{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T08:42:21Z","timestamp":1790152941341,"version":"4.0.1"},"reference-count":63,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,5,15]],"date-time":"2024-05-15T00:00:00Z","timestamp":1715731200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Rehabil. Sci."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Dual tasking (i.e., concurrent performance of motor and cognitive task) is significantly impaired in older adults with mild cognitive impairment (OAwMCI) compared to cognitively intact older adults (CIOA) and has been associated with increased fall risk. Dual task studies have primarily examined volitionally driven events, and the effects of mild cognitive impairment on reactive balance control (i.e., the ability to recover from unexpected balance threats) are unexplored. We examined the effect of cognitive tasks on reactive balance control in OAwMCI compared to CIOA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Adults &amp;gt;55 years were included and completed the Montreal Cognitive Assessment (MoCA) to categorize them as OAwMCI (MoCA: 18\u201324,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200915) or CIOA (MoCA: \u226525,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200915). Both OAwMCI [MoCA: 22.4 (2.2), 65.4 (6.1) years, 3 females] and CIOA [MoCA: 28.4 (1.3), 68.2 (5.5) years, 10 females] responded to large magnitude stance slip-like perturbations alone (single task) and while performing perceptual cognitive tasks targeting the visuomotor domain (target and tracking game). In these tasks, participants rotated their head horizontally to control a motion mouse and catch a falling target (target game) or track a moving object (track). Margin of stability (MOS) and fall outcome (harness load cell &amp;gt;30% body weight) were used to quantify reactive balance control. Cognitive performance was determined using performance error (target) and sum of errors (tracking). A 3\u2009\u00d7\u20092 repeated measures ANOVA examined the effect of group and task on MOS, and generalized estimating equations (GEE) model was used to determine changes in fall outcome between groups and tasks. 2\u2009\u00d7\u20092 repeated measures ANOVAs examined the effect of group and task on cognitive performance.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Compared to CIOA, OAwMCI exhibited significantly deteriorated MOS and greater number of falls during both single task and dual task (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&amp;lt;\u20090.05), and lower dual task tracking performance (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&amp;lt;\u20090.01). Compared to single task, both OAwMCI and CIOA exhibited significantly deteriorated perceptual cognitive performance during dual task (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&amp;lt;\u20090.05); however, no change in MOS or fall outcome between single task and dual task was observed.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Cognitive impairment may diminish the ability to compensate and provide attentional resources demanded by sensory systems to integrate perturbation specific information, resulting in deteriorated ability to recover balance control among OAwMCI.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fresc.2024.1384582","type":"journal-article","created":{"date-parts":[[2024,5,15]],"date-time":"2024-05-15T00:54:04Z","timestamp":1715734444000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":13,"title":["Perturbation-based dual task assessment in older adults with mild cognitive impairment"],"prefix":"10.3389","volume":"5","author":[{"given":"Lakshmi","family":"Kannan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica","family":"Pitts","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tony","family":"Szturm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rudri","family":"Purohit","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tanvi","family":"Bhatt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2024,5,15]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s13195-015-0099-0","article-title":"Mild cognitive impairment and deficits in instrumental activities of daily living: a systematic review","volume":"7","author":"Jekel","year":"2015","journal-title":"Alzheimer\u2019s Res Ther"},{"key":"B2","doi-asserted-by":"publisher","first-page":"1701","DOI":"10.1056\/NEJM198812293192604","article-title":"Risk factors for falls among elderly persons living in the community","volume":"319","author":"Tinetti","year":"1988","journal-title":"N Engl J Med"},{"key":"B3","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1093\/geront\/33.2.200","article-title":"Falls in dementia patients","volume":"33","author":"van Dijk","year":"1993","journal-title":"Gerontologist"},{"key":"B4","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1007\/s11556-013-0134-8","article-title":"Physical consequences of falls in the elderly: a literature review from 1995 to 2010","volume":"11","author":"Terroso","year":"2014","journal-title":"Eur Rev Aging Phys Act"},{"key":"B5","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1016\/j.cger.2017.03.002","article-title":"Falls in the aging population","volume":"33","author":"Khow","year":"2017","journal-title":"Clin Geriatr Med"},{"key":"B6","doi-asserted-by":"publisher","first-page":"afac058","DOI":"10.1093\/ageing\/afac058","article-title":"Longitudinal associations between falls and future risk of cognitive decline, the motoric cognitive risk syndrome and dementia: the einstein ageing study","volume":"51","author":"Jayakody","year":"2022","journal-title":"Age Ageing"},{"key":"B7","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1016\/S0140-6736(20)30367-6","article-title":"Dementia prevention, intervention, and care: 2020 report of the lancet commission","volume":"396","author":"Livingston","year":"2020","journal-title":"Lancet"},{"key":"B8","doi-asserted-by":"publisher","first-page":"164","DOI":"10.1002\/pri.138","article-title":"Falls reported among elderly Norwegians living at home","volume":"3","author":"Bergland","year":"1998","journal-title":"Physiother Res Int"},{"key":"B9","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/S0966-6362(01)00156-4","article-title":"Attention and the control of posture and gait: a review of an emerging area of research","volume":"16","author":"Woollacott","year":"2002","journal-title":"Gait Posture"},{"key":"B10","doi-asserted-by":"publisher","first-page":"671","DOI":"10.1123\/japa.2016-0265","article-title":"The influence of a cognitive dual task on the gait parameters of healthy older adults: a systematic review and meta-analysis","volume":"25","author":"Smith","year":"2017","journal-title":"J Aging Phys Act"},{"key":"B11","doi-asserted-by":"publisher","first-page":"2565","DOI":"10.1016\/j.apmr.2013.08.002","article-title":"Cognitive-Motor interference during functional mobility after stroke: state of the science and implications for future research","volume":"94","author":"Plummer","year":"2013","journal-title":"Arch Phys Med Rehabil"},{"key":"B12","doi-asserted-by":"publisher","first-page":"715","DOI":"10.1016\/j.neubiorev.2010.08.008","article-title":"Cognitive motor interference while walking: a systematic review and meta-analysis","volume":"35","author":"Al-Yahya","year":"2011","journal-title":"Neurosci Biobehav Rev"},{"key":"B13","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1155\/2012\/583894","article-title":"Effects of gait and cognitive task difficulty on cognitive-motor interference in aging","volume":"2012","author":"Plummer-D'Amato","year":"2012","journal-title":"J Aging Res"},{"key":"B14","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1186\/s12984-022-01095-3","article-title":"Brain activity during dual-task standing in older adults","volume":"19","author":"Kahya","year":"2022","journal-title":"J Neuroeng Rehabil"},{"key":"B15","doi-asserted-by":"publisher","first-page":"857","DOI":"10.1001\/jamaneurol.2017.0643","article-title":"Association of dual-task gait with incident dementia in mild cognitive impairment: results from the gait and brain study","volume":"74","author":"Montero-Odasso","year":"2017","journal-title":"JAMA Neurol"},{"key":"B16","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/1471-2377-14-1","article-title":"Cognitive function and gait speed under normal and dual-task walking among older adults with mild cognitive impairment","volume":"14","author":"Shimada","year":"2014","journal-title":"BMC Neurol"},{"key":"B17","doi-asserted-by":"publisher","first-page":"1068316","DOI":"10.3389\/fnagi.2023.1068316","article-title":"The effects of cognitive impairment on the multi-scale dynamics of standing postural control during visual-search in older men","volume":"15","author":"Zhou","year":"2023","journal-title":"Front Aging Neurosci"},{"key":"B18","doi-asserted-by":"publisher","first-page":"488","DOI":"10.1093\/ptj\/77.5.488","article-title":"The role of limb movements in maintaining upright stance: the \u201cchange-in-support\u201d strategy","volume":"77","author":"Maki","year":"1997","journal-title":"Phys Ther"},{"key":"B19","doi-asserted-by":"publisher","first-page":"ii12","DOI":"10.1093\/ageing\/afl078","article-title":"Control of rapid limb movements for balance recovery: age-related changes and implications for fall prevention","volume":"35","author":"Maki","year":"2006","journal-title":"Age Ageing"},{"key":"B20","doi-asserted-by":"publisher","first-page":"1339","DOI":"10.1007\/s00702-007-0657-0","article-title":"Cortical control of postural responses","volume":"114","author":"Jacobs","year":"2007","journal-title":"J Neural Transm"},{"key":"B21","doi-asserted-by":"publisher","first-page":"1478","DOI":"10.2522\/ptj.20060326","article-title":"Repeated-slip training: an emerging paradigm for prevention of slip-related falls among older adults","volume":"87","author":"Pai","year":"2007","journal-title":"Phys Ther"},{"key":"B22","doi-asserted-by":"publisher","first-page":"1619","DOI":"10.1152\/jn.1996.75.4.1619","article-title":"Influence of instruction, prediction, and afferent sensory information on the postural organization of step initiation","volume":"75","author":"Burleigh","year":"1996","journal-title":"J Neurophysiol"},{"key":"B23","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1007\/s002210050321","article-title":"Perturbed step initiation in cerebellar subjects 1. Modifications of postural responses","volume":"119","author":"Timmann","year":"1998","journal-title":"Exp Brain Res"},{"key":"B24","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1007\/s002210100858","article-title":"Perturbed step initiation in cerebellar subjects: 2. Modification of anticipatory postural adjustments","volume":"141","author":"Timmann","year":"2001","journal-title":"Exp Brain Res"},{"key":"B25","doi-asserted-by":"publisher","first-page":"476","DOI":"10.2522\/ptj.20090070","article-title":"Effect of a perturbation-based balance training program on compensatory stepping and grasping reactions in older adults: a randomized controlled trial","volume":"90","author":"Mansfield","year":"2010","journal-title":"Phys Ther"},{"key":"B26","doi-asserted-by":"publisher","first-page":"1111","DOI":"10.1016\/S0021-9290(98)00124-9","article-title":"Static versus dynamic predictions of protective stepping following waist\u2013pull perturbations in young and older adults","volume":"31","author":"Pai","year":"1998","journal-title":"J Biomech"},{"key":"B27","doi-asserted-by":"publisher","first-page":"1123","DOI":"10.2522\/ptj.20130298","article-title":"Relationships between balance and cognition in patients with subjective cognitive impairment, mild cognitive impairment, and Alzheimer disease","volume":"94","author":"Tangen","year":"2014","journal-title":"Phys Ther"},{"key":"B28","doi-asserted-by":"publisher","first-page":"252","DOI":"10.1016\/j.neuroscience.2016.06.044","article-title":"Does aging with a cortical lesion increase fall-risk: examining effect of age versus stroke on intensity modulation of reactive balance responses from slip-like perturbations","volume":"333","author":"Patel","year":"2016","journal-title":"Neuroscience"},{"key":"B29","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1556\/2060.2021.00181","article-title":"Perturbation-based balance assessment: examining reactive balance control in older adults with mild cognitive impairments","volume":"108","author":"Kannan","year":"2021","journal-title":"Physiol Int"},{"key":"B30","volume-title":"Multiple concussions and dual task paradigms: reactive postural perturbation management","author":"Dierijck","year":"2017"},{"key":"B31","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/j.heliyon.2016.e00186","article-title":"Timing of reactive stepping among individuals with sub-acute stroke: effects of \u2019single-task\u2019and \u2018dual-task\u2019conditions","volume":"2","author":"Schinkel-Ivy","year":"2016","journal-title":"Heliyon"},{"key":"B32","doi-asserted-by":"publisher","first-page":"e20","DOI":"10.1016\/j.apmr.2016.08.058","article-title":"Effect of dual-task on fall risk in chronic stroke survivors: examining reactive balance responses to forward perturbations in stance","volume":"97","author":"Bhatt","year":"2016","journal-title":"Arch Phys Med Rehabil"},{"key":"B33","doi-asserted-by":"publisher","first-page":"1256","DOI":"10.3389\/fpsyg.2020.01256","article-title":"Postural stability and cognitive performance of subjects with Parkinson\u2019s disease during a dual-task in an upright stance","volume":"11","author":"Morenilla","year":"2020","journal-title":"Front Psychol"},{"key":"B34","doi-asserted-by":"publisher","first-page":"779","DOI":"10.1016\/j.parkreldis.2014.04.001","article-title":"Dual tasking during postural stepping responses increases falls but not freezing in people with Parkinson\u2019s disease","volume":"20","author":"Jacobs","year":"2014","journal-title":"Parkinsonism Relat Disord"},{"key":"B35","doi-asserted-by":"publisher","first-page":"702","DOI":"10.1177\/1545968320935814","article-title":"Backward protective stepping during dual-task scenarios in people with Parkinson\u2019s disease: a pilot study","volume":"34","author":"Peterson","year":"2020","journal-title":"Neurorehabil Neural Repair"},{"key":"B36","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1080\/00222895.2014.971700","article-title":"Attentional demands of perturbation evoked compensatory stepping responses: examining cognitive-motor interference to large magnitude forward perturbations","volume":"47","author":"Patel","year":"2015","journal-title":"J Mot Behav"},{"key":"B37","doi-asserted-by":"publisher","first-page":"1219","DOI":"10.1016\/j.neurobiolaging.2009.07.012","article-title":"Staged decline of visual processing capacity in mild cognitive impairment and Alzheimer\u2019s disease","volume":"32","author":"Bublak","year":"2011","journal-title":"Neurobiol Aging"},{"key":"B38","doi-asserted-by":"publisher","first-page":"e10363","DOI":"10.7717\/peerj.10363","article-title":"Processing moving visual scenes during upright stance in elderly patients with mild cognitive impairment","volume":"8","author":"Kucharik","year":"2020","journal-title":"PeerJ"},{"key":"B39","doi-asserted-by":"publisher","first-page":"7746","DOI":"10.3390\/s23187746","article-title":"Cognitive task domain influences cognitive-motor interference during large-magnitude treadmill stance perturbations","volume":"23","author":"Pitts","year":"2023","journal-title":"Sensors"},{"key":"B40","doi-asserted-by":"publisher","first-page":"695","DOI":"10.1111\/j.1532-5415.2005.53221.x","article-title":"The Montreal cognitive assessment, moca: a brief screening tool for mild cognitive impairment","volume":"53","author":"Nasreddine","year":"2005","journal-title":"J Am Geriatr Soc"},{"key":"B41","first-page":"157","article-title":"Ultrasonic assessment of bone: a review","volume":"2","author":"Hans","year":"1993","journal-title":"Eur J Med"},{"key":"B42","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1007\/BF02565130","article-title":"Ultrasound transmission measurements through the os Calcis","volume":"49","author":"Zagzebski","year":"1991","journal-title":"Calcif Tissue Int"},{"key":"B43","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1016\/j.jcrs.2004.01.014","article-title":"Visual acuity measurements","volume":"30","author":"Holladay","year":"2004","journal-title":"J Cataract Refract Surg"},{"key":"B44","doi-asserted-by":"publisher","first-page":"675","DOI":"10.1016\/j.jvs.2009.05.017","article-title":"The semmes weinstein monofilament examination as a screening tool for diabetic peripheral neuropathy","volume":"50","author":"Feng","year":"2009","journal-title":"J Vasc Surg"},{"key":"B45","doi-asserted-by":"publisher","first-page":"e0189876","DOI":"10.1371\/journal.pone.0189876","article-title":"How to determine leg dominance: the agreement between self-reported and observed performance in healthy adults","volume":"12","author":"van Melick","year":"2017","journal-title":"PLoS One"},{"key":"B46","doi-asserted-by":"publisher","first-page":"S54","DOI":"10.1212\/WNL.0b013e3182872ded","article-title":"Cognition assessment using the nih toolbox","volume":"80","author":"Weintraub","year":"2013","journal-title":"Neurology"},{"key":"B47","doi-asserted-by":"publisher","first-page":"599","DOI":"10.1017\/S135561771400040X","article-title":"Nih toolbox cognition battery (nihtb-cb): list sorting test to measure working memory","volume":"20","author":"Tulsky","year":"2014","journal-title":"J Int Neuropsychol Soc"},{"key":"B48","doi-asserted-by":"publisher","first-page":"630","DOI":"10.1017\/S1355617714000319","article-title":"Nih toolbox cognitive battery (nihtb-cb): the nihtb pattern comparison processing speed test","volume":"20","author":"Carlozzi","year":"2014","journal-title":"J Int Neuropsychol Soc"},{"key":"B49","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1111\/mono.12032","article-title":"Ii. Nih toolbox cognition battery (cb): measuring executive function and attention","volume":"78","author":"Zelazo","year":"2013","journal-title":"Monogr Soc Res Child Dev"},{"key":"B50","doi-asserted-by":"publisher","first-page":"2243","DOI":"10.1016\/j.jbiomech.2011.05.039","article-title":"Automatic recognition of falls in gait-slip training: harness load cell based criteria","volume":"44","author":"Yang","year":"2011","journal-title":"J Biomech"},{"key":"B51","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.jbiomech.2004.03.025","article-title":"The condition for dynamic stability","volume":"38","author":"Hof","year":"2005","journal-title":"J Biomech"},{"key":"B52","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1016\/j.gaitpost.2014.09.023","article-title":"Integrated testing of standing balance and cognition: test\u2013retest reliability and construct validity","volume":"41","author":"Szturm","year":"2015","journal-title":"Gait Posture"},{"key":"B53","doi-asserted-by":"publisher","first-page":"736232","DOI":"10.3389\/fnetp.2021.736232","article-title":"Dual-task training program for older adults: blending gait","volume":"1","author":"Nayak","year":"2021","journal-title":"Visuomotor Cogn Train Front Netw Physiol"},{"key":"B54","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1089\/g4h.2014.0093","article-title":"Home-based computer gaming in vestibular rehabilitation of gaze and balance impairment","volume":"4","author":"Szturm","year":"2015","journal-title":"Games Health J"},{"key":"B55","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1016\/j.archger.2017.07.013","article-title":"The interacting effects of treadmill walking and different types of visuospatial cognitive task: discriminating dual task and age effects","volume":"73","author":"Nankar","year":"2017","journal-title":"Arch Gerontol Geriatr"},{"key":"B56","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1016\/j.medengphy.2019.07.018","article-title":"Comparison of selected measures of gait stability derived from center of pressure displacement signal during single and dual-task treadmill walking","volume":"74","author":"Ahmadi","year":"2019","journal-title":"Med Eng Phys"},{"key":"B57","doi-asserted-by":"publisher","first-page":"404","DOI":"10.1212\/01.wnl.0000171450.97464.49","article-title":"Increased hippocampal activation in mild cognitive impairment compared to normal aging and ad","volume":"65","author":"Dickerson","year":"2005","journal-title":"Neurology"},{"key":"B58","doi-asserted-by":"publisher","first-page":"113","DOI":"10.3233\/JAD-2009-0928","article-title":"Balance features in Alzheimer\u2019s disease and amnestic mild cognitive impairment","volume":"16","author":"Leandri","year":"2009","journal-title":"J Alzheimer\u2019s Dis"},{"key":"B59","doi-asserted-by":"publisher","first-page":"893","DOI":"10.3174\/ajnr.A1484","article-title":"Alterations in cortical thickness and white matter integrity in mild cognitive impairment measured by whole-brain cortical thickness mapping and diffusion tensor imaging","volume":"30","author":"Wang","year":"2009","journal-title":"Am J Neuroradiol"},{"key":"B60","doi-asserted-by":"publisher","first-page":"e66367","DOI":"10.1371\/journal.pone.0066367","article-title":"Mri markers for mild cognitive impairment: comparisons between white matter integrity and gray matter volume measurements","volume":"8","author":"Zhang","year":"2013","journal-title":"PLoS One"},{"key":"B61","doi-asserted-by":"publisher","first-page":"705","DOI":"10.1080\/13607863.2019.1566813","article-title":"Vestibular impairment, cognitive decline and Alzheimer\u2019s disease: balancing the evidence","volume":"24","author":"Agrawal","year":"2020","journal-title":"Aging Ment Health"},{"key":"B62","doi-asserted-by":"publisher","first-page":"1119","DOI":"10.1097\/AUD.0000000000001040","article-title":"Vestibular function in older adults with cognitive impairment: a systematic review","volume":"42","author":"Bosmans","year":"2021","journal-title":"Ear Hear"},{"key":"B63","doi-asserted-by":"publisher","first-page":"2732","DOI":"10.1093\/brain\/awh617","article-title":"Vestibular loss causes hippocampal atrophy and impaired spatial memory in humans","volume":"128","author":"Brandt","year":"2005","journal-title":"Brain"}],"container-title":["Frontiers in Rehabilitation Sciences"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fresc.2024.1384582\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,15]],"date-time":"2024-05-15T00:54:09Z","timestamp":1715734449000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fresc.2024.1384582\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5,15]]},"references-count":63,"alternative-id":["10.3389\/fresc.2024.1384582"],"URL":"https:\/\/doi.org\/10.3389\/fresc.2024.1384582","relation":{},"ISSN":["2673-6861"],"issn-type":[{"value":"2673-6861","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,5,15]]},"article-number":"1384582"}}