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As connections between the immune and nervous systems become clearer, alternate curative treatments have emerged. This case series presents three pediatric patients' treatment experiences with sudden-onset severe neuropsychiatric symptoms such as disabling anxiety, tics, eating restriction, or hallucinations, and their full recoveries following treatment of their underlying infections, inflammatory responses, and gastrointestinal dysbiosis. Treatments included antimicrobials, nutraceuticals, probiotics, and dietary changes. Converging lines of research highlight the importance of considering neuroinflammatory conditions in the differential diagnosis of children with treatment-resistant neuropsychiatric symptoms.<\/jats:p>","DOI":"10.3389\/frcha.2025.1377547","type":"journal-article","created":{"date-parts":[[2025,5,22]],"date-time":"2025-05-22T04:13:41Z","timestamp":1747887221000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":3,"title":["Case Report: Special recoveries from major mental illness in childhood: a case series"],"prefix":"10.3389","volume":"4","author":[{"given":"Elena 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