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Multi-omics technologies provide a panoramic perspective for deciphering molecular networks of aging, while Artificial Intelligence (AI) has demonstrated significant advantages in target discovery, drug screening, and clinical trial optimization. This review systematically elaborates on the pathological characteristics and molecular mechanisms of aging, analyzes the application paradigms of multi-omics in biomarker screening, mechanism elucidation, and high-throughput screening, and discusses the core value and technical bottlenecks of AI in target prediction, virtual screening, and trial design. Simultaneously, this paper addresses critical challenges including ethical controversies and data standardization currently confronting the field, and explores the prospects of precision anti-aging drug development and personalized treatment strategies driven by deep integration of multi-omics and AI. This approach offers novel theoretical frameworks and practical pathways for extending human healthspan.<\/jats:p>","DOI":"10.3389\/fragi.2026.1868486","type":"journal-article","created":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T05:40:03Z","timestamp":1785390003000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Advances in anti-aging Drug research leveraging multi-omics and artificial intelligence"],"prefix":"10.3389","volume":"7","author":[{"given":"Lijuan","family":"Gao","sequence":"first","affiliation":[{"name":"Department of Microbiology and Immunology, Institute of Geriatric Immunology, School of Medicine, Jinan University","place":["Guangzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongsheng","family":"Qin","sequence":"additional","affiliation":[{"name":"School of Environmental Engineering, Guangdong Polytechnic of Environment Protection Engineering","place":["Foshan, Guangdong, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yudai","family":"Xu","sequence":"additional","affiliation":[{"name":"The Sixth Affiliated Hospital of Jinan University (Dongguan Eastern Central Hospital), Jinan University","place":["Dongguan, Guangdong, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ju","family":"Su","sequence":"additional","affiliation":[{"name":"First Affiliated Hospital, Jinan University","place":["Guangzhou, Guangdong, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhicheng","family":"Cai","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Institute of Geriatric Immunology, School of Medicine, Jinan University","place":["Guangzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongyu","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Institute of Geriatric Immunology, School of Medicine, Jinan University","place":["Guangzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruohu","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Institute of Geriatric Immunology, School of Medicine, Jinan University","place":["Guangzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyi","family":"Mu","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Institute of Geriatric Immunology, School of Medicine, Jinan University","place":["Guangzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiying","family":"Cen","sequence":"additional","affiliation":[{"name":"Office of Scientific Research and Development, Jinan University","place":["Guangzhou, Guangdong, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chanchan","family":"Xiao","sequence":"additional","affiliation":[{"name":"First Affiliated Hospital, Jinan University","place":["Guangzhou, Guangdong, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guobing","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Institute of Geriatric Immunology, School of Medicine, Jinan University","place":["Guangzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,7,30]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"646","DOI":"10.14336\/ad.2020.0909","article-title":"Metabolomics signatures of aging: recent advances","volume":"12","author":"Adav","year":"2021","journal-title":"Aging Dis."},{"key":"B2","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1016\/j.regg.2017.02.007","article-title":"Anti-ageing therapies in alzheimer's disease","volume":"53","author":"Alonso Abreu","year":"2018","journal-title":"Rev. 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