{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T13:49:18Z","timestamp":1768571358795,"version":"3.49.0"},"reference-count":29,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2020,8,28]],"date-time":"2020-08-28T00:00:00Z","timestamp":1598572800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01CA201212"],"award-info":[{"award-number":["R01CA201212"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007210","name":"Varian Medical Systems","doi-asserted-by":"publisher","award":["Master Research Grant"],"award-info":[{"award-number":["Master Research Grant"]}],"id":[{"id":"10.13039\/100007210","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Artif. Intell."],"DOI":"10.3389\/frai.2020.00066","type":"journal-article","created":{"date-parts":[[2020,8,28]],"date-time":"2020-08-28T05:21:52Z","timestamp":1598592112000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":6,"title":["Knowledge Models as Teaching Aid for Training Intensity Modulated Radiation Therapy Planning: A Lung Cancer Case Study"],"prefix":"10.3389","volume":"3","author":[{"given":"Matt","family":"Mistro","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yang","family":"Sheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yaorong","family":"Ge","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chris R.","family":"Kelsey","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jatinder R.","family":"Palta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Cai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiuwen","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fang-Fang","family":"Yin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Q. Jackie","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2020,8,28]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1186\/s13014-016-0693-8","article-title":"A critical review of recent developments in radiotherapy for non-small cell lung cancer","volume":"11","author":"Baker","year":"2016","journal-title":"Rad. Oncol"},{"key":"B2","doi-asserted-by":"publisher","first-page":"951","DOI":"10.1118\/1.3676689","article-title":"iCycle: Integrated, multicriterial beam angle, and profile optimization for generation of coplanar and noncoplanar IMRT plans","volume":"39","author":"Breedveld","year":"2012","journal-title":"Med. Phys."},{"key":"B3","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1016\/j.radonc.2005.10.001","article-title":"Normal tissue complication probability modeling for acute esophagitis in patients treated with conformal radiation therapy for non-small cell lung cancer","volume":"77","author":"Chapet","year":"2005","journal-title":"Radiother. Oncol"},{"key":"B4","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1200\/JCO.2016.69.1378","article-title":"Impact of intensity-modulated radiation therapy technique for locally advanced non\u2013small-cell lung cancer: a secondary analysis of the NRG oncology RTOG 0617 randomized clinical trial","volume":"35","author":"Chun","year":"2017","journal-title":"Clin. Trial"},{"key":"B5","doi-asserted-by":"publisher","first-page":"336","DOI":"10.1007\/s40593-017-0157-9","article-title":"Authoring tools for designing intelligent tutoring systems: a systematic review of the literature","volume":"28","author":"Dermeval","year":"2018","journal-title":"Int. J. Artificial Intelligence Edu"},{"key":"B6","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1016\/j.ijrobp.2013.03.015","article-title":"A knowledge-based approach to improving and homogenizing intensity modulated radiation therapy planning quality among treatment centers: an example application to prostate cancer planning","volume":"87","author":"Good","year":"2013","journal-title":"Int. J. Rad. Oncol. Biol. Phys"},{"key":"B7","doi-asserted-by":"publisher","first-page":"272","DOI":"10.1120\/jacmp.v17i1.5901","article-title":"Automatic planning of head and neck treatment plans","volume":"17","author":"Hazell","year":"2016","journal-title":"J. Appl. Clin. Med. Phys"},{"key":"B8","doi-asserted-by":"publisher","first-page":"1169","DOI":"10.1016\/S0360-3016(98)00239-9","article-title":"Volumetric and dosimetric evaluation of radiation treatment plans: radiation conformity index","volume":"42","author":"Knoos","year":"1998","journal-title":"Int. J. Rad. Oncol. Biol. Phys"},{"key":"B9","doi-asserted-by":"publisher","first-page":"1442","DOI":"10.1016\/j.ijrobp.2010.07.1977","article-title":"Consideration of dose limits for organs at risk of thoracic radiotherapy: atlas for lung, proximal bronchial tree, esophagus, spinal cord, ribs, and brachial plexus","volume":"81","author":"Kong","year":"2011","journal-title":"Int. J. Rad. Oncol. Biol. Phys"},{"key":"B10","doi-asserted-by":"publisher","first-page":"503","DOI":"10.1016\/j.adro.2017.04.005","article-title":"Incorporating big data into treatment plan evaluation: development of statistical DVH metrics and visualization dashboards","volume":"2","author":"Mayo","year":"2017","journal-title":"Adv. Radiat. Oncol"},{"key":"B11","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1109\/MIS.2007.74","article-title":"Intelligent tutors for all: the constraint-based approach","volume":"22","author":"Mitrovic","year":"2007","journal-title":"IEEE Intelligent Syst"},{"key":"B12","doi-asserted-by":"publisher","first-page":"264","DOI":"10.1016\/j.compedu.2012.07.002","article-title":"The effect of positive feedback in a constraint-based intelligent tutoring system","volume":"60","author":"Mitrovic","year":"2013","journal-title":"Comp. Educ"},{"key":"B13","doi-asserted-by":"publisher","first-page":"296","DOI":"10.1016\/j.prro.2011.11.012","article-title":"Variation in external beam treatment plan quality: an inter-institutional study of planners and planning systems","volume":"2","author":"Nelms","year":"2012","journal-title":"Pract. Rad. Oncol"},{"key":"B14","doi-asserted-by":"publisher","first-page":"219","DOI":"10.3171\/jns.2000.93.supplement_3.0219","article-title":"A simple scoring ratio to index the conformity of radiosurgical treatment plans","volume":"93","author":"Paddick","year":"2000","journal-title":"J. Neurosurg"},{"key":"B15","article-title":"Review of intelligent tutoring systems using bayesian approach","volume-title":"[arXiv preprint].","author":"Santhi","year":"2013"},{"key":"B16","doi-asserted-by":"publisher","first-page":"7277","DOI":"10.1088\/0031-9155\/60\/18\/7277","article-title":"Atlas-guided prostate intensity modulated radiation therapy (IMRT) planning","volume":"60","author":"Sheng","year":"2015","journal-title":"Phys. Med. Biol"},{"key":"B17","doi-asserted-by":"publisher","first-page":"1533033819874788","DOI":"10.1177\/1533033819874788","article-title":"Incorporating case-based reasoning for radiation therapy knowledge modeling: a pelvic case study","volume":"18","author":"Sheng","year":"2019","journal-title":"Technol. Cancer Res. Treat"},{"key":"B18","doi-asserted-by":"publisher","first-page":"866","DOI":"10.1016\/j.ijrobp.2012.04.015","article-title":"Toward fully automated multicriterial plan generation: a prospective clinical study","volume":"85","author":"Voet","year":"2013","journal-title":"Int. J. Rad. Oncol. Biol. Phys"},{"key":"B19","doi-asserted-by":"publisher","first-page":"1175","DOI":"10.1016\/j.ijrobp.2013.12.046","article-title":"Fully automated volumetric modulated arc therapy plan generation for prostate cancer patients","volume":"88","author":"Voet","year":"2014","journal-title":"Int. J. Rad. Oncol. Biol. Phys"},{"key":"B20","doi-asserted-by":"publisher","first-page":"6868","DOI":"10.1118\/1.4757927","article-title":"Quantitative analysis of the factors which affect the inter-patient organ-at risk dose sparing variation in IMRT plans","volume":"39","author":"Yuan","year":"2012","journal-title":"Med. Phys"},{"key":"B21","doi-asserted-by":"publisher","first-page":"1831","DOI":"10.1088\/0031-9155\/60\/5\/1831","article-title":"Standardized beam bouquets for lung IMRT planning","volume":"60","author":"Yuan","year":"2015","journal-title":"Phys. Med. Biol"},{"key":"B22","doi-asserted-by":"publisher","first-page":"135024","DOI":"10.1088\/1361-6560\/aac8b4","article-title":"Lung IMRT planning with automatic determination of beam angle configurations","volume":"63","author":"Yuan","year":"2018","journal-title":"Phys. Med. Biol"},{"key":"B23","doi-asserted-by":"publisher","first-page":"061711","DOI":"10.1118\/1.4875700","article-title":"A DVH-guided IMRT optimization algorithm for automatic treatment planning and adaptive radiotherapy replanning","volume":"41","author":"Zarepisheh","year":"2014","journal-title":"Med. Phys"},{"key":"B24","doi-asserted-by":"publisher","first-page":"3812","DOI":"10.1002\/mp.13679","article-title":"Modeling of multiple planning target volumes for head and neck treatments in knowledge-based treatment planning","volume":"46","author":"Zhang","year":"","journal-title":"Med. Phys"},{"key":"B25","doi-asserted-by":"publisher","first-page":"1533033819857758","DOI":"10.1177\/1533033819857758","article-title":"Knowledge-based statistical inference method for plan quality quantification","volume":"18","author":"Zhang","year":"","journal-title":"Technol. Cancer Res. Treat"},{"key":"B26","doi-asserted-by":"publisher","first-page":"57","DOI":"10.3389\/fonc.2018.00057","article-title":"An ensemble approach to knowledge-based intensity-modulated radiation therapy planning","volume":"8","author":"Zhang","year":"2018","journal-title":"Front. Oncol"},{"key":"B27","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1088\/0031-9155\/56\/13\/009","article-title":"A methodology for automatic intensity-modulated radiation treatment planning for lung cancer","volume":"56","author":"Zhang","year":"2012","journal-title":"Phys. Med. Biol"},{"key":"B28","doi-asserted-by":"publisher","first-page":"719","DOI":"10.1118\/1.3539749","article-title":"A planning quality evaluation tool for prostate adaptive IMRT based on machine learning","volume":"38","author":"Zhu","year":"2011","journal-title":"Med. Phys"},{"key":"B29","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1016\/j.clon.2014.10.006","article-title":"Need for radiotherapy in low and middle income countries \u2013 the silent crisis continues","volume":"27","author":"Zubizarreta","year":"2015","journal-title":"Clin. Oncol"}],"container-title":["Frontiers in Artificial Intelligence"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/frai.2020.00066\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,8,28]],"date-time":"2020-08-28T05:21:54Z","timestamp":1598592114000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/frai.2020.00066\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8,28]]},"references-count":29,"alternative-id":["10.3389\/frai.2020.00066"],"URL":"https:\/\/doi.org\/10.3389\/frai.2020.00066","relation":{},"ISSN":["2624-8212"],"issn-type":[{"value":"2624-8212","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,8,28]]},"article-number":"66"}}