{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T05:03:48Z","timestamp":1789967028850,"version":"4.0.1"},"reference-count":39,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T00:00:00Z","timestamp":1789948800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Aging"],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>There is an increasing need to identify novel ingredients that can be safely utilized to enhance skin function and mitigate skin aging. Carotenoid supplementation shows promise in improving skin health and reducing signs of aging, owing to its antioxidant and anti-inflammatory properties.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>This randomised, double-blind, placebo-controlled study aimed to investigate the efficacy of a carotenoid supplement, CaroRite\u2122, on skin health and the visible signs of aging in healthy females.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Eighty female participants aged 40\u201355 years were recruited and randomised to receive either CaroRite\u2122 (containing 28\u201330\u00a0mg mixed carotenoids) or a placebo. Participants were instructed to take one capsule daily for 12 weeks. Outcome measures included visible signs of aging (wrinkles, skin elasticity, hydration, sebum, pigmentation, pore size, and temperature), transepidermal water loss (TEWL), dermal thickness, skin carotenoid levels, dietary carotenoid intake, and safety.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>No significant between-group differences were observed for visible signs of aging parameters (p &amp;gt; 0.05). At week 12, significant between-group differences from baseline were observed for TEWL (CaroRite\u2122 \u22124.58 \u00b1 9.43 vs. placebo 0.34 \u00b1 6.73; p = 0.011) and dermal thickness (CaroRite\u2122 139.50 \u00b1 220.21\u00a0\u03bcm vs. placebo 43.90 \u00b1 225.97\u00a0\u03bcm; p = 0.036). Skin carotenoid levels increased by 48.1% in the active group (CaroRite\u2122 +167.09 \u00b1 117.23 vs. placebo 9.42 \u00b1 47.16; p &amp;lt; 0.001), despite no significant differences in dietary carotenoid intake between groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Daily oral supplementation with CaroRite\u2122 did not reduce the visible signs of ageing after 12 weeks, however notable improvements in skin carotenoid status, TEWL and dermal thickness was found. CaroRite\u2122 demonstrated good bioavailability and was well tolerated. Overall, these findings support the use of CaroRite\u2122 as part of a comprehensive approach to potentially improving skin health, particularly for enhancing skin carotenoid status and supporting underlying structural and barrier function.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Clinical Trial Registration<\/jats:title>\n                    <jats:p>\n                      <jats:ext-link>ClinicalTrials.gov<\/jats:ext-link>\n                      , Identifier NCT06878001.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fragi.2026.1858090","type":"journal-article","created":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T04:28:07Z","timestamp":1789964887000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["CaroRite\u2122 for improving skin health and the visible signs of aging - a randomised, double-blind, placebo-controlled trial"],"prefix":"10.3389","volume":"7","author":[{"given":"Amanda","family":"Rao","sequence":"first","affiliation":[{"name":"RDC Clinical","place":["Brisbane, QLD, Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janice","family":"Pellow","sequence":"additional","affiliation":[{"name":"RDC Clinical","place":["Brisbane, QLD, Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Briskey","sequence":"additional","affiliation":[{"name":"RDC Clinical","place":["Brisbane, QLD, Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,9,21]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"2295","DOI":"10.1016\/j.jid.2018.09.001","article-title":"Transepidermal water loss measurement as a research tool","volume":"138","author":"Alexander","year":"2018","journal-title":"J. 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