{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,25]],"date-time":"2026-05-25T07:02:29Z","timestamp":1779692549705,"version":"3.53.1"},"reference-count":76,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,5,25]],"date-time":"2026-05-25T00:00:00Z","timestamp":1779667200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Aging"],"abstract":"<jats:p>The growing population of older cancer survivors faces an elevated risk of accelerated cognitive decline due to the combined effects of aging and cancer-related cognitive impairment. Loneliness and social isolation have also been linked to poorer cognitive outcomes and increased risk of Alzheimer\u2019s Disease and Related Dementias (ADRD). At the same time, regular physical activity and social support interventions may improve cognitive function and reduce risk of cognitive decline. Despite these parallel lines of evidence, few interventions have addressed these modifiable risk factors simultaneously, particularly among older cancer survivors. In this perspective, we propose that group-based exercise may provide synergistic benefits for cognitive health by addressing both physical activity and social engagement. We present a conceptual model in which participation in group exercise promotes exercise-induced neurobiological adaptations that support cognitive function while simultaneously enhancing social connectedness. These processes may reduce loneliness and social isolation, promoting cognitive engagement. We also highlight key considerations for future research, including the potential for virtual or remotely delivered group exercise to increase accessibility, the importance of group dynamics in fostering social support, and the need to incorporate validated measures of loneliness, social isolation, and cognitive function in intervention studies.<\/jats:p>","DOI":"10.3389\/fragi.2026.1835531","type":"journal-article","created":{"date-parts":[[2026,5,25]],"date-time":"2026-05-25T06:03:48Z","timestamp":1779689028000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Synergistic effects of group-based exercise to reduce loneliness and social isolation and to prevent cognitive decline among older adults with cancer"],"prefix":"10.3389","volume":"7","author":[{"given":"Heather J.","family":"Leach","sequence":"first","affiliation":[{"name":"Department of Health and Exercise Science, Colorado State University","place":["Fort Collins, CO, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaclyn A.","family":"Stephens","sequence":"additional","affiliation":[{"name":"Department of Health and Exercise Science, Colorado State University","place":["Fort Collins, CO, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diane K.","family":"Ehlers","sequence":"additional","affiliation":[{"name":"Department of Quantitative Health Sciences, Mayo Clinic","place":["Scottsdale, AZ, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,5,25]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1146\/annurev-clinpsy-050817-084903","article-title":"Cognitive effects of cancer and cancer treatments","volume":"14","author":"Ahles","year":"2018","journal-title":"Annu. Rev. Clin. Psychol."},{"key":"B2","doi-asserted-by":"publisher","first-page":"1179","DOI":"10.1158\/1055-9965.EPI-19-1318","article-title":"Prevalence of healthy behaviors among cancer survivors in the United States: how far have we come?","volume":"29","author":"Arem","year":"2020","journal-title":"Cancer Epidemiol. Biomarkers Prev."},{"key":"B3","doi-asserted-by":"publisher","first-page":"1767","DOI":"10.1080\/13607863.2024.2374933","article-title":"Evaluating the cognitive effects of interventions to reduce social isolation and loneliness in older adults: a systematic review","volume":"28","author":"Baptista","year":"2024","journal-title":"Aging Ment. Health"},{"key":"B4","doi-asserted-by":"publisher","first-page":"592","DOI":"10.1186\/s12889-015-1909-9","article-title":"GrOup based physical activity for oLder adults (GOAL) randomized controlled trial: study protocol","volume":"15","author":"Beauchamp","year":"2015","journal-title":"BMC Public Health"},{"key":"B5","doi-asserted-by":"publisher","first-page":"1029","DOI":"10.1158\/1055-9965.EPI-16-0133","article-title":"Anticipating the \u201cSilver Tsunami\u201d: prevalence trajectories and comorbidity burden among older cancer survivors in the United States","volume":"25","author":"Bluethmann","year":"2016","journal-title":"Cancer Epidemiol. Biomarkers Prev."},{"key":"B6","doi-asserted-by":"publisher","first-page":"7603345030","DOI":"10.5014\/ajot.2022.047522","article-title":"Development and initial testing of the electronic activity card sort (ACS3) among community-dwelling adults","volume":"76","author":"Boone","year":"2022","journal-title":"Am. J. Occup. Ther."},{"key":"B7","doi-asserted-by":"publisher","first-page":"e35540","DOI":"10.1002\/cncr.35540","article-title":"Aerobic exercise and CogniTIVe functioning in women with breAsT cancEr (ACTIVATE): a randomized controlled trial","volume":"131","author":"Brunet","year":"2025","journal-title":"Cancer"},{"key":"B8","doi-asserted-by":"publisher","first-page":"13","DOI":"10.53841\/bpssepr.2006.2.1.13","article-title":"Group versus individual approach? A meta-analysis of the effectiveness of interventions to promote physical activity","volume":"2","author":"Burke","year":"2006","journal-title":"Sport & Exerc. Psychol. Rev."},{"key":"B9","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1093\/ptj\/pzz090","article-title":"The effect of exercise on cancer-related cognitive impairment and applications for physical therapy: systematic review of randomized controlled trials","volume":"100","author":"Campbell","year":"2020","journal-title":"Phys. Ther."},{"key":"B10","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1123\/jsep.18.1.1","article-title":"Social influence and exercise: a meta-analysis","volume":"18","author":"Carron","year":"1996","journal-title":"J. Sport Exerc. Psy"},{"key":"B11","doi-asserted-by":"publisher","first-page":"600","DOI":"10.1177\/07334648211047347","article-title":"Telehealth use among older adults during COVID-19: associations with sociodemographic and health characteristics, technology device ownership, and technology learning","volume":"41","author":"Choi","year":"2022","journal-title":"J. Appl. Gerontol."},{"key":"B12","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1016\/j.jagp.2024.07.013","article-title":"Risk of dementia in different types of cancer survivors: a nationwide cohort study","volume":"33","author":"Chu","year":"2025","journal-title":"Am. J. Geriatr. Psychiatry"},{"key":"B13","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1249\/tjx.0000000000000250","article-title":"Scoping review of videoconference online exercise programs for cancer survivors in community settings","volume":"9","author":"Crisafio","year":"2024","journal-title":"Transl. J. Am. Coll. Sports Med."},{"key":"B14","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1093\/geronb\/gby037","article-title":"The epidemiology of social isolation: national health and aging trends study","volume":"75","author":"Cudjoe","year":"2020","journal-title":"J. Gerontol. B Psychol. Sci. Soc. Sci."},{"key":"B15","doi-asserted-by":"publisher","first-page":"e5","DOI":"10.1017\/S204579602100069X","article-title":"The role of cognitive and social leisure activities in dementia risk: assessing longitudinal associations of modifiable and non-modifiable risk factors","volume":"31","author":"Duffner","year":"2022","journal-title":"Epidemiol. Psychiatr. Sci."},{"key":"B16","doi-asserted-by":"publisher","first-page":"110","DOI":"10.3389\/fnagi.2017.00110","article-title":"Regional brain volumes moderate, but do not mediate, the effects of group-based exercise training on reductions in loneliness in older adults","volume":"9","author":"Ehlers","year":"2017","journal-title":"Front. Aging Neurosci."},{"key":"B17","doi-asserted-by":"publisher","first-page":"827","DOI":"10.1093\/her\/cyl159","article-title":"\u201cI wouldn\u201dt have been interested in just sitting round a table talking about cancer; exploring the experiences of women with breast cancer in a group exercise trial","volume":"22","author":"Emslie","year":"2007","journal-title":"Health Educ. Res."},{"key":"B18","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1111\/j.1751-9004.2011.00409.x","article-title":"Group dynamics in physical activity promotion: what works?","volume":"6","author":"Estabrooks","year":"2012","journal-title":"Soc. Personality Psychol. Compass"},{"key":"B19","doi-asserted-by":"publisher","first-page":"2043","DOI":"10.1007\/s00520-019-05278-y","article-title":"Effects of exercise interventions on social and cognitive functioning of men with prostate cancer: a meta-analysis","volume":"28","author":"Fang","year":"2020","journal-title":"Support Care Cancer"},{"key":"B20","doi-asserted-by":"publisher","first-page":"2313","DOI":"10.1177\/07334648231192053","article-title":"Social isolation and loneliness in a population study of cognitive impairment: the MYHAT study","volume":"42","author":"Fang","year":"2023","journal-title":"J. Appl. Gerontol."},{"key":"B21","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1016\/0022-3956(75)90026-6","article-title":"Mini-mental state. A practical method for grading the cognitive state of patients for the clinician","volume":"12","author":"Folstein","year":"1975","journal-title":"J. Psychiatr. Res."},{"key":"B22","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1007\/s00401-014-1377-9","article-title":"One is the deadliest number: the detrimental effects of social isolation on cerebrovascular diseases and cognition","volume":"129","author":"Friedler","year":"2015","journal-title":"Acta Neuropathol."},{"key":"B23","doi-asserted-by":"publisher","first-page":"478","DOI":"10.1080\/07317115.2023.2170843","article-title":"Measuring social isolation in older adults: a rapid review informing evidence-based research and practice","volume":"46","author":"Gardam","year":"2023","journal-title":"Clin. Gerontol."},{"key":"B24","doi-asserted-by":"publisher","first-page":"e158453","DOI":"10.1172\/JCI158453","article-title":"Biological aging processes underlying cognitive decline and neurodegenerative disease","volume":"132","author":"Gonzales","year":"2022","journal-title":"J. Clin. Invest"},{"key":"B25","doi-asserted-by":"publisher","first-page":"1228","DOI":"10.1002\/pon.5388","article-title":"Differences in cognition and physical activity in younger vs older breast cancer survivors","volume":"29","author":"Hanson","year":"2020","journal-title":"Psychooncology"},{"key":"B26","doi-asserted-by":"publisher","first-page":"e201411","DOI":"10.1001\/jamahealthforum.2020.1411","article-title":"Meeting the social needs of older adults in rural areas","volume":"1","author":"Henning-Smith","year":"2020","journal-title":"JAMA Health Forum"},{"key":"B27","doi-asserted-by":"publisher","first-page":"e2236676","DOI":"10.1001\/jamanetworkopen.2022.36676","article-title":"Interventions associated with reduced loneliness and social isolation in older adults: a systematic review and meta-analysis","volume":"5","author":"Hoang","year":"2022","journal-title":"JAMA Netw. Open"},{"key":"B28","doi-asserted-by":"publisher","first-page":"765","DOI":"10.1111\/jgs.18140","article-title":"Social isolation and 9-year dementia risk in community-dwelling medicare beneficiaries in the United States","volume":"71","author":"Huang","year":"2023","journal-title":"J. Am. Geriatr. Soc."},{"key":"B29","doi-asserted-by":"publisher","first-page":"1180","DOI":"10.1007\/s12282-025-01757-9","article-title":"Effect of exercise interventions on cognitive function in breast cancer patients and survivors: a systematic review with meta-analysis","volume":"32","author":"Hung","year":"2025","journal-title":"Breast Cancer"},{"key":"B30","doi-asserted-by":"publisher","first-page":"1113864","DOI":"10.3389\/fpubh.2023.1113864","article-title":"Loneliness and social networks of older adults in rural communities: a narrative synthesis systematic review","volume":"11","author":"Hussain","year":"2023","journal-title":"Front. Public Health"},{"key":"B31","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1017\/S1041610223000923","article-title":"Social connections as determinants of cognitive health and as targets for social interventions in persons with or at risk of Alzheimer's disease and related disorders: a scoping review","volume":"36","author":"Joshi","year":"2024","journal-title":"Int. Psychogeriatr."},{"key":"B32","doi-asserted-by":"publisher","first-page":"1287391","DOI":"10.3389\/fpsyt.2023.1287391","article-title":"The impact of loneliness and social isolation during COVID-19 on cognition in older adults: a scoping review","volume":"14","author":"Kassam","year":"2023","journal-title":"Front. Psychiatry"},{"key":"B33","doi-asserted-by":"publisher","first-page":"1215","DOI":"10.3390\/cancers15041215","article-title":"A systematic review on the potential acceleration of neurocognitive aging in older cancer survivors","volume":"15","author":"Kerstens","year":"2023","journal-title":"Cancers (Basel)"},{"key":"B34","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1186\/s13058-022-01530-2","article-title":"Effect of physical exercise on cognitive function after chemotherapy in patients with breast cancer: a randomized controlled trial (PAM study)","volume":"24","author":"Koevoets","year":"2022","journal-title":"Breast Cancer Res."},{"key":"B35","doi-asserted-by":"publisher","first-page":"1873","DOI":"10.1038\/s41386-021-01058-7","article-title":"Neurobiology of loneliness: a systematic review","volume":"46","author":"Lam","year":"2021","journal-title":"Neuropsychopharmacology"},{"key":"B36","doi-asserted-by":"publisher","first-page":"1925","DOI":"10.1093\/annonc\/mdz410","article-title":"Cancer-related cognitive impairment: an update on state of the art, detection, and management strategies in cancer survivors","volume":"30","author":"Lange","year":"2019","journal-title":"Ann. Oncol."},{"key":"B37","doi-asserted-by":"publisher","first-page":"e000221","DOI":"10.1249\/tjx.0000000000000221","article-title":"A group-based, videoconference-delivered physical activity program for cancer survivors","volume":"8","author":"Leach","year":"2023","journal-title":"Transl. J. Am. Coll. Sports Med."},{"key":"B38","doi-asserted-by":"publisher","first-page":"1601","DOI":"10.1007\/s00520-019-04670-y","article-title":"Group-based exercise interventions for increasing physical activity in cancer survivors: a systematic review of face-to-face randomized and non-randomized trials","volume":"27","author":"Leach","year":"","journal-title":"Support Care Cancer"},{"key":"B39","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1188\/19.ONF.185-197","article-title":"Effect of group dynamics-based exercise versus personal training in breast cancer survivors","volume":"46","author":"Leach","year":"","journal-title":"Oncol. Nurs. Forum"},{"key":"B40","doi-asserted-by":"publisher","first-page":"137","DOI":"10.12779\/dnd.2018.17.4.137","article-title":"Association between Alzheimer's disease and cancer risk in South Korea: an 11-year nationwide population-based study","volume":"17","author":"Lee","year":"2018","journal-title":"Dement. Neurocogn Disord."},{"key":"B41","doi-asserted-by":"publisher","first-page":"4127","DOI":"10.1002\/cncr.35508","article-title":"Social isolation, depression, and anxiety among young adult cancer survivors: the mediating role of social connectedness","volume":"130","author":"Li","year":"2024","journal-title":"Cancer"},{"key":"B42","doi-asserted-by":"publisher","first-page":"2138","DOI":"10.1200\/JCO.21.00239","article-title":"Cognitive function in older adults with cancer: assessment, management, and research opportunities","volume":"39","author":"Magnuson","year":"2021","journal-title":"J. Clin. Oncol."},{"key":"B43","doi-asserted-by":"publisher","first-page":"709","DOI":"10.1053\/j.seminoncol.2013.09.006","article-title":"Cognitive effects of cancer and its treatments at the intersection of aging: what do we know; what do we need to know?","volume":"40","author":"Mandelblatt","year":"2013","journal-title":"Semin. Oncol."},{"key":"B44","doi-asserted-by":"publisher","first-page":"JCO1800140","DOI":"10.1200\/JCO.18.00140","article-title":"Cancer-related cognitive outcomes among older breast cancer survivors in the thinking and living with cancer study","volume":"36","author":"Mandelblatt","year":"2018","journal-title":"J. Clin. Oncol."},{"key":"B45","doi-asserted-by":"publisher","first-page":"284","DOI":"10.1016\/j.amepre.2011.04.014","article-title":"Self-regulatory processes and exercise adherence in older adults: executive function and self-efficacy effects","volume":"41","author":"McAuley","year":"2011","journal-title":"Am. J. Prev. Med."},{"key":"B46","doi-asserted-by":"publisher","first-page":"1945","DOI":"10.1002\/pon.5171","article-title":"The role of social support in physical activity for cancer survivors: a systematic review","volume":"28","author":"McDonough","year":"2019","journal-title":"Psychooncology"},{"key":"B47","doi-asserted-by":"publisher","first-page":"713","DOI":"10.1007\/s11764-020-00963-y","article-title":"Social support and physical activity for cancer survivors: a qualitative review and meta-study","volume":"15","author":"McDonough","year":"2021","journal-title":"J. Cancer Surviv"},{"key":"B48","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1080\/07347332.2020.1867690","article-title":"Interventions for loneliness among adult cancer survivors: a systematic review and meta-analysis","volume":"39","author":"McElfresh","year":"2021","journal-title":"J. Psychosoc. Oncol."},{"key":"B49","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1038\/s41514-024-00136-6","article-title":"Cost of care for Alzheimer's disease and related dementias in the United States: 2016 to 2060","volume":"10","author":"Nandi","year":"2024","journal-title":"NPJ Aging"},{"key":"B50","doi-asserted-by":"publisher","first-page":"695","DOI":"10.1111\/j.1532-5415.2005.53221.x","article-title":"The Montreal cognitive assessment, MoCA: a brief screening tool for mild cognitive impairment","volume":"53","author":"Nasreddine","year":"2005","journal-title":"J. Am. Geriatr. Soc."},{"key":"B51","doi-asserted-by":"publisher","first-page":"1408","DOI":"10.1093\/geronb\/gbaa109","article-title":"Measuring older adult loneliness across countries","volume":"76","author":"Newmyer","year":"2021","journal-title":"J. Gerontol. B Psychol. Sci. Soc. Sci."},{"key":"B52","first-page":"118","article-title":"Loneliness and social isolation in older adults","volume":"122","author":"Ohiokpehai","year":"2025","journal-title":"Mo Med."},{"key":"B53","doi-asserted-by":"publisher","first-page":"3","DOI":"10.3389\/fcogn.2024.1323438","article-title":"Modifying modularity: aerobic exercise improves functional connectivity in breast cancer survivors","volume":"3","author":"Page","year":"2024","journal-title":"Front. Cognition"},{"key":"B54","doi-asserted-by":"publisher","first-page":"1295","DOI":"10.1002\/pon.3884","article-title":"Peer mentorship to promote physical activity among cancer survivors: effects on quality of life","volume":"24","author":"Pinto","year":"2015","journal-title":"Psychooncology"},{"key":"B55","doi-asserted-by":"publisher","first-page":"1463","DOI":"10.1038\/s43587-023-00472-4","article-title":"Reflections on measures of social isolation among older adults","volume":"3","author":"Pomeroy","year":"2023","journal-title":"Nat. Aging."},{"key":"B56","volume-title":"Automated Neuropsychological Assessment Metrics (ANAM): Test Administrators Guide","author":"Reeves","year":"1995"},{"key":"B57","doi-asserted-by":"publisher","first-page":"1233","DOI":"10.1007\/s11764-023-01363-8","article-title":"Recruitment rates and strategies in exercise trials in cancer survivorship: a systematic review","volume":"18","author":"Reynolds","year":"2023","journal-title":"J. Cancer Surviv"},{"key":"B58","doi-asserted-by":"publisher","first-page":"507","DOI":"10.1016\/j.neurobiolaging.2008.09.023","article-title":"When does age-related cognitive decline begin?","volume":"30","author":"Salthouse","year":"2009","journal-title":"Neurobiol. Aging"},{"key":"B59","doi-asserted-by":"publisher","first-page":"655","DOI":"10.1162\/jocn.2009.21230","article-title":"Span, CRUNCH, and beyond: working memory capacity and the aging brain","volume":"22","author":"Schneider-Garces","year":"2010","journal-title":"J. Cogn. Neurosci."},{"key":"B60","doi-asserted-by":"publisher","first-page":"729","DOI":"10.1007\/s11682-014-9329-5","article-title":"Participation in cognitively-stimulating activities is associated with brain structure and cognitive function in preclinical Alzheimer's disease","volume":"9","author":"Schultz","year":"2015","journal-title":"Brain Imaging Behav."},{"key":"B61","doi-asserted-by":"publisher","first-page":"2003","DOI":"10.1007\/s40520-020-01722-w","article-title":"Group-based physical activity as a means to reduce social isolation and loneliness among older adults","volume":"33","author":"Sebastiao","year":"2021","journal-title":"Aging Clin. Exp. Res."},{"key":"B62","doi-asserted-by":"publisher","first-page":"E397","DOI":"10.1097\/NCC.0000000000001353","article-title":"Virtually supervised exercise programs for people with cancer: a scoping review","volume":"48","author":"Smith","year":"2025","journal-title":"Cancer Nurs."},{"key":"B63","doi-asserted-by":"publisher","first-page":"186","DOI":"10.1007\/s00520-026-10366-x","article-title":"A pilot randomized controlled trial comparing the feasibility and preliminary effects of different forms of exercise-related social support for older adult survivors of cancer","volume":"34","author":"Smith-Turchyn","year":"2026","journal-title":"Support Care Cancer"},{"key":"B64","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1177\/1046496494251003","article-title":"Group cohesion effects in exercise classes","volume":"25","author":"Spink","year":"1994","journal-title":"Small Gr Res."},{"key":"B65","doi-asserted-by":"publisher","first-page":"553","DOI":"10.1016\/j.brs.2016.04.001","article-title":"Older adults improve on everyday tasks after working memory training and neurostimulation","volume":"9","author":"Stephens","year":"2016","journal-title":"Brain Stimul."},{"key":"B66","doi-asserted-by":"publisher","first-page":"22278","DOI":"10.1002\/cam4.6753","article-title":"Updated systematic review of the effects of exercise on understudied health outcomes in cancer survivors","volume":"12","author":"Sturgeon","year":"2023","journal-title":"Cancer Med."},{"key":"B67","doi-asserted-by":"publisher","first-page":"191","DOI":"10.3233\/JAD-231259","article-title":"Assessing quality of life, economic burden, and Independence across the Alzheimer's disease continuum using patient-caregiver dyad surveys","volume":"99","author":"Tahami Monfared","year":"2024","journal-title":"J. Alzheimers Dis."},{"key":"B68","doi-asserted-by":"publisher","first-page":"515","DOI":"10.5014\/ajot.2013.008482","article-title":"Performance-based measure of executive function: comparison of community and at-risk youth","volume":"67","author":"Toglia","year":"2013","journal-title":"Am. J. Occup. Ther."},{"key":"B69","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1093\/abm\/kaac048","article-title":"An examination of the longitudinal relationship between cognitive function and physical activity among older breast cancer survivors in the thinking and living with cancer study","volume":"57","author":"Tometich","year":"2023","journal-title":"Ann. Behav. Med."},{"key":"B70","doi-asserted-by":"publisher","first-page":"1117","DOI":"10.1111\/jgs.18179","article-title":"Impact of technology on social isolation: longitudinal analysis from the national health aging trends study","volume":"71","author":"Umoh","year":"2023","journal-title":"J. Am. Geriatr. Soc."},{"key":"B71","doi-asserted-by":"publisher","first-page":"308","DOI":"10.3322\/caac.70011","article-title":"Cancer treatment and survivorship statistics, 2025","volume":"75","author":"Wagle","year":"2025","journal-title":"CA Cancer J. Clin."},{"key":"B72","doi-asserted-by":"publisher","first-page":"427","DOI":"10.3390\/cancers13030427","article-title":"Cancer treatment-induced accelerated aging in cancer survivors: biology and assessment","volume":"13","author":"Wang","year":"2021","journal-title":"Cancers (Basel)"},{"key":"B73","doi-asserted-by":"publisher","first-page":"1042","DOI":"10.3390\/healthcare12101042","article-title":"Factors influencing social isolation among cancer patients: a systematic review","volume":"12","author":"Wang","year":"2024","journal-title":"Healthc. (Basel)"},{"key":"B74","doi-asserted-by":"publisher","first-page":"e1369","DOI":"10.1002\/cl2.1369","article-title":"Digital interventions to reduce social isolation and loneliness in older adults: an evidence and gap map","volume":"19","author":"Welch","year":"2023","journal-title":"Campbell Syst. Rev."},{"key":"B75","doi-asserted-by":"publisher","first-page":"792","DOI":"10.1016\/j.euo.2025.03.013","article-title":"Suffering in silence: loneliness among men with prostate cancer and the potential for exercise as connection","volume":"8","author":"Winters-Stone","year":"2025","journal-title":"Eur. Urol. Oncol."},{"key":"B76","doi-asserted-by":"publisher","first-page":"2602336","DOI":"10.1080\/20565623.2025.2602336","article-title":"Cancer and dementia incidence are strongly correlated worldwide: evidence from cross-national regression analyses","volume":"12","author":"You","year":"2026","journal-title":"Future Sci. OA"}],"container-title":["Frontiers in Aging"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fragi.2026.1835531\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,25]],"date-time":"2026-05-25T06:03:49Z","timestamp":1779689029000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fragi.2026.1835531\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,25]]},"references-count":76,"alternative-id":["10.3389\/fragi.2026.1835531"],"URL":"https:\/\/doi.org\/10.3389\/fragi.2026.1835531","relation":{},"ISSN":["2673-6217"],"issn-type":[{"value":"2673-6217","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,25]]},"article-number":"1835531"}}