{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T15:28:37Z","timestamp":1791041317810,"version":"4.1.0"},"reference-count":74,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T00:00:00Z","timestamp":1783987200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Aging"],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Aging is characterised by the progressive accumulation of advanced glycation end products (AGEs), formed through non-enzymatic glycation reactions between reducing sugars and proteins, lipids, or nucleic acids. AGEs contribute to tissue damage through irreversible protein cross-linking and receptor-mediated inflammatory signalling via the receptor for AGEs (RAGE). Elderly individuals are disproportionately affected due to cumulative oxidative stress, chronic low-grade inflammation (inflammaging), impaired renal and enzymatic clearance, and prolonged exposure to dietary AGEs. Omega-3 polyunsaturated fatty acids (PUFAs), particularly eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), may modulate these pathways through anti-inflammatory, antioxidant, and metabolic mechanisms.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>\n                      To synthesise available preclinical,\n                      <jats:italic>in vitro<\/jats:italic>\n                      , and clinical evidence on the mechanistic and therapeutic relationships between omega-3 PUFA supplementation and AGE formation, accumulation, and signalling, and to evaluate the effects of omega-3 supplementation on key age-related clinical outcomes in elderly populations, including cardiometabolic health, cognitive function, mental health, functional capacity, and quality of life.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A narrative review was conducted using searches of PubMed, Scopus, and Web of Science. Eligible study designs included\n                      <jats:italic>in vitro<\/jats:italic>\n                      experiments, animal models, randomised controlled trials (RCTs), observational studies, and systematic reviews published in English. Evidence was synthesised thematically across mechanistic and clinical domains, with priority given to studies addressing AGE-related pathways and clinically relevant endpoints.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Preclinical evidence demonstrates that omega-3 PUFAs attenuate oxidative stress and inflammatory signalling, partly through RAGE axis regulation and PPAR\u03b3 activation. Clinical studies report reductions in circulating AGEs, RAGE, and pentosidine following supplementation, alongside upregulation of protective scavenger receptors such as AGER1. Omega-3 supplementation has also been associated with improvements in inflammatory markers, cardiometabolic risk, cognitive function, and physical capacity in older adults. However, RCT evidence assessing tissue-level AGE accumulation using non-invasive measures such as skin autofluorescence remains limited in elderly populations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Omega-3 PUFAs demonstrate therapeutic potential in modulating AGE-related mechanisms and improving age-associated outcomes. Well-designed RCTs targeting tissue AGE accumulation and long-term endpoints in elderly cohorts are warranted.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fragi.2026.1872170","type":"journal-article","created":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T05:37:07Z","timestamp":1784007427000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Omega-3 fatty acids as modulators of advanced glycation end products in aging: mechanistic pathways and clinical implications - a narrative review"],"prefix":"10.3389","volume":"7","author":[{"given":"Anna","family":"Cortesi","sequence":"first","affiliation":[{"name":"Laboratory of Experimental Surgery and Surgical Research \u201cN.S. Christeas\u201d, Medical School, National and Kapodistrian University of Athens","place":["Athens, Greece"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irene P.","family":"Tzanetakou","sequence":"additional","affiliation":[{"name":"Department of Life Sciences, School of Sciences, European University Cyprus","place":["Nicosia, Cyprus"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konstantinos","family":"Giannakou","sequence":"additional","affiliation":[{"name":"Department of Health Sciences, School of Sciences, European University Cyprus","place":["Nicosia, Cyprus"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aikaterini","family":"Bograkou-Tzanetakou","sequence":"additional","affiliation":[{"name":"School of Medicine, European University Cyprus","place":["Nicosia, Cyprus"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Hadjimbei","sequence":"additional","affiliation":[{"name":"Department of Life Sciences, School of Sciences, European University Cyprus","place":["Nicosia, Cyprus"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,7,14]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1016\/j.jpsychores.2015.04.008","article-title":"Tumour necrosis factor-\u03b1 inhibitor therapy in chronic physical illness: a systematic review and meta-analysis of the effect on depression and anxiety","volume":"79","author":"Abbott","year":"2015","journal-title":"J. Psychosomatic Res."},{"key":"B2","doi-asserted-by":"publisher","first-page":"e05364","DOI":"10.1016\/j.heliyon.2020.e05364","article-title":"Is skin autofluorescence (SAF) representative of dermal advanced glycation endproducts (AGEs) in dark skin? A pilot study","volume":"6","author":"Atzeni","year":"2020","journal-title":"Heliyon"},{"key":"B3","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1186\/s41073-019-0064-8","article-title":"SANRA\u2014A scale for the quality assessment of narrative review articles","volume":"4","author":"Baethge","year":"2019","journal-title":"Res. Integr. Peer Rev."},{"key":"B4","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/s0047-6374(98)00119-5","article-title":"Mechanisms of maturation and ageing of collagen","volume":"106","author":"Bailey","year":"1998","journal-title":"Mech. Ageing Dev."},{"key":"B5","doi-asserted-by":"publisher","first-page":"3002","DOI":"10.3390\/nu17183002","article-title":"Omega-3 polyunsaturated fatty acids and cognitive decline in adults with non-dementia or mild cognitive impairment: an overview of systematic reviews","volume":"17","author":"Barros","year":"2025","journal-title":"Nutrients"},{"key":"B6","doi-asserted-by":"publisher","first-page":"740","DOI":"10.1016\/j.jamda.2015.05.021","article-title":"Effects of a vitamin D and leucine-enriched whey protein nutritional supplement on measures of sarcopenia in older adults","volume":"16","author":"Bauer","year":"2022","journal-title":"J. Am. Med. Dir. Assoc."},{"key":"B7","doi-asserted-by":"publisher","first-page":"951","DOI":"10.1172\/JCI64125","article-title":"The role of mitochondria in aging","volume":"123","author":"Bratic","year":"2013","journal-title":"J. Clin. Investigation"},{"key":"B8","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1146\/annurev.med.46.1.223","article-title":"Advanced protein glycosylation in diabetes and aging","volume":"46","author":"Brownlee","year":"1995","journal-title":"Annu. Rev. Med."},{"key":"B9","doi-asserted-by":"publisher","first-page":"581","DOI":"10.1051\/rnd:2005047","article-title":"Conversion of alpha-linolenic acid to longer-chain polyunsaturated fatty acids in human adults","volume":"45","author":"Burdge","year":"2005","journal-title":"Reprod. Nutr. Dev."},{"key":"B10","doi-asserted-by":"publisher","first-page":"645","DOI":"10.1111\/j.1365-2125.2012.04374.x","article-title":"Omega-3 polyunsaturated fatty acids and inflammatory processes: nutrition or pharmacology?","volume":"75","author":"Calder","year":"2013","journal-title":"Br. J. Clin. Pharmacol."},{"key":"B11","doi-asserted-by":"publisher","first-page":"1105","DOI":"10.1042\/BST20160474","article-title":"Omega-3 fatty acids and inflammatory processes: from molecules to man","volume":"45","author":"Calder","year":"2017","journal-title":"Biochem. Soc. Trans."},{"key":"B12","doi-asserted-by":"publisher","first-page":"1181","DOI":"10.3390\/nu12041181","article-title":"Optimal nutritional status for a well-functioning immune system is an important factor to protect against viral infections","volume":"12","author":"Calder","year":"2020","journal-title":"Nutrients"},{"key":"B13","doi-asserted-by":"publisher","first-page":"529","DOI":"10.1080\/1028415X.2017.1321813","article-title":"Omega-3 fatty acids\u2019 supplementation in Alzheimer\u2019s disease: a systematic review","volume":"21","author":"Canhada","year":"2018","journal-title":"Nutr. Neurosci."},{"key":"B14","doi-asserted-by":"publisher","first-page":"2143","DOI":"10.1200\/JCO.2000.18.10.2143","article-title":"Early depressive symptoms in cancer patients receiving interleukin-2 And\/Or interferon-\u03b1-2b therapy","volume":"18","author":"Capuron","year":"2000","journal-title":"J. Clin. Oncol."},{"key":"B15","doi-asserted-by":"publisher","first-page":"3476","DOI":"10.3390\/nu12123476","article-title":"Peroxisome proliferator-activated receptors as a molecular link between caloric restriction and circadian rhythm","volume":"12","author":"Chen","year":"2020","journal-title":"Nutrients"},{"key":"B16","doi-asserted-by":"publisher","first-page":"2645","DOI":"10.3390\/ijms18122645","article-title":"Impact of omega-3 fatty acids on the gut microbiota","volume":"18","author":"Costantini","year":"2017","journal-title":"Int. J. Mol. Sci."},{"key":"B17","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1093\/ageing\/afy169","article-title":"Sarcopenia: revised European consensus on definition and diagnosis","volume":"48","author":"Cruz-Jentoft","year":"2019","journal-title":"Age Ageing"},{"key":"B18","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1007\/s11010-011-1128-6","article-title":"n-3 polyunsaturated fatty acids prevent lipoperoxidation, modulate antioxidant enzymes, and reduce lipid content","volume":"361","author":"de Assis","year":"2013","journal-title":"Mol. Cell. Biochem."},{"key":"B19","doi-asserted-by":"publisher","first-page":"505","DOI":"10.1038\/s41569-018-0064-2","article-title":"Inflammageing: chronic inflammation in ageing, cardiovascular disease, and frailty","volume":"15","author":"Ferrucci","year":"2018","journal-title":"Nat. Rev. Cardiol."},{"key":"B20","doi-asserted-by":"publisher","first-page":"244","DOI":"10.1111\/j.1749-6632.2000.tb06651.x","article-title":"Inflamm-aging: an evolutionary perspective on immunosenescence","volume":"908","author":"Franceschi","year":"2000","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"B21","doi-asserted-by":"publisher","first-page":"576","DOI":"10.1038\/s41574-018-0059-4","article-title":"Inflammaging: a new immune-metabolic viewpoint for age-related diseases","volume":"14","author":"Franceschi","year":"2018","journal-title":"Nat. Rev. Endocrinol."},{"key":"B22","doi-asserted-by":"publisher","first-page":"1287","DOI":"10.1016\/j.jada.2004.05.214","article-title":"Advanced glycoxidation end products in commonly consumed foods","volume":"104","author":"Goldberg","year":"2004","journal-title":"J. Am. Dietetic Assoc."},{"key":"B23","doi-asserted-by":"publisher","first-page":"230","DOI":"10.1016\/j.jad.2020.06.040","article-title":"Association between skin autofluorescence of advanced glycation end products and affective disorders in the lifelines cohort study","volume":"275","author":"Hagen","year":"2020","journal-title":"J. Affect. Disord."},{"key":"B24","doi-asserted-by":"publisher","first-page":"256","DOI":"10.1097\/YIC.0000000000000179","article-title":"Advanced glycation end products among patients maintained on antipsychotics","volume":"32","author":"Hammoudeh","year":"2017","journal-title":"Int. Clin. Psychopharmacol."},{"key":"B25","doi-asserted-by":"publisher","first-page":"212","DOI":"10.1016\/j.ypmed.2004.02.030","article-title":"The omega-3 index: a new risk factor for death from coronary heart disease?","volume":"39","author":"Harris","year":"2004","journal-title":"Prev. Med."},{"key":"B26","doi-asserted-by":"publisher","first-page":"e263","DOI":"10.1016\/j.jacc.2021.12.012","article-title":"2022 AHA\/ACC\/HFSA guideline for the management of heart failure","volume":"79","author":"Heidenreich","year":"2022","journal-title":"J. Am. Coll. Cardiol."},{"key":"B27","doi-asserted-by":"publisher","first-page":"S145","DOI":"10.1046\/j.1523-1755.63.s84.16.x","article-title":"AGEs in foods: do they play a role in uremia?","volume":"63","author":"Henle","year":"2003","journal-title":"Kidney Int. Suppl."},{"key":"B28","doi-asserted-by":"publisher","first-page":"767","DOI":"10.3390\/nu13030767","article-title":"Impact of supplementation and nutritional interventions on pathogenic processes of mood disorders: a review of the evidence","volume":"13","author":"Hoepner","year":"2021","journal-title":"Nutrients"},{"key":"B29","doi-asserted-by":"publisher","first-page":"e013543","DOI":"10.1161\/JAHA.119.013543","article-title":"Marine omega-3 supplementation and cardiovascular disease: an updated meta-analysis of 13 randomized controlled trials involving 127,477 participants","volume":"8","author":"Hu","year":"2019","journal-title":"J. Am. Heart Assoc."},{"key":"B30","doi-asserted-by":"publisher","first-page":"3739","DOI":"10.3390\/nu12123739","article-title":"Effects of omega-3 fatty acids on muscle mass, muscle strength and muscle performance among the elderly: a meta-analysis","volume":"12","author":"Huang","year":"2020","journal-title":"Nutrients"},{"key":"B31","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1016\/j.physbeh.2013.10.035","article-title":"The inflamed axis: the interaction between stress, hormones, and inflammatory-related genes within key structures comprising the hypothalamic\u2013pituitary\u2013adrenal axis","volume":"124","author":"Hueston","year":"2014","journal-title":"Physiology Behav."},{"key":"B32","doi-asserted-by":"publisher","first-page":"14416","DOI":"10.1364\/OE.18.014416","article-title":"Skin color independent assessment of aging using skin autofluorescence","volume":"18","author":"Koetsier","year":"2010","journal-title":"Opt. Express"},{"key":"B33","doi-asserted-by":"publisher","first-page":"1381","DOI":"10.1001\/jamapsychiatry.2014.1319","article-title":"Effect of anti-inflammatory treatment on depression, depressive symptoms, and adverse effects: a systematic review and meta-analysis of randomized clinical trials","volume":"71","author":"K\u00f6hler","year":"2014","journal-title":"JAMA Psychiatry"},{"key":"B34","doi-asserted-by":"publisher","first-page":"679","DOI":"10.1007\/s13105-016-0506-4","article-title":"The effects of n-3 long-chain polyunsaturated fatty acid supplementation on AGEs and sRAGE in type 2 diabetes mellitus","volume":"72","author":"Kurt","year":"2016","journal-title":"J. Physiology Biochem."},{"key":"B35","doi-asserted-by":"publisher","first-page":"652","DOI":"10.1016\/j.clnu.2012.02.007","article-title":"Sarcopenia as a risk factor for falls in elderly individuals: results from the ilSIRENTE study","volume":"31","author":"Landi","year":"2012","journal-title":"Clin. Nutr."},{"key":"B36","doi-asserted-by":"publisher","first-page":"e673","DOI":"10.1038\/cddis.2013.180","article-title":"Glycation exacerbates the neuronal toxicity of beta-amyloid","volume":"4","author":"Li","year":"2012","journal-title":"Cell Death Dis."},{"key":"B37","doi-asserted-by":"publisher","first-page":"1194","DOI":"10.1016\/j.cell.2013.05.039","article-title":"The hallmarks of aging","volume":"153","author":"Lopez-Otin","year":"2013","journal-title":"Cell"},{"key":"B38","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1016\/j.cell.2022.11.001","article-title":"Hallmarks of aging: an expanding universe","volume":"186","author":"Lopez-Otin","year":"2023","journal-title":"Cell"},{"key":"B39","doi-asserted-by":"publisher","first-page":"e70094","DOI":"10.1002\/ctd2.70094","article-title":"Effect of omega-3 fatty acids on cardiovascular disease risk: a systematic review and meta-analysis with meta-regression","volume":"5","author":"Mattumpuram","year":"2025","journal-title":"Clin. Transl. Discov."},{"key":"B40","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/j.biopsych.2007.02.009","article-title":"Selective deficits in the omega-3 fatty acid docosahexaenoic acid in the orbitofrontal cortex of patients with major depressive disorder","volume":"62","author":"McNamara","year":"2007","journal-title":"Biol. Psychiatry"},{"key":"B41","doi-asserted-by":"publisher","first-page":"1324","DOI":"10.1007\/s00125-004-1451-2","article-title":"Simple non-invasive assessment of advanced glycation endproduct accumulation","volume":"47","author":"Meerwaldt","year":"2004","journal-title":"Diabetologia"},{"key":"B42","doi-asserted-by":"publisher","first-page":"224","DOI":"10.3390\/jpm13020224","article-title":"Omega-3 fatty acids supplementation in the treatment of depression: an observational study","volume":"13","author":"Mehdi","year":"2023","journal-title":"J. Personalized Med."},{"key":"B43","doi-asserted-by":"publisher","first-page":"598","DOI":"10.1093\/nutrit\/nuab095","article-title":"Does dietary fat affect advanced glycation end products and their receptors? A systematic review of clinical trials","volume":"80","author":"Mendes","year":"2022","journal-title":"Nutr. Rev."},{"key":"B44","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1038\/nri.2015.5","article-title":"The role of inflammation in depression: from evolutionary imperative to modern treatment target","volume":"16","author":"Miller","year":"2016","journal-title":"Nat. Rev. Immunol."},{"key":"B45","doi-asserted-by":"publisher","first-page":"197","DOI":"10.22514\/IJKD.2016.6","article-title":"Effects of omega-3 fatty acid supplementation on inflammatory cytokines and advanced glycation end products in patients with diabetic nephropathy: a randomized controlled trial","volume":"10","author":"Mirhashemi","year":"2016","journal-title":"Iran. J. Kidney Dis."},{"key":"B46","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1038\/s41537-021-00164-1","article-title":"Fingertip advanced glycation end products and psychotic symptoms among adolescents","volume":"7","author":"Miyashita","year":"2021","journal-title":"Npj Schizophr."},{"key":"B47","doi-asserted-by":"publisher","first-page":"870","DOI":"10.2337\/diabetes.48.4.870","article-title":"Skin collagen glycation, glycoxidation, and crosslinking are lower in subjects with long-term intensive versus conventional therapy of type 1 diabetes: relevance of glycated collagen products versus HbA1c as markers of diabetic complications","volume":"48","author":"Monnier","year":"1999","journal-title":"Diabetes"},{"key":"B48","doi-asserted-by":"publisher","first-page":"1256","DOI":"10.1038\/s41598-024-51528-7","article-title":"Skin autofluorescence, reflecting accumulation of advanced glycation end products, and the risk of dementia in a population-based cohort","volume":"14","author":"Mooldijk","year":"2024","journal-title":"Sci. Rep."},{"key":"B49","doi-asserted-by":"publisher","first-page":"2047","DOI":"10.1016\/j.jacc.2011.06.063","article-title":"Omega-3 fatty acids and cardiovascular disease","volume":"58","author":"Mozaffarian","year":"2011","journal-title":"J. Am. Coll. Cardiol."},{"key":"B50","doi-asserted-by":"publisher","first-page":"78","DOI":"10.3390\/biom8030078","article-title":"Advanced glycation endproducts and oxidative stress in type 2 diabetes mellitus","volume":"8","author":"Nowotny","year":"2018","journal-title":"Biomolecules"},{"key":"B51","doi-asserted-by":"publisher","first-page":"901","DOI":"10.1016\/j.bbi.2020.02.010","article-title":"Inflammatory markers in depression: a meta-analysis of mean differences and variability","volume":"87","author":"Osimo","year":"2020","journal-title":"Brain, Behav. Immun."},{"key":"B52","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1016\/j.fct.2013.08.014","article-title":"Advanced glycation endproducts in food and their effect on health","volume":"60","author":"Poulsen","year":"2013","journal-title":"Food Chem. Toxicol."},{"key":"B53","doi-asserted-by":"publisher","first-page":"1133","DOI":"10.1007\/s00726-010-0783-0","article-title":"Methylglyoxal, glyoxalase 1 and the dicarbonyl proteome","volume":"42","author":"Rabbani","year":"2012","journal-title":"Amino Acids"},{"key":"B54","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1016\/j.tcm.2005.05.007","article-title":"The RAGE axis and endothelial dysfunction: maladaptive roles in the diabetic vasculature and beyond","volume":"15","author":"Ramasamy","year":"2005","journal-title":"Trends Cardiovasc. Med."},{"key":"B55","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1001\/archpsyc.58.5.445","article-title":"Cytokine-associated emotional and cognitive disturbances in humans","volume":"58","author":"Reichenberg","year":"2001","journal-title":"Archives General Psychiatry"},{"key":"B56","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1161\/01.RES.84.5.489","article-title":"Activation of receptor for advanced glycation end products: a mechanism for chronic vascular dysfunction in diabetic vasculopathy","volume":"84","author":"Schmidt","year":"1999","journal-title":"Circulation Res."},{"key":"B57","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1159\/000328451","article-title":"Molecular basis of arterial stiffening: role of Glycation\u2014A mini-review","volume":"58","author":"Sell","year":"2012","journal-title":"Gerontology"},{"key":"B58","doi-asserted-by":"publisher","first-page":"1273","DOI":"10.1096\/fj.201601222","article-title":"Treating inflammation and infection in the 21st century: new hints from decoding resolution mediators and mechanisms","volume":"31","author":"Serhan","year":"2017","journal-title":"FASEB J."},{"key":"B59","doi-asserted-by":"publisher","first-page":"e2426872","DOI":"10.1001\/jamanetworkopen.2024.26872","article-title":"Omega-3 PUFA for secondary prevention of white matter lesions and neuronal integrity breakdown in older adults: a randomized clinical trial","volume":"7","author":"Shinto","year":"2024","journal-title":"JAMA Netw. Open"},{"key":"B60","doi-asserted-by":"publisher","first-page":"715","DOI":"10.1146\/annurev-biochem-061516-045037","article-title":"Oxidative stress","volume":"86","author":"Sies","year":"2017","journal-title":"Annu. Rev. Biochem."},{"key":"B61","doi-asserted-by":"publisher","first-page":"43021","DOI":"10.1007\/s11356-021-14884-5","article-title":"Exploring the therapeutic potential of omega-3 fatty acids in depression","volume":"28","author":"Sikka","year":"2021","journal-title":"Environ. Sci. Pollut. Res."},{"key":"B62","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1007\/s001250051591","article-title":"Advanced glycation end-products: a review","volume":"44","author":"Singh","year":"2001","journal-title":"Diabetologia"},{"key":"B63","doi-asserted-by":"publisher","first-page":"e673","DOI":"10.1161\/CIR.0000000000000709","article-title":"Omega-3 fatty acids for the management of hypertriglyceridemia: a science advisory from the American heart association","volume":"140","author":"Skulas-Ray","year":"2019","journal-title":"Circulation"},{"key":"B64","doi-asserted-by":"publisher","first-page":"115","DOI":"10.3945\/ajcn.114.105395","article-title":"Fish oil-derived n-3 PUFA therapy increases muscle mass and function in healthy older adults","volume":"102","author":"Smith","year":"2015","journal-title":"Am. J. Clin. Nutr."},{"key":"B65","doi-asserted-by":"publisher","first-page":"1577","DOI":"10.4088\/JCP.10m06634","article-title":"Meta-analysis of the effects of eicosapentaenoic acid (EPA) in clinical trials in depression","volume":"72","author":"Sublette","year":"2011","journal-title":"J. Clin. Psychiatry"},{"key":"B66","doi-asserted-by":"publisher","first-page":"399","DOI":"10.3390\/md21070399","article-title":"The effect of omega-3 fatty acids on sarcopenia: mechanism of action and potential efficacy","volume":"21","author":"Therdyothin","year":"2023","journal-title":"Mar. Drugs"},{"key":"B67","doi-asserted-by":"publisher","first-page":"4075","DOI":"10.3390\/nu16234075","article-title":"Omega-3 fatty acids and muscle strength\u2014Current state of knowledge and future perspectives","volume":"16","author":"Tomczyk","year":"2024","journal-title":"Nutrients"},{"key":"B68","doi-asserted-by":"publisher","first-page":"911","DOI":"10.1016\/j.jada.2010.03.018","article-title":"Advanced glycation end products in foods and a practical guide to their reduction in the diet","volume":"110","author":"Uribarri","year":"2010","journal-title":"J. Am. Dietetic Assoc."},{"key":"B69","doi-asserted-by":"publisher","first-page":"453","DOI":"10.1007\/s11892-013-0453-1","article-title":"Advanced glycation end products (AGE) and diabetes: cause, effect, or both?","volume":"14","author":"Vlassara","year":"2014","journal-title":"Curr. Diabetes Rep."},{"key":"B70","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1124\/jpet.105.097709","article-title":"Peroxisome proliferator-activated receptor gamma down-regulates receptor for advanced glycation end products and inhibits smooth muscle cell proliferation","volume":"317","author":"Wang","year":"2006","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"B71","doi-asserted-by":"publisher","first-page":"1974","DOI":"10.1136\/gutjnl-2017-314968","article-title":"A randomised trial of the effect of omega-3 polyunsaturated fatty acid supplements on the human intestinal microbiota","volume":"67","author":"Watson","year":"2018","journal-title":"Gut"},{"key":"B72","volume-title":"Ageing and Health","year":"2022"},{"key":"B73","doi-asserted-by":"publisher","first-page":"e45990","DOI":"10.1371\/journal.pone.0045990","article-title":"Omega-3 polyunsaturated fatty acids antagonize macrophage inflammation via activation of AMPK\/SIRT1 pathway","volume":"7","author":"Xue","year":"2012","journal-title":"PLoS ONE"},{"key":"B74","doi-asserted-by":"publisher","first-page":"e1824","DOI":"10.1002\/mpr.1824","article-title":"Use of skin advanced glycation end product levels measured using a simple noninvasive method as a biological marker for the diagnosis of neuropsychiatric diseases","volume":"29","author":"Yamashita","year":"2020","journal-title":"Int. J. Methods Psychiatric Res."}],"container-title":["Frontiers in Aging"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fragi.2026.1872170\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T05:37:08Z","timestamp":1784007428000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fragi.2026.1872170\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,14]]},"references-count":74,"alternative-id":["10.3389\/fragi.2026.1872170"],"URL":"https:\/\/doi.org\/10.3389\/fragi.2026.1872170","relation":{},"ISSN":["2673-6217"],"issn-type":[{"value":"2673-6217","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,14]]},"article-number":"1872170"}}