{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T06:09:27Z","timestamp":1779170967821,"version":"3.51.4"},"reference-count":21,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T00:00:00Z","timestamp":1779148800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Aging"],"abstract":"<jats:p>\n                    The longevity research field is experiencing unprecedented momentum, driven by advances in molecular biomarkers, digital health technologies, and artificial intelligence. However, established physiological measures\u2014VO\n                    <jats:sub>2<\/jats:sub>\n                    max, heart rate variability, body composition, muscle strength, among others\u2014with decades of validation are increasingly presented as novel \u201clongevity biomarkers\u201d without acknowledging their foundational research. This perspective proposes integration as the constructive path forward, creating multidimensional aging models that combine functional measures, molecular biomarkers, mechanistic studies, and longitudinal outcomes. We present a practical framework across five domains\u2014endpoint definition, biomarker validation, integration strategy, study design, and communication\u2014to guide the field from rediscovery to meaningful innovation. Longevity science\u2019s future depends on methodological rigor, transparent communication, and genuine integration of established knowledge with novel insights, ensuring that enthusiasm for new technologies translates into demonstrable improvements in healthspan and potentially lifespan.\n                  <\/jats:p>","DOI":"10.3389\/fragi.2026.1742582","type":"journal-article","created":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T05:44:08Z","timestamp":1779169448000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Building a framework for integrative longevity science: from rediscovery to innovation"],"prefix":"10.3389","volume":"7","author":[{"given":"Marta","family":"Gonzalez-Freire","sequence":"first","affiliation":[{"name":"Translational Research in Aging and Longevity Group (TRIAL Group), Health Research Institute of the Balearic Islands (IdISBa)","place":["Palma de Mallorca, Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2026,5,19]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1038\/s41591-019-0719-5","article-title":"Personal aging markers and ageotypes revealed by deep longitudinal profiling","volume":"26","author":"Ahadi","year":"2020","journal-title":"Nat. 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