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Emerging evidence reveals that epigenetic mechanisms, including DNA methylation, histone modifications, chromatin remodeling, and non-coding RNAs, are tightly coupled to metabolic pathways through key metabolites that function as cofactors or regulators of chromatin-modifying enzymes. This reciprocal interplay establishes self-reinforcing loops that sustain tumor growth, promote heterogeneity, and drive the emergence of drug-tolerant states. In this review, we summarize current knowledge on how epigenetic remodeling shapes metabolic reprogramming and, in turn, how altered metabolite pools influence chromatin states in cancer. We highlight the central role of long non-coding RNAs and other ncRNA species in coordinating epigenetic and metabolic adaptations that underpin therapy resistance. We further examine the contribution of metabolite-dependent post-translational modifications, such as acetylation, methylation, lactylation, and succinylation, to the regulation of tumor aggressiveness and treatment response. Finally, we discuss how multi-omics integration, computational network approaches, and AI-enabled modeling are accelerating the discovery of epigenetic\u2013metabolic vulnerabilities and informing the development of precision therapeutic strategies. Understanding and targeting this epigenetic\u2013metabolic axis holds substantial promise for overcoming drug resistance and improving the durability of cancer therapies.<\/jats:p>","DOI":"10.3389\/freae.2026.1755829","type":"journal-article","created":{"date-parts":[[2026,2,8]],"date-time":"2026-02-08T22:10:20Z","timestamp":1770588620000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":3,"title":["The impact of epigenetics on tumor metabolism: Friend or foe in drug response?"],"prefix":"10.3389","volume":"4","author":[{"given":"Serena","family":"Castelli","sequence":"first","affiliation":[{"name":"Department for the Promotion of Human Science and Quality of Life, San Raffaele Open University","place":["Rome, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melania","family":"Franchini","sequence":"additional","affiliation":[{"name":"Department of System Biology, Irving Cancer Research Center, Columbia University","place":["New York, NY, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luigi","family":"Ferraro","sequence":"additional","affiliation":[{"name":"Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine","place":["Miami, FL, United States"]},{"name":"Department of Public Health Sciences, University of Miami Miller School of Medicine","place":["Miami, FL, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicol\u00f2","family":"Mangraviti","sequence":"additional","affiliation":[{"name":"Department of Neuroscience and Physiology, NYU Grossman School of Medicine, NYU Langone Health","place":["New York, NY, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,2,9]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"2482","DOI":"10.1158\/1078-0432.CCR-17-3070","article-title":"Oxidative phosphorylation as an emerging target in cancer therapy","volume":"24","author":"Ashton","year":"2018","journal-title":"Clin. 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