{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T20:57:45Z","timestamp":1790456265052,"version":"4.1.0"},"reference-count":75,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T00:00:00Z","timestamp":1775779200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Aging"],"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Aging is accompanied by changes in lipid metabolism that may influence cellular homeostasis and risk for age-related disease. Circulating polyunsaturated fatty acid (PUFA) status is increasingly recognized as an important marker of metabolic health and may shift with age. Product-to-precursor ratios of fatty acids, including PUFA are commonly used as proxy indices of desaturation and elongation but do not directly reflect enzyme activity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this cross-sectional study, plasma and erythrocyte fatty acid profiles were measured by gas chromatography\u2013flame ionization detection (GC-FID) in patients (n = 1277) from a metabolic disease clinic in Brandenburg, Germany. Participants were stratified into five age groups (\u2264 34, 35\u201344, 45\u201354, 55\u201364, \u2265 65 years) and differences between groups were assessed using statistical tests.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Participants aged \u2265 65 years had higher total omega-3 (n-3) and lower total omega-6 (n-6) PUFA levels in both matrices. Eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) increased with age, whereas linoleic acid (LA) and dihomo-gamma-linolenic acid (DGLA) decreased. Ratio-based indices showed consistent age associations. The delta-5-desaturase index (D5D) and arachidonic acid (AA)\/LA ratio were positively associated with age, while elongation of very long chain fatty acids (ELOVL)2 and ELOVL6 were inversely associated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>Overall, blood PUFA profiles and multiple ratio-based indices showed consistent, age-related trends in this clinical cohort. Interpretation is limited by the cross-sectional design and the lack of key determinants of PUFA status (e.g., diet, clinical covariates, genetic information and gut\/microbiome factors). Nevertheless, these results underscore age-related shifts in PUFA composition and enzymatic proxy indices, providing new insights into lipid metabolism across the lifespan.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fragi.2026.1725187","type":"journal-article","created":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T06:03:30Z","timestamp":1775801010000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":3,"title":["Age-related alterations in fatty acid metabolism: a clinical study of erythrocyte and plasma profiles in a population from Brandenburg, Germany"],"prefix":"10.3389","volume":"7","author":[{"given":"Yingqi","family":"Yu","sequence":"first","affiliation":[{"name":"Medical Department B, Division of Hepatology, Gastroenterology, Oncology, Hematology, Palliative Care, Endocrinology and Diabetes, Brandenburg Medical School, University Hospital Ruppin-Brandenburg","place":["Neuruppin, 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