{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T03:36:00Z","timestamp":1791516960251,"version":"4.3.4"},"reference-count":158,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,11,27]],"date-time":"2025-11-27T00:00:00Z","timestamp":1764201600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Epigenet. Epigenom."],"abstract":"<jats:p>\n                    Pancreatic cancer, in particular pancreatic ductal adenocarcinoma (PDAC), is one of the most lethal malignancies with delayed diagnosis, aggressive nature, and profound therapeutic resistance. Recent research has emphasized epigenetic dysregulation not as a bystander but as a driving force in pancreatic tumorigenesis, progression, metastasis, and immune evasion. This review presents a detailed analysis of the multifaceted functions of epigenetic mechanisms like DNA methylation, histone modifications, and non-coding RNAs in shaping the pancreatic cancer epigenome. We discuss how these alterations fuel tumor heterogeneity, modulate the tumor microenvironment, and interact with key oncogenic mutations like\n                    <jats:italic>KRAS<\/jats:italic>\n                    and\n                    <jats:italic>TP53<\/jats:italic>\n                    . Further, we discuss the potential of epigenetic alterations as diagnostic, prognostic, and predictive biomarkers with an emphasis on their application in liquid biopsies. Finally, we evaluate current and prospective epigenetic therapies, their cooperation with chemotherapy and immunotherapy, and the prospects of new approaches such as CRISPR-based epigenome editing and personalized epigenetic profiling. Together, these findings point to the epigenome as a powerful window of opportunity for understanding, diagnosing, and eventually targeting pancreatic cancer.\n                  <\/jats:p>","DOI":"10.3389\/freae.2025.1723159","type":"journal-article","created":{"date-parts":[[2025,11,27]],"date-time":"2025-11-27T06:30:40Z","timestamp":1764225040000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":9,"title":["Epigenetic dysregulation in pancreatic cancer: emerging biomarkers and clinical applications"],"prefix":"10.3389","volume":"3","author":[{"given":"Hina","family":"Sultana","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abhishikt David","family":"Solomon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atif Khurshid","family":"Wani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Surendra K.","family":"Shukla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2025,11,27]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1459","DOI":"10.1016\/j.jmb.2017.02.008","article-title":"Dynamics and context-dependent roles of DNA methylation","volume":"429","author":"Ambrosi","year":"2017","journal-title":"J. Mol. Biol."},{"key":"B2","doi-asserted-by":"publisher","first-page":"512","DOI":"10.1016\/j.ccell.2018.02.003","article-title":"Loss of KDM6A activates super-enhancers to induce gender-specific squamous-like pancreatic cancer and confers sensitivity to BET inhibitors","volume":"33","author":"Andricovich","year":"2018","journal-title":"Cancer Cell"},{"key":"B3","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1097\/PPO.0000000000000647","article-title":"The gut microbiome and pancreatic cancer development and treatment","volume":"29","author":"Attebury","year":"2023","journal-title":"Cancer J."},{"key":"B4","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1038\/nature16965","article-title":"Genomic analyses identify molecular subtypes of pancreatic cancer","volume":"531","author":"Bailey","year":"2016","journal-title":"Nature"},{"key":"B5","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1038\/cr.2011.22","article-title":"Regulation of chromatin by histone modifications","volume":"21","author":"Bannister","year":"2011","journal-title":"Cell Res."},{"key":"B6","doi-asserted-by":"publisher","first-page":"1629","DOI":"10.3390\/cancers2031629","article-title":"Cancer stem cells in pancreatic cancer","volume":"2","author":"Bao","year":"2010","journal-title":"Cancers"},{"key":"B7","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1016\/j.hbpd.2020.03.010","article-title":"Differential methylation landscape of pancreatic ductal adenocarcinoma and its precancerous lesions","volume":"19","author":"Bararia","year":"2020","journal-title":"Hepatobiliary and Pancreat. Dis. Int."},{"key":"B8","doi-asserted-by":"publisher","first-page":"18","DOI":"10.21037\/apc.2019.10.01","article-title":"Targeting the epigenome of pancreatic cancer for therapy: challenges and opportunities","volume":"2","author":"Baretti","year":"2019","journal-title":"Ann. Pancreat. Cancer"},{"key":"B9","doi-asserted-by":"publisher","first-page":"823","DOI":"10.1016\/j.cell.2007.05.009","article-title":"High-resolution profiling of histone methylations in the human genome","volume":"129","author":"Barski","year":"2007","journal-title":"Cell"},{"key":"B10","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1016\/j.cell.2009.01.002","article-title":"MicroRNAs: target recognition and regulatory functions","volume":"136","author":"Bartel","year":"2009","journal-title":"Cell"},{"key":"B11","doi-asserted-by":"publisher","first-page":"423","DOI":"10.5858\/133.3.423","article-title":"Pancreatic cysts: pathologic classification, differential diagnosis, and clinical implications","volume":"133","author":"Basturk","year":"2009","journal-title":"Archives Pathology and Laboratory Med."},{"key":"B12","doi-asserted-by":"publisher","first-page":"781","DOI":"10.1101\/gad.1787609","article-title":"An operational definition of epigenetics: figure 1","volume":"23","author":"Berger","year":"2009","journal-title":"Genes Dev."},{"key":"B13","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1016\/j.molcel.2012.11.006","article-title":"Histone lysine methylation dynamics: establishment, regulation, and biological impact","volume":"48","author":"Black","year":"2012","journal-title":"Mol. Cell"},{"key":"B14","doi-asserted-by":"publisher","first-page":"101579","DOI":"10.1016\/j.tranon.2022.101579","article-title":"MicroRNAs and long non-coding RNAs in pancreatic cancer: from epigenetics to potential clinical applications","volume":"27","author":"Bravo-V\u00e1zquez","year":"2023","journal-title":"Transl. Oncol."},{"key":"B15","doi-asserted-by":"publisher","first-page":"229","DOI":"10.3322\/caac.21834","article-title":"Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"74","author":"Bray","year":"2024","journal-title":"CA A Cancer J. Clin."},{"key":"B16","doi-asserted-by":"publisher","first-page":"3421","DOI":"10.3748\/wjg.14.3421","article-title":"Hypermethylation and aberrant expression of secreted fizzled-related protein genes in pancreatic cancer","volume":"14","author":"Bu","year":"2008","journal-title":"World J. Gastroenterology"},{"key":"B17","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1038\/s41392-020-00341-1","article-title":"Beyond just a tight fortress: contribution of stroma to epithelial-mesenchymal transition in pancreatic cancer","volume":"5","author":"Bulle","year":"2020","journal-title":"Sig Transduct. Target Ther."},{"key":"B18","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1038\/s41575-019-0245-4","article-title":"Role of oncogenic KRAS in the diagnosis, prognosis and treatment of pancreatic cancer","volume":"17","author":"Buscail","year":"2020","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"B19","doi-asserted-by":"publisher","first-page":"312","DOI":"10.1016\/j.radonc.2016.04.013","article-title":"Phase I trial of vorinostat added to chemoradiation with capecitabine in pancreatic cancer","volume":"119","author":"Chan","year":"2016","journal-title":"Radiotherapy Oncol."},{"key":"B20","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1038\/bjc.2011.551","article-title":"The role of EZH2 in tumour progression","volume":"106","author":"Chang","year":"2012","journal-title":"Br. J. Cancer"},{"key":"B21","doi-asserted-by":"publisher","first-page":"669","DOI":"10.4161\/epi.28324","article-title":"The de novo DNA methyltransferase DNMT3A in development and cancer","volume":"9","author":"Chen","year":"2014","journal-title":"Epigenetics"},{"key":"B22","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1146\/annurev-biochem-103019-102815","article-title":"Role of mammalian DNA methyltransferases in development","volume":"89","author":"Chen","year":"2020","journal-title":"Annu. Rev. Biochem."},{"key":"B23","doi-asserted-by":"publisher","first-page":"723","DOI":"10.1016\/j.apsb.2019.09.006","article-title":"Epigenetic strategies synergize with PD-L1\/PD-1 targeted cancer immunotherapies to enhance antitumor responses","volume":"10","author":"Chen","year":"2020","journal-title":"Acta Pharm. Sin. B"},{"key":"B24","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1373\/clinchem.2012.196642","article-title":"Pancreatic cancer","volume":"59","author":"Chrystoja","year":"2013","journal-title":"Clin. Chem."},{"key":"B25","doi-asserted-by":"publisher","first-page":"1115","DOI":"10.1101\/gad.1652908","article-title":"Erasing the methyl mark: histone demethylases at the center of cellular differentiation and disease","volume":"22","author":"Cloos","year":"2008","journal-title":"Genes Dev."},{"key":"B26","doi-asserted-by":"publisher","first-page":"1509","DOI":"10.1007\/s00018-008-7324-y","article-title":"Methyl-CpG binding proteins: specialized transcriptional repressors or structural components of chromatin?","volume":"65","author":"Clouaire","year":"2008","journal-title":"Cell Mol. Life Sci."},{"key":"B27","doi-asserted-by":"publisher","first-page":"3140","DOI":"10.21037\/tcr-21-230","article-title":"Long non-coding RNAs regulating multiple proliferative pathways in cancer cell","volume":"10","author":"De Martino","year":"2021","journal-title":"Transl. Cancer Res."},{"key":"B28","doi-asserted-by":"publisher","first-page":"1010","DOI":"10.1101\/gad.2037511","article-title":"CpG islands and the regulation of transcription","volume":"25","author":"Deaton","year":"2011","journal-title":"Genes Dev."},{"key":"B29","doi-asserted-by":"publisher","first-page":"1051","DOI":"10.2217\/epi.15.39","article-title":"Methyl-CpG-binding domain proteins: readers of the epigenome","volume":"7","author":"Du","year":"2015","journal-title":"Epigenomics"},{"key":"B30","doi-asserted-by":"publisher","first-page":"673","DOI":"10.1159\/000320711","article-title":"Pancreatic cancer: the role of pancreatic stellate cells in tumor progression","volume":"10","author":"Dun\u00e9r","year":"2011","journal-title":"Pancreatology"},{"key":"B31","doi-asserted-by":"publisher","first-page":"5926","DOI":"10.3390\/cancers14235926","article-title":"Epigenetics in pancreatic ductal adenocarcinoma: impact on biology and utilization in diagnostics and treatment","volume":"14","author":"Elrakaybi","year":"2022","journal-title":"Cancers (Basel)"},{"key":"B32","doi-asserted-by":"publisher","first-page":"766","DOI":"10.1016\/j.cgh.2024.07.048","article-title":"Multimodal pancreatic cancer detection using methylated DNA biomarkers in pancreatic juice and plasma CA 19-9: a prospective multicenter study","volume":"23","author":"Engels","year":"2025","journal-title":"Clin. Gastroenterology Hepatology"},{"key":"B33","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1038\/s41580-023-00683-y","article-title":"Energy-driven genome regulation by ATP-dependent chromatin remodellers","volume":"25","author":"Eustermann","year":"2024","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"B34","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1146\/annurev-biochem-060308-103103","article-title":"Regulation of mRNA translation and stability by microRNAs","volume":"79","author":"Fabian","year":"2010","journal-title":"Annu. Rev. Biochem."},{"key":"B35","volume-title":"American cancer society","year":"2025"},{"key":"B36","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1186\/s13045-024-01561-6","article-title":"Current and future immunotherapeutic approaches in pancreatic cancer treatment","volume":"17","author":"Farhangnia","year":"2024","journal-title":"J. Hematol. and Oncol."},{"key":"B37","doi-asserted-by":"publisher","first-page":"1352","DOI":"10.1038\/ajg.2013.167","article-title":"Endoscopically acquired pancreatic cyst fluid microRNA 21 and 221 are associated with invasive cancer","volume":"108","author":"Farrell","year":"2013","journal-title":"Am. J. Gastroenterology"},{"key":"B38","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1038\/nrg3606","article-title":"Long non-coding RNAs: new players in cell differentiation and development","volume":"15","author":"Fatica","year":"2014","journal-title":"Nat. Rev. Genet."},{"key":"B39","doi-asserted-by":"publisher","first-page":"4266","DOI":"10.1158\/1078-0432.CCR-11-3114","article-title":"The pancreas cancer microenvironment","volume":"18","author":"Feig","year":"2012","journal-title":"Clin. Cancer Res."},{"key":"B40","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1038\/nature16490","article-title":"Insulator dysfunction and oncogene activation in IDH mutant gliomas","volume":"529","author":"Flavahan","year":"2016","journal-title":"Nature"},{"key":"B41","doi-asserted-by":"publisher","first-page":"eaal2380","DOI":"10.1126\/science.aal2380","article-title":"Epigenetic plasticity and the hallmarks of cancer","volume":"357","author":"Flavahan","year":"2017","journal-title":"Science"},{"key":"B42","doi-asserted-by":"publisher","first-page":"1268","DOI":"10.1101\/gad.190678.112","article-title":"Mutant p53: one name, many proteins","volume":"26","author":"Freed-Pastor","year":"2012","journal-title":"Genes Dev."},{"key":"B43","doi-asserted-by":"publisher","first-page":"1404","DOI":"10.1016\/j.drudis.2021.12.013","article-title":"Current clinical trials for epigenetic targets and therapeutic inhibitors for pancreatic cancer therapy","volume":"27","author":"Ganji","year":"2022","journal-title":"Drug Discov. Today"},{"key":"B44","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1186\/s13148-023-01535-4","article-title":"Circulating NPTX2 methylation as a non-invasive biomarker for prognosis and monitoring of metastatic pancreatic cancer","volume":"15","author":"Garc\u00eda-Ortiz","year":"2023","journal-title":"Clin. Epigenetics"},{"key":"B45","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1186\/s12876-015-0379-y","article-title":"Histone deacetylase (HDAC)-1, \u22122, \u22124 and \u22126 expression in human pancreatic adenocarcinoma: associations with clinicopathological parameters, tumor proliferative capacity and patients\u2019 survival","volume":"15","author":"Giaginis","year":"2015","journal-title":"BMC Gastroenterol."},{"key":"B46","doi-asserted-by":"publisher","first-page":"426","DOI":"10.3390\/biom15030426","article-title":"The prognostic, predictive and clinicopathological implications of KRT81\/HNF1A- and GATA6-Based transcriptional subtyping in pancreatic cancer","volume":"15","author":"Guenther","year":"2025","journal-title":"Biomolecules"},{"key":"B47","doi-asserted-by":"publisher","first-page":"172","DOI":"10.3390\/genes10020172","article-title":"The roles of human DNA methyltransferases and their isoforms in shaping the epigenome","volume":"10","author":"Gujar","year":"2019","journal-title":"Genes"},{"key":"B48","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1016\/j.ccell.2016.12.006","article-title":"Employing metabolism to improve the diagnosis and treatment of pancreatic cancer","volume":"31","author":"Halbrook","year":"2017","journal-title":"Cancer Cell"},{"key":"B49","doi-asserted-by":"publisher","first-page":"1729","DOI":"10.1016\/j.cell.2023.02.014","article-title":"Pancreatic cancer: advances and challenges","volume":"186","author":"Halbrook","year":"2023","journal-title":"Cell"},{"key":"B50","doi-asserted-by":"publisher","first-page":"1727","DOI":"10.1093\/annonc\/mdn351","article-title":"Pancreatic neuroendocrine tumors (PNETs): incidence, prognosis and recent trend toward improved survival","volume":"19","author":"Halfdanarson","year":"2008","journal-title":"Ann. Oncol."},{"key":"B51","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1186\/s13059-017-1215-1","article-title":"Multi-omics approaches to disease","volume":"18","author":"Hasin","year":"2017","journal-title":"Genome Biol."},{"key":"B52","doi-asserted-by":"publisher","first-page":"1707","DOI":"10.1152\/physrev.00042.2019","article-title":"Microenvironmental determinants of pancreatic cancer","volume":"100","author":"Hessmann","year":"2020","journal-title":"Physiol. Rev."},{"key":"B53","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1186\/s13148-022-01367-8","article-title":"A randomized, phase II trial of oral azacitidine (CC-486) in patients with resected pancreatic adenocarcinoma at high risk for recurrence","volume":"14","author":"Heumann","year":"2022","journal-title":"Clin. Epigenetics"},{"key":"B54","doi-asserted-by":"publisher","first-page":"1454","DOI":"10.1126\/science.aad9024","article-title":"Activation of proto-oncogenes by disruption of chromosome neighborhoods","volume":"351","author":"Hnisz","year":"2016","journal-title":"Science"},{"key":"B55","doi-asserted-by":"publisher","first-page":"487","DOI":"10.1038\/s41575-020-0300-1","article-title":"Pancreatic cancer stroma: an update on therapeutic targeting strategies","volume":"17","author":"Hosein","year":"2020","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"B56","doi-asserted-by":"publisher","first-page":"1869","DOI":"10.1177\/15353702211023473","article-title":"KDM1A and KDM3A promote tumor growth by upregulating cell cycle-associated genes in pancreatic cancer","volume":"246","author":"Hou","year":"2021","journal-title":"Exp. Biol. Med. (Maywood)"},{"key":"B57","first-page":"306","article-title":"Update on pancreatic intraepithelial neoplasia","volume":"1","author":"Hruban","year":"2008","journal-title":"Int. J. Clin. Exp. Pathol."},{"key":"B58","doi-asserted-by":"publisher","first-page":"918","DOI":"10.1158\/0008-5472.CAN-07-5714","article-title":"Cancer-associated stromal fibroblasts promote pancreatic tumor progression","volume":"68","author":"Hwang","year":"2008","journal-title":"Cancer Res."},{"key":"B59","doi-asserted-by":"publisher","first-page":"e324","DOI":"10.1038\/emm.2017.11","article-title":"Writing, erasing and reading histone lysine methylations","volume":"49","author":"Hyun","year":"2017","journal-title":"Exp. Mol. Med."},{"key":"B60","doi-asserted-by":"publisher","first-page":"5069","DOI":"10.3390\/ijms25105069","article-title":"Unveiling the molecular landscape of pancreatic ductal adenocarcinoma: insights into the role of the COMPASS-Like complex","volume":"25","author":"Jamali","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"B61","doi-asserted-by":"publisher","first-page":"1565","DOI":"10.1002\/ijc.34144","article-title":"A phase I\/II study of ivaltinostat combined with gemcitabine and erlotinib in patients with untreated locally advanced or metastatic pancreatic adenocarcinoma","volume":"151","author":"Jo","year":"2022","journal-title":"Int. J. Cancer"},{"key":"B62","doi-asserted-by":"publisher","first-page":"805","DOI":"10.1038\/nrg2651","article-title":"Rethinking how DNA methylation patterns are maintained","volume":"10","author":"Jones","year":"2009","journal-title":"Nat. Rev. Genet."},{"key":"B63","doi-asserted-by":"publisher","first-page":"2127","DOI":"10.2217\/fon-2020-1244","article-title":"EZH2 inhibition by tazemetostat: mechanisms of action, safety and efficacy in relapsed\/refractory follicular lymphoma","volume":"17","author":"Julia","year":"2021","journal-title":"Future Oncol."},{"key":"B64","doi-asserted-by":"publisher","first-page":"206","DOI":"10.1002\/cbic.201000195","article-title":"Structure and function of mammalian DNA methyltransferases","volume":"12","author":"Jurkowska","year":"2011","journal-title":"ChemBioChem"},{"key":"B65","doi-asserted-by":"publisher","first-page":"4313","DOI":"10.1039\/D3CS00100H","article-title":"Chemically induced degradation of epigenetic targets","volume":"52","author":"Kabir","year":"2023","journal-title":"Chem. Soc. Rev."},{"key":"B66","doi-asserted-by":"publisher","first-page":"1420","DOI":"10.1172\/JCI39104","article-title":"The basics of epithelial-mesenchymal transition","volume":"119","author":"Kalluri","year":"2009","journal-title":"J. Clin. Invest"},{"key":"B67","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1016\/j.semcancer.2017.11.020","article-title":"MicroRNA regulation of K-Ras in pancreatic cancer and opportunities for therapeutic intervention","volume":"54","author":"Karmakar","year":"2019","journal-title":"Seminars Cancer Biol."},{"key":"B68","doi-asserted-by":"publisher","first-page":"101461","DOI":"10.1016\/j.xcrm.2024.101461","article-title":"PRMT1 promotes pancreatic cancer development and resistance to chemotherapy","volume":"5","author":"Ku","year":"2024","journal-title":"Cell Rep. Med."},{"key":"B69","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1016\/j.ajpath.2018.09.009","article-title":"The paradoxical web of pancreatic cancer tumor microenvironment","volume":"189","author":"Lafaro","year":"2019","journal-title":"Am. J. Pathology"},{"key":"B70","doi-asserted-by":"publisher","first-page":"1285","DOI":"10.1158\/0008-5472.CAN-18-2965","article-title":"The critical role of RNA m6A methylation in cancer","volume":"79","author":"Lan","year":"2019","journal-title":"Cancer Res."},{"key":"B71","doi-asserted-by":"publisher","first-page":"3431","DOI":"10.1158\/0008-5472.CAN-20-4107","article-title":"The emerging roles of RNA m6A methylation and demethylation as critical regulators of tumorigenesis, drug sensitivity, and resistance","volume":"81","author":"Lan","year":"2021","journal-title":"Cancer Res."},{"key":"B72","doi-asserted-by":"publisher","first-page":"4050","DOI":"10.3390\/cancers14164050","article-title":"Targeting histone epigenetic modifications and DNA damage responses in synthetic lethality strategies in cancer?","volume":"14","author":"Lazo","year":"2022","journal-title":"Cancers (Basel)"},{"key":"B73","doi-asserted-by":"publisher","first-page":"5136","DOI":"10.3390\/cancers13205136","article-title":"PRMT5: an emerging target for pancreatic adenocarcinoma","volume":"13","author":"Lee","year":"2021","journal-title":"Cancers (Basel)"},{"key":"B74","doi-asserted-by":"publisher","first-page":"117936","DOI":"10.1016\/j.lfs.2020.117936","article-title":"The Ras-ERK1\/2 signaling pathway regulates H3K9ac through PCAF to promote the development of pancreatic cancer","volume":"256","author":"Li","year":"2020","journal-title":"Life Sci."},{"key":"B75","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1186\/s13148-021-01016-6","article-title":"Hypoxia promotes the metastasis of pancreatic cancer through regulating NOX4\/KDM5A-mediated histone methylation modification changes in a HIF1A-independent manner","volume":"13","author":"Li","year":"","journal-title":"Clin. Epigenetics"},{"key":"B76","doi-asserted-by":"publisher","first-page":"640587","DOI":"10.3389\/fcell.2021.640587","article-title":"MicroRNA-34a: potent tumor suppressor, cancer stem cell inhibitor, and potential anticancer therapeutic","volume":"9","author":"Li","year":"","journal-title":"Front. Cell Dev. Biol."},{"key":"B77","doi-asserted-by":"publisher","first-page":"105304","DOI":"10.1016\/j.phrs.2020.105304","article-title":"A CRISPR-Cas9 repressor for epigenetic silencing of KRAS","volume":"164","author":"Liu","year":"2021","journal-title":"Pharmacol. Res."},{"key":"B78","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1186\/s12943-025-02323-9","article-title":"Drug-induced tolerant persisters in tumor: mechanism, vulnerability and perspective implication for clinical treatment","volume":"24","author":"Liu","year":"2025","journal-title":"Mol. Cancer"},{"key":"B79","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1007\/s10142-022-00947-4","article-title":"Non-coding RNAs in human health and disease: potential function as biomarkers and therapeutic targets","volume":"23","author":"Loganathan","year":"2023","journal-title":"Funct. Integr. Genomics"},{"key":"B80","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1186\/s13046-019-1153-8","article-title":"Therapeutic challenges and current immunomodulatory strategies in targeting the immunosuppressive pancreatic tumor microenvironment","volume":"38","author":"Looi","year":"2019","journal-title":"J. Exp. and Clin. Cancer Res."},{"key":"B81","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1016\/j.canlet.2013.09.039","article-title":"The stromal compartments in pancreatic cancer: are there any therapeutic targets?","volume":"343","author":"Lunardi","year":"2014","journal-title":"Cancer Lett."},{"key":"B82","doi-asserted-by":"publisher","first-page":"817","DOI":"10.1097\/MPA.0000000000001338","article-title":"Characteristics and outcomes of pancreatic cancer by histological subtypes","volume":"48","author":"Luo","year":"2019","journal-title":"Pancreas"},{"key":"B83","doi-asserted-by":"publisher","first-page":"863","DOI":"10.1016\/j.tcb.2017.06.003","article-title":"Metabolic interactions in the tumor microenvironment","volume":"27","author":"Lyssiotis","year":"2017","journal-title":"Trends Cell Biol."},{"key":"B84","doi-asserted-by":"publisher","first-page":"1186","DOI":"10.1158\/1535-7163.MCT-06-0686","article-title":"Tumor-stroma interactions in pancreatic ductal adenocarcinoma","volume":"6","author":"Mahadevan","year":"2007","journal-title":"Mol. Cancer Ther."},{"key":"B85","doi-asserted-by":"publisher","first-page":"e70008","DOI":"10.1002\/cncy.70008","article-title":"An integrated multi-omics biomarker approach using molecular profiling and microRNAs for evaluation of pancreatic cyst fluid","volume":"133","author":"Maher","year":"2025","journal-title":"Cancer Cytopathol."},{"key":"B86","doi-asserted-by":"publisher","first-page":"902","DOI":"10.1097\/01.MP.0000086072.56290.FB","article-title":"Multicomponent analysis of the pancreatic adenocarcinoma progression model using a pancreatic intraepithelial neoplasia tissue microarray","volume":"16","author":"Maitra","year":"2003","journal-title":"Mod. Pathol."},{"key":"B87","doi-asserted-by":"publisher","first-page":"1539","DOI":"10.14309\/ajg.0000000000000284","article-title":"Novel methylated DNA markers discriminate advanced neoplasia in pancreatic cysts: Marker discovery, tissue validation, and cyst fluid testing","volume":"114","author":"Majumder","year":"2019","journal-title":"Am. J. Gastroenterol."},{"key":"B88","doi-asserted-by":"publisher","first-page":"1358","DOI":"10.1200\/JCO.2009.24.5639","article-title":"Cellular histone modification patterns predict prognosis and treatment response in resectable pancreatic adenocarcinoma: results from RTOG 9704","volume":"28","author":"Manuyakorn","year":"2010","journal-title":"J. Clin. Oncol."},{"key":"B89","doi-asserted-by":"publisher","first-page":"1069","DOI":"10.3390\/biomedicines11041069","article-title":"Circulating cell-free nucleic acids as biomarkers for diagnosis and prognosis of pancreatic cancer","volume":"11","author":"Marin","year":"2023","journal-title":"Biomedicines"},{"key":"B90","doi-asserted-by":"publisher","first-page":"6","DOI":"10.3390\/cancers10010006","article-title":"Immune evasion in pancreatic cancer: from mechanisms to therapy","volume":"10","author":"Martinez-Bosch","year":"2018","journal-title":"Cancers"},{"key":"B91","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1186\/s13059-021-02498-6","article-title":"KrasG12D induces changes in chromatin territories that differentially impact early nuclear reprogramming in pancreatic cells","volume":"22","author":"Mathison","year":"2021","journal-title":"Genome Biol."},{"key":"B92","doi-asserted-by":"publisher","first-page":"4713","DOI":"10.1158\/1078-0432.CCR-12-0035","article-title":"miRNA biomarkers in cyst fluid augment the diagnosis and management of pancreatic cysts","volume":"18","author":"Matthaei","year":"2012","journal-title":"Clin. Cancer Res."},{"key":"B93","doi-asserted-by":"publisher","first-page":"430","DOI":"10.1038\/s41580-022-00566-8","article-title":"Long non-coding RNAs: definitions, functions, challenges and recommendations","volume":"24","author":"Mattick","year":"2023","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"B94","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1038\/ng.3753","article-title":"Epigenomic reprogramming during pancreatic cancer progression links anabolic glucose metabolism to distant metastasis","volume":"49","author":"McDonald","year":"2017","journal-title":"Nat. Genet."},{"key":"B95","doi-asserted-by":"publisher","first-page":"675","DOI":"10.1128\/MCB.06365-11","article-title":"Remodelers organize cellular chromatin by counteracting intrinsic Histone-DNA sequence preferences in a class-specific manner","volume":"32","author":"Moshkin","year":"2012","journal-title":"Mol. Cell. Biol."},{"key":"B96","doi-asserted-by":"publisher","first-page":"715","DOI":"10.1136\/gutjnl-2019-318362","article-title":"Loss of Setd2 promotes Kras-induced acinar-to-ductal metaplasia and epithelia-mesenchymal transition during pancreatic carcinogenesis","volume":"69","author":"Niu","year":"2020","journal-title":"Gut"},{"key":"B97","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1186\/s12943-020-01263-w","article-title":"The role of m6A, m5C and \u03a8 RNA modifications in cancer: novel therapeutic opportunities","volume":"20","author":"Nombela","year":"2021","journal-title":"Mol. Cancer"},{"key":"B98","doi-asserted-by":"publisher","first-page":"3435","DOI":"10.3390\/cells10123435","article-title":"Aspects of the epigenetic regulation of EMT related to cancer metastasis","volume":"10","author":"Nowak","year":"2021","journal-title":"Cells"},{"key":"B99","doi-asserted-by":"publisher","first-page":"e151353","DOI":"10.1172\/jci.insight.151353","article-title":"Epigenetic drug screening defines a PRMT5 inhibitor-sensitive pancreatic cancer subtype","volume":"7","author":"Orben","year":"2022","journal-title":"JCI Insight"},{"key":"B100","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/bs.ircmb.2023.10.002","article-title":"Epigenetic therapeutic strategies in pancreatic cancer","volume":"383","author":"Orlacchio","year":"2024","journal-title":"Int. Rev. Cell Mol. Biol."},{"key":"B101","unstructured":"World cancer research fund\n          \n          \n          2022"},{"key":"B102","doi-asserted-by":"publisher","first-page":"S44","DOI":"10.1016\/j.cgh.2009.07.039","article-title":"Desmoplasia of pancreatic ductal adenocarcinoma","volume":"7","author":"Pandol","year":"2009","journal-title":"Clin. Gastroenterology Hepatology"},{"key":"B103","doi-asserted-by":"publisher","first-page":"851","DOI":"10.1001\/jama.2021.13027","article-title":"Pancreatic cancer: a review","volume":"326","author":"Park","year":"2021","journal-title":"JAMA"},{"key":"B104","doi-asserted-by":"publisher","first-page":"3","DOI":"10.4161\/epi.27473","article-title":"Non-coding RNAs as direct and indirect modulators of epigenetic regulation","volume":"9","author":"Peschansky","year":"2014","journal-title":"Epigenetics"},{"key":"B105","doi-asserted-by":"publisher","first-page":"e2116764119","DOI":"10.1073\/pnas.2116764119","article-title":"XP-524 is a dual-BET\/EP300 inhibitor that represses oncogenic KRAS and potentiates immune checkpoint inhibition in pancreatic cancer","volume":"119","author":"Principe","year":"2022","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"B106","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/bjc.2012.569","article-title":"Hyaluronan, fluid pressure, and stromal resistance in pancreas cancer","volume":"108","author":"Provenzano","year":"2013","journal-title":"Br. J. Cancer"},{"key":"B107","doi-asserted-by":"publisher","first-page":"418","DOI":"10.1016\/j.ccr.2012.01.007","article-title":"Enzymatic targeting of the Stroma ablates physical barriers to treatment of pancreatic ductal adenocarcinoma","volume":"21","author":"Provenzano","year":"2012","journal-title":"Cancer Cell"},{"key":"B108","doi-asserted-by":"publisher","first-page":"685","DOI":"10.1002\/bit.28029","article-title":"Biogenesis and mechanisms of microRNA-mediated gene regulation","volume":"119","author":"Rani","year":"2022","journal-title":"Biotechnol. Bioeng."},{"key":"B109","doi-asserted-by":"publisher","first-page":"1298","DOI":"10.1038\/ncb3629","article-title":"The impact of cellular metabolism on chromatin dynamics and epigenetics","volume":"19","author":"Reid","year":"2017","journal-title":"Nat. Cell Biol."},{"key":"B110","doi-asserted-by":"publisher","first-page":"620","DOI":"10.3390\/genes9120620","article-title":"Structural basis of DNMT1 and DNMT3A-Mediated DNA methylation","volume":"9","author":"Ren","year":"2018","journal-title":"Genes"},{"key":"B111","doi-asserted-by":"publisher","first-page":"461","DOI":"10.1093\/carcin\/21.3.461","article-title":"DNA methylation: past, present and future directions","volume":"21","author":"Robertson","year":"2000","journal-title":"Carcinogenesis"},{"key":"B112","doi-asserted-by":"publisher","first-page":"789","DOI":"10.1038\/s41576-018-0060-8","article-title":"Organizational principles of 3D genome architecture","volume":"19","author":"Rowley","year":"2018","journal-title":"Nat. Rev. Genet."},{"key":"B113","doi-asserted-by":"publisher","first-page":"11102","DOI":"10.3390\/ijms222011102","article-title":"BET proteins as attractive targets for cancer therapeutics","volume":"22","author":"Sarnik","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"B114","doi-asserted-by":"publisher","first-page":"102366","DOI":"10.1016\/j.tranon.2025.102366","article-title":"PRMT5 inhibitors: therapeutic potential in pancreatic cancer","volume":"55","author":"Schneider","year":"2025","journal-title":"Transl. Oncol."},{"key":"B115","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1016\/j.trecan.2019.01.001","article-title":"Targeting pancreatic stellate cells in cancer","volume":"5","author":"Schnittert","year":"2019","journal-title":"Trends Cancer"},{"key":"B116","unstructured":"Pancreatic cancer diagnoses and mortality rates climb; five-year survival rate for pancreatic cancer stalls at 13\n          \n          \n            \n              Sesock\n              C.\n            \n          \n          \n          2025"},{"key":"B117","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1016\/j.semcancer.2020.10.001","article-title":"Non-coding RNA biomarkers in pancreatic ductal adenocarcinoma","volume":"75","author":"Sharma","year":"2021","journal-title":"Seminars Cancer Biol."},{"key":"B118","doi-asserted-by":"publisher","first-page":"579","DOI":"10.1038\/s41586-018-0703-0","article-title":"Sensitive tumour detection and classification using plasma cell-free DNA methylomes","volume":"563","author":"Shen","year":"2018","journal-title":"Nature"},{"key":"B119","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1038\/bjc.2011.550","article-title":"Intragenic DNA methylation: implications of this epigenetic mechanism for cancer research","volume":"106","author":"Shenker","year":"2012","journal-title":"Br. J. Cancer"},{"key":"B120","doi-asserted-by":"publisher","first-page":"2249","DOI":"10.3390\/jcm10112249","article-title":"Micro-RNA analysis of pancreatic cyst fluid for diagnosing malignant transformation of intraductal papillary mucinous neoplasm by comparing intraductal papillary mucinous adenoma and carcinoma","volume":"10","author":"Shirakami","year":"2021","journal-title":"J. Clin. Med."},{"key":"B121","doi-asserted-by":"publisher","first-page":"1478","DOI":"10.1038\/s41416-021-01321-0","article-title":"Achieving clinical success with BET inhibitors as anti-cancer agents","volume":"124","author":"Shorstova","year":"2021","journal-title":"Br. J. Cancer"},{"key":"B122","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1038\/s41580-021-00441-y","article-title":"Modulation of cellular processes by histone and non-histone protein acetylation","volume":"23","author":"Shvedunova","year":"2022","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"B123","doi-asserted-by":"publisher","first-page":"5486","DOI":"10.3390\/ijms21155486","article-title":"Crosstalk between tumor and stromal cells in pancreatic ductal adenocarcinoma","volume":"21","author":"Sperb","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"B124","doi-asserted-by":"publisher","first-page":"347","DOI":"10.3390\/cimb47050347","article-title":"Emerging tumor biomarkers in pancreatic cancer and their clinical implications","volume":"47","author":"Stefanoudakis","year":"2025","journal-title":"Curr. Issues Mol. Biol."},{"key":"B125","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1038\/47412","article-title":"The language of covalent histone modifications","volume":"403","author":"Strahl","year":"2000","journal-title":"Nature"},{"key":"B126","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1017\/S1462399402004222","article-title":"Aberrant DNA methylation in cancer: potential clinical interventions","volume":"4","author":"Strathdee","year":"2002","journal-title":"Expert Rev. Mol. Med."},{"key":"B127","doi-asserted-by":"publisher","first-page":"1387","DOI":"10.1042\/BST20253036","article-title":"Chromatin insulators in gene regulation and 3D genome organization","volume":"53","author":"Sultana","year":"2025","journal-title":"Biochem. Soc. Trans."},{"key":"B128","doi-asserted-by":"publisher","first-page":"1533033820920969","DOI":"10.1177\/1533033820920969","article-title":"The roles of frequently mutated genes of pancreatic cancer in regulation of tumor microenvironment","volume":"19","author":"Sun","year":"2020","journal-title":"Technol. Cancer Res. Treat."},{"key":"B129","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1007\/s10555-025-10253-7","article-title":"Epigenetic drugs in cancer therapy","volume":"44","author":"Suraweera","year":"2025","journal-title":"Cancer Metastasis Rev."},{"key":"B130","doi-asserted-by":"publisher","first-page":"13563","DOI":"10.1038\/srep13563","article-title":"Clinicopathological significance of CDKN2A promoter hypermethylation frequency with pancreatic cancer","volume":"5","author":"Tang","year":"2015","journal-title":"Sci. Rep."},{"key":"B131","doi-asserted-by":"publisher","first-page":"212810","DOI":"10.1155\/2011\/212810","article-title":"The desmoplastic stroma plays an essential role in the accumulation and modulation of infiltrated immune cells in pancreatic adenocarcinoma","volume":"2011","author":"Tjomsland","year":"2011","journal-title":"Clin. and Developmental Immunology"},{"key":"B132","doi-asserted-by":"publisher","first-page":"112750","DOI":"10.1016\/j.ejmech.2020.112750","article-title":"Recent advances in epigenetic proteolysis targeting chimeras (Epi-PROTACs)","volume":"207","author":"Tomaselli","year":"2020","journal-title":"Eur. J. Med. Chem."},{"key":"B133","doi-asserted-by":"publisher","first-page":"490","DOI":"10.1111\/cas.14768","article-title":"The role of the SWI\/SNF chromatin remodeling complex in pancreatic ductal adenocarcinoma","volume":"112","author":"Tsuda","year":"2021","journal-title":"Cancer Sci."},{"key":"B134","doi-asserted-by":"publisher","first-page":"727","DOI":"10.1172\/JCI64535","article-title":"KDM2B promotes pancreatic cancer via Polycomb-dependent and -independent transcriptional programs","volume":"123","author":"Tzatsos","year":"2013","journal-title":"J. Clin. Invest"},{"key":"B135","doi-asserted-by":"publisher","first-page":"e350","DOI":"10.1038\/mtna.2016.61","article-title":"A MicroRNA panel in pancreatic cyst fluid for the risk stratification of pancreatic cysts in a prospective cohort","volume":"5","author":"Utomo","year":"2016","journal-title":"Mol. Ther. - Nucleic Acids"},{"key":"B136","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1016\/j.cbpa.2020.01.010","article-title":"Proteolysis targeting chimeras (PROTACs) for epigenetics research","volume":"57","author":"Vogelmann","year":"2020","journal-title":"Curr. Opin. Chem. Biol."},{"key":"B137","doi-asserted-by":"publisher","first-page":"537","DOI":"10.1097\/MOG.0b013e328363affe","article-title":"Deciphering the role of stroma in pancreatic cancer","volume":"29","author":"Waghray","year":"2013","journal-title":"Curr. Opin. Gastroenterology"},{"key":"B138","doi-asserted-by":"publisher","first-page":"404","DOI":"10.1016\/j.canlet.2014.09.029","article-title":"Next generation sequencing of pancreatic cyst fluid microRNAs from low grade-benign and high grade-invasive lesions","volume":"356","author":"Wang","year":"2015","journal-title":"Cancer Lett."},{"key":"B139","doi-asserted-by":"publisher","first-page":"1912","DOI":"10.1158\/2159-8290.CD-19-1448","article-title":"CRISPR-GEMM pooled mutagenic screening identifies KMT2D as a major modulator of immune checkpoint blockade","volume":"10","author":"Wang","year":"2020","journal-title":"Cancer Discov."},{"key":"B140","doi-asserted-by":"publisher","first-page":"2769","DOI":"10.3390\/diagnostics13172769","article-title":"SMAD proteins in TGF-\u03b2 signalling pathway in cancer: regulatory mechanisms and clinical applications","volume":"13","author":"Wang","year":"","journal-title":"Diagn. (Basel)"},{"key":"B141","doi-asserted-by":"publisher","first-page":"420","DOI":"10.1038\/s41392-023-01647-6","article-title":"Bromodomain and extraterminal (BET) proteins: biological functions, diseases and targeted therapy","volume":"8","author":"Wang","year":"","journal-title":"Sig Transduct. Target Ther."},{"key":"B142","doi-asserted-by":"publisher","first-page":"1051","DOI":"10.1016\/j.ejso.2012.08.008","article-title":"The cellular level of histone H3 lysine 4 dimethylation correlates with response to adjuvant gemcitabine in Japanese pancreatic cancer patients treated with surgery","volume":"38","author":"Watanabe","year":"2012","journal-title":"Eur. J. Surg. Oncol. (EJSO)"},{"key":"B143","doi-asserted-by":"publisher","first-page":"192","DOI":"10.1002\/ijc.32072","article-title":"Loss of KDM6A characterizes a poor prognostic subtype of human pancreatic cancer and potentiates HDAC inhibitor lethality","volume":"145","author":"Watanabe","year":"2019","journal-title":"Int. J. Cancer"},{"key":"B144","doi-asserted-by":"publisher","first-page":"52","DOI":"10.3389\/fphys.2014.00052","article-title":"Stars and stripes in pancreatic cancer: role of stellate cells and stroma in cancer progression","volume":"5","author":"Wilson","year":"2014","journal-title":"Front. Physiol."},{"key":"B145","doi-asserted-by":"publisher","first-page":"324","DOI":"10.1080\/13651820600804203","article-title":"Genetics and pathology of pancreatic cancer","volume":"8","author":"Winter","year":"2006","journal-title":"HPB Oxf."},{"key":"B146","doi-asserted-by":"publisher","first-page":"2344","DOI":"10.1136\/gutjnl-2023-330155","article-title":"DNA-Methylation signature accurately differentiates pancreatic cancer from chronic pancreatitis in tissue and plasma","volume":"72","author":"Wu","year":"2023","journal-title":"Gut"},{"key":"B147","doi-asserted-by":"publisher","first-page":"188676","DOI":"10.1016\/j.bbcan.2022.188676","article-title":"Histone deacetylases: a novel class of therapeutic targets for pancreatic cancer","volume":"1877","author":"Xiang","year":"2022","journal-title":"Biochimica Biophysica Acta (BBA) - Rev. Cancer"},{"key":"B148","doi-asserted-by":"publisher","first-page":"4820","DOI":"10.3390\/ijms24054820","article-title":"Histone modifications represent a key epigenetic feature of epithelial-to-mesenchyme transition in pancreatic cancer","volume":"24","author":"Xu","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"B149","doi-asserted-by":"publisher","first-page":"10390","DOI":"10.1074\/jbc.M117.786830","article-title":"The long non-coding RNA HOTAIR enhances pancreatic cancer resistance to TNF-Related apoptosis-inducing ligand","volume":"292","author":"Yang","year":"2017","journal-title":"J. Biol. Chem."},{"key":"B150","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1186\/s13148-019-0734-x","article-title":"Epigenetic synthetic lethality approaches in cancer therapy","volume":"11","author":"Yang","year":"2019","journal-title":"Clin. Epigenetics"},{"key":"B151","doi-asserted-by":"publisher","first-page":"6544","DOI":"10.1158\/1078-0432.CCR-12-3224","article-title":"Novel methylation biomarker panel for the early detection of pancreatic cancer","volume":"19","author":"Yi","year":"2013","journal-title":"Clin. Cancer Res."},{"key":"B152","doi-asserted-by":"publisher","first-page":"e93760","DOI":"10.1371\/journal.pone.0093760","article-title":"Diagnosis of pancreatic neoplasms using a novel method of DNA methylation analysis of mucin expression in pancreatic juice","volume":"9","author":"Yokoyama","year":"2014","journal-title":"PLoS One"},{"key":"B153","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1186\/s13072-016-0075-3","article-title":"Profiling genome-wide DNA methylation","volume":"9","author":"Yong","year":"2016","journal-title":"Epigenetics and Chromatin"},{"key":"B154","doi-asserted-by":"publisher","first-page":"1758835918816281","DOI":"10.1177\/1758835918816281","article-title":"Immunotherapy and pancreatic cancer: unique challenges and potential opportunities","volume":"10","author":"Young","year":"2018","journal-title":"Ther. Adv. Med. Oncol."},{"key":"B155","doi-asserted-by":"publisher","first-page":"2608","DOI":"10.1007\/s10620-012-2202-8","article-title":"Neuronal pentraxin II (NPTX2) is frequently down-regulated by promoter hypermethylation in pancreatic cancers","volume":"57","author":"Zhang","year":"2012","journal-title":"Dig. Dis. Sci."},{"key":"B156","doi-asserted-by":"publisher","first-page":"492","DOI":"10.1038\/s41422-020-0332-7","article-title":"Interaction between microbiota and immunity in health and disease","volume":"30","author":"Zheng","year":"2020","journal-title":"Cell Res."},{"key":"B157","doi-asserted-by":"publisher","first-page":"e156305","DOI":"10.1172\/JCI156305","article-title":"A p300\/GATA6 axis determines differentiation and wnt dependency in pancreatic cancer models","volume":"132","author":"Zhong","year":"2022","journal-title":"J. Clin. Investigation"},{"key":"B158","doi-asserted-by":"publisher","first-page":"3049","DOI":"10.3892\/mmr.2020.11435","article-title":"GAS5 mediated regulation of cell signaling (Review)","volume":"22","author":"Zhou","year":"2020","journal-title":"Mol. Med. Rep."}],"container-title":["Frontiers in Epigenetics and Epigenomics"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/freae.2025.1723159\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,27]],"date-time":"2025-11-27T06:30:45Z","timestamp":1764225045000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/freae.2025.1723159\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,27]]},"references-count":158,"alternative-id":["10.3389\/freae.2025.1723159"],"URL":"https:\/\/doi.org\/10.3389\/freae.2025.1723159","relation":{},"ISSN":["2813-706X"],"issn-type":[{"value":"2813-706X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,27]]},"article-number":"1723159"}}