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To further enhance the healthspan, biogerontologists may consider a wider range of environmental exposures from gestation through later life morbidity that comprise the Gero-Exposome. Experimental studies with rodents and nematodes document shared transcriptional responses to AirPoll. In rodents, AirPoll exposure activates gene systems for body-wide detoxification through Nrf2 and NFkB transcription factors that mediate multiple aging processes. Gestational environmental factors include maternal diet and exposure to AirPoll and cigarette smoke. Correspondingly, gestational exposure of mice to AirPoll increased adult body fat, impaired glucose clearance, and decreased adult neurogenesis in the hippocampus, a brain region damaged in dementia. Nematode larvae also respond to AirPoll with Alzheimer relevant responses. These experimental approaches could identify to interventions for expanded human health and longevity across SES gradients.<\/jats:p>","DOI":"10.3389\/fragi.2023.1273303","type":"journal-article","created":{"date-parts":[[2023,11,14]],"date-time":"2023-11-14T17:53:07Z","timestamp":1699984387000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":8,"title":["Air pollution, dementia, and lifespan in the socio-economic gradient of aging: perspective on human aging for planning future experimental studies"],"prefix":"10.3389","volume":"4","author":[{"given":"Caleb E.","family":"Finch","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2023,11,13]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"e045186","DOI":"10.1136\/bmjopen-2020-045186","article-title":"Dementia and disadvantage in the USA and England: population-based comparative study","volume":"11","author":"Arapakis","year":"2021","journal-title":"BMJ Open"},{"key":"B2","doi-asserted-by":"publisher","first-page":"1618","DOI":"10.1096\/fj.04-1945fje","article-title":"Nanometer size diesel exhaust particles are selectively toxic to dopaminergic neurons: the role of microglia, phagocytosis, and NADPH oxidase","volume":"18","author":"Block","year":"2004","journal-title":"FASEB J."},{"key":"B3","doi-asserted-by":"publisher","first-page":"e2213540","DOI":"10.1001\/jamanetworkopen.2022.13540","article-title":"Air pollution, socioeconomic status, and age-specific mortality risk in the United States","volume":"5","author":"Boing","year":"2022","journal-title":"JAMA Netw. 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