E378","DOI":"10.3390\/molecules22030378","article-title":"Plasma Membrane Na\u207a-Coupled Citrate Transporter (SLC13A5) and Neonatal Epileptic Encephalopathy","volume":"22","author":"Bhutia","year":"2017","journal-title":"Molecules"},{"key":"B3","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1016\/j.cmet.2011.06.009","article-title":"Deletion of the Mammalian INDY Homolog Mimics Aspects of Dietary Restriction and Protects against Adiposity and Insulin Resistance in Mice","volume":"14","author":"Birkenfeld","year":"2011","journal-title":"Cel. Metab."},{"key":"B4","doi-asserted-by":"publisher","first-page":"1072","DOI":"10.1016\/j.molmet.2016.08.004","article-title":"Inhibition of Citrate Cotransporter Slc13a5\/MINDY by RNAi Improves Hepatic Insulin Sensitivity and Prevents Diet-Induced Non-alcoholic Fatty Liver Disease in Mice","volume":"5","author":"Brachs","year":"2016","journal-title":"Mol. Metab."},{"key":"B5","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1111\/j.1474-9726.2005.00181.x","article-title":"Behavioral, Physical, and Demographic Changes in Drosophila Populations through Dietary Restriction","volume":"4","author":"Bross","year":"2005","journal-title":"Aging Cel."},{"key":"B6","doi-asserted-by":"publisher","first-page":"746","DOI":"10.3390\/metabo11110746","article-title":"Growth and Overall Health of Patients with SLC13A5 Citrate Transporter Disorder","volume":"11","author":"Brown","year":"2021","journal-title":"Metabolites"},{"key":"B7","doi-asserted-by":"publisher","first-page":"318","DOI":"10.1111\/j.1474-9726.2008.00380.x","article-title":"Age-Related Changes in Drosophila Midgut Are Associated with PVF2, a PDGF\/VEGF-like Growth Factor","volume":"7","author":"Choi","year":"2008","journal-title":"Aging Cell"},{"key":"B8","doi-asserted-by":"publisher","first-page":"4900","DOI":"10.1021\/acs.biochem.5b00388","article-title":"Structure-Based Identification of Inhibitors for the SLC13 Family of Na+\/Dicarboxylate Cotransporters","volume":"54","author":"Colas","year":"2015","journal-title":"Biochemistry"},{"key":"B9","doi-asserted-by":"publisher","first-page":"1972","DOI":"10.1002\/ajmg.a.62192","article-title":"A Novel Homozygous SLC13A5 Whole\u2010gene Deletion Generated by Alu\/Alu \u2010mediated Rearrangement in an Iraqi Family with Epileptic Encephalopathy","volume":"185","author":"Duan","year":"2021","journal-title":"Am. J. Med. Genet."},{"key":"B10","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1093\/gerona\/glaa203","article-title":"Nervous System Deletion of Mammalian INDY in Mice Mimics Dietary Restriction-Induced Memory Enhancement","volume":"76","author":"Fan","year":"2021","journal-title":"J. Gerontol. A, Biol. Sci. Med. Sci."},{"key":"B11","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1042\/BJ20031807","article-title":"Relevance of NAC-2, an Na+-Coupled Citrate Transporter, to Life Span, Body Size and Fat Content in Caenorhabditis Elegans","volume":"379","author":"Fei","year":"2004","journal-title":"Biochem. J."},{"key":"B12","doi-asserted-by":"publisher","first-page":"217","DOI":"10.3945\/an.11300476210.3945\/an.113.004762","article-title":"Dietary Fat and Hepatic Lipogenesis: Mitochondrial Citrate Carrier as a Sensor of Metabolic Changes1","volume":"5","author":"Ferramosca","year":"2014","journal-title":"Adv. Nutr."},{"key":"B13","doi-asserted-by":"publisher","first-page":"13","DOI":"10.3389\/fgene.2012.00013","article-title":"Indy Mutants: Live Long and Prosper","volume":"3","author":"Frankel","year":"2012","journal-title":"Front. Gene."},{"key":"B14","doi-asserted-by":"publisher","first-page":"733184","DOI":"10.3389\/fgene.2021.733184","article-title":"Evolution, Chance, and Aging","volume":"12","author":"Frankel","year":"2021","journal-title":"Front. Genet."},{"key":"B15","doi-asserted-by":"publisher","first-page":"733","DOI":"10.1161\/hypertensionaha.115.06853","article-title":"Effects of Different Dietary Interventions on Blood Pressure","volume":"67","author":"Gay","year":"2016","journal-title":"Hypertension"},{"key":"B16","doi-asserted-by":"publisher","first-page":"3238","DOI":"10.1093\/brain\/awv263","article-title":"Recessive Mutations inSLC13A5result in a Loss of Citrate Transport and Cause Neonatal Epilepsy, Developmental Delay and Teeth Hypoplasia","volume":"138","author":"Hardies","year":"2015","journal-title":"Brain"},{"key":"B17","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1002\/bies.10225","article-title":"Molecular Genetics of Aging in the Fly: Is This the End of the Beginning?","volume":"25","author":"Helfand","year":"","journal-title":"Bioessays"},{"key":"B18","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1146\/annurev.genet.37.040103.095211","article-title":"Genetics of Aging in the Fruit Fly, Drosophila melanogaster","volume":"37","author":"Helfand","year":"","journal-title":"Annu. Rev. Genet."},{"key":"B19","doi-asserted-by":"publisher","first-page":"105018","DOI":"10.1016\/j.nbd.2020.105018","article-title":"Disruption of the Sodium-dependent Citrate Transporter SLC13A5 in Mice Causes Alterations in Brain Citrate Levels and Neuronal Network Excitability in the hippocampus","volume":"143","author":"Henke","year":"2020","journal-title":"Neurobiol. Dis."},{"key":"B20","doi-asserted-by":"publisher","first-page":"4149","DOI":"10.1042\/bcj20200592","article-title":"Functional Analysis of a Species-specific Inhibitor Selective for Human Na+-Coupled Citrate Transporter (NaCT\/SLC13A5\/MINDY)","volume":"477","author":"Higuchi","year":"2020","journal-title":"Biochem. J."},{"key":"B21","doi-asserted-by":"publisher","first-page":"188","DOI":"10.1016\/j.stem.2010.12.006","article-title":"Redox Regulation by Keap1 and Nrf2 Controls Intestinal Stem Cell Proliferation in Drosophila","volume":"8","author":"Hochmuth","year":"2011","journal-title":"Cel. Stem Cel."},{"key":"B22","doi-asserted-by":"publisher","first-page":"17391","DOI":"10.1038\/srep17391","article-title":"Discovery and Characterization of Novel Inhibitors of the Sodium-Coupled Citrate Transporter (NaCT or SLC13A5)","volume":"5","author":"Huard","year":"2015","journal-title":"Sci. Rep."},{"key":"B23","doi-asserted-by":"publisher","first-page":"1165","DOI":"10.1021\/acs.jmedchem.5b01752","article-title":"Optimization of a Dicarboxylic Series for In Vivo Inhibition of Citrate Transport by the Solute Carrier 13 (SLC13) Family","volume":"59","author":"Huard","year":"2016","journal-title":"J. Med. Chem."},{"key":"B24","doi-asserted-by":"publisher","first-page":"901","DOI":"10.1016\/j.cell.2019.07.029","article-title":"Sex Differences in Intestinal Carbohydrate Metabolism Promote Food Intake and Sperm Maturation","volume":"178","author":"Hudry","year":"2019","journal-title":"Cell"},{"key":"B25","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1042\/BJ20021132","article-title":"Functional Identity of Drosophila Melanogaster Indy as a Cation-independent, Electroneutral Transporter for Tricarboxylic Acid-Cycle Intermediates","volume":"367","author":"Inoue","year":"","journal-title":"Biochem. J."},{"key":"B26","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1016\/s0006-291x(02)02669-4","article-title":"Human Na+-Coupled Citrate Transporter: Primary Structure, Genomic Organization, and Transport Function","volume":"299","author":"Inoue","year":"","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"B27","doi-asserted-by":"publisher","first-page":"949","DOI":"10.1042\/BJ20031261","article-title":"Functional Features and Genomic Organization of Mouse NaCT, a Sodium-Coupled Transporter for Tricarboxylic Acid Cycle Intermediates","volume":"378","author":"Inoue","year":"2004","journal-title":"Biochem. J."},{"key":"B28","doi-asserted-by":"publisher","first-page":"e0175465","DOI":"10.1371\/journal.pone.0175465","article-title":"Defective Enamel and Bone Development in Sodium-Dependent Citrate Transporter (NaCT) Slc13a5 Deficient Mice","volume":"12","author":"Irizarry","year":"2017","journal-title":"PLoS One"},{"key":"B29","doi-asserted-by":"publisher","first-page":"2051","DOI":"10.1042\/bcj20210211","article-title":"A home Run for Human NaCT\/SLC13A5\/INDY: Cryo-EM Structure and Homology Model to Predict Transport Mechanisms, Inhibitor Interactions and Mutational Defects","volume":"478","author":"Jaramillo-Martinez","year":"2021","journal-title":"Bioch. J."},{"key":"B30","doi-asserted-by":"publisher","first-page":"705","DOI":"10.3390\/metabo11100705","article-title":"The Role of Citrate Transporter INDY in Metabolism and Stem Cell Homeostasis","volume":"11","author":"Kannan","year":"2021","journal-title":"Metabolites"},{"key":"B31","doi-asserted-by":"publisher","first-page":"310","DOI":"10.2119\/molmed.2016.00077","article-title":"Mutations in the Na(+)\/Citrate Cotransporter NaCT (SLC13A5) in Pediatric Patients with Epilepsy and Developmental Delay","volume":"22","author":"Klotz","year":"2016","journal-title":"Mol. Med."},{"key":"B32","doi-asserted-by":"publisher","first-page":"14315","DOI":"10.1073\/pnas.222531899","article-title":"Functional Characterization and Immunolocalization of the Transporter Encoded by the Life-Extending Gene Indy","volume":"99","author":"Knauf","year":"2002","journal-title":"Proc. Natl. Acad. Sci."},{"key":"B33","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1042\/bj20060409","article-title":"The Life-Extending Gene Indy Encodes an Exchanger for Krebs-Cycle Intermediates","volume":"397","author":"Knauf","year":"2006","journal-title":"Biochem. J."},{"key":"B34","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1042\/bcj20200877","article-title":"Consequences of NaCT\/SLC13A5\/mINDY Deficiency: Good versus Evil, Separated Only by the Blood-Brain Barrier","volume":"478","author":"Kopel","year":"2021","journal-title":"Biochem. J."},{"key":"B35","doi-asserted-by":"publisher","first-page":"674","DOI":"10.1124\/mol.114.097287","article-title":"SLC13A5 Is a Novel Transcriptional Target of the Pregnane X Receptor and Sensitizes Drug-Induced Steatosis in Human Liver","volume":"87","author":"Li","year":"2015","journal-title":"Mol. Pharmacol."},{"key":"B36","doi-asserted-by":"publisher","first-page":"13890","DOI":"10.1074\/jbc.m117.783860","article-title":"Silencing of Solute Carrier Family 13 Member 5 Disrupts Energy Homeostasis and Inhibits Proliferation of Human Hepatocarcinoma Cells","volume":"292","author":"Li","year":"2017","journal-title":"J. Biol. Chem."},{"key":"B37","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1038\/hdy.1985.66","article-title":"Selection for Life Span in Drosophila Melanogaster","volume":"55","author":"Luckinbill","year":"1985","journal-title":"Heredity"},{"key":"B38","doi-asserted-by":"publisher","first-page":"622","DOI":"10.1038\/nature11542","article-title":"Structure and Mechanism of a Bacterial Sodium-Dependent Dicarboxylate Transporter","volume":"491","author":"Mancusso","year":"2012","journal-title":"Nature"},{"key":"B39","doi-asserted-by":"publisher","first-page":"3369","DOI":"10.1073\/pnas.0634985100","article-title":"Conditional Tradeoffs between Aging and Organismal Performance of Indy Long-Lived Mutant Flies","volume":"100","author":"Marden","year":"2003","journal-title":"Proc. Natl. Acad. Sci."},{"key":"B40","doi-asserted-by":"publisher","first-page":"2474","DOI":"10.1111\/epi.16699","article-title":"Neonatal Developmental and Epileptic Encephalopathy Due to Autosomal Recessive Variants in SLC13A5 Gene","volume":"61","author":"Matricardi","year":"2020","journal-title":"Epilepsia"},{"key":"B41","doi-asserted-by":"publisher","first-page":"5290","DOI":"10.3390\/ijms22105290","article-title":"Calvaria Bone Transcriptome in Mouse Models of Osteogenesis Imperfecta","volume":"22","author":"Moffatt","year":"2021","journal-title":"Ijms"},{"key":"B42","doi-asserted-by":"publisher","first-page":"256","DOI":"10.1038\/nsmb.3166","article-title":"The Bacterial Dicarboxylate Transporter VcINDY Uses a Two-Domain Elevator-Type Mechanism","volume":"23","author":"Mulligan","year":"2016","journal-title":"Nat. Struct. Mol. Biol."},{"key":"B43","doi-asserted-by":"publisher","first-page":"2277","DOI":"10.1073\/pnas.0812484106","article-title":"Long-Lived Indy Induces Reduced Mitochondrial Reactive Oxygen Species Production and Oxidative Damage","volume":"106","author":"Neretti","year":"2009","journal-title":"Proc. Natl. Acad. Sci."},{"key":"B44","doi-asserted-by":"publisher","first-page":"1048","DOI":"10.2337\/db13-0749","article-title":"The Mammalian INDY Homolog Is Induced by CREB in a Rat Model of Type 2 Diabetes","volume":"63","author":"Neusch\u00e4fer-Rube","year":"2014","journal-title":"Diabetes"},{"key":"B45","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.tox.2015.08.007","article-title":"Arylhydrocarbon Receptor-Dependent MIndy (Slc13a5) Induction as Possible Contributor to Benzo[a]Pyrene-Induced Lipid Accumulation in Hepatocytes","volume":"337","author":"Neusch\u00e4fer-Rube","year":"2015","journal-title":"Toxicology"},{"key":"B46","doi-asserted-by":"publisher","first-page":"C1215","DOI":"10.1152\/ajpcell.2001.280.5.c1215","article-title":"Cloning and Functional Characterization of a High-Affinity Na+\/dicarboxylate Cotransporter from Mouse Brain","volume":"280","author":"Pajor","year":"2001","journal-title":"Am. J. Physiol.-Cell Physiol."},{"key":"B47","doi-asserted-by":"publisher","first-page":"755","DOI":"10.1124\/mol.116.105049","article-title":"Molecular Basis for Inhibition of the Na+\/Citrate Transporter NaCT (SLC13A5) by Dicarboxylate Inhibitors","volume":"90","author":"Pajor","year":"2016","journal-title":"Mol. Pharmacol."},{"key":"B48","doi-asserted-by":"publisher","first-page":"529","DOI":"10.18632\/aging.100061","article-title":"DSir2 Mediates the Increased Spontaneous Physical Activity in Flies on Calorie Restriction","volume":"1","author":"Parashar","year":"2009","journal-title":"Aging"},{"key":"B49","doi-asserted-by":"publisher","first-page":"1086","DOI":"10.18632\/aging.100854","article-title":"Prevention of Diet-Induced Hepatic Steatosis and Hepatic Insulin Resistance by Second Generation Antisense Oligonucleotides Targeted to the Longevity Gene MIndy (Slc13a5)","volume":"7","author":"Pesta","year":"2015","journal-title":"Aging"},{"key":"B50","doi-asserted-by":"publisher","first-page":"13902","DOI":"10.1074\/jbc.h117.783860","article-title":"Flipping a Citrate Switch on Liver Cancer Cells","volume":"292","author":"Peters","year":"2017","journal-title":"J. Biol. Chem."},{"key":"B51","doi-asserted-by":"publisher","first-page":"986","DOI":"10.1002\/2211-5463.12435","article-title":"Suppressed De Novo Lipogenesis by Plasma Membrane Citrate Transporter Inhibitor Promotes Apoptosis in HepG2 Cells","volume":"8","author":"Phokrai","year":"2018","journal-title":"FEBS Open Bio."},{"key":"B52","doi-asserted-by":"publisher","first-page":"643","DOI":"10.1016\/S1262-3636(08)74599-3","article-title":"The Role of the Lipogenic Pathway in the Development of Hepatic Steatosis","volume":"34","author":"Postic","year":"2008","journal-title":"Diabetes Metab."},{"key":"B53","doi-asserted-by":"publisher","first-page":"108","DOI":"10.3389\/fgene.2012.00108","article-title":"A Gutsy Way to Extend Longevity","volume":"3","author":"Rogers","year":"2012","journal-title":"Front. Gene."},{"key":"B54","doi-asserted-by":"publisher","first-page":"335","DOI":"10.18632\/aging.100658","article-title":"Increased Mitochondrial Biogenesis Preserves Intestinal Stem Cell Homeostasis and Contributes to Longevity in Indy Mutant Flies","volume":"6","author":"Rogers","year":"2014","journal-title":"Aging"},{"key":"B55","doi-asserted-by":"publisher","first-page":"204","DOI":"10.3389\/fgene.2015.00204","article-title":"The Role of INDY in Metabolism, Health and Longevity","volume":"6","author":"Rogers","year":"2015","journal-title":"Front. Genet."},{"key":"B56","doi-asserted-by":"publisher","first-page":"47","DOI":"10.3389\/fgene.2013.00047","article-title":"Indy Mutations and Drosophila Longevity","volume":"4","author":"Rogina","year":"2013","journal-title":"Front. Genet."},{"key":"B57","doi-asserted-by":"publisher","first-page":"6303","DOI":"10.1073\/pnas.94.12.640310.1073\/pnas.94.12.6303","article-title":"Drosophila Drop-Dead Mutations Accelerate the Time Course of Age-Related Markers","volume":"94","author":"Rogina","year":"1997","journal-title":"Proc. Natl. Acad. Sci."},{"key":"B58","doi-asserted-by":"publisher","first-page":"2137","DOI":"10.1126\/science.290.5499.2137","article-title":"Extended Life-Span Conferred by Cotransporter Gene Mutations in Drosophila","volume":"290","author":"Rogina","year":"2000","journal-title":"Science"},{"key":"B59","doi-asserted-by":"publisher","first-page":"66","DOI":"10.3389\/fgene.2017.00066","article-title":"INDY-A New Link to Metabolic Regulation in Animals and Humans","volume":"8","author":"Rogina","year":"2017","journal-title":"Front. Genet."},{"key":"B60","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1038\/s41586-021-03230-x","article-title":"Structure and Inhibition Mechanism of the Human Citrate Transporter NaCT","volume":"591","author":"Sauer","year":"2021","journal-title":"Nature"},{"key":"B61","doi-asserted-by":"publisher","first-page":"16998","DOI":"10.1074\/jbc.m114.554790","article-title":"Determinants of Substrate and Cation Transport in the Human Na+\/Dicarboxylate Cotransporter NaDC3","volume":"289","author":"Schlessinger","year":"2014","journal-title":"J. Biol. Chem."},{"key":"B62","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1136\/jmedgenet-2016-103988","article-title":"SLC13A5is the Second Gene Associated with Kohlsch\u00fctter-T\u00f6nz Syndrome","volume":"54","author":"Schossig","year":"2017","journal-title":"J. Med. Genet."},{"key":"B63","doi-asserted-by":"publisher","first-page":"553","DOI":"10.18632\/aging.100791","article-title":"Knockdown of Indy\/CeNac2 Extends Caenorhabditis Elegans Life Span by Inducing AMPK\/Aak-2","volume":"7","author":"Schwarz","year":"2015","journal-title":"Aging"},{"key":"B64","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1016\/j.ajhg.2014.06.006","article-title":"Mutations in SLC13A5 Cause Autosomal-Recessive Epileptic Encephalopathy with Seizure Onset in the First Days of Life","volume":"95","author":"Thevenon","year":"2014","journal-title":"Am. J. Hum. Genet."},{"key":"B65","doi-asserted-by":"publisher","first-page":"e95","DOI":"10.1371\/journal.pgen.0030095","article-title":"No Influence of Indy on Lifespan in Drosophila after Correction for Genetic and Cytoplasmic Background Effects","volume":"3","author":"Toivonen","year":"2007","journal-title":"PLOS Genet."},{"key":"B66","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1242\/dmm.023762","article-title":"Drosophila Tools and Assays for the Study of Human Diseases","volume":"9","author":"Ugur","year":"2016","journal-title":"Dis. Model. Mech."},{"key":"B67","doi-asserted-by":"publisher","first-page":"616","DOI":"10.1002\/hep.29089","article-title":"The Human Longevity Gene Homolog INDY and Interleukin-6 Interact in Hepatic Lipid Metabolism","volume":"66","author":"von Loeffelholz","year":"2017","journal-title":"Hepatology"},{"key":"B68","doi-asserted-by":"publisher","first-page":"9262","DOI":"10.1073\/pnas.0904115106","article-title":"Long-Lived Indy and Calorie Restriction Interact to Extend Life Span","volume":"106","author":"Wang","year":"2009","journal-title":"Proc. Natl. Acad. Sci."},{"key":"B69","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.pharmthera.2017.10.003","article-title":"The longevity gene INDY ( I 'm N ot D ead Y et) in metabolic control: Potential as pharmacological target","volume":"185","author":"Willmes","year":"2018","journal-title":"Pharmacol. Ther."},{"key":"B70","doi-asserted-by":"publisher","first-page":"136083","DOI":"10.1172\/jci.insight.136083","article-title":"The Longevity Gene mIndy (I'm Not Dead, yet) Affects Blood Pressure through Sympathoadrenal Mechanisms","volume":"6","author":"Willmes","year":"2021","journal-title":"JCI Insight"},{"key":"B71","doi-asserted-by":"publisher","first-page":"58","DOI":"10.18632\/aging.100634","article-title":"Indy Gene Variation in Natural Populations Confers Fitness Advantage and Life Span Extension through Transposon Insertion","volume":"6","author":"Zhu","year":"2014","journal-title":"Aging"},{"key":"B72","doi-asserted-by":"publisher","first-page":"956","DOI":"10.1016\/s1474-4422(15)00148-9","article-title":"Mitochondrial Dysfunction and Seizures: The Neuronal Energy Crisis","volume":"14","author":"Zsurka","year":"2015","journal-title":"Lancet Neurol."}],"container-title":["Frontiers in Aging"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fragi.2021.782162\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,23]],"date-time":"2021-12-23T15:11:12Z","timestamp":1640272272000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fragi.2021.782162\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12,23]]},"references-count":72,"alternative-id":["10.3389\/fragi.2021.782162"],"URL":"https:\/\/doi.org\/10.3389\/fragi.2021.782162","relation":{},"ISSN":["2673-6217"],"issn-type":[{"value":"2673-6217","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,12,23]]},"article-number":"782162"}}