{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T16:09:35Z","timestamp":1793117375294,"version":"4.5.0"},"reference-count":41,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T00:00:00Z","timestamp":1777334400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Aging"],"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Motoric cognitive risk (MCR) syndrome, defined by subjective cognitive complaints and slow gait, is a predementia condition associated with multiple adverse outcomes. Although vitamin D deficiency and systemic inflammation have been implicated in cognitive and motor decline, their interaction in the context of MCR remains unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This cross-sectional study included 312 hospitalized adults aged \u226560 years. Serum 25(OH)D levels, systemic immune-inflammation index (SII), and standardized clinical assessments were obtained within 48 h of admission. Multivariable regression and mediation analyses were performed to evaluate associations and underlying pathways.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The prevalence of MCR was 17.9%. Older age, greater comorbidity burden, poor sleep quality, lower 25(OH)D levels, and higher SII were independently associated with MCR. Mediation analysis showed that systemic inflammation accounted for approximately one-quarter of the association between lower 25(OH)D and higher MCR risk, with the strongest indirect effect observed at 25(OH)D \u2264 20 ng\/mL.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>Vitamin D deficiency and systemic inflammation are important determinants of MCR. The identified vitamin D\u2013inflammation pathway may contribute to motoric cognitive vulnerability and provide insights for early risk stratification and preventive strategies in geriatric populations.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fragi.2026.1748389","type":"journal-article","created":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T08:08:56Z","timestamp":1777363736000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Vitamin D, systemic inflammation, and motoric cognitive risk: exploring the risk factors and mediation pathways"],"prefix":"10.3389","volume":"7","author":[{"given":"Yunhe","family":"Xu","sequence":"first","affiliation":[{"name":"Second Clinical Medical College, Chengde Medical University","place":["Chengde, Hebei, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pei","family":"Qin","sequence":"additional","affiliation":[{"name":"Department of Geriatrics, Chengde Central Hospital","place":["Chengde, Hebei, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ningqi","family":"Kang","sequence":"additional","affiliation":[{"name":"Second Clinical Medical College, Chengde Medical University","place":["Chengde, Hebei, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Li","sequence":"additional","affiliation":[{"name":"Second Clinical Medical College, Chengde Medical University","place":["Chengde, Hebei, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lijiao","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Geriatrics, Chengde Central Hospital","place":["Chengde, Hebei, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,4,28]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"214","DOI":"10.1177\/08919887241280880","article-title":"Increased systemic immune-inflammation index as a novel indicator of Alzheimer\u2019s disease severity","volume":"38","author":"Algul","year":"2024","journal-title":"J. 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