{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T10:05:42Z","timestamp":1776161142208,"version":"3.50.1"},"reference-count":51,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Aging"],"abstract":"<jats:p>Obesity and ageing are the most important risk factors for sleep apnoea syndrome (SAS); however, the role of body mass index (BMI) on sleep status in healthy older adults is unclear. To explore sleep parameters according to BMI among active older adults, we cross-sectionally examined the relationship between sleep-related parameters and BMI in 32 Japanese adults aged from 83 to 95 years without long-term care who were unaware of having SAS. Correlation and linear regression analyses were performed. Moderate or severe SAS prevalence was high in both those with low (68.8%) and high (68.8%) BMI. A higher increase in apnoea-hypopnoea index (AHI) was negatively correlated with sleep depth in the high-BMI group. In the low-BMI group, the number of awakenings and age were positively correlated with AHI. Older adults may have SAS regardless of their BMI, and the sleep status of patients with SAS may vary by BMI.<\/jats:p>","DOI":"10.3389\/fragi.2024.1331448","type":"journal-article","created":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T04:39:30Z","timestamp":1714538370000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["Sleep status of older adults with sleep apnoea syndrome may vary by body mass index"],"prefix":"10.3389","volume":"5","author":[{"given":"Yuji","family":"Tanaka","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naana","family":"Baba-Mori","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takaaki","family":"Yonaga","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuki","family":"Mochizuki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satoshi","family":"Igarashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Ando","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Kohda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasumi","family":"Ito","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenzo","family":"Soejima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daiju","family":"Sakurai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2024,5,1]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1702484","DOI":"10.1183\/13993003.02484-2017","article-title":"REM-associated sleep apnoea: prevalence and clinical significance in the HypnoLaus cohort","volume":"52","author":"Acosta-Castro","year":"2018","journal-title":"Eur. Respir. J."},{"key":"B2","doi-asserted-by":"publisher","first-page":"17","DOI":"10.5665\/sleep.1580","article-title":"The treatment of central sleep apnea syndromes in adults: practice parameters with an evidence-based literature review and meta-analyses","volume":"35","author":"Aurora","year":"2012","journal-title":"Sleep"},{"key":"B3","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1093\/sleep\/24.1.96","article-title":"The association of sleep-disordered breathing and sleep symptoms with quality of life in the Sleep Heart Health Study","volume":"24","author":"Baldwin","year":"2001","journal-title":"Sleep"},{"key":"B4","doi-asserted-by":"publisher","first-page":"400","DOI":"10.1016\/j.sleep.2007.03.003","article-title":"Sleep apnea: clinical investigations in humans","volume":"8","author":"Banno","year":"2007","journal-title":"Sleep. Med."},{"key":"B5","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1093\/sleep\/22.2.217","article-title":"Sleep apnea in acute cerebrovascular diseases: final report on 128 patients","volume":"22","author":"Bassetti","year":"1999","journal-title":"Sleep"},{"key":"B6","doi-asserted-by":"publisher","first-page":"997","DOI":"10.1093\/gerona\/glq071","article-title":"Incident sleep disordered breathing in old age","volume":"65","author":"Bliwise","year":"2010","journal-title":"J. Gerontol. A. Biol. Sci. Med. Sci."},{"key":"B7","doi-asserted-by":"publisher","first-page":"752","DOI":"10.1016\/S0140-6736(12)62167-9","article-title":"Frailty in elderly people","volume":"381","author":"Clegg","year":"2013","journal-title":"Lancet"},{"key":"B8","doi-asserted-by":"publisher","first-page":"1095","DOI":"10.1056\/NEJMoa1506459","article-title":"Adaptive servo-ventilation for central sleep apnea in systolic heart failure","volume":"373","author":"Cowie","year":"2015","journal-title":"N. Engl. J. Med."},{"key":"B9","doi-asserted-by":"publisher","first-page":"00057","DOI":"10.1183\/23120541.00057-2020","article-title":"Mortality and morbidity in obstructive sleep apnoea-hypopnoea syndrome: results from a 30-year prospective cohort study","volume":"6","author":"Dodds","year":"2020","journal-title":"ERJ Open Res."},{"key":"B10","doi-asserted-by":"publisher","first-page":"618","DOI":"10.1055\/s-0030-1265902","article-title":"Aging and sleep: physiology and pathophysiology","volume":"31","author":"Edwards","year":"2010","journal-title":"Semin. Respir. Crit. Care. Med."},{"key":"B11","doi-asserted-by":"publisher","first-page":"1217","DOI":"10.1016\/j.sleep.2012.04.010","article-title":"Sleep disturbances and risk of frailty and mortality in older men","volume":"13","author":"Ensrud","year":"2012","journal-title":"Sleep. Med."},{"key":"B12","doi-asserted-by":"publisher","first-page":"2085","DOI":"10.1111\/j.1532-5415.2009.02490.x","article-title":"Sleep disturbances and frailty status in older community-dwelling men","volume":"57","author":"Ensrud","year":"2009","journal-title":"J. Am. Geriatr. Soc."},{"key":"B13","doi-asserted-by":"publisher","first-page":"zsac259","DOI":"10.1093\/sleep\/zsac259","article-title":"Obstructive sleep apnea during REM sleep: effects on morning and evening blood pressure","volume":"46","author":"Falla","year":"2023","journal-title":"Sleep"},{"key":"B14","doi-asserted-by":"publisher","first-page":"e22680","DOI":"10.1002\/jcla.22680","article-title":"The association of hemocyte profile and obstructive sleep apnea","volume":"33","author":"Fan","year":"2019","journal-title":"J. Clin. Lab. Anal."},{"key":"B15","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1016\/j.rppnen.2016.12.001","article-title":"Hematological evaluation in males with obstructive sleep apnea before and after positive airway pressure","volume":"23","author":"Feliciano","year":"2017","journal-title":"Rev. Port. Pneumol."},{"key":"B16","doi-asserted-by":"publisher","first-page":"529","DOI":"10.1164\/ajrccm\/140.2.529","article-title":"Driving simulator performance in patients with sleep apnea","volume":"140","author":"Findley","year":"1989","journal-title":"Am. Rev. Respir. Dis."},{"key":"B17","doi-asserted-by":"publisher","first-page":"e5","DOI":"10.1016\/S2213-2600(16)00006-0","article-title":"Prevalence of sleep apnoea syndrome in the middle to old age general population","volume":"4","author":"Heinzer","year":"2016","journal-title":"Lancet Respir. Med."},{"key":"B18","doi-asserted-by":"publisher","first-page":"310","DOI":"10.1016\/S2213-2600(15)00043-0","article-title":"Prevalence of sleep-disordered breathing in the general population: the HypnoLaus study","volume":"3","author":"Heinzer","year":"2015","journal-title":"Lancet Respir. Med."},{"key":"B19","doi-asserted-by":"publisher","first-page":"9","DOI":"10.5664\/jcsm.1648","article-title":"Assessment of multiple health risks in a single obstructive sleep apnea population","volume":"8","author":"Hudgel","year":"2012","journal-title":"J. Clin. Sleep. Med."},{"key":"B20","doi-asserted-by":"publisher","first-page":"1906","DOI":"10.1016\/j.euroneuro.2015.08.014","article-title":"Increased all-cause mortality with use of psychotropic medication in dementia patients and controls: a population-based register study","volume":"25","author":"Jennum","year":"2015","journal-title":"Eur. Neuropsychopharmacol."},{"key":"B21","doi-asserted-by":"publisher","first-page":"736","DOI":"10.1016\/S0140-6736(13)60734-5","article-title":"Adult obstructive sleep apnoea","volume":"383","author":"Jordan","year":"2014","journal-title":"Lancet"},{"key":"B22","doi-asserted-by":"publisher","first-page":"479","DOI":"10.5664\/jcsm.6506","article-title":"Clinical practice guideline for diagnostic testing for adult obstructive sleep apnea: an American Academy of Sleep Medicine clinical practice guideline","volume":"13","author":"Kapur","year":"2017","journal-title":"J. Clin. Sleep. Med."},{"key":"B23","first-page":"251","article-title":"Age-related changes in sleep in depressed and healthy subjects. A meta-analysis","volume":"3","author":"Knowles","year":"1990","journal-title":"Neuropsychopharmacology"},{"key":"B24","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1016\/j.ypmed.2007.12.007","article-title":"Impact of mental health on daily living activities of Japanese elderly","volume":"46","author":"Kondo","year":"2008","journal-title":"Prev. Med."},{"key":"B25","doi-asserted-by":"publisher","first-page":"1156","DOI":"10.1378\/chest.08-1311","article-title":"Rapid eye movement-related sleep-disordered breathing: influence of age and gender","volume":"134","author":"Koo","year":"2018","journal-title":"Chest"},{"key":"B26","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1111\/j.1440-1843.2011.02081.x","article-title":"Obesity, obstructive sleep apnoea and metabolic syndrome","volume":"17","author":"Lam","year":"2012","journal-title":"Respirology"},{"key":"B27","doi-asserted-by":"publisher","first-page":"909","DOI":"10.1164\/rccm.201203-0448OC","article-title":"Cardiovascular mortality in obstructive sleep apnea in the elderly: role of long-term continuous positive airway pressure treatment: a prospective observational study","volume":"186","author":"Mart\u00ednez-Garc\u00eda","year":"2012","journal-title":"Am. J. Respir. Crit. Care. Med."},{"key":"B28","doi-asserted-by":"publisher","first-page":"1902251","DOI":"10.1183\/13993003.02251-2019","article-title":"Sleep disordered breathing and metabolic comorbidities across sex and menopausal status in East Asians: the Nagahama Study","volume":"56","author":"Matsumoto","year":"2020","journal-title":"Eur. Respir. J."},{"key":"B29","doi-asserted-by":"publisher","first-page":"1503","DOI":"10.5664\/jcsm.9886","article-title":"Prevalence of common sleep disorders in a middle-aged community sample","volume":"18","author":"McArdle","year":"2022","journal-title":"J. Clin. Sleep. Med."},{"key":"B30","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1016\/s0003-9993(95)80046-8","article-title":"Sleep apnea in patients with hemispheric stroke","volume":"76","author":"Mohsenin","year":"1995","journal-title":"Arch. Phys. Med. Rehabil."},{"key":"B31","doi-asserted-by":"publisher","first-page":"475","DOI":"10.5664\/jcsm.3690","article-title":"Effect of obstructive sleep apnea hypopnea syndrome on lipid profile: a meta-regression analysis","volume":"10","author":"Nadeem","year":"2014","journal-title":"J. Clin. Sleep. Med."},{"key":"B32","doi-asserted-by":"publisher","first-page":"2408","DOI":"10.1001\/archinte.165.20.2408","article-title":"Progression and regression of sleep-disordered breathing with changes in weight: the Sleep Heart Health Study","volume":"165","author":"Newman","year":"2005","journal-title":"Arch. Intern. Med."},{"key":"B33","doi-asserted-by":"publisher","first-page":"923","DOI":"10.1093\/sleep\/27.5.923","article-title":"Using a wrist-worn device based on peripheral arterial tonometry to diagnose obstructive sleep apnea: in-laboratory and ambulatory validation","volume":"27","author":"Nittman","year":"2004","journal-title":"Sleep"},{"key":"B34","doi-asserted-by":"publisher","first-page":"343","DOI":"10.5664\/jcsm.27875","article-title":"REM-related obstructive sleep apnea: the effect of body position","volume":"6","author":"Oksenberg","year":"2010","journal-title":"J. Clin. Sleep. Med."},{"key":"B35","doi-asserted-by":"publisher","first-page":"726","DOI":"10.1016\/j.sleep.2008.08.004","article-title":"Pulmonary capillary wedge pressure and pulmonary arterial pressure in heart failure patients with sleep-disordered breathing","volume":"10","author":"Oldenburg","year":"2009","journal-title":"Sleep. Med."},{"key":"B36","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1016\/j.ejheart.2006.08.003","article-title":"Sleep-disordered breathing in patients with symptomatic heart failure: a contemporary study of prevalence in and characteristics of 700 patients","volume":"9","author":"Oldenburg","year":"2007","journal-title":"Eur. J. Heart Fail."},{"key":"B37","doi-asserted-by":"publisher","first-page":"1050648","DOI":"10.3389\/fnagi.2022.1050648","article-title":"Instability of non-REM sleep in older women evaluated by sleep-stage transition and envelope analyses","volume":"14","author":"Park","year":"2022","journal-title":"Front. Aging Neurosci."},{"key":"B38","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1164\/ajrccm.161.2.9903139","article-title":"Time course of sleep-related breathing disorders in first-ever stroke or transient ischemic attack","volume":"161","author":"Parra","year":"2000","journal-title":"Am. J. Respir. Crit. Care. Med."},{"key":"B39","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1016\/S2213-2600(16)00054-0","article-title":"Prevention and care of respiratory failure in obese patients","volume":"4","author":"P\u00e9pin","year":"2016","journal-title":"Lancet Respir. Med."},{"key":"B40","doi-asserted-by":"publisher","first-page":"1006","DOI":"10.1093\/aje\/kws342","article-title":"Increased prevalence of sleep-disordered breathing in adults","volume":"177","author":"Peppard","year":"2013","journal-title":"Am. J. Epidemiol."},{"key":"B41","doi-asserted-by":"publisher","first-page":"410","DOI":"10.1002\/ana.21448","article-title":"Maintenance of Wakefulness test, obstructive sleep apnea syndrome, and driving risk","volume":"64","author":"Philip","year":"2008","journal-title":"Ann. Neurol."},{"key":"B42","doi-asserted-by":"publisher","first-page":"1297","DOI":"10.1097\/00004872-199917090-00009","article-title":"Recent weight gain in patients with newly diagnosed obstructive sleep apnea","volume":"17","author":"Phillips","year":"1999","journal-title":"J. Hypertens."},{"key":"B43","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1016\/j.arr.2015.07.003","article-title":"Frailty and sleep disturbances in the elderly: possible connections and clinical implications","volume":"6","author":"Piovezan","year":"2013","journal-title":"Sleep. Sci."},{"key":"B44","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1056\/NEJMoa1308659","article-title":"Upper-airway stimulation for obstructive sleep apnea","volume":"370","author":"Strollo","year":"2014","journal-title":"N. Engl. J. Med."},{"key":"B45","doi-asserted-by":"publisher","first-page":"965199","DOI":"10.3389\/fragi.2022.965199","article-title":"Super-multifactorial survey YHAB revealed high prevalence of sleep apnoea syndrome in unaware older adults and potential combinatorial factors for its initial screening","volume":"3","author":"Tanaka","year":"2022","journal-title":"Front. Aging."},{"key":"B46","doi-asserted-by":"publisher","first-page":"433","DOI":"10.5664\/jcsm.2658","article-title":"Evaluation of drug-induced sleep endoscopy as a patient selection tool for implanted upper airway stimulation for obstructive sleep apnea","volume":"9","author":"Vanderveken","year":"2013","journal-title":"J. Clin. Sleep. Med."},{"key":"B47","doi-asserted-by":"publisher","first-page":"1179","DOI":"10.1113\/jphysiol.2012.245159","article-title":"Role of nocturnal rostral fluid shift in the pathogenesis of obstructive and central sleep apnoea","volume":"591","author":"White","year":"2013","journal-title":"J. Physiol."},{"key":"B48","doi-asserted-by":"publisher","first-page":"2034","DOI":"10.1056\/NEJMoa043104","article-title":"Obstructive sleep apnea as a risk factor for stroke and death","volume":"353","author":"Yaggi","year":"2005","journal-title":"N. Engl. J. Med."},{"key":"B49","doi-asserted-by":"publisher","first-page":"809","DOI":"10.3390\/ijerph14070809","article-title":"Developing and validating an age-independent equation using multi-frequency bioelectrical impedance analysis for estimation of appendicular skeletal muscle mass and establishing a cutoff for sarcopenia","volume":"14","author":"Yamada","year":"2017","journal-title":"Int. J. Environ. Res. Public Health"},{"key":"B50","doi-asserted-by":"publisher","first-page":"1230","DOI":"10.1056\/NEJM199304293281704","article-title":"The occurrence of sleep-disordered breathing among middle-aged adults","volume":"328","author":"Young","year":"1993","journal-title":"N. Engl. J. Med."},{"key":"B51","doi-asserted-by":"publisher","first-page":"893","DOI":"10.1001\/archinte.162.8.893","article-title":"Predictors of sleep-disordered breathing in community-dwelling adults: the sleep heart health study","volume":"162","author":"Young","year":"2002","journal-title":"Arch. Intern. Med."}],"container-title":["Frontiers in Aging"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fragi.2024.1331448\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T04:39:34Z","timestamp":1714538374000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fragi.2024.1331448\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5,1]]},"references-count":51,"alternative-id":["10.3389\/fragi.2024.1331448"],"URL":"https:\/\/doi.org\/10.3389\/fragi.2024.1331448","relation":{},"ISSN":["2673-6217"],"issn-type":[{"value":"2673-6217","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,5,1]]},"article-number":"1331448"}}