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This suggests tyrosine kinase inhibition as an appealing therapeutic target for exploiting convergent mechanisms across several neurodegenerative disease (NDD) pathologies. The overlapping mechanisms of action between neurodegeneration and cancer suggest that TKIs may play a pivotal role in attenuating neurodegenerative processes, including degradation of misfolded or toxic proteins, reduction of inflammation and prevention of fibrotic events of blood vessels in the brain. In this review, we will discuss the distinct roles that select TKs have been shown to play in various disease-associated processes, as well as identify TKs that have been explored as targets for therapeutic intervention and associated pharmacological agents being investigated as treatments for NDDs.<\/jats:p>","DOI":"10.3389\/frdem.2024.1458038","type":"journal-article","created":{"date-parts":[[2024,8,16]],"date-time":"2024-08-16T04:34:51Z","timestamp":1723782891000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":13,"title":["Tyrosine kinases: multifaceted receptors at the intersection of several neurodegenerative disease-associated processes"],"prefix":"10.3389","volume":"3","author":[{"given":"Max","family":"Stevenson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norah K.","family":"Algarzae","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charbel","family":"Moussa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2024,8,16]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"336","DOI":"10.1016\/S0959-4388(00)00216-6","article-title":"NMDA receptor regulation by Src kinase signalling in excitatory synaptic transmission and plasticity","volume":"11","author":"Ali","year":"2001","journal-title":"Curr. 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