{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,18]],"date-time":"2025-11-18T06:28:23Z","timestamp":1763447303927,"version":"3.45.0"},"reference-count":49,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,11,18]],"date-time":"2025-11-18T00:00:00Z","timestamp":1763424000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Rehabil. Sci."],"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Military service is demanding and requires maintenance of optimal physical and mental health. Deployment-related incidents can precipitate the onset of physical and\/or psychological trauma necessitating appropriate pharmacological intervention. However, current strategies for medical vocational rehabilitation do not include systematic medication assessment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This study analyzed physical performance and long-term medication use in middle-aged soldiers diagnosed with physical impairments and\/or posttraumatic stress disorder. Patient records were analyzed to investigate the number of drugs, polypharmacy, drug\u2013drug interactions and drugs targeting the nervous system in relation to bicycle ergometry performance.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 172 patients were inclusion, with 45 patients (26.6%) receiving comprehensive medication. Patients with posttraumatic stress disorder, who were taking an average of 3.0 medications each, demonstrated significantly lower maximum performance than did the controls [\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200993, 217 (200\u2013250) W vs.\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200934, 250 (225\u2013267) W,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.006]. Polypharmacy [\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200942, 217 (200\u2013250) W vs.\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200934, 250 (225\u2013267) W,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.017] and drug\u2013drug interactions [\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200949, 221 (200\u2013250) W vs.\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200934,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200934, 250 (225\u2013267) W,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.024] negatively impacted maximum performance, with patients experiencing 1.6 interactions on average of varying severity. A significant negative correlation was observed between the number of drugs, anatomical-therapeutic-chemical classification, polypharmacy, number, and severity of drug\u2013drug interactions and poor maximum performance. Although no other significant differences were noted across all groups, posttraumatic stress disorder patients without medication achieved significantly greater performance than did somatic patients [\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200934, 250 (225\u2013267) vs.\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200933, 217 (200\u2013250),\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.009].\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In conclusion, highly prevalent polypharmacy may contribute to physical performance limitations, highlighting the need for further research and professional support in medication management within rehabilitation programs for mental illnesses.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fresc.2025.1605767","type":"journal-article","created":{"date-parts":[[2025,11,18]],"date-time":"2025-11-18T06:23:14Z","timestamp":1763446994000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Potential influence of long-term medication on physical performance in the context of long-term rehabilitation process in soldiers: a retrospective cohort analysis"],"prefix":"10.3389","volume":"6","author":[{"given":"Jennifer-Daniele","family":"Schmitz","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roman","family":"Korte","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas","family":"Lison","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joachim","family":"Ger\u00df","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christoph","family":"Schulze","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2025,11,18]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"588","DOI":"10.1007\/s11096-020-00976-8","article-title":"Prevalence and risk factors of drug-related problems identified in pharmacy-based medication reviews","volume":"42","author":"Sell","year":"2020","journal-title":"Int J Clin Pharm"},{"key":"B2","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1007\/s11096-015-0189-x","article-title":"Medication reviews in primary care in Sweden: importance of clinical pharmacists\u2019 recommendations on drug-related problems","volume":"38","author":"Modig","year":"2016","journal-title":"Int J Clin Pharm"},{"year":"2015","key":"B3","article-title":"Good practice guide medication error recording coding reporting assessment"},{"key":"B4","doi-asserted-by":"publisher","first-page":"230","DOI":"10.1186\/s12877-017-0621-2","article-title":"What is polypharmacy? 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