{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T18:25:50Z","timestamp":1792693550030,"version":"4.5.0"},"reference-count":125,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,9,6]],"date-time":"2024-09-06T00:00:00Z","timestamp":1725580800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100009633","name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Lab. Chip. Technol."],"abstract":"<jats:p>In this review, we discuss recent reproductive organ-on-a-chip (OoC) experiments that encompass multiple target areas of investigation, including model fabrication strategies, transport mechanisms, and immunology. We highlight fetal membrane and placental biology, OoC history and background, and the designs of reproductive OoC platforms. Reproductive OoC designs include fetal membrane models such as the Fetal Membrane-on-a-chip (FMOC) and others, placental models such as the placenta on-a-chip, and full reproductive tract models such as EVATAR. Diverse fabrication strategies and the integration of multiple model materials are explored. OoC samples can be analyzed with many analytical techniques, including mass spectrometry, fluorescence microscopy, ELISAs, impedance spectroscopy, and electrochemical techniques. The future of reproductive OoC models is a promising technology for advancing preterm birth (PTB) research, pharmacology studies, and fertility technologies.<\/jats:p>","DOI":"10.3389\/frlct.2024.1449303","type":"journal-article","created":{"date-parts":[[2024,9,6]],"date-time":"2024-09-06T00:47:29Z","timestamp":1725583649000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":13,"title":["Reproductive organ on-a-chip technologies and assessments of the fetal-maternal interface"],"prefix":"10.3389","volume":"3","author":[{"given":"Hannah A.","family":"Richards","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alison J.","family":"Eastman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dusty R.","family":"Miller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David E.","family":"Cliffel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2024,9,6]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"19201","DOI":"10.1038\/s41598-020-76062-w","article-title":"Establishment of a heart-on-a-chip microdevice based on human IPS cells for the evaluation of human heart tissue function","volume":"10","author":"Abulaiti","year":"2020","journal-title":"Sci. Rep."},{"key":"B2","doi-asserted-by":"publisher","first-page":"121531","DOI":"10.1016\/J.BIOMATERIALS.2022.121531","article-title":"Brain-on-a-Chip: recent advances in design and techniques for microfluidic models of the brain in Health and disease","volume":"285","author":"Amirifar","year":"2022","journal-title":"Biomaterials"},{"key":"B3","first-page":"98","article-title":"Thalidomide and the titanic: reconstructing the technology tragedies of the twentieth century","volume":"89","author":"Annas","year":"1999","journal-title":"J. Public Health"},{"key":"B4","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1016\/J.ADDR.2020.08.010","article-title":"Microphysiological systems of the placental barrier","author":"Arumugasaamy","year":"2020","journal-title":"Adv. Drug Deliv. Rev."},{"key":"B5","doi-asserted-by":"publisher","first-page":"1073","DOI":"10.1016\/J.KINT.2018.06.034","article-title":"Kidney-on-a-Chip: untapped opportunities","volume":"94","author":"Ashammakhi","year":"2018","journal-title":"Kidney Int."},{"key":"B6","first-page":"988","article-title":"Immunology at the maternal-fetal interface","volume-title":"Textbook of perinatal medicine","author":"Balasundaram","year":"2023"},{"key":"B7","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1080\/07388551.2022.2034733","article-title":"The revolution of PDMS microfluidics in cellular biology","volume":"43","author":"Banik","year":"2022","journal-title":"Crit. Rev. Biotechnol."},{"key":"B8","doi-asserted-by":"publisher","first-page":"FSO63","DOI":"10.4155\/FSO.15.63","article-title":"Animal models are essential to biological research: issues and perspectives","volume":"1","author":"Barr\u00e9-Sinoussi","year":"2015","journal-title":"Future Sci. OA"},{"key":"B9","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1016\/J.THERIOGENOLOGY.2007.09.021","article-title":"The pregnant sheep as a model for human pregnancy","volume":"69","author":"Barry","year":"2008","journal-title":"Theriogenology"},{"key":"B10","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1016\/B978-0-12-801238-3.64686-X","article-title":"Allantois","author":"Bazer","year":"2018","journal-title":"Encycl. Reproduction"},{"key":"B11","doi-asserted-by":"publisher","first-page":"115","DOI":"10.3390\/bioengineering7030115","article-title":"Innovative human three-dimensional tissue-engineered models as an alternative to animal testing","volume":"7","author":"B\u00e9dard","year":"2020","journal-title":"Bioengineering"},{"key":"B12","doi-asserted-by":"publisher","first-page":"1801307","DOI":"10.1002\/ADHM.201801307","article-title":"Simulating inflammation in a wound microenvironment using a dermal wound-on-a-chip model","volume":"8","author":"Biglari","year":"2019","journal-title":"Adv. Healthc. Mater."},{"key":"B13","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/J.BIOCEL.2004.05.014","article-title":"The human cytotrophoblastic cell, a mononuclear chameleon","volume":"37","author":"Bischof","year":"2005","journal-title":"Int. J. Biochem. & Cell Biol."},{"key":"B14","doi-asserted-by":"publisher","first-page":"1155","DOI":"10.1177\/1535370220924743","article-title":"Tackling rare diseases: clinical trials on chips","volume":"245","author":"Blumenrath","year":"2020","journal-title":"Exp. Biol. Med."},{"key":"B15","doi-asserted-by":"publisher","first-page":"20140066","DOI":"10.1098\/RSTB.2014.0066","article-title":"The placenta: a multifaceted, transient organ","volume":"370","author":"Burton","year":"2015","journal-title":"Philosophical Trans. R. Soc. B Biol. Sci."},{"key":"B16","doi-asserted-by":"publisher","first-page":"1509","DOI":"10.1152\/physrev.00029.2015","article-title":"Placental origins of chronic disease","volume":"96","author":"Burton","year":"2016","journal-title":"Physiol. Rev."},{"key":"B17","doi-asserted-by":"publisher","first-page":"1573","DOI":"10.3390\/mi13101573","article-title":"PDMS organ-on-chip design and fabrication: strategies for improving fluidic integration and chip robustness of rapidly prototyped microfluidic in vitro models","volume":"13","author":"Cameron","year":"2022","journal-title":"Micromachines"},{"key":"B18","volume-title":"Human embryology and developmental biology","author":"Carlson","year":"2023"},{"key":"B19","doi-asserted-by":"publisher","first-page":"R129","DOI":"10.1530\/REP-20-0354","article-title":"Animal models of human pregnancy and placentation: alternatives to the mouse","volume":"160","author":"Carter","year":"2020","journal-title":"Reproduction"},{"key":"B20","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1016\/S0010-7824(98)00059-6","article-title":"Contraceptive testing of vaginal agents in rabbits","volume":"58","author":"Castle","year":"1998","journal-title":"Contraception"},{"key":"B21","doi-asserted-by":"publisher","first-page":"884","DOI":"10.3390\/MI12080884","article-title":"Modelling the human placental interface in vitro\u2014a review","volume":"12","author":"Cherubini","year":"2021","journal-title":"Micromachines"},{"key":"B22","doi-asserted-by":"publisher","first-page":"362","DOI":"10.1007\/S13206-021-00035-Y","article-title":"A PDMS-based interdigitated platform for trophoblast invasion study under oxygen stress conditions","volume":"15","author":"Cho","year":"2021","journal-title":"Biochip J."},{"key":"B23","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1016\/J.SEMCDB.2022.03.039","article-title":"Human placental development and function","volume":"131","author":"Cindrova-Davies","year":"2022","journal-title":"Seminars Cell & Dev. Biol."},{"key":"B24","doi-asserted-by":"publisher","first-page":"848","DOI":"10.1016\/J.AJOG.2020.09.044","article-title":"Management of clinical chorioamnionitis: an evidence-based approach","volume":"223","author":"Conde-Agudelo","year":"2020","journal-title":"Am. J. Obstetrics Gynecol."},{"key":"B25","doi-asserted-by":"publisher","first-page":"1304","DOI":"10.1111\/J.1469-0691.2011.03574.X","article-title":"Chorioamnionitis: from pathogenesis to treatment","volume":"17","author":"Czikk","year":"2011","journal-title":"Clin. Microbiol. Infect."},{"key":"B26","doi-asserted-by":"publisher","first-page":"1197","DOI":"10.1016\/S0140-6736(97)09038-7","article-title":"Thalidomide: was the tragedy preventable?","volume":"351","author":"Dally","year":"1998","journal-title":"Lancet"},{"key":"B27","doi-asserted-by":"publisher","first-page":"G188","DOI":"10.1152\/AJPGI.00346.2021","article-title":"Liver-on-a-Chip devices: the pros and cons of complexity","volume":"323","author":"Dalsbecker","year":"2022","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"B28","doi-asserted-by":"publisher","first-page":"160403","DOI":"10.1016\/J.SCITOTENV.2022.160403","article-title":"Experimental human placental models for studying uptake, transport and toxicity of micro- and nanoplastics","volume":"860","author":"Dusza","year":"2023","journal-title":"Sci. Total Environ."},{"key":"B29","doi-asserted-by":"publisher","first-page":"266","DOI":"10.1152\/physiol.00036.2016","article-title":"Modeling physiological events in 2D vs. 3D cell culture","volume":"32","author":"Duval","year":"2017","journal-title":"Physiology"},{"key":"B30","doi-asserted-by":"publisher","first-page":"2795","DOI":"10.1080\/14767058.2020.1802716","article-title":"Leveraging bioengineering to assess cellular functions and communication within human fetal membranes","author":"Eastman","year":"2022","journal-title":"J. Maternal-Fetal Neonatal Med."},{"key":"B31","doi-asserted-by":"publisher","first-page":"e13352","DOI":"10.1111\/aji.13352","article-title":"Cytotrophoblasts suppress macrophage-mediated inflammation through a contact-dependent mechanism","volume":"85","author":"Eastman","year":"2021","journal-title":"Am. J. Reproductive Immunol."},{"key":"B32","doi-asserted-by":"publisher","first-page":"4315","DOI":"10.3390\/JCM12134315","article-title":"Placenta-on-a-Chip as an in vitro approach to evaluate the physiological and structural characteristics of the human placental barrier upon drug exposure: a systematic review","volume":"12","author":"Elzinga","year":"2023","journal-title":"J. Clin. Med."},{"key":"B33","doi-asserted-by":"publisher","first-page":"225","DOI":"10.3390\/BIOS14050225","article-title":"A comprehensive review of organ-on-a-chip technology and its applications","volume":"14","author":"Farhang Doost","year":"2024","journal-title":"Biosens. (Basel)"},{"key":"B34","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1039\/D2LC01132H","article-title":"Bioinspired human stomach-on-a-chip with in vivo like function and architecture","volume":"23","author":"Ferreira","year":"2023","journal-title":"Lab. Chip"},{"key":"B35","doi-asserted-by":"publisher","first-page":"1668","DOI":"10.3390\/POLYM14091668","article-title":"Applications of polymers for organ-on-chip technology in urology","volume":"14","author":"Galateanu","year":"2022","journal-title":"Polymers"},{"key":"B36","doi-asserted-by":"publisher","first-page":"771818","DOI":"10.3389\/FPHAR.2021.771818","article-title":"Organic anion transporting polypeptide 2B1 in human fetal membranes: a novel gatekeeper for drug transport during pregnancy?","volume":"12","author":"Ganguly","year":"2021","journal-title":"Front. Pharmacol."},{"key":"B37","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1146\/ANNUREV-CELLBIO-022020-024900","article-title":"Human embryogenesis: a comparative perspective","volume":"36","author":"Gerri","year":"2020","journal-title":"Annu. Rev. Cell Dev. Biol."},{"key":"B38","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1007\/s00018-022-04648-w","article-title":"A placenta-on-a-chip model to determine the regulation of FKBPL and galectin-3 in preeclampsia","volume":"80","author":"Ghorbanpour","year":"2023","journal-title":"Cell. Mol. Life Sci."},{"key":"B39","doi-asserted-by":"publisher","first-page":"6115","DOI":"10.2174\/1381612823666170825142649","article-title":"Instrumenting a fetal membrane on a chip as emerging technology for preterm birth research","volume":"23","author":"Gnecco","year":"2018","journal-title":"Curr. Pharm. Des."},{"key":"B40","doi-asserted-by":"publisher","first-page":"1758","DOI":"10.1007\/s10439-017-1797-5","article-title":"Compartmentalized culture of perivascular stroma and endothelial cells in a microfluidic model of the human endometrium","volume":"45","author":"Gnecco","year":"2017","journal-title":"Ann. Biomed. Eng."},{"key":"B41","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1016\/J.THROMRES.2004.06.038","article-title":"Growth and function of the normal human placenta","volume":"114","author":"Gude","year":"2004","journal-title":"Thrombosis Res."},{"key":"B42","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/BS.PMBTS.2016.12.001","article-title":"Comparative placental anatomy: divergent structures serving a common purpose","volume":"145","author":"Hafez","year":"2017","journal-title":"Prog. Mol. Biol. Transl. Sci."},{"key":"B43","doi-asserted-by":"publisher","first-page":"3","DOI":"10.22037\/EMERGENCY.V5I1.11281","article-title":"Epidemiology and related risk factors of preterm labor as an obstetrics emergency","volume":"5","author":"Halimiasl","year":"2017","journal-title":"Emergency"},{"key":"B44","doi-asserted-by":"publisher","first-page":"946","DOI":"10.1203\/01.PDR.0000182592.76702.E8","article-title":"Circulating interferon-gamma and white matter brain damage in preterm infants","volume":"58","author":"Hansen-Pupp","year":"2005","journal-title":"Pediatr. Res."},{"key":"B45","doi-asserted-by":"publisher","first-page":"206","DOI":"10.1097\/NMC.0B013E3182836BB7","article-title":"Chorioamnionitis: prevention and management","volume":"38","author":"Hastings-Tolsma","year":"2013","journal-title":"MCN Am. J. Maternal\/Child Nurs."},{"key":"B46","doi-asserted-by":"publisher","first-page":"2549","DOI":"10.3390\/IJMS23052549","article-title":"Alternative brain slice-on-a-chip for organotypic culture and effective fluorescence injection testing","volume":"23","author":"Herreros","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"B47","article-title":"Placenta","author":"Herrick","year":"2023","journal-title":"StatPearls"},{"key":"B48","doi-asserted-by":"publisher","first-page":"962","DOI":"10.1038\/s41467-024-45279-y","article-title":"Trophoblast stem cell-based organoid models of the human placental barrier","volume":"15","author":"Hori","year":"2024","journal-title":"Nat. Commun."},{"key":"B49","doi-asserted-by":"publisher","first-page":"467","DOI":"10.1038\/s41576-022-00466-9","article-title":"Human organs-on-chips for disease modelling, drug development and personalized medicine","volume":"23","author":"Ingber","year":"2022","journal-title":"Nat. Rev. Genet."},{"key":"B50","doi-asserted-by":"publisher","first-page":"53","DOI":"10.2147\/SCCAA.S58696","article-title":"Amniotic membrane-derived stem cells: immunomodulatory properties and potential clinical application","volume":"7","author":"Insausti","year":"2014","journal-title":"Stem Cells Cloning Adv. Appl."},{"key":"B51","doi-asserted-by":"publisher","first-page":"4578","DOI":"10.1038\/s41467-024-48910-0","article-title":"Mucus production, host-microbiome interactions, hormone sensitivity, and innate immune responses modeled in human cervix chips","volume":"15","author":"Izadifar","year":"2024","journal-title":"Nat. Commun."},{"key":"B52","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1038\/S41390-021-01633-0","article-title":"Chorioamnionitis and neonatal outcomes","volume":"91","author":"Jain","year":"2022","journal-title":"Pediatr. Res."},{"key":"B53","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1016\/J.BIOS.2015.08.012","article-title":"Heart-on-a-Chip based on stem cell biology","volume":"75","author":"Jastrzebska","year":"2016","journal-title":"Biosens. Bioelectron."},{"key":"B54","doi-asserted-by":"publisher","first-page":"33","DOI":"10.3389\/FMOLB.2020.00033","article-title":"Is it time to start transitioning from 2D to 3D cell culture?","volume":"7","author":"Jensen","year":"2020","journal-title":"Front. Mol. Biosci."},{"key":"B55","doi-asserted-by":"publisher","first-page":"1241815","DOI":"10.3389\/fphar.2023.1241815","article-title":"Microfluidic technology and simulation models in studying pharmacokinetics during pregnancy","volume":"14","author":"Kammala","year":"2023","journal-title":"Front. Pharmacol."},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1002\/9781444393927","article-title":"The placenta: from development to disease","author":"Kay","year":"2011","journal-title":"Placenta Dev. Dis."},{"key":"B57","doi-asserted-by":"publisher","first-page":"126759","DOI":"10.1016\/J.JHAZMAT.2021.126759","article-title":"Molecular mechanisms of environmental toxin cadmium at the feto-maternal interface investigated using an organ-on-chip (FMi-OOC) model","volume":"422","author":"Kim","year":"2022","journal-title":"J. Hazard. Mater."},{"key":"B58","doi-asserted-by":"publisher","first-page":"2216","DOI":"10.3390\/MI13122216","article-title":"Trophoblast migration with different oxygen levels in a gel-patterned microfluidic system","volume":"13","author":"Ko","year":"2022","journal-title":"Micromachines"},{"key":"B59","doi-asserted-by":"publisher","first-page":"5392","DOI":"10.1038\/s41467-022-32916-7","article-title":"Streptococcus agalactiae CadD alleviates metal stress and promotes intracellular survival in macrophages and ascending infection during pregnancy","volume":"13","author":"Korir","year":"2022","journal-title":"Nat. Commun."},{"key":"B60","doi-asserted-by":"publisher","first-page":"2581","DOI":"10.1039\/C7LC00488E","article-title":"Thermoplastic elastomer with advanced hydrophilization and bonding performances for rapid (30 s) and easy molding of microfluidic devices","volume":"17","author":"Lachaux","year":"2017","journal-title":"Lab. Chip"},{"key":"B61","doi-asserted-by":"publisher","first-page":"1046","DOI":"10.3109\/14767058.2015.1038518","article-title":"Placenta-on-A-Chip: a novel platform to study the biology of the human placenta","volume":"29","author":"Lee","year":"2016","journal-title":"J. Maternal-Fetal & Neonatal Med."},{"key":"B62","doi-asserted-by":"publisher","first-page":"3079","DOI":"10.1039\/C8LC00910D","article-title":"Human stomach-on-a-chip with luminal flow and peristaltic-like motility","volume":"18","author":"Lee","year":"2018","journal-title":"Lab. Chip"},{"key":"B63","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1097\/BTO.0000000000000229","article-title":"Dehydrated human amnion\/chorion membrane (DHACM) allografts as a therapy for orthopedic tissue repair","volume":"32","author":"Lei","year":"2017","journal-title":"Tech. Orthop."},{"key":"B64","doi-asserted-by":"publisher","first-page":"107240","DOI":"10.1016\/J.ISCI.2023.107240","article-title":"Development of a human IPSC-derived placental barrier-on-chip model","volume":"26","author":"Lermant","year":"2023","journal-title":"iScience"},{"key":"B65","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1038\/s43586-022-00118-6","article-title":"A guide to the organ-on-a-chip","volume":"2","author":"Leung","year":"2022","journal-title":"Nat. Rev. Methods Prim."},{"key":"B66","doi-asserted-by":"publisher","first-page":"959299","DOI":"10.3389\/FONC.2022.959299","article-title":"Design and fabrication of a liver-on-a-chip reconstructing tissue-tissue interfaces","volume":"12","author":"Liu","year":"2022","journal-title":"Front. Oncol."},{"key":"B67","doi-asserted-by":"publisher","first-page":"430","DOI":"10.1016\/S0140-6736(14)61698-6","article-title":"Global, regional, and national causes of Child mortality in 2000-13, with projections to inform post-2015 priorities: an updated systematic analysis","volume":"385","author":"Liu","year":"2015","journal-title":"Lancet"},{"key":"B68","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1016\/J.TIPS.2020.11.009","article-title":"Organ-on-a-Chip: a new paradigm for drug development","volume":"42","author":"Ma","year":"2021","journal-title":"Trends Pharmacol. Sci."},{"key":"B69","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1186\/s40168-022-01400-1","article-title":"Vaginal microbiome-host interactions modeled in a human vagina-on-a-chip","volume":"10","author":"Mahajan","year":"2022","journal-title":"Microbiome"},{"key":"B70","doi-asserted-by":"publisher","first-page":"1016","DOI":"10.1172\/JCI41211","article-title":"The placenta: transcriptional, epigenetic, and physiological integration during development","volume":"120","author":"Maltepe","year":"2010","journal-title":"J. Clin. Invest"},{"key":"B71","doi-asserted-by":"publisher","first-page":"144","DOI":"10.18063\/IJB.V4I2.144","article-title":"Fabrication of biomimetic placental barrier structures within a microfluidic device utilizing two-photon polymerization","volume":"4","author":"Mandt","year":"2024","journal-title":"Int. J. Bioprinting"},{"key":"B72","doi-asserted-by":"publisher","first-page":"8922","DOI":"10.1038\/s41598-023-36020-8","article-title":"A platform to reproducibly evaluate human colon permeability and damage","volume":"13","author":"Marr","year":"2023","journal-title":"Sci. Rep."},{"key":"B73","doi-asserted-by":"publisher","first-page":"5462","DOI":"10.1016\/J.BIOMATERIALS.2014.03.052","article-title":"Micromolded gelatin hydrogels for extended culture of engineered cardiac tissues","volume":"35","author":"McCain","year":"2014","journal-title":"Biomaterials"},{"key":"B74","doi-asserted-by":"publisher","first-page":"G178","DOI":"10.1149\/2.0711916jes","article-title":"Communication\u2014microfluidic electrochemical acetylcholine detection in the presence of chlorpyrifos","volume":"166","author":"McClain","year":"2019","journal-title":"J. Electrochem Soc."},{"key":"B75","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1053\/J.SEMPERI.2017.07.012","article-title":"Preterm prelabor rupture of the membranes: a disease of the fetal membranes","volume":"41","author":"Menon","year":"2017","journal-title":"Seminars Perinatology"},{"key":"B76","doi-asserted-by":"publisher","first-page":"15278","DOI":"10.1038\/S41598-022-19422-Y","article-title":"3D microfluidics-assisted modeling of glucose transport in placental malaria","volume":"12","author":"Mosavati","year":"2022","journal-title":"Sci. Rep."},{"key":"B77","doi-asserted-by":"publisher","first-page":"8755","DOI":"10.3390\/IJMS21228755","article-title":"Development of an organ-on-a-chip-device for study of placental pathologies","volume":"21","author":"Mosavati","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"B78","doi-asserted-by":"publisher","first-page":"3576","DOI":"10.1021\/ACSABM.2C00041","article-title":"Advances in organ-on-a-chip materials and devices","volume":"5","author":"Nahak","year":"2022","journal-title":"ACS Appl. Bio Mater"},{"key":"B79","doi-asserted-by":"publisher","first-page":"459","DOI":"10.1039\/C3LC51160J","article-title":"Oxygen levels in thermoplastic microfluidic devices during cell culture","volume":"14","author":"Ochs","year":"2014","journal-title":"Lab. Chip"},{"key":"B80","doi-asserted-by":"publisher","first-page":"4814","DOI":"10.1039\/D1LC00744K","article-title":"Rapid prototyping of cell culture microdevices using parylene-coated 3D prints","volume":"21","author":"O\u2019Grady","year":"2021","journal-title":"Lab. Chip"},{"key":"B81","doi-asserted-by":"publisher","first-page":"891","DOI":"10.3389\/FPHYS.2020.00891","article-title":"Interleukin (IL)-6: a friend or foe of pregnancy and parturition? Evidence from functional studies in fetal membrane cells","volume":"11","author":"Omere","year":"2020","journal-title":"Front. Physiol."},{"key":"B83","doi-asserted-by":"publisher","first-page":"2273","DOI":"10.1021\/acsabm.2c00121","article-title":"Transport of maternally administered pharmaceutical agents across the placental barrier in vitro","volume":"5","author":"Pemathilaka","year":"2022","journal-title":"ACS Appl. Bio Mater"},{"key":"B84","doi-asserted-by":"publisher","first-page":"1800112","DOI":"10.1002\/GCH2.201800112","article-title":"Placenta-on-a-Chip: in vitro study of caffeine transport across placental barrier using liquid chromatography mass spectrometry","volume":"3","author":"Pemathilaka","year":"","journal-title":"Glob. Challenges"},{"key":"B85","doi-asserted-by":"publisher","first-page":"20190031","DOI":"10.1098\/RSFS.2019.0031","article-title":"Drug transport across the human placenta: review of placenta-on-a-chip and previous approaches","volume":"9","author":"Pemathilaka","year":"","journal-title":"Interface Focus"},{"key":"B86","doi-asserted-by":"publisher","first-page":"20190031","DOI":"10.1098\/RSFS.2019.0031","article-title":"Drug transport across the human placenta: review of placenta-on-a-chip and previous approaches","volume":"9","author":"Pemathilaka","year":"","journal-title":"Interface Focus"},{"key":"B87","doi-asserted-by":"publisher","first-page":"788","DOI":"10.1016\/J.TIBTECH.2020.11.014","article-title":"Multiorgan-on-a-Chip: a systemic approach to model and decipher inter-organ communication","volume":"39","author":"Picollet-D\u2019hahan","year":"2021","journal-title":"Trends Biotechnol."},{"key":"B88","doi-asserted-by":"publisher","first-page":"265","DOI":"10.3390\/MI10040265","article-title":"Gelatin-coated microfluidic channels for 3D microtissue formation: on-chip production and characterization","volume":"10","author":"Pitingolo","year":"2019","journal-title":"Micromachines"},{"key":"B89","doi-asserted-by":"publisher","first-page":"546","DOI":"10.1039\/D0LC01013H","article-title":"A 3-dimensional microfluidic platform for modeling human extravillous trophoblast invasion and toxicological screening","volume":"21","author":"Pu","year":"2021","journal-title":"Lab. Chip"},{"key":"B90","doi-asserted-by":"publisher","first-page":"1956","DOI":"10.1039\/D0LC01323D","article-title":"Extracellular vesicle mediated feto-maternal HMGB1 signaling induces preterm birth","volume":"21","author":"Radnaa","year":"2021","journal-title":"Lab. Chip"},{"key":"B91","doi-asserted-by":"publisher","DOI":"10.1038\/NATURE.2017.21712","article-title":"Mini reproductive system on a chip mimics human menstrual cycle","author":"Reardon","year":"2017","journal-title":"Nature"},{"key":"B92","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1016\/J.SINY.2011.08.003","article-title":"Inflammatory response in acute chorioamnionitis","volume":"17","author":"Redline","year":"2012","journal-title":"Seminars Fetal Neonatal Med."},{"key":"B93","doi-asserted-by":"publisher","first-page":"8945","DOI":"10.1096\/fj.201900020RR","article-title":"Amnion membrane organ-on-chip: an innovative approach to study cellular interactions","volume":"33","author":"Richardson","year":"2019","journal-title":"FASEB J."},{"key":"B94","doi-asserted-by":"publisher","first-page":"715","DOI":"10.3389\/FPHYS.2020.00715","article-title":"Organ-on-chip technology: the future of feto-maternal interface research?","volume":"11","author":"Richardson","year":"","journal-title":"Front. Physiol."},{"key":"B95","doi-asserted-by":"publisher","DOI":"10.54844\/PRM.2022.0104","article-title":"Fetal membrane at the feto-maternal interface: an underappreciated and understudied intrauterine tissue","volume":"1","author":"Richardson","year":"2022","journal-title":"Placenta reproductive Med."},{"key":"B96","doi-asserted-by":"publisher","first-page":"4486","DOI":"10.1039\/D0LC00875C","article-title":"Modeling ascending infection with a feto-maternal interface organ-on-chip","volume":"20","author":"Richardson","year":"","journal-title":"Lab. Chip"},{"key":"B126","doi-asserted-by":"publisher","first-page":"1570","DOI":"10.1007\/s43032-020-00184-9","article-title":"Fetal membrane organ-on-chip: an innovative approach to study cellular interactions","volume":"27","author":"Richardson","year":"","journal-title":"Reprod. Sci."},{"key":"B97","doi-asserted-by":"publisher","first-page":"4574","DOI":"10.1039\/D2LC00691J","article-title":"Testing of drugs using human feto-maternal interface organ-on-chips provide insights into pharmacokinetics and efficacy","volume":"22","author":"Richardson","year":"2022","journal-title":"Lab. Chip"},{"key":"B98","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/J.IJSU.2019.10.015","article-title":"The current state of animal models in research: a review","volume":"72","author":"Robinson","year":"2019","journal-title":"Int. J. Surg."},{"key":"B99","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1016\/J.DEVCEL.2021.12.022","article-title":"Early human embryonic development: blastocyst Formation to gastrulation","volume":"57","author":"Rossant","year":"2022","journal-title":"Dev. Cell"},{"key":"B100","doi-asserted-by":"publisher","first-page":"100035","DOI":"10.1016\/J.VESIC.2024.100035","article-title":"A multi-organ, feto-maternal interface organ-on-chip, models pregnancy pathology and is a useful preclinical extracellular vesicle drug trial platform","volume":"3","author":"Safarzadeh","year":"","journal-title":"Extracell. vesicle"},{"key":"B101","doi-asserted-by":"publisher","first-page":"100035","DOI":"10.1016\/J.VESIC.2024.100035","article-title":"A multi-organ, feto-maternal interface organ-on-chip, models pregnancy pathology and is a useful preclinical extracellular vesicle drug trial platform","volume":"3","author":"Safarzadeh","year":"","journal-title":"Extracell. vesicle"},{"key":"B102","doi-asserted-by":"publisher","first-page":"127946","DOI":"10.1016\/J.SNB.2020.127946","article-title":"A lab-on-a-chip system with an embedded porous membrane-based impedance biosensor array for nanoparticle risk assessment on placental bewo trophoblast cells","volume":"312","author":"Schuller","year":"2020","journal-title":"Sensors Actuators B Chem."},{"key":"B103","doi-asserted-by":"publisher","first-page":"dev190629","DOI":"10.1242\/DEV.190629","article-title":"Mechanisms of human embryo development: from cell fate to tissue shape and back","volume":"147","author":"Shahbazi","year":"2020","journal-title":"Development"},{"key":"B104","doi-asserted-by":"publisher","DOI":"10.1101\/2021.01.03.424836","article-title":"Dynamic persistence of intracellular bacterial communities of uropathogenic Escherichia coli in a human bladder-chip model of urinary tract infections","author":"Sharma","year":"2021","journal-title":"bioRxiv"},{"key":"B105","doi-asserted-by":"publisher","first-page":"1912","DOI":"10.3390\/IJMS24031912","article-title":"Fabrication and characterization techniques of in vitro 3D tissue models","volume":"24","author":"Shyam","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"B106","doi-asserted-by":"publisher","first-page":"100246","DOI":"10.1016\/J.APSADV.2022.100246","article-title":"Journey of organ on a chip technology and its role in future healthcare scenario","volume":"9","author":"Singh","year":"2022","journal-title":"Appl. Surf. Sci. Adv."},{"key":"B107","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1021\/acsbiomaterials.2c01080","article-title":"Translational nanomedicines across human reproductive organs modeling on microfluidic chips: state-of-the-art and future prospects","volume":"9","author":"Sood","year":"2023","journal-title":"ACS Biomater. Sci. Eng."},{"key":"B108","doi-asserted-by":"publisher","first-page":"536","DOI":"10.3390\/MI9100536","article-title":"Organs-on-a-Chip module: a review from the development and applications perspective","volume":"9","author":"Sosa-Hern\u00e1ndez","year":"2018","journal-title":"Micromachines (Basel)"},{"key":"B109","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1016\/J.BIOTNO.2024.01.001","article-title":"Organ-on-Chip technology: opportunities and challenges","volume":"5","author":"Srivastava","year":"2024","journal-title":"Biotechnol. Notes"},{"key":"B110","doi-asserted-by":"publisher","first-page":"2000066","DOI":"10.1002\/ANBR.202000066","article-title":"3D cell culture\u2014can it Be as popular as 2D cell culture?","volume":"1","author":"Sun","year":"2021","journal-title":"Adv. NanoBiomed Res."},{"key":"B111","doi-asserted-by":"publisher","first-page":"1139229","DOI":"10.3389\/FPHAR.2023.1139229","article-title":"Revolutionizing drug development: harnessing the potential of organ-on-chip technology for disease modeling and drug discovery","volume":"14","author":"Sunildutt","year":"2023","journal-title":"Front. Pharmacol."},{"key":"B112","doi-asserted-by":"publisher","first-page":"931609","DOI":"10.3389\/FCELL.2022.931609","article-title":"Exosomes from Ureaplasma parvum-infected ectocervical epithelial cells promote feto-maternal interface inflammation but are insufficient to cause preterm delivery","volume":"10","author":"Tantengco","year":"2022","journal-title":"Front. Cell Dev. Biol."},{"key":"B113","doi-asserted-by":"publisher","first-page":"420","DOI":"10.3390\/mi13030420","article-title":"Electrochemical glue for binding chitosan\u2013alginate hydrogel fibers for cell culture","volume":"13","author":"Utagawa","year":"2022","journal-title":"Micromachines"},{"key":"B114","doi-asserted-by":"publisher","first-page":"845","DOI":"10.1016\/J.JACBTS.2019.10.008","article-title":"Limitations of animal studies for predicting toxicity in clinical trials: is it time to rethink our current approach?","volume":"4","author":"Van Norman","year":"2019","journal-title":"JACC Basic Transl. Sci."},{"key":"B115","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1002\/IJGO.13195","article-title":"Global burden of preterm birth","volume":"150","author":"Walani","year":"2020","journal-title":"Int. J. Gynecol. & Obstetrics"},{"key":"B116","doi-asserted-by":"publisher","first-page":"6889","DOI":"10.3390\/S22186889","article-title":"Kidney-on-a-Chip: mechanical stimulation and sensor integration","volume":"22","author":"Wang","year":"2022","journal-title":"Sensors"},{"key":"B117","doi-asserted-by":"publisher","first-page":"1061","DOI":"10.1177\/1535370214542068","article-title":"The relevance and potential roles of microphysiological systems in biology and medicine","volume":"239","author":"Wikswo","year":"2014","journal-title":"Exp. Biol. Med."},{"key":"B118","doi-asserted-by":"publisher","first-page":"14584","DOI":"10.1038\/ncomms14584","article-title":"A microfluidic culture model of the human reproductive tract and 28-day menstrual cycle","volume":"8","author":"Xiao","year":"2017","journal-title":"Nat. Commun."},{"key":"B119","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1039\/D3LC00737E","article-title":"Faster sperm selected by rheotaxis leads to superior early embryonic development in vitro","volume":"24","author":"Yaghoobi","year":"2024","journal-title":"Lab. Chip"},{"key":"B120","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1016\/J.PLACENTA.2024.01.006","article-title":"Visual identification of three kinds of human decidual tissues from elective termination of pregnancy","volume":"146","author":"Yin","year":"2024","journal-title":"Placenta"},{"key":"B121","doi-asserted-by":"publisher","first-page":"461","DOI":"10.1016\/J.ADDR.2021.03.010","article-title":"Organ-on-a-Chip technology for the study of the female reproductive system","volume":"173","author":"Young","year":"2021","journal-title":"Adv. Drug Deliv. Rev."},{"key":"B122","doi-asserted-by":"publisher","first-page":"e2000526","DOI":"10.1002\/adbi.202000526","article-title":"Human organs-on-chips: a review of the state-of-the-art, current prospects, and future challenges","volume":"6","author":"Zarrintaj","year":"2022","journal-title":"Adv. Biol."},{"key":"B123","doi-asserted-by":"publisher","first-page":"017002","DOI":"10.35848\/1347-4065\/ACA265","article-title":"Microfabrication of polydimethylsiloxane\u2013parylene hybrid microelectrode array integrated into a multi-organ-on-a-chip","volume":"62","author":"Zhang","year":"2022","journal-title":"Jpn. J. Appl. Phys."},{"key":"B124","doi-asserted-by":"publisher","first-page":"1107182","DOI":"10.3389\/fendo.2023.1107182","article-title":"Regulators involved in trophoblast syncytialization in the placenta of intrauterine growth restriction","volume":"14","author":"Zhou","year":"2023","journal-title":"Front. Endocrinol."},{"key":"B125","doi-asserted-by":"publisher","first-page":"3356","DOI":"10.1021\/acsbiomaterials.8b00653","article-title":"Placental barrier-on-a-chip: modeling placental inflammatory responses to bacterial infection","volume":"4","author":"Zhu","year":"2018","journal-title":"ACS Biomater. Sci. Eng."}],"container-title":["Frontiers in Lab on a Chip Technologies"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/frlct.2024.1449303\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,6]],"date-time":"2024-09-06T00:47:38Z","timestamp":1725583658000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/frlct.2024.1449303\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,6]]},"references-count":125,"alternative-id":["10.3389\/frlct.2024.1449303"],"URL":"https:\/\/doi.org\/10.3389\/frlct.2024.1449303","relation":{},"ISSN":["2813-3862"],"issn-type":[{"value":"2813-3862","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,9,6]]},"article-number":"1449303"}}