{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T06:07:06Z","timestamp":1789020426724,"version":"build-2803163510"},"reference-count":57,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T00:00:00Z","timestamp":1788998400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Artif. Intell."],"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Obesity is a critical global health challenge due to its close association with cardiovascular and metabolic risk. At the molecular level, the lipotoxic environment alters the structure, dynamics, and connectivity of the mitochondrial network. Despite advances in cell biology and digital health, there is a lack of lightweight computational tools capable of integrating clinical records with molecular and photomicrographic data in a standardized way. This study presents the design, development, and feasibility assessment of a decoupled software prototype and an interactive prompt engineering framework for integrating clinical and histological mitochondrial data in molecular obesity research.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methodology<\/jats:title>\n                    <jats:p>A client-side software architecture was designed using HTML5, CSS3, and the IndexedDB API for the transactional and anonymized persistence of medical records (coded using the ICD-10 classification) and micrographs of human placental tissue (obtained using transmission electron microscopy, immunofluorescence, and immunohistochemistry for the evaluation of mitochondrial fusion molecular markers such as Mitofusin-2, nitrotyrosine). For interpretive processing, a framework of prompts structured under the Chain-of-Thought paradigm was built, designed to interact with Large-Scale Language Models (LLMs). The interface\u2019s usability, local storage performance, and the consistency of AI-assisted reasoning were evaluated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The developed platform enabled the seamless and instantaneous management of independent patient tabs (unique storage keys mitochondria_001 to 010), achieving local read\/write latency without reliance on external servers or transmission of sensitive personal data. The prompt framework proved effective in guiding LLMs in translating mitochondrial biomarkers and clinical data into structured summaries of oxidative stress status and metabolic risk. The lack of a trained computer vision model for automatic segmentation is declared as the main limitation of the current study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The software prototype and prompt interface provide a low-cost, secure (data privacy-oriented), and clinically intuitive solution for translational data management in obesity. This work demonstrates the feasibility of integrating heterogeneous biomedical parameters using conversational AI tools and local storage, laying the groundwork for the future incorporation of image segmentation algorithms.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/frai.2026.1923426","type":"journal-article","created":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T05:33:12Z","timestamp":1789018392000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["System architecture and interactive LLM prompt framework for the integration of clinical and mitochondrial data in obesity: a software prototype and feasibility study"],"prefix":"10.3389","volume":"9","author":[{"given":"Karenth Milena","family":"Rodr\u00edguez-C\u00f3rdoba","sequence":"first","affiliation":[{"name":"University of Guadalajara","place":["Guadalajara, Mexico"]},{"name":"Clinica Sanitas Sebastian de Belalcazar","place":["Cali, Colombia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William Dar\u00edo","family":"\u00c1vila-D\u00edaz","sequence":"additional","affiliation":[{"name":"Postdoctoral University of Guadalajara","place":["Guadalajara, Mexico"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,9,10]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1186\/s12910-020-00550-0","article-title":"Explainable AI in medicine: providing confidence or encouraging trust?","volume":"21","author":"Amann","year":"2020","journal-title":"BMC Med. 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