{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,24]],"date-time":"2026-01-24T14:08:17Z","timestamp":1769263697701,"version":"3.49.0"},"reference-count":43,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T00:00:00Z","timestamp":1769126400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Rehabil. Sci."],"abstract":"<jats:p>\n                    Gerstmann\u2013Str\u00e4ussler\u2013Scheinker syndrome (GSS) is a genetic, autosomal dominant prion brain disease that causes ataxia and slow cognitive decline. Herein, we describe a 34-year-old woman (S.C.B.) diagnosed with GSS (variant Pro102Leu). In 2018, she presented with gait instability without falls, early fatigue, and dizziness; after 3\u2005years, urinary incontinence, initial insomnia and rapid-eye movement sleep behavior disorder, writing difficulties, and occasional dysphagia had appeared. S.C.B. was admitted to the Neurorehabilitation Unit due to the progressive worsening of her balance and walking ability [Timed Up and Go (TUG): not evaluated; Berg Balance Scale (BERG): 5\/56]. At admission, neurological, neuropsychological, physiotherapeutic, occupational, and speech assessments were performed. She was completely dependent in basic (ADL) and instrumental activities of daily living (iADL) (ADL: 5\/6; iADL: 4\/8; Barthel Index: 60); furthermore, moderate cognitive decline and depressive symptoms were observed. After 4\u2005weeks of\n                    <jats:italic>intensive motor-cognitive rehabilitation treatment<\/jats:italic>\n                    , an improvement was observed in all the intervention areas, leading to a global gain in autonomy (TUG: 1\u2005min 50\u2005s; BERG: 10\/56; Barthel Index: 70). This case report highlights the importance of tailored motor-cognitive rehabilitation and how these interventions can enhance patients\u2019 quality of life and their ability to cope with their symptoms. In conclusion, this case contributes to a broader understanding of treatment options that clinicians can propose to patients.\n                  <\/jats:p>","DOI":"10.3389\/fresc.2025.1599247","type":"journal-article","created":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T06:46:29Z","timestamp":1769150789000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Case Report: Intensive multidisciplinary motor-cognitive rehabilitation treatment in Gerstmann\u2013Str\u00e4ussler\u2013Scheinker syndrome"],"prefix":"10.3389","volume":"6","author":[{"given":"A.","family":"De Laurenzis","sequence":"first","affiliation":[{"name":"Movement Disorders Rehabilitation Department, Moriggia-Pelascini Hospital","place":["Gravedona ed Uniti, Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Siri","sequence":"additional","affiliation":[{"name":"Movement Disorders Rehabilitation Department, Moriggia-Pelascini Hospital","place":["Gravedona ed Uniti, Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Bandirali","sequence":"additional","affiliation":[{"name":"Movement Disorders Rehabilitation Department, Moriggia-Pelascini Hospital","place":["Gravedona ed Uniti, Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Lucca","sequence":"additional","affiliation":[{"name":"Movement Disorders Rehabilitation Department, Moriggia-Pelascini Hospital","place":["Gravedona ed Uniti, Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Covaia","sequence":"additional","affiliation":[{"name":"Movement Disorders Rehabilitation Department, Moriggia-Pelascini Hospital","place":["Gravedona ed Uniti, Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Ferrari","sequence":"additional","affiliation":[{"name":"Department of Brain and Behavioral Sciences, University of Pavia","place":["Pavia, Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Zaffina","sequence":"additional","affiliation":[{"name":"Department of Brain and Behavioral Sciences, University of Pavia","place":["Pavia, Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Canesi","sequence":"additional","affiliation":[{"name":"Movement Disorders Rehabilitation Department, Moriggia-Pelascini Hospital","place":["Gravedona ed Uniti, Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2026,1,23]]},"reference":[{"key":"B1","first-page":"9","article-title":"La valutazione della disfagia: sviluppo di una nuova scala del rischio di malnutrizione e polmonite ab ingestis","volume":"5","author":"Amitrano","year":"2009","journal-title":"Logopedia 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