{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T10:58:19Z","timestamp":1790679499911,"version":"4.1.0"},"reference-count":320,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T00:00:00Z","timestamp":1790640000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Epigenet. Epigenom."],"abstract":"<jats:p>\n                    DNA methylation is a key epigenetic mechanism that mediates gene expression and informs cellular identity. Methyl-CpG binding protein 2 (MeCP2) is a protein capable of recognizing and interpreting the methylated DNA code to bring about phenotypic outcomes through co-factor interactions. Altered DNA methylation patterns and MeCP2 function, therefore, disrupt cellular epigenetic homeostasis and contribute to human diseases. MeCP2 loss-of-function or amplification events are responsible for Rett syndrome and\n                    <jats:italic>MECP2<\/jats:italic>\n                    duplication syndrome, respectively, where patients present with multisystem pathophysiology. Growing evidence suggests that MeCP2 contributes to immune dysregulation in these syndromes and is a key epigenetic regulator in additional inflammatory conditions. Research in past decades has functionally linked MeCP2 to tumorigenesis across cancer types, where it can support and inhibit oncogenic properties in a contextual manner. The precise mechanistic role of MeCP2 in non-neuronal and cancer models is underexplored. Here, we summarize the diverse epigenetic functionalities of MeCP2 influenced by its molecular structure, regulation, and co-factor interactions and discuss how MeCP2 regulates immune homeostasis and tumorigenesis.\n                  <\/jats:p>","DOI":"10.3389\/freae.2026.1917394","type":"journal-article","created":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T10:17:11Z","timestamp":1790677031000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["MeCP2 functions as a DNA methylation reader in immune homeostasis and cancer"],"prefix":"10.3389","volume":"4","author":[{"given":"Grace C.","family":"Stroman","sequence":"first","affiliation":[{"name":"Department of Pharmacology, University of North Carolina","place":["Chapel Hill, NC, United States"]},{"name":"Lineberger Comprehensive Cancer Center, University of North Carolina","place":["Chapel Hill, NC, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clara","family":"Mellows","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, University of North Carolina","place":["Chapel Hill, NC, United States"]},{"name":"Lineberger Comprehensive Cancer Center, University of North Carolina","place":["Chapel Hill, NC, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin","family":"Pruitt","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, University of North Carolina","place":["Chapel Hill, NC, United States"]},{"name":"Lineberger Comprehensive Cancer Center, University of North Carolina","place":["Chapel Hill, NC, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,9,29]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"42051","DOI":"10.1074\/jbc.M111.300541","article-title":"The chromatin-binding protein HMGN1 regulates the expression of methyl CpG-Binding protein 2 (MECP2) and affects the behavior of mice","volume":"286","author":"Abuhatzira","year":"2011","journal-title":"J. Biol. Chem."},{"key":"B2","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1007\/BF00356163","article-title":"The X-Linked methylated DNA binding protein, Mecp2, is subject to X inactivation in the mouse","volume":"6","author":"Adler","year":"1995","journal-title":"Mamm. Genome"},{"key":"B3","doi-asserted-by":"publisher","first-page":"5402","DOI":"10.1093\/nar\/gkm599","article-title":"MeCP2 interacts with HP1 and modulates its heterochromatin association during myogenic differentiation","volume":"35","author":"Agarwal","year":"2007","journal-title":"Nucleic Acids Res."},{"key":"B4","doi-asserted-by":"publisher","first-page":"3895","DOI":"10.1182\/blood-2006-08-040147","article-title":"The C\/EBPdelta tumor suppressor is silenced by hypermethylation in acute myeloid leukemia","volume":"109","author":"Agrawal","year":"2007","journal-title":"Blood"},{"key":"B5","doi-asserted-by":"publisher","first-page":"505","DOI":"10.1016\/j.tig.2023.02.009","article-title":"ATRX, a guardian of chromatin","volume":"39","author":"Aguilera","year":"2023","journal-title":"Trends Genet."},{"key":"B6","doi-asserted-by":"publisher","first-page":"108553","DOI":"10.1016\/j.mrrev.2025.108553","article-title":"Rett syndrome: pathogenicity and regulation of MECP2 (human) and Mecp2 (mouse) genes and their protein products through various molecular mechanisms","volume":"796","author":"Ahmad","year":"2025","journal-title":"Mutat. Res. - Rev. Mutat. Res."},{"key":"B7","doi-asserted-by":"publisher","first-page":"104371","DOI":"10.1016\/j.braindev.2025.104371","article-title":"MECP2 duplication syndrome: recent advances in pathophysiology and therapeutic perspectives","volume":"47","author":"Akaba","year":"2025","journal-title":"Brain Dev."},{"key":"B8","doi-asserted-by":"publisher","first-page":"113789","DOI":"10.1016\/j.isci.2025.113789","article-title":"miR-199a functions downstream of MeCP2 in neurons of MECP2 duplication syndrome models","volume":"28","author":"Akaba","year":"2025","journal-title":"iScience"},{"key":"B9","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1038\/13810","article-title":"Rett syndrome is caused by mutations in X-Linked MECP2, encoding methyl-cpg-binding protein 2","volume":"23","author":"Amir","year":"1999","journal-title":"Nat. Genet."},{"key":"B10","doi-asserted-by":"publisher","first-page":"2617","DOI":"10.1007\/s11033-012-2348-7","article-title":"Mutant P53 binds to estrogen receptor negative promoter via DNMT1 and HDAC1 in MDA-MB-468 breast cancer cells","volume":"40","author":"Arabsolghar","year":"2013","journal-title":"Mol. Biol. Rep."},{"key":"B11","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1016\/j.nbd.2005.07.005","article-title":"Hippocampal synaptic plasticity is impaired in the Mecp2-Null mouse model of Rett syndrome","volume":"21","author":"Asaka","year":"2006","journal-title":"Neurobiol. Dis."},{"key":"B12","doi-asserted-by":"publisher","first-page":"17587","DOI":"10.1038\/s41598-021-97060-6","article-title":"A prelude to the proximity interaction mapping of CXXC5","volume":"11","author":"Ayaz","year":"2021","journal-title":"Sci. Rep."},{"key":"B13","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1186\/1471-2121-13-19","article-title":"Knock-down of methyl CpG-Binding protein 2 (MeCP2) causes alterations in cell proliferation and nuclear lamins expression in mammalian cells","volume":"13","author":"Babbio","year":"2012","journal-title":"BMC Cell Biol."},{"key":"B14","doi-asserted-by":"publisher","first-page":"6335","DOI":"10.1093\/emboj\/cdg604","article-title":"Methyl-CpG binding proteins identify novel sites of epigenetic inactivation in human cancer","volume":"22","author":"Ballestar","year":"2003","journal-title":"EMBO J."},{"key":"B15","doi-asserted-by":"publisher","first-page":"726","DOI":"10.1038\/nrc3130","article-title":"A decade of exploring the cancer epigenome \u2014 biological and translational implications","volume":"11","author":"Baylin","year":"2011","journal-title":"Nat. Rev. Cancer"},{"key":"B16","doi-asserted-by":"publisher","first-page":"236","DOI":"10.3389\/fncel.2014.00236","article-title":"MeCP2 post-translational modifications: a mechanism to control its involvement in synaptic plasticity and homeostasis?","volume":"8","author":"Bellini","year":"2014","journal-title":"Front. Cell. Neurosci."},{"key":"B17","doi-asserted-by":"publisher","first-page":"538","DOI":"10.1158\/2159-8290.CD-22-1038","article-title":"Early-onset cancer in the gastrointestinal tract is on the rise\u2014evidence and implications","volume":"13","author":"Ben-Aharon","year":"2023","journal-title":"Cancer Discov."},{"key":"B18","doi-asserted-by":"publisher","first-page":"1358","DOI":"10.1038\/sj.onc.1209179","article-title":"The methyl-cpg-binding protein MECP2 is required for prostate cancer cell growth","volume":"25","author":"Bernard","year":"2006","journal-title":"Oncogene"},{"key":"B19","doi-asserted-by":"publisher","first-page":"366","DOI":"10.1186\/s13046-019-1341-6","article-title":"A central role for MeCP2 in the epigenetic repression of miR-200c during epithelial-to-mesenchymal transition of glioma","volume":"38","author":"Bian","year":"2019","journal-title":"J. Exp. and Clin. Cancer Res. CR"},{"key":"B20","doi-asserted-by":"publisher","first-page":"2704","DOI":"10.1038\/sj.onc.1205357","article-title":"MeCP2 and MBD2 expression during normal and pathological growth of the human mammary gland","volume":"21","author":"Billard","year":"2002","journal-title":"Oncogene"},{"key":"B21","doi-asserted-by":"publisher","first-page":"1767","DOI":"10.18632\/aging.203901","article-title":"The novel lncRNA GPC5-AS1 stabilizes GPC5 mRNA by competitively binding with miR-93\/106a to suppress gastric cancer cell proliferation","volume":"14","author":"Bo","year":"2022","journal-title":"Aging"},{"key":"B22","doi-asserted-by":"publisher","first-page":"1020","DOI":"10.1038\/nn.2371","article-title":"Balanced gene regulation by an embryonic brain ncRNA is critical for adult hippocampal GABA circuitry","volume":"12","author":"Bond","year":"2009","journal-title":"Nat. Neurosci."},{"key":"B23","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1186\/s13041-020-00695-1","article-title":"MeCP2 gates spatial learning-induced alternative splicing events in the mouse hippocampus","volume":"13","author":"Brito","year":"2020","journal-title":"Mol. Brain"},{"key":"B24","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1007\/s00109-003-0497-9","article-title":"A WW domain binding region in methyl-cpg-binding protein MeCP2: impact on Rett syndrome","volume":"82","author":"Buschdorf","year":"2004","journal-title":"J. of Mol. Med. Berlin, Ger."},{"key":"B25","doi-asserted-by":"publisher","first-page":"e2320383121","DOI":"10.1073\/pnas.2320383121","article-title":"RIPK1 activation in Mecp2-Deficient microglia promotes inflammation and glutamate release in RTT","volume":"121","author":"Cao","year":"2024","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"B26","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1016\/S0887-8994(02)00624-0","article-title":"Identification of MeCP2 mutations in a series of females with autistic disorder","volume":"28","author":"Carney","year":"2003","journal-title":"Pediatr. Neurol."},{"key":"B27","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1177\/1947601913489020","article-title":"Identification of TET1 partners that control its DNA-demethylating function","volume":"4","author":"Cartron","year":"2013","journal-title":"Genes and Cancer"},{"key":"B28","doi-asserted-by":"publisher","first-page":"576362","DOI":"10.3389\/fonc.2020.576362","article-title":"Identification of novel MeCP2 cancer-associated target genes and post-translational modifications","volume":"10","author":"Castro-Piedras","year":"2020","journal-title":"Front. Oncol."},{"key":"B29","doi-asserted-by":"publisher","first-page":"422","DOI":"10.1016\/j.neuron.2007.10.001","article-title":"The story of Rett syndrome: from clinic to neurobiology","volume":"56","author":"Chahrour","year":"2007","journal-title":"Neuron"},{"key":"B30","doi-asserted-by":"publisher","first-page":"1224","DOI":"10.1126\/science.1153252","article-title":"MeCP2, a key contributor to neurological disease, activates and represses transcription","volume":"320","author":"Chahrour","year":"2008","journal-title":"Science"},{"key":"B31","doi-asserted-by":"publisher","first-page":"6569","DOI":"10.1038\/sj.onc.1207882","article-title":"Mechanisms underlying lack of insulin-like growth factor-binding Protein-3 expression in non-small-cell lung cancer","volume":"23","author":"Chang","year":"2004","journal-title":"Oncogene"},{"key":"B32","doi-asserted-by":"publisher","first-page":"452","DOI":"10.1186\/s12935-020-01541-z","article-title":"Epigenetic regulation of osteopontin splicing isoform c defines its role as a microenvironmental factor to promote the survival of Colon cancer cells from 5-FU treatment","volume":"20","author":"Chang","year":"2020","journal-title":"Cancer Cell Int."},{"key":"B33","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1002\/dneu.22126","article-title":"Differential methylation of the Micro-RNA 7b gene targets postnatal maturation of murine neuronal Mecp2 gene expression","volume":"74","author":"Chen","year":"2014","journal-title":"Dev. Neurobiol."},{"key":"B34","doi-asserted-by":"publisher","first-page":"44543","DOI":"10.1038\/srep44543","article-title":"Mecp2-Mediated epigenetic silencing of miR-137 contributes to colorectal adenoma-carcinoma sequence and tumor progression via relieving the suppression of c-Met","volume":"7","author":"Chen","year":"2017","journal-title":"Sci. Rep."},{"key":"B35","doi-asserted-by":"publisher","first-page":"154364","DOI":"10.1016\/j.prp.2023.154364","article-title":"Inhibiting lncRNA NEAT1 facilitates the sensitization of melanoma cells to cisplatin through modulating the miR-519c-3p-MeCP2 axis","volume":"243","author":"Chen","year":"2023","journal-title":"Pathology - Res. Pract."},{"key":"B36","doi-asserted-by":"publisher","first-page":"4256","DOI":"10.7150\/thno.94738","article-title":"Methyl-CpG-Binding 2 K271 lactylation-mediated M2 macrophage polarization inhibits atherosclerosis","volume":"14","author":"Chen","year":"2024","journal-title":"Theranostics"},{"key":"B37","doi-asserted-by":"publisher","first-page":"798","DOI":"10.1111\/jnc.12523","article-title":"SUMOylation of MeCP2 is essential for transcriptional repression and hippocampal synapse development","volume":"128","author":"Cheng","year":"2014","journal-title":"J. Neurochem."},{"key":"B38","doi-asserted-by":"publisher","first-page":"547","DOI":"10.1016\/j.devcel.2014.01.032","article-title":"MeCP2 suppresses nuclear microRNA processing and dendritic growth by regulating the DGCR8\/Drosha complex","volume":"28","author":"Cheng","year":"2014","journal-title":"Dev. Cell"},{"key":"B39","doi-asserted-by":"publisher","first-page":"42790","DOI":"10.1038\/srep42790","article-title":"Regulation of mRNA splicing by MeCP2 via epigenetic modifications in the brain","volume":"7","author":"Cheng","year":"2017","journal-title":"Sci. Rep."},{"key":"B40","doi-asserted-by":"publisher","first-page":"4303","DOI":"10.1093\/hmg\/ddy331","article-title":"The long non-coding RNA NEAT1 is elevated in polyglutamine repeat expansion diseases and protects from disease gene-dependent toxicities","volume":"27","author":"Cheng","year":"2018","journal-title":"Hum. Mol. Genet."},{"key":"B41","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1007\/s12264-021-00784-8","article-title":"Loss of O-GlcNAcylation on MeCP2 at threonine 203 leads to neurodevelopmental disorders","volume":"38","author":"Cheng","year":"2021","journal-title":"Neurosci. Bull."},{"key":"B42","doi-asserted-by":"publisher","first-page":"e1009087","DOI":"10.1371\/journal.pgen.1009087","article-title":"Quantitative analysis questions the role of MeCP2 as a global regulator of alternative splicing","volume":"16","author":"Chhatbar","year":"2020","journal-title":"PLoS Genet."},{"key":"B43","doi-asserted-by":"publisher","first-page":"14995","DOI":"10.1073\/pnas.1903549116","article-title":"Quantitative modelling predicts the impact of DNA methylation on RNA polymerase II traffic","volume":"116","author":"Cholewa-Waclaw","year":"2019","journal-title":"Proc. Natl. Acad. Sci."},{"key":"B44","doi-asserted-by":"publisher","first-page":"834","DOI":"10.1126\/science.1175371","article-title":"Lysine acetylation targets protein complexes and Co-Regulates major cellular functions","volume":"325","author":"Choudhary","year":"2009","journal-title":"Sci. (New York, N.Y.)"},{"key":"B45","doi-asserted-by":"publisher","first-page":"1789","DOI":"10.1038\/s41594-024-01373-9","article-title":"Differential dynamics specify MeCP2 function at nucleosomes and methylated DNA","volume":"31","author":"Chua","year":"2024","journal-title":"Nat. Struct. and Mol. Biol."},{"key":"B46","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1016\/j.molcel.2019.10.033","article-title":"MeCP2 represses enhancers through chromosome topology-associated DNA methylation","volume":"77","author":"Clemens","year":"2020","journal-title":"Mol. Cell"},{"key":"B47","doi-asserted-by":"publisher","first-page":"1731","DOI":"10.1136\/ard.2009.122903","article-title":"Genetic association between methyl-cpg-binding protein 2 (MECP2) and primary sj\u00f6gren\u2019s syndrome","volume":"69","author":"Cobb","year":"2010","journal-title":"Ann. Rheumatic Dis."},{"key":"B48","doi-asserted-by":"publisher","first-page":"941","DOI":"10.1093\/hmg\/10.9.941","article-title":"MECP2 is highly mutated in X-Linked mental retardation","volume":"10","author":"Couvert","year":"2001","journal-title":"Hum. Mol. Genet."},{"key":"B49","doi-asserted-by":"publisher","first-page":"6681","DOI":"10.1093\/nar\/gkp723","article-title":"MeCP2\/H3meK9 are involved in IL-6 gene silencing in pancreatic adenocarcinoma cell lines","volume":"37","author":"Dandrea","year":"2009","journal-title":"Nucleic Acids Res."},{"key":"B50","doi-asserted-by":"publisher","first-page":"442","DOI":"10.1111\/j.1349-7006.2003.tb01462.x","article-title":"MeCP2 and promoter methylation cooperatively regulate E-Cadherin gene expression in colorectal carcinoma","volume":"94","author":"Darwanto","year":"2003","journal-title":"Cancer Sci."},{"key":"B51","doi-asserted-by":"publisher","first-page":"540","DOI":"10.4161\/cbt.3.6.845","article-title":"MDR1 promoter hypermethylation in MCF-7 human breast cancer cells: changes in chromatin structure induced by treatment with 5-Aza-Cytidine","volume":"3","author":"David","year":"2004","journal-title":"Cancer Biol. and Ther."},{"key":"B52","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1016\/j.devcel.2011.03.012","article-title":"Pancreatic \u03b2 cell identity is maintained by DNA methylation-mediated repression of arx","volume":"20","author":"Dhawan","year":"2011","journal-title":"Dev. Cell"},{"key":"B53","doi-asserted-by":"publisher","first-page":"703632","DOI":"10.3389\/fimmu.2021.703632","article-title":"A biological circuit involving Mef2c, Mef2d, and Hdac9 controls the immunosuppressive functions of CD4+Foxp3+ T-Regulatory cells","volume":"12","author":"Di Giorgio","year":"2021","journal-title":"Front. Immunol."},{"key":"B54","doi-asserted-by":"publisher","first-page":"e71570","DOI":"10.1096\/fj.202503014RR","article-title":"MECP2 insufficiency attenuates RUNX2-Dependent osteoblast differentiation via miR-126-3p\/DKK1-Mediated canonical wnt signaling inhibition in Rett syndrome","volume":"40","author":"Dong","year":"2026","journal-title":"FASEB J."},{"key":"B55","doi-asserted-by":"publisher","first-page":"102844","DOI":"10.1016\/j.omtn.2026.102844","article-title":"microRNA-422a promotes HIV replication and innate immune evasion by targeting MECP2","volume":"37","author":"Du","year":"2026","journal-title":"Mol. Ther. Nucleic Acids"},{"key":"B56","doi-asserted-by":"publisher","first-page":"1180","DOI":"10.1016\/j.bbagen.2018.02.005","article-title":"Tyr120Asp mutation alters domain flexibility and dynamics of MeCP2 DNA binding domain leading to impaired DNA interaction: atomistic characterization of a Rett syndrome causing mutation","volume":"1862","author":"D\u2019Annessa","year":"2018","journal-title":"Biochimica Biophysica Acta. General Subj."},{"key":"B57","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1038\/nature12348","article-title":"Activity-dependent phosphorylation of MeCP2 threonine 308 regulates interaction with NCoR","volume":"499","author":"Ebert","year":"2013","journal-title":"Nature"},{"key":"B58","doi-asserted-by":"publisher","first-page":"1844","DOI":"10.1128\/MCB.22.6.1844-1857.2002","article-title":"Precipitous release of Methyl-CpG binding protein 2 and histone deacetylase 1 from the methylated human multidrug resistance gene (MDR1) on activation","volume":"22","author":"El-Osta","year":"2002","journal-title":"Mol. Cell. Biol."},{"key":"B59","doi-asserted-by":"publisher","first-page":"294","DOI":"10.1016\/S0140-6736(24)00360-X","article-title":"Colorectal cancer","volume":"404","author":"Eng","year":"2024","journal-title":"Lancet"},{"key":"B60","doi-asserted-by":"publisher","first-page":"540","DOI":"10.1101\/gr.258400.119","article-title":"Suppressor mutations in Mecp2-Null mice implicate the DNA damage response in Rett syndrome pathology","volume":"30","author":"Enikanolaiye","year":"2020","journal-title":"Genome Res."},{"key":"B61","doi-asserted-by":"publisher","first-page":"1783","DOI":"10.1158\/2159-8290.CD-24-0296","article-title":"The epigenetic hallmarks of cancer","volume":"14","author":"Esteller","year":"2024","journal-title":"Cancer Discov."},{"key":"B62","doi-asserted-by":"publisher","first-page":"3394","DOI":"10.3748\/wjg.v10.i23.3394","article-title":"Expression of Dnmt1, demethylase, MeCP2 and methylation of tumor-related genes in human gastric cancer","volume":"10","author":"Fang","year":"2004","journal-title":"World J. Gastroenterology"},{"key":"B63","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/j.ejim.2023.05.036","article-title":"How epigenetics impacts on human diseases","volume":"114","author":"Farsetti","year":"2023","journal-title":"Eur. J. Intern. Med."},{"key":"B64","doi-asserted-by":"publisher","first-page":"864","DOI":"10.1080\/15476286.2015.1060394","article-title":"The extended AT-Hook is a novel RNA binding motif","volume":"12","author":"Filarsky","year":"2015","journal-title":"RNA Biol."},{"key":"B65","doi-asserted-by":"publisher","first-page":"3114","DOI":"10.1093\/hmg\/ddq214","article-title":"The MeCP2\/YY1 interaction regulates ANT1 expression at 4q35: novel hints for Rett syndrome pathogenesis","volume":"19","author":"Forlani","year":"2010","journal-title":"Hum. Mol. Genet."},{"key":"B66","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1038\/nature14319","article-title":"Disruption of DNA-Methylation-Dependent long gene repression in Rett syndrome","volume":"522","author":"Gabel","year":"2015","journal-title":"Nature"},{"key":"B67","doi-asserted-by":"publisher","first-page":"4395","DOI":"10.1021\/bi9019753","article-title":"Unique physical properties and interactions of the domains of methylated DNA binding protein 2","volume":"49","author":"Ghosh","year":"2010","journal-title":"Biochemistry"},{"key":"B68","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1016\/j.pharmthera.2017.11.002","article-title":"Readers of DNA methylation, the MBD family as potential therapeutic targets","volume":"184","author":"Ginder","year":"2018","journal-title":"Pharmacol. and Ther."},{"key":"B69","doi-asserted-by":"publisher","first-page":"2778","DOI":"10.1038\/s41598-025-86114-8","article-title":"Integrated gene expression and alternative splicing analysis in human and mouse models of Rett syndrome","volume":"15","author":"Gioiosa","year":"2025","journal-title":"Sci. Rep."},{"key":"B70","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1007\/s00018-023-04719-6","article-title":"MiR-422a promotes adipogenesis via MeCP2 downregulation in human bone marrow mesenchymal stem cells","volume":"80","author":"Giuliani","year":"2023","journal-title":"Cell. Mol. Life Sci. CMLS"},{"key":"B71","doi-asserted-by":"publisher","first-page":"5657","DOI":"10.1038\/s41467-019-13527-1","article-title":"DNA methylation directs microRNA biogenesis in mammalian cells","volume":"10","author":"Glaich","year":"2019","journal-title":"Nat. Commun."},{"key":"B72","doi-asserted-by":"publisher","first-page":"2077","DOI":"10.3390\/cells13242077","article-title":"Molecular mechanisms of Rett syndrome: emphasizing the roles of monoamine, immunity, and mitochondrial dysfunction","volume":"13","author":"Gon\u00e7alez","year":"2024","journal-title":"Cells"},{"key":"B73","first-page":"2443","article-title":"DNA methylation regulator-based signature for predicting clear cell renal cell carcinoma prognosis","volume":"15","author":"Gong","year":"2023","journal-title":"Am. J. Transl. Res."},{"key":"B74","doi-asserted-by":"publisher","first-page":"2894","DOI":"10.1128\/MCB.06728-11","article-title":"Phosphorylation of distinct sites in MeCP2 modifies cofactor associations and the dynamics of transcriptional regulation","volume":"32","author":"Gonzales","year":"2012","journal-title":"Mol. Cell. Biol."},{"key":"B75","doi-asserted-by":"publisher","first-page":"ddag031","DOI":"10.1093\/hmg\/ddag031","article-title":"MeCP2 NID interaction with RNA: implications for rett syndrome-relevant protein regulation","volume":"35","author":"Good","year":"2026","journal-title":"Hum. Mol. Genet."},{"key":"B76","doi-asserted-by":"publisher","first-page":"3119","DOI":"10.1038\/onc.2012.331","article-title":"Epigenetic regulation of CD133\/PROM1 expression in glioma stem cells by Sp1\/Myc and promoter methylation","volume":"32","author":"Gopisetty","year":"2013","journal-title":"Oncogene"},{"key":"B77","first-page":"3226","article-title":"Epigenetic silencing of miR-137 induces resistance to bicalutamide by targeting TRIM24 in prostate cancer cells","volume":"11","author":"Guan","year":"2019","journal-title":"Am. J. Transl. Res."},{"key":"B78","doi-asserted-by":"publisher","first-page":"372","DOI":"10.1074\/mcp.O113.027870","article-title":"Immunoaffinity enrichment and mass spectrometry analysis of protein methylation","volume":"13","author":"Guo","year":"2014","journal-title":"Mol. and Cell. Proteomics MCP"},{"key":"B79","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1038\/nn.3607","article-title":"Distribution, recognition and regulation of Non-CpG methylation in the adult mammalian brain","volume":"17","author":"Guo","year":"2014","journal-title":"Nat. Neurosci."},{"key":"B80","doi-asserted-by":"publisher","first-page":"414","DOI":"10.2174\/1568009622666220223115216","article-title":"Increase in cisplatin resistance by MeCP2 in human gastric cancer through the activation of the AKT pathway by facilitating PDK-1 transcription","volume":"22","author":"Guo","year":"2022","journal-title":"Curr. Cancer Drug Targets"},{"key":"B81","doi-asserted-by":"publisher","first-page":"2943","DOI":"10.1016\/j.celrep.2017.02.072","article-title":"Demethylated HSATII DNA and HSATII RNA foci sequester PRC1 and MeCP2 into cancer-specific nuclear bodies","volume":"18","author":"Hall","year":"2017","journal-title":"Cell Rep."},{"key":"B82","doi-asserted-by":"publisher","first-page":"590","DOI":"10.1002\/art.37804","article-title":"Association of an activity-enhancing variant of IRAK1 and an MECP2\u2013IRAK1 haplotype with increased susceptibility to rheumatoid arthritis","volume":"65","author":"Han","year":"2013","journal-title":"Arthritis and Rheumatism"},{"key":"B83","doi-asserted-by":"publisher","first-page":"646559","DOI":"10.3389\/fonc.2021.646559","article-title":"LINC00518 promotes cell proliferation by regulating the cell cycle of lung adenocarcinoma through miR-185-3p targeting MECP2","volume":"11","author":"Han","year":"2021","journal-title":"Front. Oncol."},{"key":"B84","doi-asserted-by":"publisher","first-page":"254","DOI":"10.1038\/ng1516","article-title":"Brahma links the SWI\/SNF chromatin-remodeling complex with MeCP2-Dependent transcriptional silencing","volume":"37","author":"Harikrishnan","year":"2005","journal-title":"Nat. Genet."},{"key":"B85","doi-asserted-by":"publisher","first-page":"288","DOI":"10.1016\/j.isci.2019.06.031","article-title":"Sex-based mhrt methylation chromatinizes MeCP2 in the heart","volume":"17","author":"Harikrishnan","year":"2019","journal-title":"iScience"},{"key":"B86","doi-asserted-by":"publisher","first-page":"e62589","DOI":"10.1371\/journal.pone.0062589","article-title":"Multiple-to-Multiple relationships between microRNAs and target genes in gastric cancer","volume":"8","author":"Hashimoto","year":"2013","journal-title":"PloS One"},{"key":"B87","doi-asserted-by":"publisher","first-page":"6538","DOI":"10.1128\/MCB.18.11.6538","article-title":"Identification and characterization of a family of mammalian Methyl-CpG binding proteins","volume":"18","author":"Hendrich","year":"1998","journal-title":"Mol. Cell. Biol."},{"key":"B88","doi-asserted-by":"publisher","first-page":"251","DOI":"10.17998\/jlc.2025.08.26","article-title":"Association between metabolites and hepatocellular carcinoma: findings from a two-sample Mendelian randomization study","volume":"25","author":"Hoang","year":"2025","journal-title":"J. Liver Cancer"},{"key":"B89","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1038\/ng1491","article-title":"Loss of silent-chromatin looping and impaired imprinting of DLX5 in Rett syndrome","volume":"37","author":"Horike","year":"2005","journal-title":"Nat. Genet."},{"key":"B90","doi-asserted-by":"publisher","first-page":"D261","DOI":"10.1093\/nar\/gkr1122","article-title":"PhosphoSitePlus: a comprehensive resource for investigating the structure and function of experimentally determined post-translational modifications in man and mouse","volume":"40","author":"Hornbeck","year":"2012","journal-title":"Nucleic Acids Res."},{"key":"B91","doi-asserted-by":"publisher","first-page":"962","DOI":"10.1038\/ng0906-962","article-title":"Testing for association between MeCP2 and the brahma-associated SWI\/SNF chromatin-remodeling complex","volume":"38","author":"Hu","year":"2006","journal-title":"Nat. Genet."},{"key":"B92","doi-asserted-by":"publisher","first-page":"2921","DOI":"10.1007\/s00213-022-06176-8","article-title":"The role of MeCP2 and the BDNF\/trkB signaling pathway in the stress resilience of mice subjected to CSDS","volume":"239","author":"Huang","year":"2022","journal-title":"Psychopharmacology"},{"key":"B93","doi-asserted-by":"publisher","first-page":"e560","DOI":"10.1016\/j.wneu.2022.12.063","article-title":"Methyl-CpG binding protein 2 as a potential diagnostic and prognostic marker facilitates glioma progression through activation of Wnt\/\u03b2-Catenin pathway","volume":"171","author":"Huang","year":"2023","journal-title":"World Neurosurg."},{"key":"B94","doi-asserted-by":"publisher","first-page":"225","DOI":"10.2147\/BCTT.S506783","article-title":"Telomere maintenance-related genes are essential for prognosis in breast cancer","volume":"17","author":"Huang","year":"2025","journal-title":"Breast Cancer Targets Ther."},{"key":"B95","doi-asserted-by":"publisher","first-page":"1018","DOI":"10.1002\/glia.22483","article-title":"Involvement of miR-181 in neuroinflammatory responses of astrocytes","volume":"61","author":"Hutchison","year":"2013","journal-title":"Glia"},{"key":"B96","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1124\/mol.110.064311","article-title":"Up-Regulation of the \u03bc-Opioid receptor gene is mediated through chromatin remodeling and transcriptional factors in differentiated neuronal cells","volume":"78","author":"Hwang","year":"2010","journal-title":"Mol. Pharmacol."},{"key":"B97","doi-asserted-by":"publisher","first-page":"13859","DOI":"10.1074\/jbc.M111.309864","article-title":"Methyl CpG-Binding protein isoform MeCP2_e2 is dispensable for Rett syndrome phenotypes but essential for embryo viability and placenta development","volume":"287","author":"Itoh","year":"2012","journal-title":"J. Biol. Chem."},{"key":"B98","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1016\/j.leukres.2014.11.009","article-title":"Azacitidine for the treatment of relapsed and refractory AML in older patients","volume":"39","author":"Itzykson","year":"2015","journal-title":"Leukemia Res."},{"key":"B99","doi-asserted-by":"publisher","first-page":"148","DOI":"10.3390\/genes8060148","article-title":"CpG and Non-CpG methylation in epigenetic gene regulation and brain function","volume":"8","author":"Jang","year":"2017","journal-title":"Genes"},{"key":"B100","doi-asserted-by":"publisher","first-page":"49479","DOI":"10.1074\/jbc.M409070200","article-title":"Components of the DNA methylation system of chromatin control are RNA-binding proteins","volume":"279","author":"Jeffery","year":"2004","journal-title":"J. Biol. Chem."},{"key":"B101","doi-asserted-by":"publisher","first-page":"ra25","DOI":"10.1126\/scisignal.2004824","article-title":"MeCP2 reinforces STAT3 signaling and the generation of effector CD4+ T cells by promoting miR-124-Mediated suppression of SOCS5","volume":"7","author":"Jiang","year":"2014","journal-title":"Sci. Signal."},{"key":"B102","doi-asserted-by":"publisher","first-page":"7959","DOI":"10.1111\/jcmm.15428","article-title":"MeCP2 inhibits proliferation and migration of breast cancer via suppression of epithelial-mesenchymal transition","volume":"24","author":"Jiang","year":"2020","journal-title":"J. Cell. Mol. Med."},{"key":"B103","doi-asserted-by":"publisher","first-page":"5767","DOI":"10.1038\/s41467-021-26084-3","article-title":"Rett syndrome linked to defects in forming the MeCP2\/Rbfox\/LASR complex in mouse models","volume":"12","author":"Jiang","year":"2021","journal-title":"Nat. Commun."},{"key":"B104","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1038\/561","article-title":"Methylated DNA and MeCP2 recruit histone deacetylase to repress transcription","volume":"19","author":"Jones","year":"1998","journal-title":"Nat. Genet."},{"key":"B105","doi-asserted-by":"publisher","first-page":"1721","DOI":"10.1021\/ac7021025","article-title":"Complications in the Assignment of 14 and 28 Da Mass Shift Detected by Mass Spectrometry as in vivo Methylation from Endogenous Proteins","volume":"80","author":"Jung","year":"2008","journal-title":"Anal. Chem."},{"key":"B106","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1093\/hmg\/ddad150","article-title":"MeCP2 ubiquitination and sumoylation, in search of a function","volume":"33","author":"Kalani","year":"2023","journal-title":"Hum. Mol. Genet."},{"key":"B107","doi-asserted-by":"publisher","first-page":"1921","DOI":"10.1093\/nar\/28.9.1921","article-title":"MeCP2 driven transcriptional repression in vitro: selectivity for methylated DNA, action at a distance and contacts with the basal transcription machinery","volume":"28","author":"Kaludov","year":"2000","journal-title":"Nucleic Acids Res."},{"key":"B108","doi-asserted-by":"publisher","first-page":"1413","DOI":"10.3892\/or.2019.7275","article-title":"High expression of bone morphogenetic protein (BMP) 6 and BMP7 are associated with higher immune cell infiltration and better survival in estrogen receptor-positive breast cancer","volume":"42","author":"Katsuta","year":"2019","journal-title":"Oncol. Rep."},{"key":"B109","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1016\/j.devcel.2009.12.017","article-title":"ATRX partners with cohesin and MeCP2 and contributes to developmental silencing of imprinted genes in the brain","volume":"18","author":"Kernohan","year":"2010","journal-title":"Dev. Cell"},{"key":"B110","doi-asserted-by":"publisher","first-page":"8356","DOI":"10.1093\/nar\/gku564","article-title":"Analysis of neonatal brain lacking ATRX or MeCP2 reveals changes in nucleosome density, CTCF binding and chromatin looping","volume":"42","author":"Kernohan","year":"2014","journal-title":"Nucleic Acids Res."},{"key":"B111","doi-asserted-by":"publisher","first-page":"1028","DOI":"10.1080\/15592294.2017.1391429","article-title":"MeCP2 interacts with chromosomal microRNAs in brain","volume":"12","author":"Khan","year":"2017","journal-title":"Epigenetics"},{"key":"B112","doi-asserted-by":"publisher","first-page":"1186","DOI":"10.1158\/1940-6207.CAPR-14-0127","article-title":"Epigenetic DNA methylation of antioxidative stress regulator NRF2 in human prostate cancer","volume":"7","author":"Khor","year":"2014","journal-title":"Cancer Prev. Res. Phila. Pa."},{"key":"B113","doi-asserted-by":"publisher","first-page":"3379","DOI":"10.1021\/bi500424z","article-title":"Unusual characteristics of the DNA binding domain of epigenetic regulatory protein MeCP2 determine its binding specificity","volume":"53","author":"Khrapunov","year":"2014","journal-title":"Biochemistry"},{"key":"B114","doi-asserted-by":"publisher","first-page":"C857","DOI":"10.1152\/ajpcell.00169.2006","article-title":"Epigenetic regulation of integrin-linked kinase expression depending on adhesion of gastric carcinoma cells","volume":"292","author":"Kim","year":"2007","journal-title":"Am. J. Physiology-Cell Physiology"},{"key":"B115","doi-asserted-by":"publisher","first-page":"4195","DOI":"10.18632\/oncotarget.6549","article-title":"Epigenetic modification of TLR4 promotes activation of NF-\u03baB by regulating methyl-cpg-binding domain protein 2 and Sp1 in gastric cancer","volume":"7","author":"Kim","year":"2016","journal-title":"Oncotarget"},{"key":"B116","doi-asserted-by":"publisher","first-page":"4806","DOI":"10.1074\/jbc.M209923200","article-title":"Methyl-CpG-Binding protein, MeCP2, is a target molecule for maintenance DNA methyltransferase, Dnmt1","volume":"278","author":"Kimura","year":"2003","journal-title":"J. Biol. Chem."},{"key":"B117","doi-asserted-by":"publisher","first-page":"15114","DOI":"10.1073\/pnas.1618737114","article-title":"DNA methylation in the gene body influences MeCP2-Mediated gene repression","volume":"113","author":"Kinde","year":"2016","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"B118","doi-asserted-by":"publisher","first-page":"1034","DOI":"10.1086\/339553","article-title":"A mutation hot spot for nonspecific X-Linked mental retardation in the MECP2 gene causes the PPM-X syndrome","volume":"70","author":"Klauck","year":"2002","journal-title":"Am. J. Hum. Genet."},{"key":"B119","doi-asserted-by":"publisher","first-page":"1513","DOI":"10.1038\/nn2010","article-title":"Homeostatic regulation of MeCP2 expression by a CREB-induced microRNA","volume":"10","author":"Klein","year":"2007","journal-title":"Nat. Neurosci."},{"key":"B120","doi-asserted-by":"publisher","first-page":"667","DOI":"10.1016\/j.molcel.2005.07.021","article-title":"DNA binding selectivity of MeCP2 due to a requirement for A\/T sequences adjacent to Methyl-CpG","volume":"19","author":"Klose","year":"2005","journal-title":"Mol. Cell"},{"key":"B121","doi-asserted-by":"publisher","first-page":"989","DOI":"10.4161\/cbt.3.10.1137","article-title":"Expression analysis of the epigenetic methyltransferases and Methyl-CpG binding protein families in the normal B-Cell and B-Cell chronic lymphocytic leukemia (CLL)","volume":"3","author":"Kn","year":"2004","journal-title":"Cancer Biol. and Ther."},{"key":"B122","doi-asserted-by":"publisher","first-page":"5011","DOI":"10.1021\/bi0359271","article-title":"DNA binding of methyl-cpg-binding protein MeCP2 in human MCF7 cells","volume":"43","author":"Koch","year":"2004","journal-title":"Biochemistry"},{"key":"B123","doi-asserted-by":"publisher","first-page":"34115","DOI":"10.1074\/jbc.M105747200","article-title":"The ski protein family is required for MeCP2-Mediated transcriptional repression","volume":"276","author":"Kokura","year":"2001","journal-title":"J. Biol. Chem."},{"key":"B124","doi-asserted-by":"publisher","first-page":"4509","DOI":"10.1038\/sj.onc.1206695","article-title":"Promoter methylation and silencing of the tissue factor pathway Inhibitor-2 (TFPI-2), a gene encoding an inhibitor of matrix metalloproteinases in human glioma cells","volume":"22","author":"Konduri","year":"2003","journal-title":"Oncogene"},{"key":"B125","doi-asserted-by":"publisher","first-page":"1818","DOI":"10.1093\/nar\/gkh349","article-title":"The major form of MeCP2 has a novel N-Terminus generated by alternative splicing","volume":"32","author":"Kriaucionis","year":"2004","journal-title":"Nucleic Acids Res."},{"key":"B126","doi-asserted-by":"publisher","first-page":"11596","DOI":"10.1128\/jvi.76.22.11596-11604.2002","article-title":"Protein interactions targeting the latency-associated nuclear antigen of kaposi\u2019s sarcoma-associated herpesvirus to cell chromosomes","volume":"76","author":"Krithivas","year":"2002","journal-title":"J. Virology"},{"key":"B127","doi-asserted-by":"publisher","first-page":"e6953","DOI":"10.1371\/journal.pone.0006953","article-title":"Insulin gene expression is regulated by DNA methylation","volume":"4","author":"Kuroda","year":"2009","journal-title":"PloS One"},{"key":"B128","doi-asserted-by":"publisher","first-page":"3029","DOI":"10.1093\/hmg\/ddw156","article-title":"MeCP2 Co-Ordinates liver lipid metabolism with the NCoR1\/HDAC3 corepressor complex","volume":"25","author":"Kyle","year":"2016","journal-title":"Hum. Mol. Genet."},{"key":"B129","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1111\/j.1399-0004.2012.01861.x","article-title":"MEF2C mutations are a rare cause of rett or severe rett-Like encephalopathies","volume":"82","author":"Lambert","year":"2012","journal-title":"Clin. Genet."},{"key":"B130","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1007\/s00412-021-00753-0","article-title":"Ectopic expression of pericentric HSATII RNA results in nuclear RNA accumulation, MeCP2 recruitment, and cell division defects","volume":"130","author":"Landers","year":"2021","journal-title":"Chromosoma"},{"key":"B131","doi-asserted-by":"publisher","first-page":"350","DOI":"10.1002\/pros.23274","article-title":"Promoter CpG-Site methylation of the KAI1 metastasis suppressor gene contributes to its epigenetic repression in prostate cancer","volume":"77","author":"Lee","year":"2017","journal-title":"Prostate"},{"key":"B132","doi-asserted-by":"publisher","first-page":"3140","DOI":"10.1038\/s41467-020-16907-0","article-title":"MeCP2 regulates gene expression through recognition of H3K27me3","volume":"11","author":"Lee","year":"2020","journal-title":"Nat. Commun."},{"key":"B133","doi-asserted-by":"publisher","first-page":"378","DOI":"10.1158\/1541-7786.MCR-11-0314","article-title":"The stress oncoprotein LEDGF\/P75 interacts with the methyl CpG binding protein MeCP2 and influences its transcriptional activity","volume":"10","author":"Leoh","year":"2012","journal-title":"Mol. Cancer Res. MCR"},{"key":"B134","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1016\/j.str.2024.10.016","article-title":"LEDGF interacts with the NID domain of MeCP2 and modulates MeCP2 condensates","volume":"33","author":"Lesire","year":"2025","journal-title":"Struct. Lond. Engl."},{"key":"B135","doi-asserted-by":"publisher","first-page":"905","DOI":"10.1016\/0092-8674(92)90610-O","article-title":"Purification, sequence, and cellular localization of a novel chromosomal protein that binds to methylated DNA","volume":"69","author":"Lewis","year":"1992","journal-title":"Cell"},{"key":"B136","doi-asserted-by":"publisher","first-page":"e1006129","DOI":"10.1371\/journal.pgen.1006129","article-title":"Misregulation of alternative splicing in a mouse model of Rett syndrome","volume":"12","author":"Li","year":"2016","journal-title":"PLoS Genet."},{"key":"B137","first-page":"1356","article-title":"MeCP2 level is associated with hepatocellular carcinoma development in chronic hepatitis B patients under antiviral therapy","volume":"11","author":"Li","year":"2018","journal-title":"Int. J. Clin. Exp. Pathology"},{"key":"B138","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1016\/j.ebiom.2018.07.013","article-title":"The long noncoding RNA MEG3 and its target miR-147 regulate JAK\/STAT pathway in advanced chronic myeloid leukemia","volume":"34","author":"Li","year":"2018","journal-title":"EBioMedicine"},{"key":"B139","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1038\/s41389-019-0135-1","article-title":"Hypomethylation at non-CpG\/CpG sites in the promoter of HIF-1\u03b1 gene combined with enhanced H3K9Ac modification contribute to maintain higher HIF-1\u03b1 expression in breast cancer","volume":"8","author":"Li","year":"2019","journal-title":"Oncogenesis"},{"key":"B140","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1016\/j.yexcr.2018.12.020","article-title":"MeCP2 promotes endothelial-to-mesenchymal transition in human endothelial cells by downregulating BMP7 expression","volume":"375","author":"Li","year":"2019","journal-title":"Exp. Cell Res."},{"key":"B141","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1080\/1354750X.2021.1903999","article-title":"MeCP2 attenuates cardiomyocyte Hypoxia\/reperfusion-induced injury via regulation of the SFRP4\/Wnt\/\u03b2-Catenin axis","volume":"26","author":"Li","year":"2021","journal-title":"Biomarkers Biochem. Indic. Expo. Response, Susceptibility Chem."},{"key":"B142","doi-asserted-by":"publisher","first-page":"778","DOI":"10.1038\/s41590-024-01811-2","article-title":"MEF2C regulates NK cell effector functions through control of lipid metabolism","volume":"25","author":"Li J.","year":"2024","journal-title":"Nat. Immunol."},{"key":"B143","doi-asserted-by":"publisher","first-page":"1370254","DOI":"10.3389\/fimmu.2024.1370254","article-title":"Autoimmune and neuropsychiatric phenotypes in a Mecp2 transgenic mouse model on C57BL\/6 background","volume":"15","author":"Li Y.","year":"2024","journal-title":"Front. Immunol."},{"key":"B144","doi-asserted-by":"publisher","first-page":"3365","DOI":"10.18632\/oncotarget.22973","article-title":"MAGE-A11 is activated through TFCP2\/ZEB1 binding sites de-Methylation as well as histone modification and facilitates ESCC tumor growth","volume":"9","author":"Liu","year":"2018","journal-title":"Oncotarget"},{"key":"B145","first-page":"4277","article-title":"Silencing miR-454 suppresses cell proliferation, migration and invasion via directly targeting MECP2 in renal cell carcinoma","volume":"12","author":"Liu","year":"2020","journal-title":"Am. J. Transl. Res."},{"key":"B146","first-page":"1578","article-title":"A genome-wide analysis reveals the MeCP2-Dependent regulation of genes in BGC-823 cells","volume":"13","author":"Liu","year":"2020","journal-title":"Int. J. Clin. Exp. Pathology"},{"key":"B147","doi-asserted-by":"publisher","first-page":"1943","DOI":"10.1016\/j.neuron.2024.04.007","article-title":"MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons","volume":"112","author":"Liu","year":"2024","journal-title":"Neuron"},{"key":"B148","doi-asserted-by":"crossref","DOI":"10.1007\/978-3-031-89525-8_9","article-title":"Rett syndrome: thinking beyond brain borders","volume-title":"Brain-Body Connections: Bidirectional Communication Between the Brain and Body Systems","author":"Liu","year":""},{"key":"B149","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41583-025-00926-1","article-title":"Exploring the complexity of MECP2 function in Rett syndrome","volume":"13","author":"Liu","year":"","journal-title":"Nat. Rev. Neurosci."},{"key":"B150","doi-asserted-by":"publisher","first-page":"eadg7112","DOI":"10.1126\/sciadv.adg7112","article-title":"FOXA1 O-GlcNAcylation\u2013Mediated transcriptional switch governs metastasis capacity in breast cancer","volume":"9","author":"Liu","year":"2026","journal-title":"Sci. Adv."},{"key":"B151","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1038\/s41572-020-00240-3","article-title":"Hepatocellular carcinoma","volume":"7","author":"Llovet","year":"2021","journal-title":"Nat. Rev. Dis. Prim."},{"key":"B152","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1007\/s12031-023-02177-0","article-title":"Transcriptional inhibition of the Mecp2 promoter by MeCP2E1 and MeCP2E2 isoforms suggests negative auto-regulatory feedback that can be moderated by metformin","volume":"74","author":"Lockman","year":"2024","journal-title":"J. Mol. Neurosci."},{"key":"B153","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1042\/BSR20100124","article-title":"A brain-derived MeCP2 complex supports a role for MeCP2 in RNA processing","volume":"31","author":"Long","year":"2011","journal-title":"Biosci. Rep."},{"key":"B154","doi-asserted-by":"publisher","first-page":"1747","DOI":"10.1126\/science.1076469","article-title":"Corepressor-dependent silencing of chromosomal regions encoding neuronal genes","volume":"298","author":"Lunyak","year":"2002","journal-title":"Science"},{"key":"B155","doi-asserted-by":"publisher","first-page":"758","DOI":"10.3390\/cancers12030758","article-title":"MeCP2 promotes colorectal cancer metastasis by modulating ZEB1 transcription","volume":"12","author":"Luo","year":"2020","journal-title":"Cancers"},{"key":"B156","doi-asserted-by":"publisher","first-page":"3225","DOI":"10.1038\/s41467-026-71432-w","article-title":"MeCP2 gene dosage-dependent neurodevelopmentally restricted defects arise by aberrant activation of cell fate-determining bivalent genes","volume":"17","author":"Luoni","year":"2026","journal-title":"Nat. Commun."},{"key":"B157","doi-asserted-by":"publisher","first-page":"898","DOI":"10.1038\/nn.3434","article-title":"Rett syndrome mutations abolish the interaction of MeCP2 with the NCoR\/SMRT Co-Repressor","volume":"16","author":"Lyst","year":"2013","journal-title":"Nat. Neurosci."},{"key":"B158","doi-asserted-by":"publisher","first-page":"1585","DOI":"10.1096\/fj.14.11.1585","article-title":"Regional methylation of the 5\u2019 end CpG island of BRCA1 is associated with reduced gene expression in human somatic cells","volume":"14","author":"Magdinier","year":"2000","journal-title":"FASEB J."},{"key":"B159","doi-asserted-by":"publisher","first-page":"489","DOI":"10.3389\/fonc.2019.00489","article-title":"DNA methylation readers and cancer: mechanistic and therapeutic applications","volume":"9","author":"Mahmood","year":"2019","journal-title":"Front. Oncol."},{"key":"B160","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1038\/sj.cdd.4401979","article-title":"Regulation of myofibroblast transdifferentiation by DNA methylation and MeCP2: implications for wound healing and fibrogenesis","volume":"14","author":"Mann","year":"2007","journal-title":"Cell Death and Differ."},{"key":"B161","doi-asserted-by":"publisher","first-page":"112148","DOI":"10.1016\/j.celrep.2023.112148","article-title":"DDX47, MeCP2, and other functionally heterogeneous factors protect cells from harmful R loops","volume":"42","author":"Marchena-Cruz","year":"2023","journal-title":"Cell Rep."},{"key":"B162","doi-asserted-by":"publisher","first-page":"2318","DOI":"10.1128\/JVI.01097-09","article-title":"The latency-associated nuclear antigen interacts with MeCP2 and nucleosomes through separate domains","volume":"84","author":"Matsumura","year":"2010","journal-title":"J. Virology"},{"key":"B163","doi-asserted-by":"publisher","first-page":"676","DOI":"10.1016\/j.tig.2022.03.010","article-title":"DNA methylation: a historical perspective","volume":"38","author":"Mattei","year":"2022","journal-title":"Trends Genet."},{"key":"B164","doi-asserted-by":"publisher","first-page":"1256","DOI":"10.1038\/cr.2013.110","article-title":"Intragenic DNA methylation modulates alternative splicing by recruiting MeCP2 to promote exon recognition","volume":"23","author":"Maunakea","year":"2013","journal-title":"Cell Res."},{"key":"B165","doi-asserted-by":"publisher","first-page":"1741","DOI":"10.4161\/rna.26921","article-title":"Chromatin context and ncRNA highlight targets of MeCP2 in brain","volume":"10","author":"Maxwell","year":"2013","journal-title":"RNA Biol."},{"key":"B166","doi-asserted-by":"publisher","first-page":"113299","DOI":"10.1016\/j.isci.2025.113299","article-title":"SELEX identifies high-affinity RNA targets for chromatin-binding proteins PARP1 and MeCP2","volume":"28","author":"Melikishvili","year":"2025","journal-title":"iScience"},{"key":"B167","doi-asserted-by":"publisher","first-page":"113227","DOI":"10.1016\/j.jbc.2026.113227","article-title":"DNA methylation, nucleic acid structure, and rett mutations tune MeCP2 binding affinity and cooperativity","volume":"4","author":"Melikishvili","year":"2026","journal-title":"J. Biol. Chem."},{"key":"B168","doi-asserted-by":"publisher","first-page":"1417","DOI":"10.1016\/j.cell.2012.11.022","article-title":"MeCP2 binds to 5hmC enriched within active genes and accessible chromatin in the nervous system","volume":"151","author":"Mell\u00e9n","year":"2012","journal-title":"Cell"},{"key":"B169","doi-asserted-by":"publisher","first-page":"11819","DOI":"10.1007\/s13277-014-2336-8","article-title":"Epigenetic silencing of methyl-cpg-binding protein 2 gene affects proliferation, invasion, migration, and apoptosis of human osteosarcoma cells","volume":"35","author":"Meng","year":"2014","journal-title":"Tumor Biol."},{"key":"B170","doi-asserted-by":"publisher","first-page":"3009","DOI":"10.1007\/s13277-014-2935-4","article-title":"Preliminary screening of differentially expressed genes involved in methyl-cpg-binding protein 2 gene-mediated proliferation in human osteosarcoma cells","volume":"36","author":"Meng","year":"2015","journal-title":"Tumor Biol."},{"key":"B171","doi-asserted-by":"publisher","first-page":"598","DOI":"10.1016\/j.cellsig.2012.11.023","article-title":"MeCP2 modulates the canonical wnt pathway activation by targeting SFRP4 in rheumatoid arthritis fibroblast-like synoviocytes in rats","volume":"25","author":"Miao","year":"2013","journal-title":"Cell. Signal."},{"key":"B172","doi-asserted-by":"publisher","first-page":"e1354","DOI":"10.1371\/journal.pone.0001354","article-title":"High levels of MeCP2 depress MHC class I expression in neuronal cells","volume":"2","author":"Miralv\u00e8s","year":"2007","journal-title":"PloS One"},{"key":"B173","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1038\/ng1327","article-title":"A previously unidentified MECP2 open reading frame defines a new protein isoform relevant to Rett syndrome","volume":"36","author":"Mnatzakanian","year":"2004","journal-title":"Nat. Genet."},{"key":"B174","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1038\/npp.2012.112","article-title":"DNA methylation and its basic function","volume":"38","author":"Moore","year":"2013","journal-title":"Neuropsychopharmacology"},{"key":"B175","doi-asserted-by":"publisher","first-page":"1398","DOI":"10.1053\/j.gastro.2019.07.029","article-title":"Fibrogenic activity of MECP2 is regulated by phosphorylation in hepatic stellate cells","volume":"157","author":"Moran-Salvador","year":"2019","journal-title":"Gastroenterology"},{"key":"B176","doi-asserted-by":"publisher","first-page":"1934","DOI":"10.1038\/sj.bjc.6601392","article-title":"MeCP2 and MBD2 expression in human neoplastic and non-neoplastic breast tissue and its association with oestrogen receptor status","volume":"89","author":"M\u00fcller","year":"2003","journal-title":"Br. J. Cancer"},{"key":"B177","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1186\/1471-2407-10-297","article-title":"Promoter- and cell-specific epigenetic regulation of CD44, cyclin D2, GLIPR1 and PTEN by Methyl-CpG binding proteins and histone modifications","volume":"10","author":"M\u00fcller","year":"2010","journal-title":"BMC Cancer"},{"key":"B178","doi-asserted-by":"publisher","first-page":"1168","DOI":"10.1054\/bjoc.2001.2041","article-title":"Loss of expression of HDAC-recruiting methyl-cpg-binding domain proteins in human cancer","volume":"85","author":"M\u00fcller-Tidow","year":"2001","journal-title":"Br. J. Cancer"},{"key":"B179","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1038\/nature09544","article-title":"L1 retrotransposition in neurons is modulated by MeCP2","volume":"468","author":"Muotri","year":"2010","journal-title":"Nature"},{"key":"B180","doi-asserted-by":"publisher","first-page":"e3003444","DOI":"10.1371\/journal.pbio.3003444","article-title":"PRMT5 regulates alternative splicing of TCF3 under hypoxia to promote EMT and invasion in breast cancer","volume":"23","author":"Mutnuru","year":"2025","journal-title":"PLOS Biol."},{"key":"B181","doi-asserted-by":"publisher","first-page":"4886","DOI":"10.1093\/nar\/21.21.4886","article-title":"Dissection of the Methyl-CpG binding domain from the chromosomal protein MeCP2","volume":"21","author":"Nan","year":"1993","journal-title":"Nucleic Acids Res."},{"key":"B182","doi-asserted-by":"publisher","first-page":"471","DOI":"10.1016\/S0092-8674(00)81887-5","article-title":"MeCP2 is a transcriptional repressor with abundant binding sites in genomic chromatin","volume":"88","author":"Nan","year":"1997","journal-title":"Cell"},{"key":"B183","doi-asserted-by":"publisher","first-page":"386","DOI":"10.1038\/30764","article-title":"Transcriptional repression by the methyl-cpg-binding protein MeCP2 involves a histone deacetylase complex","volume":"393","author":"Nan","year":"1998","journal-title":"Nature"},{"key":"B184","doi-asserted-by":"publisher","first-page":"2709","DOI":"10.1073\/pnas.0608056104","article-title":"Interaction between chromatin proteins MECP2 and ATRX is disrupted by mutations that cause inherited mental retardation","volume":"104","author":"Nan","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"B185","doi-asserted-by":"publisher","first-page":"2683","DOI":"10.3390\/cancers15102683","article-title":"The epigenetic reader methyl-cpg-binding protein 2 (MeCP2) is an emerging oncogene in cancer biology","volume":"15","author":"Nejati-Koshki","year":"2023","journal-title":"Cancers"},{"key":"B186","doi-asserted-by":"publisher","first-page":"113538","DOI":"10.1016\/j.celrep.2023.113538","article-title":"MeCP2 represses the activity of topoisomerase II\u03b2 in long neuronal genes","volume":"42","author":"Nettles","year":"2023","journal-title":"Cell Rep."},{"key":"B187","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1158\/2159-8290.CD-15-0341","article-title":"MECP2 is a frequently amplified oncogene with a novel epigenetic mechanism that mimics the role of activated RAS in malignancy","volume":"6","author":"Neupane","year":"2016","journal-title":"Cancer Discov."},{"key":"B188","doi-asserted-by":"publisher","first-page":"3636","DOI":"10.1093\/nar\/gkae051","article-title":"Extending MeCP2 interactome: canonical nucleosomal histones interact with MeCP2","volume":"52","author":"Ortega-Alarcon","year":"2024","journal-title":"Nucleic Acids Res."},{"key":"B189","doi-asserted-by":"publisher","first-page":"E5363","DOI":"10.1073\/pnas.1722546115","article-title":"Activity-dependent aberrations in gene expression and alternative splicing in a mouse model of Rett syndrome","volume":"115","author":"Osenberg","year":"2018","journal-title":"Proc. Natl. Acad. Sci."},{"key":"B190","doi-asserted-by":"publisher","first-page":"3319","DOI":"10.3390\/ijms26073319","article-title":"SRSF9-Mediated exon recognition promotes exon 2 inclusion in Mecp2 Pre-mRNA alternative splicing","volume":"26","author":"Oshizuki","year":"2025","journal-title":"Int. J. Mol. Sci."},{"key":"B191","doi-asserted-by":"publisher","first-page":"3779","DOI":"10.1158\/0008-5472.CAN-08-1976","article-title":"A tumor-protective role for human kallikrein-related peptidase 6 in breast cancer mediated by inhibition of epithelial-to-mesenchymal transition","volume":"69","author":"Pampalakis","year":"2009","journal-title":"Cancer Res."},{"key":"B192","doi-asserted-by":"publisher","first-page":"3645","DOI":"10.26355\/eurrev_201905_17788","article-title":"Upregulated exosomal miR-221\/222 promotes cervical cancer via repressing methyl-cpg-binding domain protein 2","volume":"23","author":"Pan","year":"2019","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"B193","doi-asserted-by":"publisher","first-page":"408","DOI":"10.18632\/genesandcancer.84","article-title":"A novel MeCP2 acetylation site regulates interaction with ATRX and HDAC1","volume":"6","author":"Pandey","year":"2015","journal-title":"Genes and Cancer"},{"key":"B194","doi-asserted-by":"publisher","first-page":"3880","DOI":"10.1038\/s41467-024-47395-1","article-title":"MeCP2 binds to methylated DNA independently of phase separation and heterochromatin organisation","volume":"15","author":"Pantier","year":"2024","journal-title":"Nat. Commun."},{"key":"B195","doi-asserted-by":"publisher","first-page":"759","DOI":"10.1016\/s0006-291x(03)00253-5","article-title":"Methyl-CpG-DNA binding proteins in human prostate cancer: expression of CXXC sequence containing MBD1 and repression of MBD2 and MeCP2","volume":"302","author":"Patra","year":"2003","journal-title":"Biochem. Biophysical Res. Commun."},{"key":"B196","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1016\/j.freeradbiomed.2020.02.023","article-title":"Compromised immune\/inflammatory responses in Rett syndrome","volume":"152","author":"Pecorelli","year":"2020","journal-title":"Free Radic. Biol. Med."},{"key":"B197","doi-asserted-by":"publisher","first-page":"112637","DOI":"10.1016\/j.mce.2025.112637","article-title":"MeCP2 attenuates inflammation and regulates T cell phenotype via SFRP4 suppression in preeclampsia","volume":"609","author":"Peng","year":"2025","journal-title":"Mol. Cell. Endocrinol."},{"key":"B198","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1016\/j.yexcr.2004.04.024","article-title":"DNA methylation control of tissue polarity and cellular differentiation in the mammary epithelium","volume":"298","author":"Plachot","year":"2004","journal-title":"Exp. Cell Res."},{"key":"B199","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/bs.pmbts.2016.09.001","article-title":"Molecular and cellular changes during cancer progression resulting from genetic and epigenetic alterations","volume":"144","author":"Pruitt","year":"2016","journal-title":"Prog. Mol. Biol. Transl. Sci."},{"key":"B200","doi-asserted-by":"publisher","first-page":"5229","DOI":"10.1038\/sj.onc.1210329","article-title":"Epigenetic inactivation of the tissue inhibitor of Metalloproteinase-2 (TIMP-2) gene in human prostate tumors","volume":"26","author":"Pulukuri","year":"2007","journal-title":"Oncogene"},{"key":"B201","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1186\/s13148-015-0131-z","article-title":"Epigenetic synergy between decitabine and platinum derivatives","volume":"7","author":"Qin","year":"2015","journal-title":"Clin. Epigenetics"},{"key":"B202","doi-asserted-by":"publisher","first-page":"306","DOI":"10.1093\/glycob\/cwx006","article-title":"MeCP2 regulated glycogenes contribute to proliferation and apoptosis of gastric cancer cells","volume":"27","author":"Qin","year":"2017","journal-title":"Glycobiology"},{"key":"B203","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1186\/s12935-022-02489-y","article-title":"MeCP2 confers 5-Fluorouracil resistance in gastric cancer via upregulating the NOX4\/PKM2 pathway","volume":"22","author":"Qin","year":"2022","journal-title":"Cancer Cell Int."},{"key":"B204","doi-asserted-by":"publisher","first-page":"1527","DOI":"10.1158\/0008-5472.CAN-08-3609","article-title":"Methylation-mediated repression of GADD45alpha in prostate cancer and its role as a potential therapeutic target","volume":"69","author":"Ramachandran","year":"2009","journal-title":"Cancer Res."},{"key":"B205","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1007\/s12253-011-9423-6","article-title":"P53 binds to estrogen receptor 1 promoter in human breast cancer cells","volume":"18","author":"Rasti","year":"2012","journal-title":"Pathology and Oncol. Res."},{"key":"B206","doi-asserted-by":"publisher","first-page":"736","DOI":"10.1158\/0008-5472.CAN-12-2601","article-title":"Epigenetic regulation by Z-DNA silencer function controls cancer-associated ADAM-12 expression in breast cancer: cross-talk between MeCP2 and NF1 transcription factor family","volume":"73","author":"Ray","year":"2013","journal-title":"Cancer Res."},{"key":"B207","doi-asserted-by":"publisher","first-page":"1494","DOI":"10.1158\/0008-5472.CAN-14-2391","article-title":"Targeting calcium signaling induces epigenetic reactivation of tumor suppressor genes in cancer","volume":"76","author":"Raynal","year":"2016","journal-title":"Cancer Res."},{"key":"B208","doi-asserted-by":"publisher","first-page":"4894","DOI":"10.1038\/sj.onc.1208662","article-title":"Multiple mechanisms induce transcriptional silencing of a subset of genes, including oestrogen receptor \u03b1, in response to deacetylase inhibition by valproic acid and trichostatin A","volume":"24","author":"Reid","year":"2005","journal-title":"Oncogene"},{"key":"B209","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1007\/s00018-024-05185-4","article-title":"CRL4DCAF13 E3 ubiquitin ligase targets MeCP2 for degradation to prevent DNA hypermethylation and ensure normal transcription in growing oocytes","volume":"81","author":"Ren","year":"2024","journal-title":"Cell. Mol. Life Sci. CMLS"},{"key":"B210","doi-asserted-by":"publisher","first-page":"720","DOI":"10.1016\/j.celrep.2016.09.049","article-title":"MECP2 is post-transcriptionally regulated during human neurodevelopment by combinatorial action of RNA-binding proteins and miRNAs","volume":"17","author":"Rodrigues","year":"2016","journal-title":"Cell Rep."},{"key":"B211","doi-asserted-by":"publisher","first-page":"1001","DOI":"10.1001\/jama.2024.12848","article-title":"Renal cell carcinoma: a review","volume":"332","author":"Rose","year":"2024","journal-title":"JAMA"},{"key":"B212","doi-asserted-by":"publisher","first-page":"1136","DOI":"10.1038\/s41467-017-01062-w","article-title":"Resistance to checkpoint blockade therapy through inactivation of antigen presentation","volume":"8","author":"Sade-Feldman","year":"2017","journal-title":"Nat. Commun."},{"key":"B213","doi-asserted-by":"publisher","first-page":"561","DOI":"10.1053\/jhep.2001.22507","article-title":"Expression of mRNA for DNA methyltransferases and methyl-cpg-binding proteins and DNA methylation status on CpG islands and pericentromeric satellite regions during human hepatocarcinogenesis","volume":"33","author":"Saito","year":"2001","journal-title":"Hepatol. Baltim. Md"},{"key":"B214","doi-asserted-by":"publisher","first-page":"4822","DOI":"10.1038\/sj.onc.1205581","article-title":"The expression of DNA methyltransferases and methyl-cpg-binding proteins is not associated with the methylation status of p14ARF, p16INK4a and RASSF1A in human lung cancer cell lines","volume":"21","author":"Sato","year":"2002","journal-title":"Oncogene"},{"key":"B215","doi-asserted-by":"publisher","first-page":"870","DOI":"10.1177\/0961203313497119","article-title":"Overexpression of methyl-cpg-binding protein 2 and autoimmunity: evidence from MECP2 duplication syndrome, lupus, MECP2 transgenic and Mecp2 deficient mice","volume":"22","author":"Sawalha","year":"2013","journal-title":"Lupus"},{"key":"B216","doi-asserted-by":"publisher","first-page":"e1727","DOI":"10.1371\/journal.pone.0001727","article-title":"Common variants within MECP2 confer risk of systemic lupus erythematosus","volume":"3","author":"Sawalha","year":"2008","journal-title":"PloS One"},{"key":"B217","doi-asserted-by":"publisher","first-page":"941493","DOI":"10.3389\/fcell.2022.941493","article-title":"MeCP2 heterochromatin organization is modulated by arginine methylation and serine phosphorylation","volume":"10","author":"Schmidt","year":"2022","journal-title":"Front. Cell Dev. Biol."},{"key":"B218","doi-asserted-by":"publisher","first-page":"889","DOI":"10.1007\/s40265-016-0585-0","article-title":"Azacitidine: a review in myelodysplastic syndromes and acute myeloid leukaemia","volume":"76","author":"Scott","year":"2016","journal-title":"Drugs"},{"key":"B219","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.toxlet.2023.04.004","article-title":"Epigenetic reader MeCP2 repressed WIF1 boosts lung fibroblast proliferation, migration and pulmonary fibrosis","volume":"381","author":"Sha","year":"2023","journal-title":"Toxicol. Lett."},{"key":"B220","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1093\/hmg\/11.2.115","article-title":"Insight into Rett syndrome: MeCP2 levels display Tissue- and cell-specific differences and correlate with neuronal maturation","volume":"11","author":"Shahbazian","year":"2002","journal-title":"Hum. Mol. Genet."},{"key":"B221","doi-asserted-by":"publisher","first-page":"1740","DOI":"10.1210\/me.2004-0011","article-title":"Release of methyl CpG binding proteins and histone deacetylase 1 from the estrogen receptor \u03b1 (ER) promoter upon reactivation in ER-Negative human breast cancer cells","volume":"19","author":"Sharma","year":"2005","journal-title":"Mol. Endocrinol."},{"key":"B222","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1016\/j.neulet.2018.03.020","article-title":"MeCP2 overexpression inhibits proliferation, migration and invasion of C6 glioma by modulating ERK signaling and gene expression","volume":"674","author":"Sharma","year":"","journal-title":"Neurosci. Lett."},{"key":"B223","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1007\/s12031-018-1112-4","article-title":"MeCP2 differentially regulate the myelin MBP and PLP protein expression in oligodendrocytes and C6 glioma","volume":"65","author":"Sharma","year":"","journal-title":"J. Mol. Neurosci. MN"},{"key":"B224","doi-asserted-by":"publisher","first-page":"4132","DOI":"10.1093\/hmg\/ddx300","article-title":"MeCP2_E1 N-Terminal modifications affect its degradation rate and are disrupted by the Ala2Val rett mutation","volume":"26","author":"Sheikh","year":"2017","journal-title":"Hum. Mol. Genet."},{"key":"B225","doi-asserted-by":"publisher","first-page":"606","DOI":"10.1208\/s12248-011-9300-y","article-title":"Epigenetic CpG demethylation of the promoter and reactivation of the expression of Neurog1 by curcumin in prostate LNCaP cells","volume":"13","author":"Shu","year":"2011","journal-title":"AAPS J."},{"key":"B226","doi-asserted-by":"publisher","first-page":"12","DOI":"10.3322\/caac.21820","article-title":"Cancer statistics, 2024","volume":"74","author":"Siegel","year":"2024","journal-title":"CA A Cancer J. Clin."},{"key":"B227","doi-asserted-by":"publisher","first-page":"621","DOI":"10.1016\/j.omtn.2021.12.030","article-title":"Analysis of the circRNA and T-UCR populations identifies convergent pathways in mouse and human models of Rett syndrome","volume":"27","author":"Siqueira","year":"2021","journal-title":"Mol. Ther. Nucleic Acids"},{"key":"B228","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1016\/j.molcel.2010.01.030","article-title":"Neuronal MeCP2 is expressed at near histone-octamer levels and globally alters the chromatin state","volume":"37","author":"Skene","year":"2010","journal-title":"Mol. Cell"},{"key":"B229","doi-asserted-by":"publisher","first-page":"1898","DOI":"10.1053\/j.gastro.2009.12.044","article-title":"Functional switching of TGF-Beta1 signaling in liver cancer via epigenetic modulation of a single CpG site in TTP promoter","volume":"138","author":"Sohn","year":"2010","journal-title":"Gastroenterology"},{"key":"B230","doi-asserted-by":"publisher","first-page":"860","DOI":"10.3892\/mmr.2015.4612","article-title":"Lentivirus-mediated knockdown of MeCP2 inhibits the growth of colorectal cancer cells in vitro","volume":"13","author":"Song","year":"2016","journal-title":"Mol. Med. Rep."},{"key":"B231","doi-asserted-by":"publisher","first-page":"eadt5937","DOI":"10.1126\/sciadv.adt5937","article-title":"MeCP2 interacts with the super elongation complex to regulate transcription","volume":"11","author":"Sonn","year":"2025","journal-title":"Sci. Adv."},{"key":"B232","doi-asserted-by":"publisher","first-page":"1593","DOI":"10.1096\/fj.09-143057","article-title":"Partial silencing of methyl cytosine protein binding 2 (MECP2) in mesenchymal stem cells induces senescence with an increase in damaged DNA","volume":"24","author":"Squillaro","year":"2010","journal-title":"FASEB J."},{"key":"B233","doi-asserted-by":"publisher","first-page":"28295","DOI":"10.1038\/srep28295","article-title":"Brain phosphorylation of MeCP2 at serine 164 is developmentally regulated and globally alters its chromatin association","volume":"6","author":"Stefanelli","year":"2016","journal-title":"Sci. Rep."},{"key":"B234","doi-asserted-by":"publisher","first-page":"1182","DOI":"10.1016\/S0140-6736(25)00261-2","article-title":"Pancreatic cancer","volume":"405","author":"Stoop","year":"2025","journal-title":"Lancet"},{"key":"B235","doi-asserted-by":"publisher","first-page":"422","DOI":"10.1016\/j.neuroscience.2013.11.043","article-title":"Ethanol induced acetylation of histone at G9a Exon1 and G9a-Mediated histone H3 dimethylation leads to neurodegeneration in neonatal mice","volume":"258","author":"Subbanna","year":"2014","journal-title":"Neuroscience"},{"key":"B236","doi-asserted-by":"publisher","first-page":"e2415309","DOI":"10.1002\/advs.202415309","article-title":"MeCP2 lactylation protects against ischemic brain injury by transcriptionally regulating neuronal apoptosis","volume":"12","author":"Sun","year":"2025","journal-title":"Adv. Sci. Weinheim, Baden-Wurttemberg, Ger."},{"key":"B237","doi-asserted-by":"publisher","first-page":"8688","DOI":"10.1038\/sj.onc.1207182","article-title":"Direct association between PU.1 and MeCP2 that recruits mSin3A-HDAC complex for PU.1-Mediated transcriptional repression","volume":"22","author":"Suzuki","year":"2003","journal-title":"Oncogene"},{"key":"B238","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1038\/ng1330","article-title":"Epigenetic inactivation of SFRP genes allows constitutive WNT signaling in colorectal cancer","volume":"36","author":"Suzuki","year":"2004","journal-title":"Nat. Genet."},{"key":"B239","doi-asserted-by":"publisher","first-page":"1147","DOI":"10.1038\/sj.bjc.6604259","article-title":"Frequent epigenetic inactivation of wnt antagonist genes in breast cancer","volume":"98","author":"Suzuki","year":"2008","journal-title":"Br. J. Cancer"},{"key":"B240","doi-asserted-by":"publisher","first-page":"396","DOI":"10.1093\/jnci\/djj093","article-title":"Epigenetic modulation of tumor suppressor CCAAT\/enhancer binding protein alpha activity in lung cancer","volume":"98","author":"Tada","year":"2006","journal-title":"J. Natl. Cancer Inst."},{"key":"B241","doi-asserted-by":"publisher","first-page":"10552","DOI":"10.1038\/ncomms10552","article-title":"MeCP2 SUMOylation rescues Mecp2-Mutant-Induced behavioural deficits in a mouse model of Rett syndrome","volume":"7","author":"Tai","year":"2016","journal-title":"Nat. Commun."},{"key":"B242","doi-asserted-by":"publisher","first-page":"1533033820909125","DOI":"10.1177\/1533033820909125","article-title":"MiR-384 inhibits malignant biological behavior such as proliferation and invasion of osteosarcoma by regulating IGFBP3","volume":"19","author":"Tan","year":"2020","journal-title":"Technol. Cancer Res. and Treat."},{"key":"B243","doi-asserted-by":"publisher","first-page":"2884","DOI":"10.1093\/nar\/gkr1066","article-title":"MeCP2 binds to nucleosome free (linker DNA) regions and to H3K9\/H3K27 methylated nucleosomes in the brain","volume":"40","author":"Thambirajah","year":"2012","journal-title":"Nucleic Acids Res."},{"key":"B244","doi-asserted-by":"publisher","first-page":"613","DOI":"10.1016\/j.molcel.2013.05.021","article-title":"Defining the RGG\/RG motif","volume":"50","author":"Thandapani","year":"2013","journal-title":"Mol. Cell"},{"key":"B245","doi-asserted-by":"publisher","first-page":"1602","DOI":"10.1016\/j.jmb.2019.10.004","article-title":"The molecular basis of MeCP2 function in the brain","volume":"432","author":"Tillotson","year":"2020","journal-title":"J. of Mol. Biol. Read. DNA Modifications"},{"key":"B246","doi-asserted-by":"publisher","first-page":"eadq4529","DOI":"10.1126\/scitranslmed.adq4529","article-title":"Modulating alternative splicing of MECP2 is a potential therapeutic strategy for Rett syndrome","volume":"18","author":"Tirumala","year":"2026","journal-title":"Sci. Transl. Med."},{"key":"B247","doi-asserted-by":"publisher","first-page":"8572","DOI":"10.1128\/MCB.00650-06","article-title":"Aberrant promoter methylation of the ABCG2 gene in renal carcinoma","volume":"26","author":"To","year":"2006","journal-title":"Mol. Cell. Biol."},{"key":"B248","doi-asserted-by":"publisher","first-page":"34845","DOI":"10.18632\/oncotarget.9197","article-title":"MECP2 promotes the growth of gastric cancer cells by suppressing miR-338-Mediated antiproliferative effect","volume":"7","author":"Tong","year":"2016","journal-title":"Oncotarget"},{"key":"B249","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1038\/s41389-020-0239-7","article-title":"MeCP2 facilitates breast cancer growth via promoting ubiquitination-mediated P53 degradation by inhibiting RPL5\/RPL11 transcription","volume":"9","author":"Tong","year":"","journal-title":"Oncogenesis"},{"key":"B250","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1038\/s41389-020-00281-z","article-title":"MiR-22, regulated by MeCP2, suppresses gastric cancer cell proliferation by inducing a deficiency in endogenous S-Adenosylmethionine","volume":"9","author":"Tong","year":"","journal-title":"Oncogenesis"},{"key":"B251","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1074\/mcp.O112.018366","article-title":"Global identification and characterization of both O-GlcNAcylation and phosphorylation at the murine synapse","volume":"11","author":"Trinidad","year":"2012","journal-title":"Mol. and Cell. Proteomics MCP"},{"key":"B252","doi-asserted-by":"publisher","first-page":"5122","DOI":"10.3390\/ijms24065122","article-title":"A comprehensive and integrative approach to MeCP2 disease transcriptomics","volume":"24","author":"Trostle","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"B253","doi-asserted-by":"publisher","first-page":"1887","DOI":"10.1016\/j.celrep.2015.08.028","article-title":"miR-199a links MeCP2 with mTOR signaling and its dysregulation leads to Rett syndrome phenotypes","volume":"12","author":"Tsujimura","year":"2015","journal-title":"Cell Rep."},{"key":"B254","doi-asserted-by":"publisher","first-page":"2458","DOI":"10.1093\/eurheartj\/ehaf130","article-title":"SLC31A1 loss depletes mitochondrial copper and promotes cardiac fibrosis","volume":"46","author":"Tu","year":"2025","journal-title":"Eur. Heart J."},{"key":"B255","doi-asserted-by":"publisher","first-page":"15536","DOI":"10.1073\/pnas.242566899","article-title":"Transcriptional profiling of a mouse model for Rett syndrome reveals subtle transcriptional changes in the brain","volume":"99","author":"Tudor","year":"2002","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"B256","doi-asserted-by":"publisher","first-page":"e2310344120","DOI":"10.1073\/pnas.2310344120","article-title":"Activity-induced MeCP2 phosphorylation regulates retinogeniculate synapse refinement","volume":"120","author":"Tzeng","year":"2023","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"B257","doi-asserted-by":"publisher","first-page":"5445","DOI":"10.1038\/s41380-026-03630-3","article-title":"MSK1 mediates BDNF-dependent MeCP2-S421 phosphorylation in postnatal striatal development and psychiatric-relevant behaviours","volume":"31","author":"Varela-Andr\u00e9s","year":"2026","journal-title":"Mol. Psychiatry"},{"key":"B258","doi-asserted-by":"publisher","first-page":"555","DOI":"10.1101\/gr.147942.112","article-title":"Dynamic DNA methylation across diverse human cell lines and tissues","volume":"23","author":"Varley","year":"2013","journal-title":"Genome Res."},{"key":"B259","doi-asserted-by":"publisher","first-page":"2161","DOI":"10.1093\/hmg\/ddab182","article-title":"Aberrant lung lipids cause respiratory impairment in a Mecp2-Deficient mouse model of Rett syndrome","volume":"30","author":"Vashi","year":"2021","journal-title":"Hum. Mol. Genet."},{"key":"B260","doi-asserted-by":"publisher","first-page":"e74662","DOI":"10.1371\/journal.pone.0074662","article-title":"Comprehensive analysis of LANA interacting proteins essential for viral genome tethering and persistence","volume":"8","author":"Verma","year":"2013","journal-title":"PLoS ONE"},{"key":"B261","doi-asserted-by":"publisher","first-page":"1106","DOI":"10.1002\/ijc.25126","article-title":"miR-212 is downregulated and suppresses methyl-cpg-binding protein MeCP2 in human gastric cancer","volume":"127","author":"Wada","year":"2010","journal-title":"Int. J. Cancer"},{"key":"B262","doi-asserted-by":"publisher","first-page":"13284","DOI":"10.1074\/mcp.M111.013284","article-title":"A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles","volume":"10","author":"Wagner","year":"2011","journal-title":"Mol. and Cell. Proteomics MCP"},{"key":"B263","doi-asserted-by":"publisher","first-page":"33808","DOI":"10.1074\/jbc.C114.611558","article-title":"RING finger protein 4 (RNF4) derepresses gene expression from DNA methylation","volume":"289","author":"Wang","year":"2014","journal-title":"J. Biol. Chem."},{"key":"B264","doi-asserted-by":"publisher","first-page":"5582","DOI":"10.1021\/pr100394u","article-title":"An informatics-assisted label-free quantitation strategy that depicts phosphoproteomic profiles in lung cancer cell invasion","volume":"9","author":"Wang","year":"2010","journal-title":"J. Proteome Res."},{"key":"B265","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1038\/s41389-020-00258-y","article-title":"Methyl-CpG-Binding protein 2 drives the Furin\/TGF-\u03921\/Smad axis to promote epithelial\u2013mesenchymal transition in pancreatic cancer cells","volume":"9","author":"Wang","year":"2020","journal-title":"Oncogenesis"},{"key":"B266","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1038\/s41422-020-0288-7","article-title":"Rett syndrome-causing mutations compromise MeCP2-Mediated liquid-liquid phase separation of chromatin","volume":"30","author":"Wang","year":"2020","journal-title":"Cell Res."},{"key":"B267","doi-asserted-by":"publisher","first-page":"3243","DOI":"10.1111\/cas.15011","article-title":"Methyl CpG binding protein 2 promotes colorectal cancer metastasis by regulating N6-Methyladenosine methylation through methyltransferase-like 14","volume":"112","author":"Wang","year":"2021","journal-title":"Cancer Sci."},{"key":"B268","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1186\/s12943-022-01504-0","article-title":"A plasma SNORD33 signature predicts platinum benefit in metastatic triple-negative breast cancer patients","volume":"21","author":"Wang","year":"2022","journal-title":"Mol. Cancer"},{"key":"B269","doi-asserted-by":"publisher","first-page":"18518","DOI":"10.1038\/s41598-022-21328-8","article-title":"Bioinformatics analysis of prognostic value and immunological role of MeCP2 in pan-cancer","volume":"12","author":"Wang","year":"2022","journal-title":"Sci. Rep."},{"key":"B270","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1016\/j.atherosclerosis.2023.05.009","article-title":"Exercise-induced endothelial Mecp2 lactylation suppresses atherosclerosis via the Ereg\/MAPK signalling pathway","volume":"375","author":"Wang","year":"2023","journal-title":"Atherosclerosis"},{"key":"B271","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1007\/s12640-026-00796-0","article-title":"MicroRNA-132 alleviates ischemia-reperfusion-induced neuronal apoptosis by targeting Mecp2 in stroke models","volume":"44","author":"Wang","year":"2026","journal-title":"Neurotox. Res."},{"key":"B272","doi-asserted-by":"publisher","first-page":"224","DOI":"10.1136\/jmg.38.4.224","article-title":"Angelman syndrome phenotype associated with mutations in MECP2, a gene encoding a methyl CpG binding protein","volume":"38","author":"Watson","year":"2001","journal-title":"J. Med. Genet."},{"key":"B273","doi-asserted-by":"publisher","first-page":"5374","DOI":"10.1038\/s41467-026-71741-0","article-title":"MeCP2 requires interactions with nucleosome linker DNA to read chromatin DNA methylation","volume":"17","author":"Watson","year":"2026","journal-title":"Nat. Commun."},{"key":"B274","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1038\/s41572-024-00516-y","article-title":"Glioma","volume":"10","author":"Weller","year":"2024","journal-title":"Nat. Rev. Dis. Prim."},{"key":"B275","doi-asserted-by":"publisher","first-page":"811","DOI":"10.1016\/j.omtn.2020.12.019","article-title":"circFOXM1 contributes to sorafenib resistance of hepatocellular carcinoma cells by regulating MECP2 via miR-1324","volume":"23","author":"Weng","year":"2021","journal-title":"Mol. Ther. Nucleic Acids"},{"key":"B276","doi-asserted-by":"publisher","first-page":"860","DOI":"10.3390\/cells10040860","article-title":"MECP2 increases the pro-inflammatory response of microglial cells and phosphorylation at serine 423 regulates neuronal gene expression upon neuroinflammation","volume":"10","author":"Wittrahm","year":"2021","journal-title":"Cells"},{"key":"B277","doi-asserted-by":"publisher","first-page":"15134","DOI":"10.1038\/ncomms15134","article-title":"Intron retention is regulated by altered MeCP2-Mediated splicing factor recruitment","volume":"8","author":"Wong","year":"2017","journal-title":"Nat. Commun."},{"key":"B278","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1016\/j.taap.2015.07.010","article-title":"Melittin induces PTCH1 expression by down-regulating MeCP2 in human hepatocellular carcinoma SMMC-7721 cells","volume":"288","author":"Wu","year":"2015","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"B279","doi-asserted-by":"publisher","first-page":"e12929","DOI":"10.1111\/acel.12929","article-title":"Tau overexpression impairs neuronal endocytosis by decreasing the GTPase dynamin 1 through the miR\u2010132\/MeCP2 pathway","volume":"18","author":"Xie","year":"2019","journal-title":"Aging Cell"},{"key":"B280","doi-asserted-by":"publisher","DOI":"10.1016\/j.jare.2026.01.048","article-title":"Pan-cancer epigenetic landscape of human tumor-associated macrophages reveals crucial enhancers governing their heterogenous formation by pol II pausing modulation","volume":"18","author":"Xiong","year":"2026","journal-title":"J. Adv. Res."},{"key":"B281","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1186\/1746-1596-7-33","article-title":"The expression patterns and correlations of Claudin-6, Methy-CpG binding protein 2, DNA methyltransferase 1, histone deacetylase 1, acetyl-histone H3 and acetyl-histone H4 and their clinicopathological significance in breast invasive ductal carcinomas","volume":"7","author":"Xu","year":"2012","journal-title":"Diagn. Pathol."},{"key":"B282","doi-asserted-by":"publisher","first-page":"14476","DOI":"10.18632\/oncotarget.7507","article-title":"MeCP2 suppresses LIN28A expression via binding to its Methylated-CpG islands in pancreatic cancer cells","volume":"7","author":"Xu","year":"2016","journal-title":"Oncotarget"},{"key":"B283","doi-asserted-by":"publisher","first-page":"504","DOI":"10.4161\/epi.24449","article-title":"Holocarboxylase synthetase synergizes with methyl CpG binding protein 2 and DNA methyltransferase 1 in the transcriptional repression of long-terminal repeats","volume":"8","author":"Xue","year":"2013","journal-title":"Epigenetics"},{"key":"B284","doi-asserted-by":"publisher","first-page":"1397","DOI":"10.2147\/BCTT.S545732","article-title":"Down-regulation of lncRNA CKMT2-AS1 predicts poor prognosis and promotes breast cancer progression","volume":"17","author":"Xue","year":"2025","journal-title":"Breast Cancer Targets Ther."},{"key":"B285","doi-asserted-by":"publisher","first-page":"1293","DOI":"10.1093\/ibd\/izz020","article-title":"Whole exome sequencing of ulcerative colitis\u2013associated colorectal cancer based on novel somatic mutations identified in Chinese patients","volume":"25","author":"Yan","year":"2019","journal-title":"Inflamm. Bowel Dis."},{"key":"B286","doi-asserted-by":"publisher","first-page":"163ra158","DOI":"10.1126\/scitranslmed.3004430","article-title":"Overexpression of Methyl-CpG binding protein 2 impairs TH1 responses","volume":"4","author":"Yang","year":"2012","journal-title":"Sci. Transl. Med."},{"key":"B287","doi-asserted-by":"publisher","first-page":"2706","DOI":"10.1021\/acschembio.6b00450","article-title":"Binding analysis of Methyl-CpG binding domain of MeCP2 and Rett syndrome mutations","volume":"11","author":"Yang","year":"2016","journal-title":"ACS Chem. Biol."},{"key":"B288","doi-asserted-by":"publisher","first-page":"1931","DOI":"10.3892\/ol.2018.8868","article-title":"DNA methylation contributes to silencing the expression of Linc00086 in gastric cancer","volume":"16","author":"Yang","year":"2018","journal-title":"Oncol. Lett."},{"key":"B289","doi-asserted-by":"publisher","first-page":"556","DOI":"10.1161\/CIRCULATIONAHA.120.045765","article-title":"Extracellular vesicle\u2013mediated delivery of circular RNA SCMH1 promotes functional recovery in rodent and nonhuman primate ischemic stroke models","volume":"142","author":"Yang","year":"2020","journal-title":"Circulation"},{"key":"B290","doi-asserted-by":"publisher","first-page":"RP89912","DOI":"10.7554\/eLife.89912","article-title":"Mecp2 fine-tunes quiescence exit by targeting nuclear receptors","volume":"12","author":"Yang","year":"2024","journal-title":"eLife"},{"key":"B291","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1042\/BSR20080032","article-title":"Silencing of MBD1 and MeCP2 in prostate-cancer-derived PC3 cells produces differential gene expression profiles and cellular phenotypes","volume":"28","author":"Yaqinuddin","year":"2008","journal-title":"Biosci. Rep."},{"key":"B292","doi-asserted-by":"publisher","first-page":"19416","DOI":"10.1073\/pnas.0707442104","article-title":"Integrated epigenomic analyses of neuronal MeCP2 reveal a role for long-range interaction with active genes","volume":"104","author":"Yasui","year":"2007","journal-title":"Proc. Natl. Acad. Sci."},{"key":"B293","doi-asserted-by":"publisher","first-page":"2447","DOI":"10.1093\/hmg\/ddt640","article-title":"Mice with an isoform-ablating Mecp2 exon 1 mutation recapitulate the neurologic deficits of Rett syndrome","volume":"23","author":"Yasui","year":"2014","journal-title":"Hum. Mol. Genet."},{"key":"B294","doi-asserted-by":"publisher","first-page":"17551","DOI":"10.1073\/pnas.0507856102","article-title":"Regulation of RNA splicing by the methylation-dependent transcriptional repressor Methyl-CpG binding protein 2","volume":"102","author":"Young","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"B295","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/8829649","article-title":"SFRP4 is a potential biomarker for the prognosis and immunotherapy for gastric cancer","volume":"2022","author":"Yu","year":"2022","journal-title":"J. Oncol."},{"key":"B296","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1038\/s41420-024-01803-z","article-title":"Cancer epigenetics: from laboratory studies and clinical trials to precision medicine","volume":"10","author":"Yu","year":"2024","journal-title":"Cell Death Discov."},{"key":"B297","doi-asserted-by":"publisher","first-page":"e7691","DOI":"10.1097\/MD.0000000000007691","article-title":"MECP2 expression in gastric cancer and its correlation with clinical pathological parameters","volume":"96","author":"Zhang","year":"2017","journal-title":"Medicine"},{"key":"B298","doi-asserted-by":"publisher","first-page":"728","DOI":"10.1111\/bjh.14739","article-title":"Research on the epigenetic regulation mechanism of the PTPN6 gene in advanced chronic myeloid leukaemia","volume":"178","author":"Zhang","year":"2017","journal-title":"Br. J. Haematol."},{"key":"B299","first-page":"3542","article-title":"MiR-106a* inhibits oral squamous cell carcinoma progression by directly targeting MeCP2 and suppressing the Wnt\/\u03b2-Catenin signaling pathway","volume":"10","author":"Zhang","year":"2018","journal-title":"Am. J. Transl. Res."},{"key":"B300","doi-asserted-by":"publisher","first-page":"4766","DOI":"10.26355\/eurrev_202005_21165","article-title":"MicroRNA-1324 inhibits cell proliferative ability and invasiveness by targeting MECP2 in gastric cancer","volume":"24","author":"Zhang","year":"2020","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"B301","doi-asserted-by":"publisher","first-page":"5136","DOI":"10.1038\/s41467-024-49368-w","article-title":"m5C methylated lncRncr3-MeCP2 interaction restricts miR124a-Initiated neurogenesis","volume":"15","author":"Zhang","year":"2024","journal-title":"Nat. Commun."},{"key":"B302","doi-asserted-by":"publisher","first-page":"416","DOI":"10.1186\/s12964-024-01797-2","article-title":"Involvement of HDAC2-Mediated Kcnq2\/Kcnq3 genes transcription repression activated by EREG\/EGFR-ERK-Runx1 signaling in bone cancer pain","volume":"22","author":"Zhang","year":"2024","journal-title":"Cell Commun. Signal. CCS"},{"key":"B303","doi-asserted-by":"publisher","first-page":"38135","DOI":"10.1038\/s41598-025-21877-8","article-title":"Immunomodulation of behavior impairment via spleen-specific targeting lipid nanoparticles in a MeCP2 transgenic mouse model","volume":"15","author":"Zhang","year":"2025","journal-title":"Sci. Rep."},{"key":"B304","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1111\/febs.17282","article-title":"USP15 inhibits hypoxia-induced IL-6 signaling by deubiquitinating and stabilizing MeCP2","volume":"292","author":"Zhang","year":"2025","journal-title":"FEBS J."},{"key":"B305","doi-asserted-by":"publisher","first-page":"115999","DOI":"10.1016\/j.isci.2026.115999","article-title":"Alternative splicing regulates FGGY-derived neoantigen presentation and promotes immune evasion in metabolic-associated hepatocellular carcinoma","volume":"29","author":"Zhao","year":"2026","journal-title":"iScience"},{"key":"B306","first-page":"OL1876","article-title":"MECP2 promotes cell proliferation by activating ERK1\/2 and inhibiting P38 activity in human hepatocellular carcinoma HEPG2 cells","volume":"59","author":"Zhao","year":"2013","journal-title":"Cell. and Mol. Biol. (Noisy-le-Grand, France)"},{"key":"B307","doi-asserted-by":"publisher","first-page":"e368","DOI":"10.1038\/oncsis.2017.60","article-title":"MeCP2, a target of miR-638, facilitates gastric cancer cell proliferation through activation of the MEK1\/2-ERK1\/2 signaling pathway by upregulating GIT1","volume":"6","author":"Zhao","year":"2017","journal-title":"Oncogenesis"},{"key":"B308","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1016\/j.ebiom.2017.01.021","article-title":"MeCP2 promotes gastric cancer progression through regulating FOXF1\/Wnt5a\/\u03b2-Catenin and MYOD1\/Caspase-3 signaling pathways","volume":"16","author":"Zhao","year":"2017","journal-title":"EBioMedicine"},{"key":"B309","first-page":"5183","article-title":"MECP2 promotes the migration and invasion of gastric cancer cells by modulating the Notch1\/c-Myc\/mTOR signaling pathways by suppressing FBXW7 transcription","volume":"12","author":"Zhao","year":"2022","journal-title":"Am. J. Cancer Res."},{"key":"B310","doi-asserted-by":"publisher","first-page":"540","DOI":"10.1038\/s41423-022-00841-w","article-title":"MEF2C promotes M1 macrophage polarization and Th1 responses","volume":"19","author":"Zhao","year":"2022","journal-title":"Cell. and Mol. Immunol."},{"key":"B311","doi-asserted-by":"publisher","first-page":"810","DOI":"10.1186\/s12967-025-06880-x","article-title":"Hepatic stellate cell-specific miR-214 expression alleviates liver fibrosis without boosting steatosis and inflammation","volume":"23","author":"Zhao","year":"2025","journal-title":"J. Transl. Med."},{"key":"B312","doi-asserted-by":"publisher","first-page":"17836","DOI":"10.1038\/s41598-018-36168-8","article-title":"Genomic and regulatory characteristics of significant transcription factors in colorectal cancer metastasis","volume":"8","author":"Zhou","year":"2018","journal-title":"Sci. Rep."},{"key":"B313","doi-asserted-by":"publisher","first-page":"2231","DOI":"10.1002\/1878-0261.12700","article-title":"Linc\u2010ROR promotes the progression of breast cancer and decreases the sensitivity to rapamycin through miR\u2010194\u20103p targeting MECP2","volume":"14","author":"Zhou","year":"2020","journal-title":"Mol. Oncol."},{"key":"B314","doi-asserted-by":"publisher","first-page":"e2119078119","DOI":"10.1073\/pnas.2119078119","article-title":"Disruption of MeCP2\u2013TCF20 complex underlies distinct neurodevelopmental disorders","volume":"119","author":"Zhou","year":"2022","journal-title":"Proc. Natl. Acad. Sci."},{"key":"B315","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1097\/FJC.0000000000001647","article-title":"The ubiquitin ligase HERC2 promotes ang II-Induced cardiac hypertrophy through destabilization of MeCP2 to enhance Lin28a expression","volume":"85","author":"Zhou","year":"2025","journal-title":"J. Cardiovasc. Pharmacol."},{"key":"B316","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1007\/s10549-012-2235-x","article-title":"Role of ornithine decarboxylase in regulation of estrogen receptor alpha expression and growth in human breast cancer cells","volume":"136","author":"Zhu","year":"2012","journal-title":"Breast Cancer Res. Treat."},{"key":"B317","doi-asserted-by":"publisher","first-page":"228","DOI":"10.3892\/ijmm.2018.3581","article-title":"miR-19a\/b and MeCP2 repress reciprocally to regulate multidrug resistance in gastric cancer cells","volume":"42","author":"Zhu","year":"2018","journal-title":"Int. J. Mol. Med."},{"key":"B318","doi-asserted-by":"publisher","first-page":"185","DOI":"10.3892\/or.2013.2459","article-title":"Epigenetic silencing of Bcl-2, CEBPA and P14(ARF) by the AML1-ETO oncoprotein contributing to growth arrest and differentiation block in the U937 cell line","volume":"30","author":"Zhuang","year":"2013","journal-title":"Oncol. Rep."},{"key":"B319","doi-asserted-by":"publisher","first-page":"695","DOI":"10.4161\/epi.20733","article-title":"SIRT1-Mediated deacetylation of MeCP2 contributes to BDNF expression","volume":"7","author":"Zocchi","year":"2012","journal-title":"Epigenetics"},{"key":"B320","doi-asserted-by":"publisher","first-page":"722","DOI":"10.1002\/humu.21253","article-title":"Mutations in MEF2C from the 5q14.3q15 microdeletion syndrome region are a frequent cause of severe mental retardation and diminish MECP2 and CDKL5 expression","volume":"31","author":"Zweier","year":"2010","journal-title":"Hum. Mutat."}],"container-title":["Frontiers in Epigenetics and Epigenomics"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/freae.2026.1917394\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T10:17:16Z","timestamp":1790677036000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/freae.2026.1917394\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,29]]},"references-count":320,"alternative-id":["10.3389\/freae.2026.1917394"],"URL":"https:\/\/doi.org\/10.3389\/freae.2026.1917394","relation":{},"ISSN":["2813-706X"],"issn-type":[{"value":"2813-706X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,29]]},"article-number":"1917394"}}